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Palo Alto Investors, LLC Portfolio Analytics

Investment Analysis & Holdings Breakdown

Comprehensive portfolio analytics for Palo Alto Investors, LLC with $540.4M in long positions as of Q3 2025, 98% allocated to Healthcare, and 67% concentrated in top 10 positions.

Portfolio Value
$540.4M
Top 10 Concentration
67%
Top Sector
Healthcare (98%)
US Exposure
93%
Market Cap Focus
Mid Cap
Countries
5

Composition Analysis

Portfolio breakdown by sector, industry, and market capitalization

Sector Allocation

Healthcare: 97.90%HealthcareFinancial Services: 1.20%
Healthcare
97.90%
Financial Services
1.20%

Industry Breakdown

8 industries across all sectors

Biotechnology: 86.50%BiotechnologyDrug Manufacturers - General: 4.81%Medical - Instruments & Supplies: 3.00%Medical - Devices: 1.54%Medical - Diagnostics & Research: 1.40%Insurance - Brokers: 1.23%2 more: 0.66%
Biotechnology
Healthcare
86.50%
Drug Manufacturers - General
Healthcare
4.81%
Medical - Instruments & Supplies
Healthcare
3.00%
Medical - Devices
Healthcare
1.54%
Medical - Diagnostics & Research
Healthcare
1.40%
Insurance - Brokers
Financial Services
1.23%
Drug Manufacturers - Specialty & Generic
Healthcare
0.47%
Medical - Healthcare Plans
Healthcare
0.19%

Filter by Sector

Select a sector to filter industries

Market Cap Distribution

Large Cap ($10B - $200B): 33.86%Large Cap ($10B - $200B)Mid Cap ($2B - $10B): 40.06%Mid Cap ($2B - $10B)Small Cap ($300M - $2B): 22.97%Small Cap ($300M - $2B)Micro Cap ($50M - $300M): 2.39%Nano Cap (< $50M): 0.02%N/A (ETF or Unknown): 0.70%
Large Cap ($10B - $200B)
33.86%
Mid Cap ($2B - $10B)
40.06%
Small Cap ($300M - $2B)
22.97%
Micro Cap ($50M - $300M)
2.39%
Nano Cap (< $50M)
0.02%
N/A (ETF or Unknown)
0.70%

Portfolio Concentration

Top 10 Holdings %
67.23%
Top 20 Holdings %
88.93%
Top 50 Holdings %
100.0%
Top 100 Holdings %
100.0%

Geographic Exposure

Portfolio breakdown by country of incorporation

Domestic (US)
93.02%
International
6.98%
Countries
5
Largest Int'l Market
Ireland - 3.41%
United States of America
93.02% ($502.6M)
39 holdings
Ireland
3.41% ($18.4M)
2 holdings
Jersey
3.00% ($16.2M)
1 holdings
Switzerland
0.49% ($2.7M)
1 holdings
Netherlands
0.07% ($402.2K)
1 holdings

Holding Behavior

Investment patterns and position management analysis

Portfolio Stability & Commitment

Avg. Top 10
29.4 quarters
Avg. Top 20
21 quarters
Avg. All Positions
14.4 quarters
Median Holding Period
6 quarters
Persistence Rate
72.73%
Persistent Holdings Weight
86.23%
Persistent Positions
32
Longest Held
Prothena Corporation plc Ordinary Shares logo
Prothena Corporation plc Ordinary SharesPRTA - 49 quarters

Position Sizing & Influence

Current Quarter

Avg. New Position
0.36%
Avg. Position Weight
2.27%
Largest Position
Insmed, Inc. logo
Insmed, Inc.INSM - 13.11%
Largest Ownership Stake
eHealth, Inc. logo
eHealth, Inc.EHTH - 5.05%
Avg. Ownership Stake
0.94%
Ownership Stake >5%
1
Ownership Stake >1%
11

Historical (Since Q2 2013)

Avg. New Position
1.86%
Avg. Ownership Stake
2.91%
Largest Position
United Therapeutics Corp logo
United Therapeutics CorpUTHR - 36.29% (Q4 2013)
Largest Ownership Stake
eHealth, Inc. logo
eHealth, Inc.EHTH - 9.89% (Q2 2023)

Portfolio Turnover

Current Quarter

Turnover Ratio
19.2%
Value Traded
$103.87M
Positions Added
3
Positions Exited
4

Historical (Since Q2 2013)

Avg. Turnover Ratio
6.3%
Avg. Positions Added
3
Avg. Positions Exited
2
Highest Turnover
19.2%
Q3 2025
Lowest Turnover
0.7%
Q3 2022

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