Kymera Therapeutics

KYMR • NASDAQ

Kymera Therapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by Nello Mainolfi, with a market cap of $5.7B. As of Q3 2025, 113% of shares are held by 205 institutional investors, with BAKER BROS. ADVISORS LP as the largest holder at 9.3%.

CEONello Mainolfi

Market Cap$5.7B

Biotechnology

Healthcare

Employees186.0

Websitekymeratx.com

Country

United States of America

Overview

Overview of institutional ownership in KYMR as of Q3 2025 with a market cap of $4.0B

All Institutions

Institutions: 205
Value Held: $4.6B
Shares Held: 80.8M
Avg Position: $22.3M
Median Position: $1.4M

Hedge Funds

Hedge Funds: 38
Value Held: $839.6M
Shares Held: 14.8M
Avg Position: $22.1M
Median Position: $6.2M

Ownership Breakdown

Institutional (non-HF)

92.25%

$3.7B

Hedge Funds

20.75%

$839.6M

Retail & Other

Based on market cap of $4.0B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in KYMR as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	Scott Lawrence Lessing President	$376.5M 2.73% of portfolio	9.30% 6.7M shares	Q3 2020 Held for 5y 3m	$13.8B
venBio Select Advisor LLC RIA/Wealth	Behzad Aghazadeh Managing Partner	$359.4M 4.65% of portfolio	8.88% 6.4M shares	Q3 2021 Held for 4y 3m	$7.7B
FMR LLC Institution	-	$332.8M 0.02% of portfolio	8.22% 5.9M shares	Q3 2020 Held for 5y 3m	$1.92T
B BVF INC/IL Institution	-	$311.5M 12.63% of portfolio	7.70% 5.5M shares	Q3 2020 Held for 5y 3m	$2.5B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$306.9M 0.00% of portfolio	7.58% 5.4M shares	Q3 2020 Held for 5y 3m	$6.69T
WELLINGTON MANAGEMENT CO LLP Long Only Manager	Jean Marie Hynes CEO	$294.1M 0.05% of portfolio	7.27% 5.2M shares	Q3 2020 Held for 5y 3m	$571.21B
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	Robert W Sharps President	$288.5M 0.03% of portfolio	7.13% 5.1M shares	Q3 2020 Held for 5y 3m	$912.31B
A Atlas Venture Life Science Advisors, LLC Institution	-	$277.1M 36.82% of portfolio	6.85% 4.9M shares	Q4 2021 Held for 4 years	$752.6M
BlackRock, Inc. Institution	Laurence D. Fink CEO	$247.1M 0.00% of portfolio	6.11% 4.4M shares	Q3 2020 Held for 5y 3m	$5.67T
S Siren, L.L.C. Institution	-	$194.0M 7.60% of portfolio	4.79% 3.4M shares	Q3 2024 Held for 1y 3m	$2.6B

Net Capital Flow

Institutional buying and selling activity for KYMR in Q3 2025

Traded: +$169.0M
Buyers: 119
Sellers: 90
Total Bought: +$454.0M
Total Sold: −$284.9M
Avg Position: $18.6M

Biggest Buyers

Institution	Net Bought	Current Position
Holocene Advisors, LP Hedge Fund•Long/Short	+$47.6M +840.3K shares	$47.6M 840.3K shares
A Alyeska Investment Group, L.P. Hedge Fund•Multi-Strategy	+$32.0M +565.1K shares	$34.8M 615.1K shares
FEDERATED INVESTORS INC /PA/ Long Only Manager	+$31.6M +558.7K shares	$31.6M 558.7K shares
T T. Rowe Price Investment Management, Inc. Insurance Manager	+$29.5M +520.6K shares	$34.6M 611.2K shares
STATE STREET CORP Institution	+$26.3M +465.0K shares	$114.3M 2.0M shares
FMR LLC Institution	+$25.3M +447.6K shares	$332.8M 5.9M shares
GOLDMAN SACHS GROUP INC Institution	+$24.5M +432.7K shares	$40.3M 711.4K shares
Pictet Asset Management Holding SA Long Only Manager	+$19.5M +341.3K shares	$19.8M 346.8K shares
S Squarepoint Ops LLC Hedge Fund•Quant	+$18.0M +317.9K shares	$19.9M 351.2K shares
F First Turn Management, LLC Hedge Fund•Long/Short	+$15.7M +277.7K shares	$15.7M 277.7K shares

Biggest Sellers

Institution	Net Sold	Current Position
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	−$99.7M −1.8M shares	$288.5M 5.1M shares
R Redmile Group, LLC Hedge Fund•Sector	−$35.1M −803.3K shares	Sold Off 0 shares
Woodline Partners LP Hedge Fund•Long/Short	−$14.2M −250.1K shares	$14.0M 248.0K shares
SUVRETTA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	−$12.0M −275.0K shares	Sold Off 0 shares
venBio Select Advisor LLC RIA/Wealth	−$11.6M −205.6K shares	$359.4M 6.4M shares
VANGUARD GROUP INC Institution	−$11.2M −198.1K shares	$306.9M 5.4M shares
WELLINGTON MANAGEMENT CO LLP Long Only Manager	−$10.0M −176.4K shares	$294.1M 5.2M shares
VOLORIDGE INVESTMENT MANAGEMENT, LLC Hedge Fund•Multi-Strategy	−$7.1M −162.3K shares	Sold Off 0 shares
Boxer Capital Management, LLC Hedge Fund•Long/Short	−$6.4M −112.9K shares	$18.1M 319.1K shares
GILDER GAGNON HOWE & CO LLC RIA/Wealth	−$4.7M −82.3K shares	$14.0M 246.7K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited KYMR in Q3 2025

New Positions: 25
New Value: $88.8M
Exited Positions: 38
Exited Value: $82.0M

New Positions

Institution	Position Value
Holocene Advisors, LP Hedge Fund•Long/Short	$47.6M 840.3K shares
F First Turn Management, LLC Hedge Fund•Long/Short	$15.7M 277.7K shares
B BRAIDWELL LP Hedge Fund•Multi-Strategy	$15.7M 276.7K shares
EAM Investors, LLC Long Only Manager	$3.2M 57.6K shares
Nicholas Investment Partners, LP Long Only Manager	$3.0M 52.6K shares
Knights of Columbus Asset Advisors LLC Long Only Manager	$1.1M 18.9K shares
WESTWOOD HOLDINGS GROUP INC Institution	$618.4K 10.9K shares
P Perbak Capital Partners LLP Institution	$424.7K 7.5K shares
Legato Capital Management LLC Fund of Funds	$383.9K 6.8K shares
B Bryce Point Capital, LLC Hedge Fund•Market Neutral	$335.1K 5.9K shares

Exited Positions

Institution	Previous Position
R Redmile Group, LLC Hedge Fund•Sector	$35.1M 803.3K shares
SUVRETTA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	$12.0M 275.0K shares
VOLORIDGE INVESTMENT MANAGEMENT, LLC Hedge Fund•Multi-Strategy	$7.1M 162.3K shares
ExodusPoint Capital Management, LP Hedge Fund•Multi-Strategy	$4.4M 101.0K shares
A AXA Institution	$4.0M 91.0K shares
Monashee Investment Management LLC Hedge Fund•Sector	$3.7M 85.0K shares
Weiss Asset Management LP Hedge Fund•Multi-Strategy	$2.2M 50.8K shares
M MAVEN SECURITIES Ltd Private Equity	$2.2M 50.0K shares
S Skandinaviska Enskilda Banken AB Institution	$1.7M 38.1K shares
R ROYCE & ASSOCIATES LLC Institution	$1.5M 33.8K shares

Options Activity

Institutions with the largest Call and Put options positions in KYMR as of Q3 2025

Call Positions: 4
Call Value: $8.1M
Put Positions: 5
Put Value: $3.3M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$5.1M 906.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.3M 226.0 contracts
Caption Management, LLC Hedge Fund•Long/Short	$1.1M 186.0 contracts
J JANE STREET GROUP, LLC Institution	$667.9K 118.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$2.2M 383.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$786.7K 139.0 contracts
J JANE STREET GROUP, LLC Institution	$333.9K 59.0 contracts
Ikarian Capital, LLC Hedge Fund•Event Driven	- - contracts
Caption Management, LLC Hedge Fund•Long/Short	- - contracts

Most Committed Institutions

Institutions with KYMR as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
A Atlas Venture Life Science Advisors, LLC Institution	-	36.82% $277.1M	6.85% 4.9M shares	Q4 2021 Held for 4 years	$752.6M
AJU IB Investment Co., Ltd. Real Assets	Benjamin Jason Weprin CEO	22.47% $25.9M	0.64% 457.1K shares	Q4 2024 Held for 1 year	$115.1M
Merck & Co., Inc. Institution	Robert M. Davis CEO	20.06% $43.7M	1.08% 772.2K shares	Q4 2024 Held for 1 year	$217.8M
B BVF INC/IL Institution	-	12.63% $311.5M	7.70% 5.5M shares	Q3 2020 Held for 5y 3m	$2.5B
S Siren, L.L.C. Institution	-	7.60% $194.0M	4.79% 3.4M shares	Q3 2024 Held for 1y 3m	$2.6B
Boxer Capital Management, LLC Hedge Fund•Long/Short	Aaron Isaac Davis CEO	5.95% $18.1M	0.45% 319.1K shares	Q4 2024 Held for 1 year	$303.5M
venBio Select Advisor LLC RIA/Wealth	Behzad Aghazadeh Managing Partner	4.65% $359.4M	8.88% 6.4M shares	Q3 2021 Held for 4y 3m	$7.7B
Foresite Capital Management VI LLC Venture Capital	James Bruce Tananbaum CEO	3.20% $8.3M	0.20% 146.3K shares	Q4 2024 Held for 1 year	$258.9M
Octagon Capital Advisors LP Hedge Fund•Sector	Ting (Nmn) Jia Founder	3.20% $20.4M	0.50% 360.0K shares	Q2 2025 Held for 6 months	$637.4M
N Nextech Invest, Ltd. Institution	-	2.94% $19.3M	0.48% 340.9K shares	Q2 2025 Held for 6 months	$657.0M

Hedge Fund Spotlight

Discover hedge funds investing in KYMR

BAKER BROS. ADVISORS LP

Hedge Fund • Sector

Portfolio ManagerScott Lawrence Lessing

Portfolio Value: $13.8B
Positions: 89
Last Reported: Q3 2025

Sector Allocation

Position in Kymera Therapeutics

Market Value: $376.5M
Shares Held: 6.7M
Portfolio Weight: 2.73%
Owned Since: 2020-Q3

Top Holding	Sector	Market Value	Weight
1 BGNE BeiGene, Inc. BGNE	Unknown Unknown	$3.0B	21.73%
2 Incyte INCY	Biotechnology Healthcare	$2.6B	18.90%
3 Madrigal Pharmaceuticals, Inc. MDGL	Biotechnology Healthcare	$982.3M	7.12%

View full profile

Kymera Therapeutics

Overview

All Institutions

Hedge Funds

Ownership Breakdown

Biggest Investors

Net Capital Flow

Biggest Buyers

Biggest Sellers

Entry and Exit Activity

New Positions

Exited Positions

Options Activity

Call Positions

Put Positions

Most Committed Institutions

Hedge Fund Spotlight

Position in Kymera Therapeutics

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