Rhythm Pharmaceuticals, Inc.
RYTM • NASDAQ
Rhythm Pharmaceuticals, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by David P. Meeker, M.D., with a market cap of $7.1B. As of Q3 2025, 107% of shares are held by 261 institutional investors, with BlackRock, Inc. as the largest holder at 9.49%.
President and Chief Executive OfficerDavid P. Meeker, M.D.
Market Cap$7.1B
Biotechnology
Healthcare
Employees226.0
Websiterhythmtx.com
Country
United States of America
Overview
Overview of institutional ownership in RYTM as of Q3 2025 with a market cap of $6.7B
All Institutions
- Institutions
- 261
- Value Held
- $7.2B
- Shares Held
- 70.9M
- Avg Position
- $27.6M
- Median Position
- $2.0M
Hedge Funds
- Hedge Funds
- 51
- Value Held
- $2.3B
- Shares Held
- 22.3M
- Avg Position
- $44.9M
- Median Position
- $5.0M
Ownership Breakdown
Based on market cap of $6.7B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.
Biggest Investors
Institutions with the largest positions in RYTM as of Q3 2025
| Institution | Position Value |
|---|---|
B BlackRock, Inc. Institution | $636.5M 0.01% of portfolio |
 RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short | $573.8M 7.13% of portfolio |
B BAKER BROS. ADVISORS LP Hedge Fund•Sector | $566.0M 5.24% of portfolio |
 VANGUARD GROUP INC Institution | $504.6M 0.01% of portfolio |
 PRIMECAP MANAGEMENT CO/CA/ Long Only Manager | $430.5M 0.33% of portfolio |
 NEA Management Company, LLC Venture Capital | $293.9M 16.13% of portfolio |
 PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short | $288.4M 8.35% of portfolio |
 FMR LLC Institution | $216.6M 0.01% of portfolio |
 STATE STREET CORP Institution | $204.9M 0.01% of portfolio |
 GOLDMAN SACHS GROUP INC Institution | $191.2M 0.03% of portfolio |
Net Capital Flow
Institutional buying and selling activity for RYTM in Q3 2025
- Net Flow
- +$294.8M
- Buyers
- 108
- Sellers
- 98
- Total Bought
- +$741.3M
- Total Sold
- −$446.5M
- Avg Position
- $30.1M
Biggest Buyers
| Institution | Net Bought |
|---|---|
VANGUARD GROUP INC Institution | +$142.1M +1.4M shares |
 ALLIANCEBERNSTEIN L.P. Long Only Manager | +$92.7M +918.2K shares |
 JPMORGAN CHASE & CO Institution | +$40.9M +404.5K shares |
 LORD, ABBETT & CO. LLC Long Only Manager | +$37.5M +371.7K shares |
 BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy | +$29.9M +295.9K shares |
 Pictet Asset Management Holding SA Long Only Manager | +$26.9M +266.9K shares |
 RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant | +$23.4M +231.7K shares |
 UBS GLOBAL ASSET MANAGEMENT AMERICAS INC Long Only Manager | +$21.2M +209.8K shares |
A ADAGE CAPITAL PARTNERS GP LLC Institution | +$20.5M +203.0K shares |
FMR LLC Institution | +$19.4M +191.7K shares |
Biggest Sellers
| Institution | Net Sold |
|---|---|
PRIMECAP MANAGEMENT CO/CA/ Long Only Manager | −$62.1M −615.2K shares |
 WESTFIELD CAPITAL MANAGEMENT CO LP Long Only Manager | −$56.6M −560.5K shares |
S Sofinnova Ventures Inc Venture Capital | −$34.2M −339.0K shares |
 Hood River Capital Management LLC Long Only Manager | −$31.1M −307.9K shares |
 Checkpoint Capital L.P. Hedge Fund•Sector | −$29.9M −296.3K shares |
 HENDERSON GROUP PLC Institution | −$25.4M −251.0K shares |
 BARCLAYS PLC Institution | −$21.1M −208.8K shares |
 Marshall Wace LLP Institution | −$20.6M −204.4K shares |
 Rock Springs Capital Management LP Hedge Fund•Sector | −$14.5M −144.1K shares |
 Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy | −$10.8M −170.8K shares |
Entry and Exit Activity
Institutions that initiated new positions or completely exited RYTM in Q3 2025
- New Positions
- 28
- New Value
- $143.7M
- Exited Positions
- 17
- Exited Value
- $23.8M
New Positions
| Institution | Position Value |
|---|---|
 Capital Research Global Investors RIA/Wealth | $60.4M 598.2K shares |
 JENNISON ASSOCIATES LLC Long Only Manager | $41.6M 411.6K shares |
 First Light Asset Management, LLC Hedge Fund•Sector | $18.2M 180.5K shares |
 Partner Fund Management, L.P. Hedge Fund•Sector | $4.9M 48.2K shares |
 WCM INVESTMENT MANAGEMENT/CA Long Only Manager | $4.8M 47.7K shares |
 Rhenman & Partners Asset Management AB RIA/Wealth | $3.5M 35.0K shares |
 EFG Asset Management Corp. Long Only Manager | $2.0M 20.3K shares |
 Burkehill Global Management, LP Hedge Fund•Event Driven | $2.0M 20.0K shares |
Q Quantedge Capital Pte Ltd Institution | $1.8M 17.8K shares |
I INCEPTIONR LLC Hedge Fund•Quant | $755.6K 7.5K shares |
Exited Positions
| Institution | Previous Position |
|---|---|
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy | $10.8M 170.8K shares |
 Schonfeld Strategic Advisors LLC Hedge Fund•Multi-Strategy | $4.9M 78.0K shares |
C Cubist Systematic Strategies, LLC Institution | $4.1M 64.6K shares |
J Jump Financial, LLC Institution | $1.1M 17.7K shares |
 Atom Investors LP Hedge Fund•Market Neutral | $939.4K 14.9K shares |
 Point72 Ltd RIA/Wealth | $830.9K 13.1K shares |
 Caption Management, LLC Hedge Fund•Long/Short | $476.5K 7.5K shares |
A AXQ CAPITAL, LP Hedge Fund•Market Neutral | $288.1K 4.6K shares |
 TUDOR INVESTMENT CORP ET AL Hedge Fund•Multi-Strategy | $269.9K 4.3K shares |
A AMERIFLEX GROUP, INC. Institution | $22.1K 360.0 shares |
Options Activity
Institutions with the largest Call and Put options positions in RYTM as of Q3 2025
- Call Positions
- 8
- Call Value
- $50.2M
- Put Positions
- 6
- Put Value
- $15.1M
Call Positions
| Institution | Position Value |
|---|---|
 SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity | $26.2M 2.6K contracts |
J JANE STREET GROUP, LLC Institution | $7.4M 730.0 contracts |
 CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy | $5.2M 512.0 contracts |
Caption Management, LLC Hedge Fund•Long/Short | $5.1M 501.0 contracts |
 BANK OF MONTREAL /CAN/ Institution | $3.8M 380.0 contracts |
 MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy | $2.6M 255.0 contracts |
S SIG BROKERAGE, LP Institution | - - contracts |
N NOMURA HOLDINGS INC Institution | - - contracts |
Put Positions
| Institution | Position Value |
|---|---|
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity | $11.1M 1.1K contracts |
Caption Management, LLC Hedge Fund•Long/Short | $2.3M 225.0 contracts |
J JANE STREET GROUP, LLC Institution | $1.5M 147.0 contracts |
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy | $303.0K 30.0 contracts |
S Sofinnova Ventures Inc Venture Capital | - - contracts |
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy | - - contracts |
Most Committed Institutions
Institutions with RYTM as the highest % of their portfolio as of Q3 2025
| Institution | Portfolio Weight |
|---|---|
Checkpoint Capital L.P. Hedge Fund•Sector | 41.06% $77.1M |
NEA Management Company, LLC Venture Capital | 16.13% $293.9M |
N Nan Fung Group Holdings Ltd Institution | 9.14% $5.0M |
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short | 8.35% $288.4M |
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short | 7.13% $573.8M |
O Opaleye Management Inc. Hedge Fund•Long/Short | 6.64% $46.6M |
 SILVERARC CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short | 5.42% $37.4M |
B BAKER BROS. ADVISORS LP Hedge Fund•Sector | 5.24% $566.0M |
Rock Springs Capital Management LP Hedge Fund•Sector | 4.25% $72.4M |
S Siren, L.L.C. Institution | 2.12% $50.5M |
Hedge Fund Spotlight
Discover hedge funds investing in RYTM
ORBIMED ADVISORS LLC
Hedge Fund • Sector
Portfolio ManagerSam Block Iii
- Portfolio Value
- $4.1B
- Positions
- 96
- Last Reported
- Q3 2025
Sector Allocation
Position in Rhythm Pharmaceuticals, Inc.
- Market Value
- $21.7M
- Shares Held
- 215.2K
- Portfolio Weight
- 0.53%
- Owned Since
- 2023-Q3
| Top Holding | Sector | Market Value | Weight |
|---|---|---|---|
Biotechnology Healthcare | $251.7M | 6.11% | |
Medical - Devices Healthcare | $237.2M | 5.75% | |
Drug Manufacturers - General Healthcare | $229.8M | 5.57% |
