Akari Therapeutics

AKTX • NASDAQ

Akari Therapeutics is a pharmaceutical preparations company on NASDAQ, led by Samir R. Patel, M.D.. As of Q3 2025, 15 institutional investors hold shares in this company, with total holdings valued at $1.2M. Cresset Asset Management, LLC is the largest holder with a position valued at $830.7K.

Chief Executive Officer and principal executive officerSamir R. Patel, M.D.

PHARMACEUTICAL PREPARATIONS

Employees12.0

Websiteakaritx.com

Country

United States of America

Overview

Overview of institutional ownership in AKTX as of Q3 2025

All Institutions

Institutions: 15
Value Held: $1.2M
Shares Held: 1.1M
Avg Position: $77.3K
Median Position: $10.1K

Hedge Funds

Hedge Funds: 1
Value Held: $147.5K
Shares Held: 146.0K
Avg Position: $147.5K
Median Position: $147.5K

Biggest Investors

Institutions with the largest positions in AKTX as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
Cresset Asset Management, LLC RIA/Wealth	Jack Alan Ablin Founder	$830.7K 0.00% of portfolio	0.00% 822.5K shares	Q2 2024 Held for 1y 5m	$25.7B
P Palo Alto Investors, LLC Hedge Fund•Long/Short	Angela Elizabeth Nguyen-Dinh CCO	$147.5K 0.03% of portfolio	0.00% 146.0K shares	Q4 2024 Held for 11 months	$540.4M
HighTower Advisors, LLC RIA/Wealth	Robert David Oros CEO	$80.0K 0.00% of portfolio	0.00% 79.2K shares	Q2 2025 Held for 5 months	$87.7B
Omnia Family Wealth, LLC RIA/Wealth	Steven Alan Wagner CEO	$28.7K 0.01% of portfolio	0.00% 28.4K shares	Q4 2022 Held for 2y 11m	$308.0M
HPM Partners LLC RIA/Wealth	Kurt Patrick Miscinski President	$23.9K 0.00% of portfolio	0.00% 23.6K shares	Q2 2023 Held for 2y 5m	$61.7B
T TWO SIGMA SECURITIES, LLC Institution	-	$20.0K 0.00% of portfolio	0.00% 19.8K shares	Q3 2025 Held for 2 months	$675.6M
Independent Advisor Alliance RIA/Wealth	Robert Paul Russo CEO	$11.0K 0.00% of portfolio	0.00% 10.9K shares	Q3 2025 Held for 2 months	$3.8B
A Accent Capital Management, LLC RIA/Wealth	Nitin Natvarlal Kumbhani CEO	$10.1K 0.00% of portfolio	0.00% 10.0K shares	Q4 2024 Held for 11 months	$233.7M
Goss Wealth Management LLC RIA/Wealth	Alexander Thomas Goss CEO	$6.9K 0.00% of portfolio	0.00% 6.8K shares	Q2 2025 Held for 5 months	$21.8B
Cornerstone Planning Group LLC RIA/Wealth	Christopher Kendall Abts President	$285.0 0.00% of portfolio	0.00% 7.0 shares	Q3 2023 Held for 2y 2m	$611.7M

Net Capital Flow

Institutional buying and selling activity for AKTX in Q3 2025

Traded: +$577.9K
Buyers: 6
Sellers: 3
Total Bought: +$843.2K
Total Sold: −$265.3K
Avg Position: $68.2K

Biggest Buyers

Institution	Net Bought	Current Position
Cresset Asset Management, LLC RIA/Wealth	+$812.1K +804.1K shares	$830.7K 822.5K shares
T TWO SIGMA SECURITIES, LLC Institution	+$20.0K +19.8K shares	$20.0K 19.8K shares
Independent Advisor Alliance RIA/Wealth	+$11.0K +10.9K shares	$11.0K 10.9K shares
Cornerstone Planning Group LLC RIA/Wealth	+$81.4 +2.0 shares	$285.0 7.0 shares
UBS Group AG Institution	+$61.0 +-2.1K shares	$61.0 60.0 shares
E EverSource Wealth Advisors, LLC RIA/Wealth	+$44.0 +-4.3K shares	$44.0 44.0 shares

Biggest Sellers

Institution	Net Sold	Current Position
S SABBY MANAGEMENT, LLC Institution	−$210.3K −179.8K shares	Sold Off 0 shares
Omnia Family Wealth, LLC RIA/Wealth	−$34.6K −34.3K shares	$28.7K 28.4K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	−$20.4K −17.4K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited AKTX in Q3 2025

New Positions: 1
New Value: $11.0K
Exited Positions: 2
Exited Value: $230.7K

New Positions

Institution	Position Value
Independent Advisor Alliance RIA/Wealth	$11.0K 10.9K shares

Exited Positions

Institution	Previous Position
S SABBY MANAGEMENT, LLC Institution	$210.3K 179.8K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	$20.4K 17.4K shares

Options Activity

Institutions with the largest Call and Put options positions in AKTX as of Q3 2025

Call Positions: 0
Call Value: -
Put Positions: 0
Put Value: -

Call Positions

Institution	Position Value
No call positions found

Put Positions

Institution	Position Value
No put positions found

Most Committed Institutions

Institutions with AKTX as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
P Palo Alto Investors, LLC Hedge Fund•Long/Short	Angela Elizabeth Nguyen-Dinh CCO	0.03% $147.5K	0.00% 146.0K shares	Q4 2024 Held for 11 months	$540.4M
Omnia Family Wealth, LLC RIA/Wealth	Steven Alan Wagner CEO	0.01% $28.7K	0.00% 28.4K shares	Q4 2022 Held for 2y 11m	$308.0M
A Accent Capital Management, LLC RIA/Wealth	Nitin Natvarlal Kumbhani CEO	0.00% $10.1K	0.00% 10.0K shares	Q4 2024 Held for 11 months	$233.7M
Cresset Asset Management, LLC RIA/Wealth	Jack Alan Ablin Founder	0.00% $830.7K	0.00% 822.5K shares	Q2 2024 Held for 1y 5m	$25.7B
T TWO SIGMA SECURITIES, LLC Institution	-	0.00% $20.0K	0.00% 19.8K shares	Q3 2025 Held for 2 months	$675.6M
Independent Advisor Alliance RIA/Wealth	Robert Paul Russo CEO	0.00% $11.0K	0.00% 10.9K shares	Q3 2025 Held for 2 months	$3.8B
HighTower Advisors, LLC RIA/Wealth	Robert David Oros CEO	0.00% $80.0K	0.00% 79.2K shares	Q2 2025 Held for 5 months	$87.7B
Cornerstone Planning Group LLC RIA/Wealth	Christopher Kendall Abts President	0.00% $285.0	0.00% 7.0 shares	Q3 2023 Held for 2y 2m	$611.7M
HPM Partners LLC RIA/Wealth	Kurt Patrick Miscinski President	0.00% $23.9K	0.00% 23.6K shares	Q2 2023 Held for 2y 5m	$61.7B
Goss Wealth Management LLC RIA/Wealth	Alexander Thomas Goss CEO	0.00% $6.9K	0.00% 6.8K shares	Q2 2025 Held for 5 months	$21.8B

Hedge Fund Spotlight

Discover hedge funds investing in AKTX

Palo Alto Investors, LLC

Hedge Fund • Long/Short

Portfolio ManagerAngela Elizabeth Nguyen-Dinh

Portfolio Value: $540.4M
Positions: 44
Last Reported: Q3 2025

Sector Allocation

Position in Akari Therapeutics

Market Value: $147.5K
Shares Held: 146.0K
Portfolio Weight: 0.03%
Owned Since: 2024-Q4

Top Holding	Sector	Market Value	Weight
1 Insmed INSM	Biotechnology Healthcare	$70.8M	13.11%
2 PTC Therapeutics PTCT	Biotechnology Healthcare	$52.9M	9.80%
3 Acadia Pharmaceuticals ACAD	Biotechnology Healthcare	$52.6M	9.74%