AnaptysBio, Inc.

ANAB • NASDAQ

AnaptysBio, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by John Doe, with a market cap of $1.2B. As of Q3 2025, 114% of shares are held by 165 institutional investors, with EcoR1 Capital, LLC as the largest holder at 28.17%.

CEOJohn Doe

Market Cap$1.2B

Biotechnology

Healthcare

Employees117.0

Websiteanaptysbio.com

Country

United States of America

Overview

Overview of institutional ownership in ANAB as of Q3 2025 with a market cap of $856.5M

All Institutions

Institutions: 165
Value Held: $980.5M
Shares Held: 31.7M
Avg Position: $5.9M
Median Position: $475.6K

Hedge Funds

Hedge Funds: 32
Value Held: $527.5M
Shares Held: 17.2M
Avg Position: $16.5M
Median Position: $2.0M

Ownership Breakdown

Institutional (non-HF)

52.9%

$453.1M

Hedge Funds

61.58%

$527.5M

Retail & Other

Based on market cap of $856.5M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in ANAB as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
EcoR1 Capital, LLC Hedge Fund•Sector	Scott Eric Perlen CFO	$241.3M 11.58% of portfolio	28.17% 7.9M shares	Q4 2019 Held for 5y 11m	$2.1B
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	Steven Alan Cohen CEO	$69.4M 0.16% of portfolio	8.10% 2.3M shares	Q4 2021 Held for 3y 11m	$43.2B
B BlackRock, Inc. Institution	-	$52.7M 0.00% of portfolio	6.16% 1.7M shares	Q1 2017 Held for 8y 8m	$5.67T
MORGAN STANLEY RIA/Wealth	Jed Finn CEO	$47.7M 0.00% of portfolio	5.56% 1.6M shares	Q1 2017 Held for 8y 8m	$1.65T
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	Dan Michael Berkovitz Chairman	$46.5M 0.04% of portfolio	5.43% 1.5M shares	Q1 2017 Held for 8y 8m	$121.98B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$45.2M 0.00% of portfolio	5.28% 1.5M shares	Q1 2017 Held for 8y 8m	$6.69T
T TANG CAPITAL MANAGEMENT LLC Institution	-	$40.8M 1.61% of portfolio	4.77% 1.3M shares	Q4 2019 Held for 5y 11m	$2.5B
First Light Asset Management, LLC Hedge Fund•Sector	Mathew Paul Arens CEO	$30.3M 2.86% of portfolio	3.54% 990.2K shares	Q2 2023 Held for 2y 5m	$1.1B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$26.7M 0.00% of portfolio	3.12% 873.4K shares	Q1 2017 Held for 8y 8m	$2.88T
A Assenagon Asset Management S.A. Institution	-	$25.7M 0.04% of portfolio	3.00% 839.9K shares	Q2 2022 Held for 3y 5m	$67.7B

Net Capital Flow

Institutional buying and selling activity for ANAB in Q3 2025

Traded: −$136.8M
Buyers: 80
Sellers: 71
Total Bought: +$143.3M
Total Sold: −$280.1M
Avg Position: $5.4M

Biggest Buyers

Institution	Net Bought	Current Position
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$40.3M +1.3M shares	$46.5M 1.5M shares
A Assenagon Asset Management S.A. Institution	+$25.2M +823.0K shares	$25.7M 839.9K shares
Soleus Capital Management, L.P. Hedge Fund•Long/Short	+$9.3M +305.0K shares	$19.2M 626.0K shares
D D. E. Shaw & Co., Inc. Institution	+$7.3M +237.0K shares	$10.7M 349.4K shares
ARROWSTREET CAPITAL LIMITED PARTNERSHIP Hedge Fund•Quant	+$6.7M +219.6K shares	$11.3M 370.5K shares
FEDERATED INVESTORS INC /PA/ Long Only Manager	+$5.7M +185.1K shares	$5.9M 193.3K shares
J JANE STREET GROUP, LLC Institution	+$4.2M +136.4K shares	$5.5M 181.1K shares
S Skandinaviska Enskilda Banken AB Institution	+$3.4M +111.7K shares	$4.4M 145.2K shares
SECTORAL ASSET MANAGEMENT INC Venture Capital	+$3.4M +110.6K shares	$6.0M 194.5K shares
B BNP PARIBAS ARBITRAGE, SA Institution	+$3.1M +102.0K shares	$3.2M 105.7K shares

Biggest Sellers

Institution	Net Sold	Current Position
First Light Asset Management, LLC Hedge Fund•Sector	−$78.1M −2.5M shares	$30.3M 990.2K shares
FRANKLIN RESOURCES INC Institution	−$75.3M −307.2K shares	$11.6M 47.3K shares
BANK OF AMERICA CORP /DE/ Institution	−$29.1M −949.6K shares	$3.9M 127.2K shares
S Sofinnova Ventures Inc Venture Capital	−$23.8M −778.1K shares	$7.8M 254.3K shares
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	−$11.4M −373.9K shares	$9.2M 299.3K shares
VICTORY CAPITAL MANAGEMENT INC Long Only Manager	−$10.0M −328.0K shares	$6.2M 204.1K shares
MORGAN STANLEY RIA/Wealth	−$9.6M −313.6K shares	$47.7M 1.6M shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	−$6.4M −209.3K shares	$69.4M 2.3M shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	−$4.3M −139.8K shares	$3.8M 123.3K shares
P Palo Alto Investors, LLC Hedge Fund•Long/Short	−$4.3M −139.3K shares	$20.6M 673.5K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited ANAB in Q3 2025

New Positions: 13
New Value: $1.3M
Exited Positions: 14
Exited Value: $5.8M

New Positions

Institution	Position Value
C Campbell & CO Investment Adviser LLC Hedge Fund•Quant Macro	$559.8K 18.3K shares
C CLS Investments, LLC Institution	$420.7K 13.7K shares
D DRW Securities, LLC Institution	$208.5K 6.6K shares
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$100.9K 3.3K shares
P Persistent Asset Partners Ltd Institution	$23.1K 754.0 shares
W WHITE BAY PT LLC Institution	$5.2K 170.0 shares
O Optiver Holding B.V. Institution	$2.8K 90.0 shares
MONTAG A & ASSOCIATES INC RIA/Wealth	$276.0 9.0 shares
Stone House Investment Management, LLC RIA/Wealth	$153.0 5.0 shares
Sunbelt Securities, Inc. RIA/Wealth	$122.0 4.0 shares

Exited Positions

Institution	Previous Position
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	$2.1M 92.9K shares
UBS OCONNOR LLC Long Only Manager	$855.3K 38.5K shares
FMB WEALTH MANAGEMENT RIA/Wealth	$790.1K 35.6K shares
SummitTX Capital, L.P. Hedge Fund•Multi-Strategy	$742.2K 33.4K shares
A Allianz Asset Management AG Institution	$337.4K 15.2K shares
Exome Asset Management LLC Hedge Fund•Sector	$333.0K 15.0K shares
C Corton Capital Inc. Institution	$266.5K 12.0K shares
Glenmede Investment Management, LP Long Only Manager	$167.5K 7.5K shares
S SG Americas Securities, LLC Institution	$109.2K 4.9K shares
B BIT Capital GmbH Institution	$60.1K 2.7K shares

Options Activity

Institutions with the largest Call and Put options positions in ANAB as of Q3 2025

Call Positions: 6
Call Value: $8.9M
Put Positions: 5
Put Value: $14.5M

Call Positions

Institution	Position Value
Ikarian Capital, LLC Hedge Fund•Event Driven	$4.9M 1.6K contracts
BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds	$1.9M 606.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.0M 330.0 contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$618.5K 202.0 contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$309.3K 101.0 contracts
J JANE STREET GROUP, LLC Institution	$208.2K 68.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$6.5M 2.1K contracts
Ikarian Capital, LLC Hedge Fund•Event Driven	$4.9M 1.6K contracts
BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds	$1.9M 606.0 contracts
J JANE STREET GROUP, LLC Institution	$998.2K 326.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$214.3K 70.0 contracts

Most Committed Institutions

Institutions with ANAB as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
EcoR1 Capital, LLC Hedge Fund•Sector	Scott Eric Perlen CFO	11.58% $241.3M	28.17% 7.9M shares	Q4 2019 Held for 5y 11m	$2.1B
S Sanofi Institution	-	9.67% $25.2M	2.94% 821.9K shares	Q4 2024 Held for 11 months	$260.4M
P Palo Alto Investors, LLC Hedge Fund•Long/Short	Angela Elizabeth Nguyen-Dinh CCO	3.82% $20.6M	2.41% 673.5K shares	Q3 2020 Held for 5y 2m	$540.4M
SECTORAL ASSET MANAGEMENT INC Venture Capital	Jerome Georges Pfund CEO	3.73% $6.0M	0.70% 194.5K shares	Q2 2025 Held for 5 months	$159.6M
First Light Asset Management, LLC Hedge Fund•Sector	Mathew Paul Arens CEO	2.86% $30.3M	3.54% 990.2K shares	Q2 2023 Held for 2y 5m	$1.1B
H HighMark Wealth Management LLC RIA/Wealth	Todd Edward Arens Managing Partner	1.95% $4.4M	0.48% 135.1K shares	Q1 2025 Held for 8 months	$227.1M
T TANG CAPITAL MANAGEMENT LLC Institution	-	1.61% $40.8M	4.77% 1.3M shares	Q4 2019 Held for 5y 11m	$2.5B
6 683 Capital Management, LLC Hedge Fund•Long/Short	Ari Jonathan Zweiman Managing Partner	1.58% $16.7M	1.96% 547.0K shares	Q1 2025 Held for 8 months	$1.1B
Soleus Capital Management, L.P. Hedge Fund•Long/Short	Guy Bezalel Levy CIO	1.05% $19.2M	2.24% 626.0K shares	Q4 2024 Held for 11 months	$1.8B
D DCF Advisers, LLC Institution	-	0.69% $1.5M	0.17% 48.0K shares	Q1 2025 Held for 8 months	$212.2M

Hedge Fund Spotlight

Discover hedge funds investing in ANAB

Squarepoint Ops LLC

Hedge Fund • Quant

Portfolio ManagerMichael Gottlieb

Portfolio Value: $46.9B
Positions: 2,529
Last Reported: Q3 2025

Sector Allocation

Position in AnaptysBio, Inc.

Market Value: $2.1M
Shares Held: 68.0K
Portfolio Weight: 0.00%
Owned Since: 2022-Q2

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