Insmed

INSM • NASDAQ

Insmed is a biotechnology company in the healthcare sector on NASDAQ, led by Dr. Martina Flammer, with a market cap of $43.7B. As of Q3 2025, 100% of shares are held by 553 institutional investors, with JPMORGAN CHASE & CO as the largest holder at 10.9%.

Chief Medical OfficerDr. Martina Flammer

Market Cap$43.7B

Biotechnology

Healthcare

Employees912.0

Websiteinsmed.com

Country

United States of America

Overview

Overview of institutional ownership in INSM as of Q3 2025 with a market cap of $30.4B

All Institutions

Institutions: 553
Value Held: $30.3B
Shares Held: 210.7M
Avg Position: $54.8M
Median Position: $1.3M

Hedge Funds

Hedge Funds: 81
Value Held: $4.3B
Shares Held: 30.2M
Avg Position: $53.7M
Median Position: $6.4M

Ownership Breakdown

Institutional (non-HF)

85.24%

$25.9B

Hedge Funds

14.28%

$4.3B

Retail & Other

0.481%

$146.5M

Based on market cap of $30.4B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in INSM as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
JPMORGAN CHASE & CO Institution	Jamie Dimon CEO	$3.3B 0.21% of portfolio	10.90% 23.0M shares	≤ Q2 2013 Held for 12y 5m+	$1.56T
D Darwin Global Management, Ltd. Institution	-	$2.9B 80.55% of portfolio	9.68% 20.5M shares	Q2 2024 Held for 1y 5m	$3.6B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$2.9B 0.04% of portfolio	9.43% 19.9M shares	≤ Q2 2013 Held for 12y 5m+	$6.69T
B BlackRock, Inc. Institution	-	$1.8B 0.03% of portfolio	5.85% 12.4M shares	≤ Q2 2013 Held for 12y 5m+	$5.67T
FMR LLC Institution	-	$1.3B 0.07% of portfolio	4.34% 9.2M shares	≤ Q2 2013 Held for 12y 5m+	$1.92T
C Capital International Investors Institution	-	$1.1B 0.18% of portfolio	3.57% 7.6M shares	Q1 2024 Held for 1y 8m	$615.90B
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	Robert W Sharps President	$998.2M 0.11% of portfolio	3.28% 6.9M shares	Q1 2014 Held for 11y 8m	$912.31B
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	Scott Lawrence Lessing President	$965.4M 8.94% of portfolio	3.17% 6.7M shares	≤ Q2 2013 Held for 12y 5m+	$10.8B
D D. E. Shaw & Co., Inc. Institution	-	$814.7M 0.70% of portfolio	2.68% 5.7M shares	≤ Q2 2013 Held for 12y 5m+	$115.81B
Artisan Partners Limited Partnership Long Only Manager	Eric Richard Colson CEO	$711.1M 1.02% of portfolio	2.34% 4.9M shares	Q2 2024 Held for 1y 5m	$69.5B

Net Capital Flow

Institutional buying and selling activity for INSM in Q3 2025

Net Flow: +$281.5M
Buyers: 200
Sellers: 263
Total Bought: +$4.6B
Total Sold: −$4.3B
Avg Position: $59.5M

Biggest Buyers

Institution	Net Bought	Current Position
JPMORGAN CHASE & CO Institution	+$1.1B +7.4M shares	$3.3B 23.0M shares
FMR LLC Institution	+$588.7M +4.1M shares	$1.3B 9.2M shares
VANGUARD GROUP INC Institution	+$330.0M +2.3M shares	$2.9B 19.9M shares
D D. E. Shaw & Co., Inc. Institution	+$321.8M +2.2M shares	$814.7M 5.7M shares
O Orbis Allan Gray Ltd RIA/Wealth	+$248.7M +1.7M shares	$468.2M 3.3M shares
Artisan Partners Limited Partnership Long Only Manager	+$233.8M +1.6M shares	$711.1M 4.9M shares
UBS Group AG Institution	+$194.8M +1.4M shares	$237.1M 1.6M shares
B BlackRock, Inc. Institution	+$176.0M +1.2M shares	$1.8B 12.4M shares
D Darwin Global Management, Ltd. Institution	+$157.6M +1.1M shares	$2.9B 20.5M shares
R ROYAL BANK OF CANADA Institution	+$133.6M +927.5K shares	$195.2M 1.4M shares

Biggest Sellers

Institution	Net Sold	Current Position
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	−$619.1M −4.3M shares	$998.2M 6.9M shares
A ADAGE CAPITAL PARTNERS GP LLC Institution	−$231.4M −1.6M shares	$180.4M 1.3M shares
Deep Track Capital, LP Hedge Fund•Long/Short	−$176.1M −1.8M shares	Sold Off 0 shares
HENDERSON GROUP PLC Institution	−$157.0M −1.1M shares	$173.2M 1.2M shares
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	−$145.4M −1.0M shares	$965.4M 6.7M shares
GOLDMAN SACHS GROUP INC Institution	−$141.4M −981.6K shares	$119.4M 829.3K shares
Holocene Advisors, LP Hedge Fund•Long/Short	−$134.4M −933.1K shares	$156.1M 1.1M shares
WESTFIELD CAPITAL MANAGEMENT CO LP Long Only Manager	−$122.6M −851.4K shares	$70.3M 487.9K shares
GANNETT WELSH & KOTLER Long Only Manager	−$96.8M −672.5K shares	$86.7M 601.8K shares
J JANE STREET GROUP, LLC Institution	−$80.8M −561.2K shares	$114.0M 791.7K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited INSM in Q3 2025

New Positions: 94
New Value: $227.5M
Exited Positions: 67
Exited Value: $608.4M

New Positions

Institution	Position Value
BANK OF NOVA SCOTIA / Institution	$72.9M 506.2K shares
I ING GROEP NV Institution	$53.8M 373.5K shares
N Nearwater Capital Markets, Ltd Institution	$28.8M 200.0K shares
CAISSE DE DEPOT ET PLACEMENT DU QUEBEC Fund of Funds	$23.7M 164.4K shares
EULAV Asset Management Long Only Manager	$13.0M 90.0K shares
MCRAE CAPITAL MANAGEMENT INC RIA/Wealth	$3.9M 27.2K shares
F Fieldview Capital Management, LLC Hedge Fund•Long/Short	$2.9M 20.2K shares
WEST MICHIGAN ADVISORS, LLC RIA/Wealth	$2.5M 17.6K shares
NEXT CENTURY GROWTH INVESTORS LLC Long Only Manager	$2.3M 15.8K shares
IMC-Chicago, LLC RIA/Wealth	$2.2M 15.3K shares

Exited Positions

Institution	Previous Position
Deep Track Capital, LP Hedge Fund•Long/Short	$176.1M 1.8M shares
H HRT FINANCIAL LLC Institution	$73.4M 729.6K shares
A Alyeska Investment Group, L.P. Hedge Fund•Multi-Strategy	$60.8M 603.7K shares
Weiss Asset Management LP Hedge Fund•Multi-Strategy	$34.2M 339.8K shares
C Cubist Systematic Strategies, LLC Institution	$28.5M 283.1K shares
H HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND Institution	$25.2M 250.1K shares
A AXA Institution	$22.8M 226.6K shares
S Squarepoint Ops LLC Hedge Fund•Quant	$21.2M 210.6K shares
J Jump Financial, LLC Institution	$18.3M 181.6K shares
PANAGORA ASSET MANAGEMENT INC Hedge Fund•Quant	$15.1M 149.6K shares

Options Activity

Institutions with the largest Call and Put options positions in INSM as of Q3 2025

Call Positions: 36
Call Value: $555.7M
Put Positions: 31
Put Value: $617.0M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$122.2M 8.5K contracts
A Artia Global Partners LP Hedge Fund•Long/Short	$57.6M 4.0K contracts
Caption Management, LLC Hedge Fund•Long/Short	$54.4M 3.8K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$49.0M 3.4K contracts
J JANE STREET GROUP, LLC Institution	$34.3M 2.4K contracts
Affinity Asset Advisors, LLC Hedge Fund•Long/Short	$29.5M 2.1K contracts
BANK OF AMERICA CORP /DE/ Institution	$27.7M 1.9K contracts
P PEAK6 LLC Institution	$24.0M 1.7K contracts
CITIGROUP INC Institution	$22.6M 1.6K contracts
GOLDMAN SACHS GROUP INC Institution	$18.7M 1.3K contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$141.0M 9.8K contracts
J JANE STREET GROUP, LLC Institution	$112.7M 7.8K contracts
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC Hedge Fund•Long/Short	$72.0M 5.0K contracts
6 683 Capital Management, LLC Hedge Fund•Long/Short	$54.0M 3.8K contracts
Caption Management, LLC Hedge Fund•Long/Short	$46.9M 3.3K contracts
BANK OF AMERICA CORP /DE/ Institution	$32.0M 2.2K contracts
P Parallax Volatility Advisers, LLC Hedge Fund•Vol Arbitrage	$29.9M 2.1K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$28.1M 1.9K contracts
Integral Health Asset Management, LLC Hedge Fund•Sector	$14.4M 1.0K contracts
Ikarian Capital, LLC Hedge Fund•Event Driven	$14.4M 1.0K contracts

Most Committed Institutions

Institutions with INSM as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
D Darwin Global Management, Ltd. Institution	-	80.55% $2.9B	9.68% 20.5M shares	Q2 2024 Held for 1y 5m	$3.6B
A Artia Global Partners LP Hedge Fund•Long/Short	Onusa Nmn Chantanapongwanij Managing Partner	18.55% $105.4M	0.35% 732.2K shares	Q4 2023 Held for 1y 11m	$568.3M
N NWI MANAGEMENT LP Hedge Fund•Global Macro	Jayachandrika Hariharan Managing Partner	18.00% $147.0M	0.48% 1.0M shares	Q3 2024 Held for 1y 2m	$816.7M
Integral Health Asset Management, LLC Hedge Fund•Sector	Bhagwan Jay Rao CIO	17.41% $230.4M	0.76% 1.6M shares	Q4 2023 Held for 1y 11m	$1.3B
P Palo Alto Investors, LLC Hedge Fund•Long/Short	Angela Elizabeth Nguyen-Dinh CCO	13.11% $70.8M	0.23% 491.8K shares	≤ Q2 2013 Held for 12y 5m+	$540.4M
Patient Square Capital LP Private Equity	Adam Mark Fliss Founder	12.57% $47.0M	0.15% 326.4K shares	Q3 2024 Held for 1y 2m	$373.9M
D Duquesne Family Office LLC Institution	-	10.94% $349.0M	1.15% 2.4M shares	Q2 2024 Held for 1y 5m	$3.2B
E Eagle Health Investments LP Hedge Fund•Long/Short	Gary Johnathan Stern Founder	10.27% $39.1M	0.13% 271.6K shares	Q2 2024 Held for 1y 5m	$380.9M
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	Scott Lawrence Lessing President	8.94% $965.4M	3.17% 6.7M shares	≤ Q2 2013 Held for 12y 5m+	$10.8B
F First Turn Management, LLC Hedge Fund•Long/Short	Lisa Gable Wheatley Managing Partner	6.91% $46.1M	0.15% 319.8K shares	Q2 2024 Held for 1y 5m	$666.0M

Hedge Fund Spotlight

Discover hedge funds investing in INSM

Jain Global LLC

Hedge Fund • Multi-Strategy

Portfolio ManagerRobert Nmn Jain

Portfolio Value: $7.1B
Positions: 839
Last Reported: Q3 2025

Sector Allocation

Position in Insmed

Market Value: $8.1M
Shares Held: 55.9K
Portfolio Weight: 0.11%
Owned Since: 2025-Q2

Top Holding	Sector	Market Value	Weight
1 iShares Core S&P 500 ETF IVV	ETF ETF	$663.4M	9.30%
2 GLD SPDR Gold Trust GLD	Unknown Unknown	$530.3M	7.44%
3 Tesla, Inc. TSLA	Auto - Manufacturers Consumer Cyclical	$371.5M	5.21%

View full profile

Insmed

Overview

All Institutions

Hedge Funds

Ownership Breakdown

Biggest Investors

Net Capital Flow

Biggest Buyers

Biggest Sellers

Entry and Exit Activity

New Positions

Exited Positions

Options Activity

Call Positions

Put Positions

Most Committed Institutions

Hedge Fund Spotlight

Position in Insmed

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