Soleno Therapeutics

SLNO • NASDAQ

Soleno Therapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by Anish Bhatnagar, with a market cap of $2.3B. As of Q3 2025, 122% of shares are held by 234 institutional investors, with FMR LLC as the largest holder at 15.05%.

CEOAnish Bhatnagar

Market Cap$2.3B

Biotechnology

Healthcare

Employees42.0

Websitesoleno.life

Country

United States of America

Overview

Overview of institutional ownership in SLNO as of Q3 2025 with a market cap of $3.6B

All Institutions

Institutions: 234
Value Held: $4.4B
Shares Held: 65.2M
Avg Position: $18.8M
Median Position: $1.6M

Hedge Funds

Hedge Funds: 48
Value Held: $776.3M
Shares Held: 11.5M
Avg Position: $16.2M
Median Position: $4.0M

Ownership Breakdown

Institutional (non-HF)

100.89%

$3.6B

Hedge Funds

21.61%

$776.3M

Retail & Other

Based on market cap of $3.6B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in SLNO as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
FMR LLC Institution	-	$540.8M 0.03% of portfolio	15.05% 8.0M shares	Q2 2024 Held for 1y 6m	$1.92T
HENDERSON GROUP PLC Institution	Ali Dibadj CEO	$409.5M 0.19% of portfolio	11.40% 6.1M shares	Q3 2023 Held for 2y 3m	$218.74B
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	Robert W Sharps President	$263.8M 0.03% of portfolio	7.34% 3.9M shares	Q1 2024 Held for 1y 9m	$912.31B
BlackRock, Inc. Institution	Laurence D. Fink CEO	$236.1M 0.00% of portfolio	6.57% 3.5M shares	Q4 2022 Held for 3 years	$5.67T
VANGUARD GROUP INC Institution	Salim Ramji CEO	$189.8M 0.00% of portfolio	5.28% 2.8M shares	Q1 2015 Held for 10y 9m	$6.69T
venBio Select Advisor LLC RIA/Wealth	Behzad Aghazadeh Managing Partner	$174.3M 2.25% of portfolio	4.85% 2.6M shares	Q4 2023 Held for 2 years	$7.7B
WELLINGTON MANAGEMENT CO LLP Long Only Manager	Jean Marie Hynes CEO	$156.3M 0.03% of portfolio	4.35% 2.3M shares	Q4 2023 Held for 2 years	$571.21B
Vivo Capital, LLC Venture Capital	Frank Fang-Chien Kung Managing Partner	$154.0M 12.39% of portfolio	4.29% 2.3M shares	Q3 2023 Held for 2y 3m	$1.2B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$146.9M 0.01% of portfolio	4.09% 2.2M shares	Q2 2020 Held for 5y 6m	$2.88T
Invesco Ltd. ETF Provider	Brian Christopher Hartigan CEO	$101.4M 0.02% of portfolio	2.82% 1.5M shares	Q1 2024 Held for 1y 9m	$633.08B

Net Capital Flow

Institutional buying and selling activity for SLNO in Q3 2025

Traded: +$577.9M
Buyers: 172
Sellers: 97
Total Bought: +$1.4B
Total Sold: −$863.8M
Avg Position: $15.5M

Biggest Buyers

Institution	Net Bought	Current Position
FMR LLC Institution	+$315.1M +4.7M shares	$540.8M 8.0M shares
WELLINGTON MANAGEMENT CO LLP Long Only Manager	+$114.3M +1.7M shares	$156.3M 2.3M shares
B BRAIDWELL LP Hedge Fund•Multi-Strategy	+$86.7M +1.3M shares	$86.7M 1.3M shares
Invesco Ltd. ETF Provider	+$57.8M +854.6K shares	$101.4M 1.5M shares
STATE STREET CORP Institution	+$51.9M +768.1K shares	$146.9M 2.2M shares
HENDERSON GROUP PLC Institution	+$50.6M +748.3K shares	$409.5M 6.1M shares
COMMODORE CAPITAL LP Hedge Fund•Long/Short	+$50.0M +740.0K shares	$91.3M 1.4M shares
FRANKLIN RESOURCES INC Institution	+$43.9M +649.3K shares	$56.5M 835.8K shares
BlackRock, Inc. Institution	+$43.8M +647.5K shares	$236.1M 3.5M shares
Hood River Capital Management LLC Long Only Manager	+$41.5M +613.4K shares	$41.5M 613.4K shares

Biggest Sellers

Institution	Net Sold	Current Position
A ADAGE CAPITAL PARTNERS GP LLC Institution	−$147.0M −2.2M shares	$94.7M 1.4M shares
Vivo Capital, LLC Venture Capital	−$113.6M −1.7M shares	$154.0M 2.3M shares
Carlyle Group L.P. Institution	−$72.1M −861.0K shares	Sold Off 0 shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$71.3M −1.1M shares	$30.4M 450.1K shares
N Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. Institution	−$42.1M −502.4K shares	Sold Off 0 shares
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	−$36.1M −430.4K shares	Sold Off 0 shares
WESTFIELD CAPITAL MANAGEMENT CO LP Long Only Manager	−$35.9M −530.6K shares	$60.8M 899.2K shares
RTW INVESTMENTS, LLC Hedge Fund•Sector	−$35.6M −424.4K shares	Sold Off 0 shares
A Assenagon Asset Management S.A. Institution	−$21.0M −250.4K shares	Sold Off 0 shares
MORGAN STANLEY RIA/Wealth	−$18.5M −274.2K shares	$11.2M 165.8K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited SLNO in Q3 2025

New Positions: 42
New Value: $257.1M
Exited Positions: 49
Exited Value: $314.4M

New Positions

Institution	Position Value
B BRAIDWELL LP Hedge Fund•Multi-Strategy	$86.7M 1.3M shares
Hood River Capital Management LLC Long Only Manager	$41.5M 613.4K shares
E EVENTIDE ASSET MANAGEMENT, LLC Long Only Manager	$31.6M 467.4K shares
JENNISON ASSOCIATES LLC Long Only Manager	$23.6M 349.1K shares
K KINGDON CAPITAL MANAGEMENT, L.L.C. Hedge Fund•Long/Short	$20.3M 301.0K shares
G GREAT POINT PARTNERS LLC Private Equity	$15.2M 225.0K shares
FRONTIER CAPITAL MANAGEMENT CO LLC Long Only Manager	$8.0M 118.3K shares
P PEREGRINE CAPITAL MANAGEMENT LLC Long Only Manager	$6.3M 93.0K shares
F Freestone Grove Partners LP Hedge Fund•Multi-Strategy	$3.4M 50.6K shares
ALGERT COLDIRON INVESTORS LLC Hedge Fund•Quant	$2.8M 41.0K shares

Exited Positions

Institution	Previous Position
Carlyle Group L.P. Institution	$72.1M 861.0K shares
N Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. Institution	$42.1M 502.4K shares
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	$36.1M 430.4K shares
RTW INVESTMENTS, LLC Hedge Fund•Sector	$35.6M 424.4K shares
A Assenagon Asset Management S.A. Institution	$21.0M 250.4K shares
SILVERARC CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	$17.1M 204.6K shares
TCG Crossover Management, LLC Venture Capital	$15.6M 186.3K shares
Atika Capital Management LLC Hedge Fund•Long/Short	$10.1M 120.5K shares
F First Turn Management, LLC Hedge Fund•Long/Short	$7.2M 86.3K shares
L Longwood Capital Partners LLC Institution	$5.3M 63.4K shares

Options Activity

Institutions with the largest Call and Put options positions in SLNO as of Q3 2025

Call Positions: 27
Call Value: $145.7M
Put Positions: 21
Put Value: $168.0M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$27.2M 4.0K contracts
Hudson Bay Capital Management LP Hedge Fund•Multi-Strategy	$17.6M 2.6K contracts
Ally Bridge Group LLC Hedge Fund•Sector	$16.9M 2.5K contracts
Ikarian Capital, LLC Hedge Fund•Event Driven	$11.9M 1.8K contracts
J JANE STREET GROUP, LLC Institution	$11.1M 1.6K contracts
Frigate Ventures LP RIA/Wealth	$8.8M 1.3K contracts
Centiva Capital, LP Hedge Fund•Multi-Strategy	$7.4M 1.1K contracts
N Nantahala Capital Management, LLC Hedge Fund•Multi-Strategy	$6.8M 1.0K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$6.0M 889.0 contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$4.6M 687.0 contracts

Put Positions

Institution	Position Value
Caption Management, LLC Hedge Fund•Long/Short	$68.7M 10.2K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$28.5M 4.2K contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$14.0M 2.1K contracts
Hudson Bay Capital Management LP Hedge Fund•Multi-Strategy	$10.1M 1.5K contracts
J JANE STREET GROUP, LLC Institution	$7.1M 1.1K contracts
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$6.8M 1.0K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$6.1M 898.0 contracts
LEUCADIA NATIONAL CORP Institution	$5.0M 742.0 contracts
BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds	$3.6M 538.0 contracts
Ikarian Capital, LLC Hedge Fund•Event Driven	$3.4M 500.0 contracts

Most Committed Institutions

Institutions with SLNO as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
Ally Bridge Group LLC Hedge Fund•Sector	Slanix Paul T Alex President	17.12% $20.4M	0.57% 302.5K shares	Q4 2023 Held for 2 years	$119.4M
Vivo Capital, LLC Venture Capital	Frank Fang-Chien Kung Managing Partner	12.39% $154.0M	4.29% 2.3M shares	Q3 2023 Held for 2y 3m	$1.2B
DIADEMA PARTNERS LP Hedge Fund•Long/Short	Timothy Beau Bassett CIO	8.36% $12.0M	0.33% 177.3K shares	Q4 2024 Held for 1 year	$143.3M
A Artia Global Partners LP Hedge Fund•Long/Short	Onusa Nmn Chantanapongwanij Managing Partner	8.00% $45.4M	1.26% 672.2K shares	Q1 2024 Held for 1y 9m	$568.3M
T Tri Locum Partners LP Hedge Fund•Long/Short	Prashanth Nmn Jayaram CIO	7.00% $30.5M	0.85% 450.6K shares	Q1 2025 Held for 9 months	$435.1M
G GREAT POINT PARTNERS LLC Private Equity	Jeffrey Robert Jay Managing Partner	6.71% $15.2M	0.42% 225.0K shares	Q3 2025 Held for 3 months	$226.8M
Catalio Capital Management, LP Venture Capital	Olga Eduardovna Maltseva COO	5.23% $28.3M	0.79% 418.2K shares	Q1 2025 Held for 9 months	$540.9M
COMMODORE CAPITAL LP Hedge Fund•Long/Short	Robert Egen Turrell Atkinson Managing Partner	4.46% $91.3M	2.54% 1.4M shares	Q3 2023 Held for 2y 3m	$2.0B
N Nantahala Capital Management, LLC Hedge Fund•Multi-Strategy	Wilmot B. Harkey Managing Partner	3.61% $58.4M	1.63% 863.8K shares	Q4 2019 Held for 6 years	$1.6B
B BRAIDWELL LP Hedge Fund•Multi-Strategy	Brian James Kreiter CEO	3.50% $86.7M	2.41% 1.3M shares	Q3 2025 Held for 3 months	$2.5B