Ascendis Pharma

ASND • NASDAQ

Ascendis Pharma is a publicly traded company on NASDAQ. As of Q3 2025, 253 institutional investors hold shares in this company, with total holdings valued at $11.5B. RA CAPITAL MANAGEMENT, LLC is the largest holder with a position valued at $2.0B.

Employees879.0

Websiteascendispharma.com

Overview

Overview of institutional ownership in ASND as of Q3 2025

All Institutions

Institutions: 253
Value Held: $11.5B
Shares Held: 57.7M
Avg Position: $45.4M
Median Position: $2.0M

Hedge Funds

Hedge Funds: 48
Value Held: $2.8B
Shares Held: 14.2M
Avg Position: $58.9M
Median Position: $6.6M

Biggest Investors

Institutions with the largest positions in ASND as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	$2.0B 25.39% of portfolio	0.00% 10.3M shares	Q4 2022 Held for 2y 11m	$8.1B
WESTFIELD CAPITAL MANAGEMENT CO LP Long Only Manager	William Albert Muggia CEO	$1.0B 4.39% of portfolio	0.00% 5.3M shares	Q4 2022 Held for 2y 11m	$23.8B
venBio Select Advisor LLC RIA/Wealth	Behzad Aghazadeh Managing Partner	$1.0B 13.14% of portfolio	0.00% 5.1M shares	Q3 2025 Held for 2 months	$7.7B
FMR LLC Institution	-	$889.0M 0.05% of portfolio	0.00% 4.5M shares	Q4 2022 Held for 2y 11m	$1.92T
HENDERSON GROUP PLC Institution	Ali Dibadj CEO	$859.4M 0.39% of portfolio	0.00% 4.3M shares	Q4 2022 Held for 2y 11m	$218.74B
Artisan Partners Limited Partnership Long Only Manager	Eric Richard Colson CEO	$739.7M 1.07% of portfolio	0.00% 3.7M shares	Q4 2022 Held for 2y 11m	$69.5B
C Capital International Investors Institution	-	$608.5M 0.10% of portfolio	0.00% 3.1M shares	Q4 2022 Held for 2y 11m	$615.90B
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ Long Only Manager	Edward Murray Maloney CEO	$374.3M 0.12% of portfolio	0.00% 1.9M shares	Q4 2022 Held for 2y 11m	$322.72B
WELLINGTON MANAGEMENT CO LLP Long Only Manager	Edmund Wellington Iii President	$357.6M 0.06% of portfolio	0.00% 1.8M shares	Q4 2022 Held for 2y 11m	$571.21B
FRANKLIN RESOURCES INC Institution	Gregory E. Johnson CEO	$316.1M 0.08% of portfolio	0.00% 1.6M shares	Q4 2022 Held for 2y 11m	$395.56B

Net Capital Flow

Institutional buying and selling activity for ASND in Q3 2025

Net Flow: +$177.9M
Buyers: 104
Sellers: 93
Total Bought: +$765.5M
Total Sold: −$587.7M
Avg Position: $44.8M

Biggest Buyers

Institution	Net Bought	Current Position
WELLINGTON MANAGEMENT CO LLP Long Only Manager	+$175.1M +880.8K shares	$357.6M 1.8M shares
PRINCIPAL FINANCIAL GROUP INC Institution	+$152.2M +765.6K shares	$157.8M 793.7K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	+$35.9M +180.8K shares	$36.6M 183.9K shares
F FRED ALGER MANAGEMENT INC Long Only Manager	+$33.2M +166.9K shares	$33.9M 170.7K shares
ORBIMED ADVISORS LLC Hedge Fund•Sector	+$31.3M +157.5K shares	$38.2M 191.9K shares
MORGAN STANLEY RIA/Wealth	+$30.2M +152.0K shares	$80.9M 406.8K shares
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	+$24.8M +124.6K shares	$216.4M 1.1M shares
GOLDMAN SACHS GROUP INC Institution	+$22.8M +114.7K shares	$129.8M 653.0K shares
UBS Group AG Institution	+$22.4M +112.4K shares	$38.8M 195.2K shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$20.2M +101.7K shares	$34.7M 174.6K shares

Biggest Sellers

Institution	Net Sold	Current Position
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$111.3M −559.7K shares	$5.5M 27.6K shares
A ADAGE CAPITAL PARTNERS GP LLC Institution	−$79.3M −459.6K shares	Sold Off 0 shares
Artisan Partners Limited Partnership Long Only Manager	−$53.6M −269.5K shares	$739.7M 3.7M shares
Woodline Partners LP Hedge Fund•Long/Short	−$40.4M −203.0K shares	$20.4M 102.5K shares
WESTFIELD CAPITAL MANAGEMENT CO LP Long Only Manager	−$38.1M −191.5K shares	$1.0B 5.3M shares
FRANKLIN RESOURCES INC Institution	−$32.5M −163.5K shares	$316.1M 1.6M shares
HENDERSON GROUP PLC Institution	−$20.8M −104.7K shares	$859.4M 4.3M shares
Marshall Wace LLP Institution	−$19.8M −99.5K shares	$3.5M 17.7K shares
S Standard Life Aberdeen plc Institution	−$17.9M −90.2K shares	$9.8M 49.4K shares
R READYSTATE ASSET MANAGEMENT LP Hedge Fund•Multi-Strategy	−$17.0M −85.3K shares	$3.1M 15.6K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited ASND in Q3 2025

New Positions: 37
New Value: $1.2B
Exited Positions: 20
Exited Value: $99.0M

New Positions

Institution	Position Value
venBio Select Advisor LLC RIA/Wealth	$1.0B 5.1M shares
N NEW YORK STATE COMMON RETIREMENT FUND Institution	$33.8M 169.9K shares
G GCIC Ltd. Institution	$21.9M 110.0K shares
BRAUN STACEY ASSOCIATES INC Private Equity	$18.7M 93.9K shares
M MOORE CAPITAL MANAGEMENT, LP Hedge Fund•Global Macro	$17.9M 90.0K shares
Hudson Bay Capital Management LP Hedge Fund•Multi-Strategy	$15.7M 78.9K shares
Ally Bridge Group LLC Hedge Fund•Sector	$10.2M 51.1K shares
CASTLEARK MANAGEMENT LLC Long Only Manager	$8.5M 42.7K shares
LAZARD ASSET MANAGEMENT LLC Long Only Manager	$8.3M 41.7K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$7.1M 36.0K shares

Exited Positions

Institution	Previous Position
A ADAGE CAPITAL PARTNERS GP LLC Institution	$79.3M 459.6K shares
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$7.0M 40.4K shares
S Saturn V Capital Management LLC Hedge Fund•Sector	$6.6M 38.2K shares
Verition Fund Management LLC Hedge Fund•Multi-Strategy	$2.6M 15.3K shares
Caption Management, LLC Hedge Fund•Long/Short	$1.1M 6.5K shares
X XTX Topco Ltd Institution	$1.0M 6.1K shares
Walleye Trading LLC RIA/Wealth	$449.6K 2.6K shares
AIGEN INVESTMENT MANAGEMENT, LP Hedge Fund•Long/Short	$254.6K 1.5K shares
R Squared Ltd Private Equity	$209.2K 1.2K shares
H Headlands Technologies LLC Institution	$206.4K 1.2K shares

Options Activity

Institutions with the largest Call and Put options positions in ASND as of Q3 2025

Call Positions: 13
Call Value: $94.3M
Put Positions: 10
Put Value: $27.7M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$23.2M 1.2K contracts
Caption Management, LLC Hedge Fund•Long/Short	$21.0M 1.1K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$18.6M 938.0 contracts
J JANE STREET GROUP, LLC Institution	$14.6M 736.0 contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$4.6M 230.0 contracts
L LMR Partners LLP Institution	$4.2M 210.0 contracts
Walleye Trading LLC RIA/Wealth	$3.3M 165.0 contracts
GOLDMAN SACHS GROUP INC Institution	$1.7M 83.0 contracts
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	$1.5M 75.0 contracts
D D. E. Shaw & Co., Inc. Institution	$994.1K 50.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$12.2M 616.0 contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$4.0M 200.0 contracts
Caption Management, LLC Hedge Fund•Long/Short	$3.0M 149.0 contracts
J JANE STREET GROUP, LLC Institution	$2.8M 139.0 contracts
Lighthouse Investment Partners, LLC Fund of Funds	$2.0M 100.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.7M 84.0 contracts
Walleye Trading LLC RIA/Wealth	$1.6M 80.0 contracts
C CSS LLC/IL Institution	$397.6K 20.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$59.6K 3.0 contracts
W WOLVERINE TRADING, LLC Institution	- - contracts

Most Committed Institutions

Institutions with ASND as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	25.39% $2.0B	0.00% 10.3M shares	Q4 2022 Held for 2y 11m	$8.1B
R Resolute Capital Asset Partners LLC Hedge Fund•Long/Short	James Aquinas Hillary CEO	17.38% $32.9M	0.00% 165.7K shares	Q1 2025 Held for 8 months	$189.5M
venBio Select Advisor LLC RIA/Wealth	Behzad Aghazadeh Managing Partner	13.14% $1.0B	0.00% 5.1M shares	Q3 2025 Held for 2 months	$7.7B
Ally Bridge Group LLC Hedge Fund•Sector	Slanix Paul T Alex President	8.50% $10.2M	0.00% 51.1K shares	Q3 2025 Held for 2 months	$119.4M
T Tri Locum Partners LP Hedge Fund•Long/Short	Prashanth Nmn Jayaram CIO	7.99% $34.8M	0.00% 174.8K shares	Q1 2025 Held for 8 months	$435.1M
G GREAT POINT PARTNERS LLC Private Equity	Jeffrey Robert Jay Managing Partner	6.57% $14.9M	0.00% 75.0K shares	Q2 2025 Held for 5 months	$226.8M
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	Joseph Eric Edelman CEO	6.27% $216.4M	0.00% 1.1M shares	Q2 2025 Held for 5 months	$3.5B
Catalio Capital Management, LP Venture Capital	Olga Eduardovna Maltseva COO	5.33% $28.8M	0.00% 145.0K shares	Q4 2024 Held for 11 months	$540.9M
N Nan Fung Group Holdings Ltd Institution	-	4.98% $2.7M	0.00% 13.6K shares	Q1 2024 Held for 1y 8m	$54.3M
WESTFIELD CAPITAL MANAGEMENT CO LP Long Only Manager	William Albert Muggia CEO	4.39% $1.0B	0.00% 5.3M shares	Q4 2022 Held for 2y 11m	$23.8B

Hedge Fund Spotlight

Discover hedge funds investing in ASND

ExodusPoint Capital Management, LP

Hedge Fund • Multi-Strategy

Portfolio ManagerMichael Robert Gelband

Portfolio Value: $7.1B
Positions: 1,351
Last Reported: Q3 2025

Sector Allocation

Position in Ascendis Pharma

Market Value: $4.9M
Shares Held: 24.7K
Portfolio Weight: 0.07%
Owned Since: 2025-Q3

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