uniQure

QURE • NASDAQ

uniQure is a biotechnology company in the healthcare sector on NASDAQ, led by Matthew Kapusta, with a market cap of $1.2B. As of Q3 2025, 90% of shares are held by 219 institutional investors, with FMR LLC as the largest holder at 9.84%.

CEOMatthew Kapusta

Market Cap$1.2B

Biotechnology

Healthcare

Employees480.0

Websiteuniqure.com

Country

United States of America

Overview

Overview of institutional ownership in QURE as of Q3 2025 with a market cap of $3.6B

All Institutions

Institutions: 219
Value Held: $3.2B
Shares Held: 55.3M
Avg Position: $14.7M
Median Position: $1.8M

Hedge Funds

Hedge Funds: 58
Value Held: $1.3B
Shares Held: 22.3M
Avg Position: $22.4M
Median Position: $8.2M

Ownership Breakdown

Institutional (non-HF)

53.51%

$1.9B

Hedge Funds

36.21%

$1.3B

Retail & Other

10.28%

$369.6M

Based on market cap of $3.6B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in QURE as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
FMR LLC Institution	-	$353.7M 0.02% of portfolio	9.84% 6.1M shares	Q1 2014 Held for 11y 8m	$1.92T
venBio Select Advisor LLC RIA/Wealth	Behzad Aghazadeh Managing Partner	$259.4M 3.36% of portfolio	7.21% 4.4M shares	Q4 2024 Held for 11 months	$7.7B
RTW INVESTMENTS, LLC Hedge Fund•Sector	Peter M Fong President	$258.3M 3.20% of portfolio	7.18% 4.4M shares	Q3 2024 Held for 1y 2m	$8.1B
EcoR1 Capital, LLC Hedge Fund•Sector	Scott Eric Perlen CFO	$232.8M 11.17% of portfolio	6.48% 4.0M shares	Q4 2024 Held for 11 months	$2.1B
S Standard Life Aberdeen plc Institution	-	$171.6M 0.27% of portfolio	4.77% 2.9M shares	Q4 2023 Held for 1y 11m	$63.2B
FRANKLIN RESOURCES INC Institution	Gregory E. Johnson CEO	$116.1M 0.03% of portfolio	3.23% 2.0M shares	Q3 2024 Held for 1y 2m	$395.36B
B BlackRock, Inc. Institution	-	$84.4M 0.00% of portfolio	2.35% 1.4M shares	Q1 2017 Held for 8y 8m	$5.67T
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$84.3M 0.00% of portfolio	2.34% 1.4M shares	Q2 2018 Held for 7y 5m	$2.88T
F FRED ALGER MANAGEMENT INC Long Only Manager	Daniel Cayley Chung CEO	$75.3M 0.29% of portfolio	2.09% 1.3M shares	Q3 2025 Held for 2 months	$25.8B
JPMORGAN CHASE & CO Institution	Jamie Dimon CEO	$67.1M 0.00% of portfolio	1.87% 1.1M shares	Q4 2015 Held for 9y 11m	$1.56T

Net Capital Flow

Institutional buying and selling activity for QURE in Q3 2025

Traded: +$225.5M
Buyers: 145
Sellers: 81
Total Bought: +$1.1B
Total Sold: −$897.1M
Avg Position: $13.6M

Biggest Buyers

Institution	Net Bought	Current Position
FMR LLC Institution	+$284.6M +4.9M shares	$353.7M 6.1M shares
F FRED ALGER MANAGEMENT INC Long Only Manager	+$75.3M +1.3M shares	$75.3M 1.3M shares
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	+$53.3M +913.2K shares	$53.3M 913.2K shares
Eversept Partners, LLC Hedge Fund•Long/Short	+$51.2M +877.4K shares	$51.2M 877.4K shares
JENNISON ASSOCIATES LLC Long Only Manager	+$50.2M +859.4K shares	$58.3M 999.5K shares
venBio Select Advisor LLC RIA/Wealth	+$47.8M +819.4K shares	$259.4M 4.4M shares
A Artia Global Partners LP Hedge Fund•Long/Short	+$38.5M +658.8K shares	$38.5M 658.8K shares
FARALLON CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$32.2M +551.0K shares	$33.0M 565.0K shares
N Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. Institution	+$30.5M +521.7K shares	$30.5M 521.7K shares
Deep Track Capital, LP Hedge Fund•Long/Short	+$28.2M +483.1K shares	$28.2M 483.1K shares

Biggest Sellers

Institution	Net Sold	Current Position
Vestal Point Capital, LP Hedge Fund•Long/Short	−$202.8M −3.5M shares	$13.1M 225.0K shares
LEUCADIA NATIONAL CORP Institution	−$117.1M −2.0M shares	$5.3M 90.5K shares
S Sofinnova Ventures Inc Venture Capital	−$83.0M −1.4M shares	$8.0M 136.9K shares
N Nantahala Capital Management, LLC Hedge Fund•Multi-Strategy	−$61.0M −1.0M shares	$58.8M 1.0M shares
Integral Health Asset Management, LLC Hedge Fund•Sector	−$43.8M −750.0K shares	$35.0M 600.0K shares
RTW INVESTMENTS, LLC Hedge Fund•Sector	−$42.8M −733.3K shares	$258.3M 4.4M shares
JPMORGAN CHASE & CO Institution	−$38.4M −658.3K shares	$67.1M 1.1M shares
AMERIPRISE FINANCIAL INC Institution	−$35.2M −603.0K shares	$9.3M 158.9K shares
MORGAN STANLEY RIA/Wealth	−$34.3M −586.8K shares	$18.8M 321.5K shares
M MACQUARIE GROUP LTD Institution	−$26.1M −448.0K shares	$15.1M 258.2K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited QURE in Q3 2025

New Positions: 48
New Value: $172.7M
Exited Positions: 19
Exited Value: $28.4M

New Positions

Institution	Position Value
A Artia Global Partners LP Hedge Fund•Long/Short	$38.5M 658.8K shares
N Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. Institution	$30.5M 521.7K shares
D Darwin Global Management, Ltd. Institution	$23.3M 400.0K shares
S Siren, L.L.C. Institution	$16.1M 275.2K shares
Soleus Capital Management, L.P. Hedge Fund•Long/Short	$11.7M 200.0K shares
BOONE CAPITAL MANAGEMENT LLC Hedge Fund•Long/Short	$8.6M 147.3K shares
R Rosalind Advisors, Inc. Institution	$7.3M 125.0K shares
Patient Square Capital LP Private Equity	$4.4M 75.0K shares
APIS CAPITAL ADVISORS, LLC Hedge Fund•Long/Short	$3.7M 63.8K shares
L Longaeva Partners L.P. Institution	$3.2M 55.0K shares

Exited Positions

Institution	Previous Position
SCHRODER INVESTMENT MANAGEMENT GROUP RIA/Wealth	$9.7M 693.3K shares
P Pale Fire Capital SE Institution	$7.4M 529.8K shares
A Avidity Partners Management LP Hedge Fund•Long/Short	$2.9M 207.0K shares
M MOORE CAPITAL MANAGEMENT, LP Hedge Fund•Global Macro	$2.4M 175.0K shares
UBS GLOBAL ASSET MANAGEMENT AMERICAS INC Long Only Manager	$1.5M 110.6K shares
UBS OCONNOR LLC Long Only Manager	$884.8K 63.5K shares
Main Management ETF Advisors, LLC Institution	$786.5K 56.4K shares
J JANE STREET GROUP, LLC Institution	$703.0K 50.4K shares
Centiva Capital, LP Hedge Fund•Multi-Strategy	$697.0K 50.0K shares
SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC Hedge Fund•Distressed	$537.2K 38.5K shares

Options Activity

Institutions with the largest Call and Put options positions in QURE as of Q3 2025

Call Positions: 26
Call Value: $221.1M
Put Positions: 21
Put Value: $231.7M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$53.0M 9.1K contracts
J JANE STREET GROUP, LLC Institution	$37.3M 6.4K contracts
Caption Management, LLC Hedge Fund•Long/Short	$22.2M 3.8K contracts
S Sofinnova Ventures Inc Venture Capital	$17.5M 3.0K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$15.8M 2.7K contracts
Centiva Capital, LP Hedge Fund•Multi-Strategy	$13.6M 2.3K contracts
BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds	$12.8M 2.2K contracts
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	$11.7M 2.0K contracts
D D. E. Shaw & Co., Inc. Institution	$8.2M 1.4K contracts
W WOLVERINE TRADING, LLC Institution	$6.6M 1.1K contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$51.6M 8.8K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$35.3M 6.0K contracts
Caption Management, LLC Hedge Fund•Long/Short	$30.2M 5.2K contracts
J JANE STREET GROUP, LLC Institution	$29.5M 5.1K contracts
S Sofinnova Ventures Inc Venture Capital	$29.2M 5.0K contracts
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$17.5M 3.0K contracts
BARCLAYS PLC Institution	$11.1M 1.9K contracts
N NOMURA HOLDINGS INC Institution	$5.8M 999.0 contracts
W WOLVERINE TRADING, LLC Institution	$5.5M 923.0 contracts
S SPHERA FUNDS MANAGEMENT LTD. Institution	$4.4M 750.0 contracts

Most Committed Institutions

Institutions with QURE as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
Boxer Capital Management, LLC Hedge Fund•Long/Short	Aaron Isaac Davis CEO	15.38% $46.7M	1.30% 800.0K shares	Q4 2024 Held for 11 months	$303.5M
EcoR1 Capital, LLC Hedge Fund•Sector	Scott Eric Perlen CFO	11.17% $232.8M	6.48% 4.0M shares	Q4 2024 Held for 11 months	$2.1B
A Artia Global Partners LP Hedge Fund•Long/Short	Onusa Nmn Chantanapongwanij Managing Partner	6.77% $38.5M	1.07% 658.8K shares	Q3 2025 Held for 2 months	$568.3M
StemPoint Capital LP Hedge Fund•Long/Short	Sean Chua Tan President	6.15% $30.5M	0.85% 522.2K shares	Q4 2024 Held for 11 months	$495.9M
6 683 Capital Management, LLC Hedge Fund•Long/Short	Ari Jonathan Zweiman Managing Partner	5.89% $62.5M	1.74% 1.1M shares	Q4 2016 Held for 8y 11m	$1.1B
P Privium Fund Management B.V. Institution	-	4.05% $22.5M	0.63% 386.0K shares	Q4 2021 Held for 3y 11m	$556.3M
Eversept Partners, LLC Hedge Fund•Long/Short	Rishi Rasesh Shah President	3.92% $51.2M	1.42% 877.4K shares	Q3 2025 Held for 2 months	$1.3B
SILVERARC CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Devesh Sharad Gandhi Founder	3.85% $26.6M	0.74% 455.0K shares	Q4 2024 Held for 11 months	$689.7M
N Nantahala Capital Management, LLC Hedge Fund•Multi-Strategy	Daniel J. Mack Managing Partner	3.64% $58.8M	1.64% 1.0M shares	Q4 2016 Held for 8y 11m	$1.6B
B Birchview Capital, LP Hedge Fund•Value	Matthew William Strobeck CIO	3.53% $4.6M	0.13% 78.7K shares	Q3 2024 Held for 1y 2m	$130.3M

Hedge Fund Spotlight

Discover hedge funds investing in QURE

Vestal Point Capital, LP

Hedge Fund • Long/Short

Portfolio ManagerRyan Christopher Wilder

Portfolio Value: $2.0B
Positions: 76
Last Reported: Q3 2025

Sector Allocation

Position in uniQure

Market Value: $13.1M
Shares Held: 225.0K
Portfolio Weight: 0.67%
Owned Since: 2023-Q4

Top Holding	Sector	Market Value	Weight
1 Arcellx, Inc. ACLX	Biotechnology Healthcare	$102.6M	5.21%
2 Nuvalent, Inc. NUVL	Biotechnology Healthcare	$95.1M	4.83%
3 Alcon ALC	Medical - Instruments & Supplies Healthcare	$82.0M	4.16%