Omeros

OMER • NASDAQ

Omeros is a biotechnology company in the healthcare sector on NASDAQ, led by Gregory A. Demopulos, M.D., with a market cap of $719.6M. As of Q3 2025, 48% of shares are held by 132 institutional investors, with BlackRock, Inc. as the largest holder at 6.54%.

President, Chief Executive Officer and Chairman of the Board of DirectorsGregory A. Demopulos, M.D.

Market Cap$719.6M

Biotechnology

Healthcare

Employees198.0

Websiteomeros.com

Country

United States of America

Overview

Overview of institutional ownership in OMER as of Q3 2025 with a market cap of $279.0M

All Institutions

Institutions: 132
Value Held: $134.7M
Shares Held: 32.9M
Avg Position: $1.0M
Median Position: $105.5K

Hedge Funds

Hedge Funds: 15
Value Held: $18.8M
Shares Held: 4.6M
Avg Position: $1.3M
Median Position: $495.8K

Ownership Breakdown

Institutional (non-HF)

41.56%

$116.0M

Hedge Funds

6.73%

$18.8M

Retail & Other

51.72%

$144.3M

Based on market cap of $279.0M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in OMER as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
B BlackRock, Inc. Institution	-	$18.3M 0.00% of portfolio	6.54% 4.5M shares	Q3 2013 Held for 12y 2m	$5.67T
INGALLS & SNYDER LLC RIA/Wealth	Adam David Janovic Managing Partner	$16.8M 0.57% of portfolio	6.03% 4.1M shares	≤ Q2 2013 Held for 12y 5m+	$2.9B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$13.7M 0.00% of portfolio	4.92% 3.3M shares	≤ Q2 2013 Held for 12y 5m+	$6.69T
MORGAN STANLEY RIA/Wealth	Jed Finn CEO	$8.2M 0.00% of portfolio	2.92% 2.0M shares	≤ Q2 2013 Held for 12y 5m+	$1.65T
S STIFEL FINANCIAL CORP Long Only Manager	Adam Vartan Topalian CIO	$7.4M 0.01% of portfolio	2.66% 1.8M shares	Q3 2014 Held for 11y 2m	$109.37B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$6.3M 0.00% of portfolio	2.26% 1.5M shares	≤ Q2 2013 Held for 12y 5m+	$1.57T
Polar Securities Inc. Hedge Fund•Multi-Strategy	Richard Gregory Lemaich CEO	$6.1M 0.18% of portfolio	2.20% 1.5M shares	Q3 2025 Held for 2 months	$3.4B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$5.1M 0.00% of portfolio	1.82% 1.2M shares	≤ Q2 2013 Held for 12y 5m+	$2.88T
D D. E. Shaw & Co., Inc. Institution	-	$4.1M 0.00% of portfolio	1.48% 1.0M shares	Q3 2017 Held for 8y 2m	$115.81B
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	Scott David Hoffman CEO	$3.8M 0.01% of portfolio	1.37% 933.3K shares	Q1 2021 Held for 4y 8m	$62.0B

Net Capital Flow

Institutional buying and selling activity for OMER in Q3 2025

Traded: +$15.7M
Buyers: 71
Sellers: 39
Total Bought: +$23.3M
Total Sold: −$7.7M
Avg Position: $962.3K

Biggest Buyers

Institution	Net Bought	Current Position
Polar Securities Inc. Hedge Fund•Multi-Strategy	+$6.1M +1.5M shares	$6.1M 1.5M shares
MORGAN STANLEY RIA/Wealth	+$2.6M +634.2K shares	$8.2M 2.0M shares
B BlackRock, Inc. Institution	+$1.6M +401.2K shares	$18.3M 4.5M shares
JPMORGAN CHASE & CO Institution	+$1.6M +384.2K shares	$1.7M 416.2K shares
S STIFEL FINANCIAL CORP Long Only Manager	+$1.2M +289.4K shares	$7.4M 1.8M shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	+$1.1M +263.1K shares	$3.8M 933.3K shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$965.6K +235.5K shares	$1.6M 393.2K shares
J JANE STREET GROUP, LLC Institution	+$802.4K +195.7K shares	$1.2M 281.1K shares
GEODE CAPITAL MANAGEMENT LLC ETF Provider	+$678.7K +165.5K shares	$6.3M 1.5M shares
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	+$637.1K +155.4K shares	$2.4M 578.2K shares

Biggest Sellers

Institution	Net Sold	Current Position
D D. E. Shaw & Co., Inc. Institution	−$2.6M −642.2K shares	$4.1M 1.0M shares
DeepCurrents Investment Group LLC Hedge Fund•Multi-Strategy	−$1.7M −407.2K shares	$495.8K 120.9K shares
Marshall Wace LLP Institution	−$1.1M −277.2K shares	$1.9M 464.2K shares
UBS Group AG Institution	−$653.6K −159.4K shares	$2.9M 709.1K shares
Graham Capital Management, L.P. Hedge Fund•Multi-Strategy	−$271.0K −66.1K shares	$141.3K 34.5K shares
X XTX Topco Ltd Institution	−$191.3K −63.8K shares	Sold Off 0 shares
N NOMURA HOLDINGS INC Institution	−$183.6K −44.8K shares	$179.1K 43.7K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	−$156.6K −38.2K shares	$1.4M 344.5K shares
C Corton Capital Inc. Institution	−$116.9K −39.0K shares	Sold Off 0 shares
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	−$115.3K −28.1K shares	$41.0K 10.0K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited OMER in Q3 2025

New Positions: 6
New Value: $6.3M
Exited Positions: 8
Exited Value: $425.9K

New Positions

Institution	Position Value
Polar Securities Inc. Hedge Fund•Multi-Strategy	$6.1M 1.5M shares
Q Quadrature Capital Ltd Institution	$88.2K 21.5K shares
Quantinno Capital Management LP Hedge Fund•Market Neutral	$74.7K 18.2K shares
O Optiver Holding B.V. Institution	$2.2K 538.0 shares
Hanson McClain, Inc. RIA/Wealth	$234.0 57.0 shares
Hartland & Co., LLC RIA/Wealth	$107.0 26.0 shares

Exited Positions

Institution	Previous Position
X XTX Topco Ltd Institution	$191.3K 63.8K shares
C Corton Capital Inc. Institution	$116.9K 39.0K shares
S STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM Institution	$52.3K 17.4K shares
H HSBC HOLDINGS PLC Institution	$34.8K 11.2K shares
RAYMOND JAMES FINANCIAL INC RIA/Wealth	$29.3K 9.8K shares
C CBIZ Investment Advisory Services, LLC RIA/Wealth	$900.0 300.0 shares
Caitong International Asset Management Co., Ltd RIA/Wealth	$312.0 104.0 shares
Ameritas Advisory Services, LLC RIA/Wealth	$93.0 31.0 shares

Options Activity

Institutions with the largest Call and Put options positions in OMER as of Q3 2025

Call Positions: 8
Call Value: $9.0M
Put Positions: 10
Put Value: $10.2M

Call Positions

Institution	Position Value
Polar Securities Inc. Hedge Fund•Multi-Strategy	$5.6M 13.7K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$2.3M 5.6K contracts
W WOLVERINE TRADING, LLC Institution	$405.5K 970.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$337.8K 824.0 contracts
INGALLS & SNYDER LLC RIA/Wealth	$176.3K 430.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$76.3K 186.0 contracts
J JANE STREET GROUP, LLC Institution	$58.6K 143.0 contracts
Sonora Investment Management Group, LLC RIA/Wealth	$49.2K 120.0 contracts

Put Positions

Institution	Position Value
Affinity Asset Advisors, LLC Hedge Fund•Long/Short	$4.6M 11.3K contracts
Caption Management, LLC Hedge Fund•Long/Short	$1.3M 3.3K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.3M 3.2K contracts
LEUCADIA NATIONAL CORP Institution	$1.2M 3.0K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$697.8K 1.7K contracts
CAPSTONE INVESTMENT ADVISORS, LLC Hedge Fund•Multi-Strategy	$456.7K 1.1K contracts
W WOLVERINE TRADING, LLC Institution	$295.9K 708.0 contracts
J JANE STREET GROUP, LLC Institution	$155.0K 378.0 contracts
TORONTO DOMINION BANK Institution	$102.5K 250.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	- - contracts

Most Committed Institutions

Institutions with OMER as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
DeepCurrents Investment Group LLC Hedge Fund•Multi-Strategy	Kai Zheng President	1.22% $495.8K	0.18% 120.9K shares	Q4 2023 Held for 1y 11m	$40.6M
INGALLS & SNYDER LLC RIA/Wealth	Adam David Janovic Managing Partner	0.57% $16.8M	6.03% 4.1M shares	≤ Q2 2013 Held for 12y 5m+	$2.9B
Polar Securities Inc. Hedge Fund•Multi-Strategy	Richard Gregory Lemaich CEO	0.18% $6.1M	2.20% 1.5M shares	Q3 2025 Held for 2 months	$3.4B
AMERICAN FINANCIAL GROUP INC Institution	S. Craig Lindner CEO	0.10% $262.9K	0.09% 64.1K shares	≤ Q2 2013 Held for 12y 5m+	$253.5M
Newbridge Financial Services Group, Inc. RIA/Wealth	Robert Pendelton Spitler CEO	0.08% $551.5K	0.20% 134.5K shares	Q2 2025 Held for 5 months	$667.8M
MINDSET WEALTH MANAGEMENT, LLC RIA/Wealth	Seth William Webb Hickle Managing Partner	0.07% $246.0K	0.09% 60.0K shares	Q3 2024 Held for 1y 2m	$366.9M
Breakwater Investment Management RIA/Wealth	Bethany Anne Steinhaus Managing Partner	0.03% $69.9K	0.03% 17.0K shares	Q1 2024 Held for 1y 8m	$268.6M
Badgley Phelps Wealth Managers, LLC RIA/Wealth	Julie Louise Parisio Roy CEO	0.02% $1.1M	0.39% 263.6K shares	Q2 2023 Held for 2y 5m	$4.8B
C Cypress Capital Group RIA/Wealth	Dana S. Kilborne CEO	0.02% $172.2K	0.06% 42.0K shares	Q4 2017 Held for 7y 11m	$836.4M
Stordahl Capital Management, Inc. RIA/Wealth	William Jason Stordahl Managing Partner	0.02% $93.7K	0.03% 22.9K shares	Q4 2024 Held for 11 months	$476.1M

Hedge Fund Spotlight

Discover hedge funds investing in OMER

TWO SIGMA INVESTMENTS LLC

Hedge Fund • Multi-Strategy

Portfolio ManagerScott David Hoffman

Portfolio Value: $62.0B
Positions: 3,252
Last Reported: Q3 2025

Sector Allocation

Position in Omeros

Market Value: $3.8M
Shares Held: 933.3K
Portfolio Weight: 0.01%
Owned Since: 2021-Q1

Top Holding	Sector	Market Value	Weight
1 SPDR S&P 500 ETF Trust SPY	ETF ETF	$680.4M	1.10%
2 Financial Select Sector SPDR Fund XLF	ETF ETF	$582.6M	0.94%
3 Consumer Staples Select Sector SPDR Fund XLP	ETF ETF	$489.6M	0.79%