Janux Therapeutics

JANX • NASDAQ

Janux Therapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by David Campbell, with a market cap of $920.3M. As of Q3 2025, 108% of shares are held by 168 institutional investors, with RA CAPITAL MANAGEMENT, LLC as the largest holder at 18.62%.

President and Chief Executive OfficerDavid Campbell

Market Cap$920.3M

Biotechnology

Healthcare

Employees68.0

Websitejanuxrx.com

Country

United States of America

Overview

Overview of institutional ownership in JANX as of Q3 2025 with a market cap of $1.5B

All Institutions

Institutions: 168
Value Held: $1.6B
Shares Held: 65.1M
Avg Position: $9.5M
Median Position: $703.1K

Hedge Funds

Hedge Funds: 35
Value Held: $631.2M
Shares Held: 25.8M
Avg Position: $18.0M
Median Position: $2.4M

Ownership Breakdown

Institutional (non-HF)

65.35%

$959.8M

Hedge Funds

42.97%

$631.2M

Retail & Other

Based on market cap of $1.5B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in JANX as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	$273.5M 3.40% of portfolio	18.62% 11.2M shares	Q2 2021 Held for 4y 5m	$8.1B
FMR LLC Institution	-	$221.3M 0.01% of portfolio	15.07% 9.1M shares	Q2 2021 Held for 4y 5m	$1.92T
HENDERSON GROUP PLC Institution	Ali Dibadj CEO	$115.0M 0.05% of portfolio	7.82% 4.7M shares	Q2 2021 Held for 4y 5m	$218.74B
B BlackRock, Inc. Institution	-	$91.2M 0.00% of portfolio	6.21% 3.7M shares	Q2 2021 Held for 4y 5m	$5.67T
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	Dr. Senai Nmn Asefaw CIO	$71.4M 2.11% of portfolio	4.86% 2.9M shares	Q2 2024 Held for 1y 5m	$3.4B
A ADAGE CAPITAL PARTNERS GP LLC Institution	-	$67.8M 0.11% of portfolio	4.62% 2.8M shares	Q2 2021 Held for 4y 5m	$63.0B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$59.1M 0.00% of portfolio	4.02% 2.4M shares	Q2 2021 Held for 4y 5m	$6.69T
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$46.2M 0.00% of portfolio	3.15% 1.9M shares	Q3 2021 Held for 4y 2m	$2.88T
ORBIMED ADVISORS LLC Hedge Fund•Sector	Sam Block Iii CFO	$43.2M 1.05% of portfolio	2.94% 1.8M shares	Q2 2021 Held for 4y 5m	$4.1B
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	Steven Alan Cohen CEO	$41.8M 0.10% of portfolio	2.85% 1.7M shares	Q2 2024 Held for 1y 5m	$43.2B

Net Capital Flow

Institutional buying and selling activity for JANX in Q3 2025

Traded: −$599.4K
Buyers: 80
Sellers: 82
Total Bought: +$160.3M
Total Sold: −$160.9M
Avg Position: $8.3M

Biggest Buyers

Institution	Net Bought	Current Position
T T. Rowe Price Investment Management, Inc. Insurance Manager	+$23.8M +972.7K shares	$23.8M 972.7K shares
ORBIMED ADVISORS LLC Hedge Fund•Sector	+$13.6M +555.8K shares	$43.2M 1.8M shares
STATE STREET CORP Institution	+$12.3M +503.4K shares	$46.2M 1.9M shares
T TANG CAPITAL MANAGEMENT LLC Institution	+$12.2M +500.0K shares	$17.1M 700.0K shares
B BlackRock, Inc. Institution	+$8.0M +328.1K shares	$91.2M 3.7M shares
GOLDMAN SACHS GROUP INC Institution	+$7.5M +306.6K shares	$16.0M 655.1K shares
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	+$7.1M +288.9K shares	$8.6M 351.0K shares
R READYSTATE ASSET MANAGEMENT LP Hedge Fund•Multi-Strategy	+$6.5M +264.4K shares	$23.5M 960.4K shares
A ADAGE CAPITAL PARTNERS GP LLC Institution	+$6.1M +250.0K shares	$67.8M 2.8M shares
HENDERSON GROUP PLC Institution	+$5.9M +240.8K shares	$115.0M 4.7M shares

Biggest Sellers

Institution	Net Sold	Current Position
EcoR1 Capital, LLC Hedge Fund•Sector	−$34.0M −1.5M shares	Sold Off 0 shares
C Cormorant Asset Management, LLC Hedge Fund•Long/Short	−$15.9M −650.0K shares	$20.8M 850.0K shares
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	−$12.9M −527.9K shares	$30.9M 1.3M shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	−$10.6M −433.7K shares	$41.8M 1.7M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$10.5M −428.3K shares	$19.6M 802.8K shares
Caption Management, LLC Hedge Fund•Long/Short	−$9.0M −367.0K shares	$2.2M 90.0K shares
BANK OF AMERICA CORP /DE/ Institution	−$8.9M −366.0K shares	$12.1M 493.5K shares
Woodline Partners LP Hedge Fund•Long/Short	−$5.3M −215.0K shares	$25.1M 1.0M shares
FRANKLIN RESOURCES INC Institution	−$4.4M −181.4K shares	$21.7M 887.8K shares
S Skandinaviska Enskilda Banken AB Institution	−$4.1M −177.8K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited JANX in Q3 2025

New Positions: 18
New Value: $28.8M
Exited Positions: 22
Exited Value: $54.4M

New Positions

Institution	Position Value
T T. Rowe Price Investment Management, Inc. Insurance Manager	$23.8M 972.7K shares
CONGRESS ASSET MANAGEMENT CO /MA Long Only Manager	$1.4M 55.8K shares
Q Quadrature Capital Ltd Institution	$656.5K 26.9K shares
F FOX RUN MANAGEMENT, L.L.C. Hedge Fund•Quant	$593.7K 24.3K shares
R Raiffeisen Bank International AG Institution	$568.8K 24.0K shares
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	$377.9K 15.5K shares
O OXFORD ASSET MANAGEMENT Institution	$347.2K 14.2K shares
S STIFEL FINANCIAL CORP Long Only Manager	$276.3K 11.3K shares
I INCEPTIONR LLC Hedge Fund•Quant	$244.6K 10.0K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$240.6K 9.8K shares

Exited Positions

Institution	Previous Position
EcoR1 Capital, LLC Hedge Fund•Sector	$34.0M 1.5M shares
S Skandinaviska Enskilda Banken AB Institution	$4.1M 177.8K shares
First Light Asset Management, LLC Hedge Fund•Sector	$3.5M 149.6K shares
StemPoint Capital LP Hedge Fund•Long/Short	$2.1M 89.9K shares
T TWINBEECH CAPITAL LP Hedge Fund•Quant	$1.9M 81.9K shares
ExodusPoint Capital Management, LP Hedge Fund•Multi-Strategy	$1.7M 74.7K shares
R Ratan Capital Management LP Hedge Fund•Long/Short	$1.1M 13.3K shares
FARALLON CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	$1.1M 48.0K shares
Aquatic Capital Management LLC Hedge Fund•Quant	$993.9K 43.0K shares
ZACKS INVESTMENT MANAGEMENT RIA/Wealth	$877.1K 38.0K shares

Options Activity

Institutions with the largest Call and Put options positions in JANX as of Q3 2025

Call Positions: 8
Call Value: $14.6M
Put Positions: 7
Put Value: $5.2M

Call Positions

Institution	Position Value
Logos Global Management LP Hedge Fund•Long/Short	$12.2M 5.0K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$1.2M 476.0 contracts
Caption Management, LLC Hedge Fund•Long/Short	$457.0K 187.0 contracts
N NOMURA HOLDINGS INC Institution	$454.6K 186.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$307.9K 126.0 contracts
CITIGROUP INC Institution	- - contracts
J JANE STREET GROUP, LLC Institution	- - contracts
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	- - contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$4.1M 1.7K contracts
N NOMURA HOLDINGS INC Institution	$454.6K 186.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$354.4K 145.0 contracts
J JANE STREET GROUP, LLC Institution	$290.8K 119.0 contracts
CITIGROUP INC Institution	- - contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	- - contracts
Caption Management, LLC Hedge Fund•Long/Short	- - contracts

Most Committed Institutions

Institutions with JANX as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
A Avalon Ventures Management, LLC Institution	-	9.17% $1.3M	0.09% 53.3K shares	Q2 2025 Held for 5 months	$14.2M
Prosight Management, LP Hedge Fund•Long/Short	William Lawrence Hawkins Managing Partner	5.61% $21.1M	1.44% 865.4K shares	Q3 2024 Held for 1y 2m	$376.7M
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	3.40% $273.5M	18.62% 11.2M shares	Q2 2021 Held for 4y 5m	$8.1B
MPM Oncology Impact Management LP Institution	Christian Albrecht Wulf Von Schimmelmann Managing Partner	2.46% $15.0M	1.02% 614.3K shares	Q3 2024 Held for 1y 2m	$610.9M
F First Turn Management, LLC Hedge Fund•Long/Short	Lisa Gable Wheatley Managing Partner	2.35% $15.6M	1.06% 639.7K shares	Q4 2024 Held for 11 months	$666.0M
R READYSTATE ASSET MANAGEMENT LP Hedge Fund•Multi-Strategy	David Barnett Grossman Managing Partner	2.34% $23.5M	1.60% 960.4K shares	Q3 2024 Held for 1y 2m	$1.0B
Logos Global Management LP Hedge Fund•Long/Short	Graham Gordon Walmsley Managing Partner	2.31% $22.9M	1.56% 935.0K shares	Q1 2024 Held for 1y 8m	$987.5M
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	Dr. Senai Nmn Asefaw CIO	2.11% $71.4M	4.86% 2.9M shares	Q2 2024 Held for 1y 5m	$3.4B
C Cormorant Asset Management, LLC Hedge Fund•Long/Short	Bihua Chen CEO	1.62% $20.8M	1.41% 850.0K shares	Q1 2024 Held for 1y 8m	$1.3B
ORBIMED ADVISORS LLC Hedge Fund•Sector	Sam Block Iii CFO	1.05% $43.2M	2.94% 1.8M shares	Q2 2021 Held for 4y 5m	$4.1B

Hedge Fund Spotlight

Discover hedge funds investing in JANX

ORBIMED ADVISORS LLC

Hedge Fund • Sector

Portfolio ManagerSam Block Iii

Portfolio Value: $4.1B
Positions: 96
Last Reported: Q3 2025

Sector Allocation

Position in Janux Therapeutics

Market Value: $43.2M
Shares Held: 1.8M
Portfolio Weight: 1.05%
Owned Since: 2021-Q2

Top Holding	Sector	Market Value	Weight
1 Edgewise Therapeutics, Inc. EWTX	Biotechnology Healthcare	$251.7M	6.11%
2 Boston Scientific BSX	Medical - Devices Healthcare	$237.2M	5.75%
3 Eli Lilly LLY	Drug Manufacturers - General Healthcare	$229.8M	5.57%