SAB Biotherapeutics

SABS • NASDAQ

SAB Biotherapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by Samuel J. Reich, with a market cap of $181.4M. As of Q3 2025, 269% of shares are held by 34 institutional investors, with Vivo Capital, LLC as the largest holder at 100.0%.

Chief Executive OfficerSamuel J. Reich

Market Cap$181.4M

Biotechnology

Healthcare

Employees57.0

Websitesab.bio

Country

United States of America

Overview

Overview of institutional ownership in SABS as of Q3 2025 with a market cap of $20.9M

All Institutions

Institutions: 34
Value Held: $56.3M
Shares Held: 28.0M
Avg Position: $1.7M
Median Position: $30.9K

Hedge Funds

Hedge Funds: 7
Value Held: $28.4M
Shares Held: 14.1M
Avg Position: $4.1M
Median Position: $4.4M

Ownership Breakdown

Institutional (non-HF)

133.28%

$27.9M

Hedge Funds

135.9%

$28.4M

Retail & Other

Based on market cap of $20.9M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in SABS as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
Vivo Capital, LLC Venture Capital	Jack Bech Nielsen Managing Partner	$23.0M 1.85% of portfolio	100.00% 11.4M shares	Q3 2025 Held for 2 months	$1.2B
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	$8.8M 0.11% of portfolio	42.28% 4.4M shares	Q3 2025 Held for 2 months	$8.1B
COMMODORE CAPITAL LP Hedge Fund•Long/Short	Michael Jonathan Kramarz Managing Partner	$8.8M 0.43% of portfolio	42.28% 4.4M shares	Q3 2025 Held for 2 months	$2.0B
Woodline Partners LP Hedge Fund•Long/Short	Karl Heinz Kroeker CIO	$5.7M 0.03% of portfolio	27.38% 2.9M shares	Q3 2025 Held for 2 months	$21.3B
Sessa Capital IM, L.P. Hedge Fund•Long/Short	Jae Hong President	$4.4M 0.11% of portfolio	21.12% 2.2M shares	Q4 2023 Held for 1y 11m	$3.9B
B BVF INC/IL Institution	-	$1.9M 0.08% of portfolio	8.96% 932.7K shares	Q4 2023 Held for 1y 11m	$2.5B
S SPHERA FUNDS MANAGEMENT LTD. Institution	-	$1.1M 0.27% of portfolio	5.44% 566.4K shares	Q3 2025 Held for 2 months	$416.3M
VANGUARD GROUP INC Institution	Salim Ramji CEO	$735.2K 0.00% of portfolio	3.51% 365.8K shares	Q4 2021 Held for 3y 11m	$6.69T
H HB Wealth Management, LLC Institution	-	$618.1K 0.00% of portfolio	2.95% 307.5K shares	Q3 2024 Held for 1y 2m	$14.7B
A AWM Investment Company, Inc. Hedge Fund•Event Driven	David Michael Greenhouse President	$402.0K 0.04% of portfolio	1.92% 200.0K shares	Q3 2025 Held for 2 months	$1.1B

Net Capital Flow

Institutional buying and selling activity for SABS in Q3 2025

Traded: +$52.5M
Buyers: 22
Sellers: 6
Total Bought: +$52.5M
Total Sold: −$59.6K
Avg Position: $1.5M

Biggest Buyers

Institution	Net Bought	Current Position
Vivo Capital, LLC Venture Capital	+$23.0M +11.4M shares	$23.0M 11.4M shares
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	+$8.8M +4.4M shares	$8.8M 4.4M shares
COMMODORE CAPITAL LP Hedge Fund•Long/Short	+$8.8M +4.4M shares	$8.8M 4.4M shares
Woodline Partners LP Hedge Fund•Long/Short	+$5.7M +2.9M shares	$5.7M 2.9M shares
Sessa Capital IM, L.P. Hedge Fund•Long/Short	+$3.5M +1.7M shares	$4.4M 2.2M shares
S SPHERA FUNDS MANAGEMENT LTD. Institution	+$1.1M +566.4K shares	$1.1M 566.4K shares
H HB Wealth Management, LLC Institution	+$618.1K +307.5K shares	$618.1K 307.5K shares
A AWM Investment Company, Inc. Hedge Fund•Event Driven	+$402.0K +200.0K shares	$402.0K 200.0K shares
VANGUARD GROUP INC Institution	+$167.6K +83.4K shares	$735.2K 365.8K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	+$140.3K +69.8K shares	$162.5K 80.8K shares

Biggest Sellers

Institution	Net Sold	Current Position
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$29.9K −17.1K shares	Sold Off 0 shares
Creative Planning RIA/Wealth	−$20.8K −11.9K shares	Sold Off 0 shares
Sachetta, LLC RIA/Wealth	−$7.2K −4.1K shares	Sold Off 0 shares
B BlackRock, Inc. Institution	−$1.3K −667.0 shares	$12.7K 6.3K shares
A Advisor Group Holdings, Inc. Institution	−$234.1 −113.0 shares	$10.0K 4.8K shares
RAYMOND JAMES FINANCIAL INC RIA/Wealth	−$79.0 −45.0 shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited SABS in Q3 2025

New Positions: 7
New Value: $30.3M
Exited Positions: 4
Exited Value: $58.0K

New Positions

Institution	Position Value
Vivo Capital, LLC Venture Capital	$23.0M 11.4M shares
Woodline Partners LP Hedge Fund•Long/Short	$5.7M 2.9M shares
S SPHERA FUNDS MANAGEMENT LTD. Institution	$1.1M 566.4K shares
A AWM Investment Company, Inc. Hedge Fund•Event Driven	$402.0K 200.0K shares
DIMENSIONAL FUND ADVISORS LP Long Only Manager	$31.7K 15.8K shares
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	$30.2K 15.0K shares
C CAXTON CORP Institution	$22.0K 10.9K shares

Exited Positions

Institution	Previous Position
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$29.9K 17.1K shares
Creative Planning RIA/Wealth	$20.8K 11.9K shares
Sachetta, LLC RIA/Wealth	$7.2K 4.1K shares
RAYMOND JAMES FINANCIAL INC RIA/Wealth	$79.0 45.0 shares

Options Activity

Institutions with the largest Call and Put options positions in SABS as of Q3 2025

Call Positions: 0
Call Value: -
Put Positions: 0
Put Value: -

Call Positions

Institution	Position Value
No call positions found

Put Positions

Institution	Position Value
No put positions found

Most Committed Institutions

Institutions with SABS as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
Vivo Capital, LLC Venture Capital	Jack Bech Nielsen Managing Partner	1.85% $23.0M	100.00% 11.4M shares	Q3 2025 Held for 2 months	$1.2B
COMMODORE CAPITAL LP Hedge Fund•Long/Short	Michael Jonathan Kramarz Managing Partner	0.43% $8.8M	42.28% 4.4M shares	Q3 2025 Held for 2 months	$2.0B
S SPHERA FUNDS MANAGEMENT LTD. Institution	-	0.27% $1.1M	5.44% 566.4K shares	Q3 2025 Held for 2 months	$416.3M
Sessa Capital IM, L.P. Hedge Fund•Long/Short	Jae Hong President	0.11% $4.4M	21.12% 2.2M shares	Q4 2023 Held for 1y 11m	$3.9B
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	0.11% $8.8M	42.28% 4.4M shares	Q3 2025 Held for 2 months	$8.1B
C CAXTON CORP Institution	-	0.10% $22.0K	0.11% 10.9K shares	Q3 2025 Held for 2 months	$22.9M
B BVF INC/IL Institution	-	0.08% $1.9M	8.96% 932.7K shares	Q4 2023 Held for 1y 11m	$2.5B
A AWM Investment Company, Inc. Hedge Fund•Event Driven	David Michael Greenhouse President	0.04% $402.0K	1.92% 200.0K shares	Q3 2025 Held for 2 months	$1.1B
Woodline Partners LP Hedge Fund•Long/Short	Karl Heinz Kroeker CIO	0.03% $5.7M	27.38% 2.9M shares	Q3 2025 Held for 2 months	$21.3B
F First PREMIER Bank Institution	-	0.01% $38.2K	0.18% 19.0K shares	Q4 2021 Held for 3y 11m	$421.2M

Hedge Fund Spotlight

Discover hedge funds investing in SABS

COMMODORE CAPITAL LP

Hedge Fund • Long/Short

Portfolio ManagerMichael Jonathan Kramarz

Portfolio Value: $2.0B
Positions: 37
Last Reported: Q3 2025

Sector Allocation

Position in SAB Biotherapeutics

Market Value: $8.8M
Shares Held: 4.4M
Portfolio Weight: 0.43%
Owned Since: 2025-Q3

Top Holding	Sector	Market Value	Weight
1 Merus N.V. MRUS	Biotechnology Healthcare	$331.9M	16.20%
2 Nuvalent, Inc. NUVL	Biotechnology Healthcare	$121.1M	5.91%
3 Xenon Pharmaceuticals XENE	Biotechnology Healthcare	$108.4M	5.29%