CRISPR Therapeutics

CRSP • NASDAQ

CRISPR Therapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by Julianne Bruno, with a market cap of $5.4B. As of Q3 2025, 79% of shares are held by 425 institutional investors, with ARK Investment Management LLC as the largest holder at 10.76%.

Chief Operating OfficerJulianne Bruno

Market Cap$5.4B

Biotechnology

Healthcare

Employees407.0

Websitecrisprtx.com

Country

United States of America

Overview

Overview of institutional ownership in CRSP as of Q3 2025 with a market cap of $5.9B

All Institutions

Institutions: 425
Value Held: $4.7B
Shares Held: 72.1M
Avg Position: $11.0M
Median Position: $380.4K

Hedge Funds

Hedge Funds: 18
Value Held: $242.5M
Shares Held: 3.7M
Avg Position: $13.5M
Median Position: $2.0M

Ownership Breakdown

Institutional (non-HF)

75.14%

$4.4B

Hedge Funds

4.11%

$242.5M

Retail & Other

20.75%

$1.2B

Based on market cap of $5.9B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in CRSP as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
ARK Investment Management LLC ETF Provider	Catherine Duddy Wood CEO	$634.3M 3.84% of portfolio	10.76% 9.8M shares	Q2 2017 Held for 8y 5m	$16.5B
B BlackRock, Inc. Institution	-	$456.9M 0.01% of portfolio	7.75% 7.1M shares	Q3 2017 Held for 8y 2m	$5.67T
C Capital International Investors Institution	-	$366.1M 0.06% of portfolio	6.21% 5.6M shares	Q3 2018 Held for 7y 2m	$615.90B
O Orbis Allan Gray Ltd RIA/Wealth	Don Lynn Ray Managing Partner	$322.9M 1.39% of portfolio	5.48% 5.0M shares	Q4 2024 Held for 11 months	$23.3B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$259.7M 0.01% of portfolio	4.41% 4.0M shares	Q2 2018 Held for 7y 5m	$2.88T
T T. Rowe Price Investment Management, Inc. Insurance Manager	John Edward Robison President	$212.7M 0.13% of portfolio	3.61% 3.3M shares	Q3 2022 Held for 3y 2m	$161.58B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$153.3M 0.00% of portfolio	2.60% 2.4M shares	Q2 2017 Held for 8y 5m	$6.69T
UBS Group AG Institution	Sergio P. Ermotti CEO	$151.6M 0.03% of portfolio	2.57% 2.3M shares	Q4 2016 Held for 8y 11m	$511.54B
S Sumitomo Mitsui Trust Holdings, Inc. Institution	-	$140.2M 0.08% of portfolio	2.38% 2.2M shares	Q1 2022 Held for 3y 8m	$173.79B
Nikko Asset Management Americas, Inc. Long Only Manager	James Mark Beyer Wesley CEO	$140.2M 1.36% of portfolio	2.38% 2.2M shares	Q3 2018 Held for 7y 2m	$10.3B

Net Capital Flow

Institutional buying and selling activity for CRSP in Q3 2025

Traded: +$95.4M
Buyers: 218
Sellers: 170
Total Bought: +$534.9M
Total Sold: −$439.5M
Avg Position: $9.7M

Biggest Buyers

Institution	Net Bought	Current Position
O Orbis Allan Gray Ltd RIA/Wealth	+$143.7M +2.2M shares	$322.9M 5.0M shares
SR ONE CAPITAL MANAGEMENT, LP Venture Capital	+$64.1M +989.8K shares	$132.1M 2.0M shares
B BlackRock, Inc. Institution	+$63.8M +983.8K shares	$456.9M 7.1M shares
MORGAN STANLEY RIA/Wealth	+$57.5M +886.5K shares	$90.6M 1.4M shares
STATE STREET CORP Institution	+$47.7M +736.6K shares	$259.7M 4.0M shares
JPMORGAN CHASE & CO Institution	+$17.6M +272.3K shares	$38.5M 593.4K shares
O'Neil Global Advisors, Inc. Hedge Fund•Multi-Strategy	+$10.9M +168.7K shares	$10.9M 168.7K shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$9.6M +148.2K shares	$10.8M 167.1K shares
R ROYAL BANK OF CANADA Institution	+$8.4M +129.0K shares	$30.2M 466.2K shares
T TANG CAPITAL MANAGEMENT LLC Institution	+$6.5M +100.0K shares	$6.5M 100.0K shares

Biggest Sellers

Institution	Net Sold	Current Position
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	−$50.0M −771.7K shares	$37.1M 573.0K shares
UBS GLOBAL ASSET MANAGEMENT AMERICAS INC Long Only Manager	−$46.9M −964.7K shares	Sold Off 0 shares
NEA Management Company, LLC Venture Capital	−$34.3M −529.3K shares	$68.6M 1.1M shares
UBS Group AG Institution	−$32.7M −504.5K shares	$151.6M 2.3M shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	−$32.5M −501.3K shares	$67.7M 1.0M shares
T T. Rowe Price Investment Management, Inc. Insurance Manager	−$26.0M −400.4K shares	$212.7M 3.3M shares
ARK Investment Management LLC ETF Provider	−$25.6M −395.6K shares	$634.3M 9.8M shares
V Versant Venture Management, LLC Institution	−$22.7M −349.7K shares	$9.6M 148.8K shares
BANK OF AMERICA CORP /DE/ Institution	−$21.0M −324.3K shares	$72.9M 1.1M shares
BANK OF MONTREAL /CAN/ Institution	−$19.9M −306.5K shares	$12.1M 187.2K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited CRSP in Q3 2025

New Positions: 34
New Value: $19.4M
Exited Positions: 55
Exited Value: $83.4M

New Positions

Institution	Position Value
O'Neil Global Advisors, Inc. Hedge Fund•Multi-Strategy	$10.9M 168.7K shares
PATHWAY CAPITAL MANAGEMENT, LP Fund of Funds	$3.2M 50.0K shares
Kassira Wealth Management LLC RIA/Wealth	$1.0M 15.7K shares
Merit Financial Group, LLC RIA/Wealth	$677.7K 10.5K shares
S SIG BROKERAGE, LP Institution	$427.0K 6.6K shares
Ausdal Financial Partners, Inc. RIA/Wealth	$331.7K 5.1K shares
Summit Financial, LLC RIA/Wealth	$308.2K 4.8K shares
Quantinno Capital Management LP Hedge Fund•Market Neutral	$306.0K 4.7K shares
Meeder Advisory Services, Inc. Long Only Manager	$267.1K 4.1K shares
Retirement Planning Group RIA/Wealth	$241.1K 3.7K shares

Exited Positions

Institution	Previous Position
UBS GLOBAL ASSET MANAGEMENT AMERICAS INC Long Only Manager	$46.9M 964.7K shares
J Jump Financial, LLC Institution	$17.3M 356.3K shares
Integral Health Asset Management, LLC Hedge Fund•Sector	$4.9M 100.0K shares
Y Y-Intercept Ltd Institution	$1.9M 39.2K shares
S Squarepoint Ops LLC Hedge Fund•Quant	$1.5M 30.3K shares
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$1.2M 25.1K shares
IMC-Chicago, LLC RIA/Wealth	$1.1M 23.1K shares
E Entropy Technologies, LP Hedge Fund•Quant Macro	$1.1M 21.7K shares
E EXCHANGE TRADED CONCEPTS, LLC Institution	$902.5K 18.6K shares
Engineers Gate Manager LP Hedge Fund•Quant	$809.5K 16.6K shares

Options Activity

Institutions with the largest Call and Put options positions in CRSP as of Q3 2025

Call Positions: 35
Call Value: $225.1M
Put Positions: 21
Put Value: $200.8M

Call Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$55.2M 8.5K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$35.7M 5.5K contracts
Caption Management, LLC Hedge Fund•Long/Short	$29.4M 4.5K contracts
D D. E. Shaw & Co., Inc. Institution	$23.4M 3.6K contracts
J JANE STREET GROUP, LLC Institution	$23.2M 3.6K contracts
P PEAK6 LLC Institution	$10.7M 1.6K contracts
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$7.3M 1.1K contracts
S Squarepoint Ops LLC Hedge Fund•Quant	$7.0M 1.1K contracts
Walleye Trading LLC RIA/Wealth	$6.3M 976.0 contracts
TUDOR INVESTMENT CORP ET AL Hedge Fund•Multi-Strategy	$4.2M 644.0 contracts

Put Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$57.6M 8.9K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$45.7M 7.1K contracts
P PEAK6 LLC Institution	$24.1M 3.7K contracts
BANK OF MONTREAL /CAN/ Institution	$11.9M 1.8K contracts
J JANE STREET GROUP, LLC Institution	$10.9M 1.7K contracts
BANK OF AMERICA CORP /DE/ Institution	$10.9M 1.7K contracts
BARCLAYS PLC Institution	$9.4M 1.5K contracts
Caption Management, LLC Hedge Fund•Long/Short	$5.8M 900.0 contracts
Walleye Trading LLC RIA/Wealth	$4.8M 745.0 contracts
D D. E. Shaw & Co., Inc. Institution	$4.5M 702.0 contracts

Most Committed Institutions

Institutions with CRSP as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
SR ONE CAPITAL MANAGEMENT, LP Venture Capital	Simeon John George CEO	19.11% $132.1M	2.24% 2.0M shares	Q1 2024 Held for 1y 8m	$691.4M
PATHWAY CAPITAL MANAGEMENT, LP Fund of Funds	Ashok Kumar Tripathi President	15.95% $3.2M	0.06% 50.0K shares	Q3 2025 Held for 2 months	$20.3M
V Versant Venture Management, LLC Institution	-	4.54% $9.6M	0.16% 148.8K shares	Q1 2018 Held for 7y 8m	$212.5M
EcoR1 Capital, LLC Hedge Fund•Sector	Scott Eric Perlen CFO	4.32% $90.0M	1.53% 1.4M shares	Q1 2024 Held for 1y 8m	$2.1B
ARK Investment Management LLC ETF Provider	Catherine Duddy Wood CEO	3.84% $634.3M	10.76% 9.8M shares	Q2 2017 Held for 8y 5m	$16.5B
NEA Management Company, LLC Venture Capital	Mohamad Hassan Makhzoumi CEO	3.76% $68.6M	1.16% 1.1M shares	Q4 2016 Held for 8y 11m	$1.8B
Green Alpha Advisors, LLC Long Only Manager	Garvin Frederic Jabusch Founder	3.45% $3.6M	0.06% 55.0K shares	Q4 2020 Held for 4y 11m	$103.4M
Del-Sette Capital Management, LLC RIA/Wealth	Iii Hermes Del-Sette Managing Partner	2.52% $4.1M	0.07% 62.5K shares	Q2 2025 Held for 5 months	$160.9M
O'Neil Global Advisors, Inc. Hedge Fund•Multi-Strategy	Steven Lawrence Birch CEO	2.14% $10.9M	0.19% 168.7K shares	Q3 2025 Held for 2 months	$510.4M
O Orbis Allan Gray Ltd RIA/Wealth	Don Lynn Ray Managing Partner	1.39% $322.9M	5.48% 5.0M shares	Q4 2024 Held for 11 months	$23.3B