Stoke Therapeutics, Inc.

STOK • NASDAQ

Stoke Therapeutics, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Ian F. Smith, with a market cap of $1.8B. As of Q3 2025, 122% of shares are held by 150 institutional investors, with FMR LLC as the largest holder at 12.53%.

Interim Chief Executive OfficerIan F. Smith

Market Cap$1.8B

Biotechnology

Healthcare

Employees110.0

Websitestoketherapeutics.com

Country

United States of America

Overview

Overview of institutional ownership in STOK as of Q3 2025 with a market cap of $1.3B

All Institutions

Institutions: 150
Value Held: $1.6B
Shares Held: 67.7M
Avg Position: $10.5M
Median Position: $699.5K

Hedge Funds

Hedge Funds: 22
Value Held: $521.5M
Shares Held: 22.9M
Avg Position: $23.7M
Median Position: $3.2M

Ownership Breakdown

Institutional (non-HF)

81.75%

$1.1B

Hedge Funds

40.5%

$521.5M

Retail & Other

Based on market cap of $1.3B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in STOK as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
FMR LLC Institution	-	$161.3M 0.01% of portfolio	12.53% 6.9M shares	Q2 2019 Held for 6y 5m	$1.92T
B BlackRock, Inc. Institution	-	$140.7M 0.00% of portfolio	10.93% 6.0M shares	Q2 2019 Held for 6y 5m	$5.67T
RTW INVESTMENTS, LLC Hedge Fund•Sector	Peter M Fong President	$120.4M 1.49% of portfolio	9.35% 5.1M shares	Q2 2019 Held for 6y 5m	$8.1B
L Lynx1 Capital Management LP Hedge Fund•Sector	Weston Agnew Nichols CIO	$109.9M 22.37% of portfolio	9.86% 5.4M shares	Q3 2023 Held for 2y 2m	$491.3M
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	Scott Lawrence Lessing President	$108.9M 1.01% of portfolio	8.46% 4.6M shares	Q3 2022 Held for 3y 2m	$10.8B
R Redmile Group, LLC Hedge Fund•Sector	Jeremy Charles Green Managing Partner	$98.1M 9.55% of portfolio	7.62% 4.2M shares	Q2 2019 Held for 6y 5m	$1.0B
MORGAN STANLEY RIA/Wealth	Jed Finn CEO	$83.1M 0.01% of portfolio	6.45% 3.5M shares	Q2 2019 Held for 6y 5m	$1.65T
TORONTO DOMINION BANK Institution	Leo Salom CEO	$74.6M 0.15% of portfolio	5.79% 3.2M shares	Q4 2024 Held for 11 months	$51.2B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$74.4M 0.00% of portfolio	5.77% 3.2M shares	Q2 2019 Held for 6y 5m	$6.69T
S Skorpios Trust Institution	-	$53.0M 99.68% of portfolio	4.12% 2.3M shares	Q4 2021 Held for 3y 11m	$53.2M

Net Capital Flow

Institutional buying and selling activity for STOK in Q3 2025

Net Flow: −$36.2M
Buyers: 48
Sellers: 62
Total Bought: +$91.4M
Total Sold: −$127.7M
Avg Position: $10.9M

Biggest Buyers

Institution	Net Bought	Current Position
R ROYAL BANK OF CANADA Institution	+$18.1M +771.7K shares	$21.5M 915.8K shares
WELLINGTON MANAGEMENT CO LLP Long Only Manager	+$14.1M +600.7K shares	$17.3M 737.8K shares
Polar Capital Holdings Plc Long Only Manager	+$10.3M +439.8K shares	$31.1M 1.3M shares
A Assenagon Asset Management S.A. Institution	+$8.5M +362.3K shares	$21.2M 900.3K shares
HENDERSON GROUP PLC Institution	+$7.4M +315.6K shares	$7.9M 334.5K shares
VANGUARD GROUP INC Institution	+$5.1M +217.6K shares	$74.4M 3.2M shares
Checkpoint Capital L.P. Hedge Fund•Sector	+$5.0M +212.0K shares	$5.0M 212.0K shares
GEODE CAPITAL MANAGEMENT LLC ETF Provider	+$4.1M +174.1K shares	$27.0M 1.1M shares
Invesco Ltd. ETF Provider	+$3.9M +167.9K shares	$4.9M 208.1K shares
O Opaleye Management Inc. Hedge Fund•Long/Short	+$2.8M +119.9K shares	$16.0M 682.0K shares

Biggest Sellers

Institution	Net Sold	Current Position
Marshall Wace LLP Institution	−$36.0M −1.5M shares	$18.1M 768.3K shares
S Skorpios Trust Institution	−$23.5M −1.0M shares	$53.0M 2.3M shares
FMR LLC Institution	−$12.9M −547.9K shares	$161.3M 6.9M shares
D DAFNA Capital Management LLC Hedge Fund•Event Driven	−$7.8M −332.2K shares	$4.0M 169.8K shares
C CI Private Wealth, LLC RIA/Wealth	−$7.5M −659.8K shares	Sold Off 0 shares
BANK OF AMERICA CORP /DE/ Institution	−$7.0M −298.6K shares	$5.9M 249.5K shares
GRANAHAN INVESTMENT MANAGEMENT INC/MA Long Only Manager	−$6.5M −278.5K shares	$6.0M 253.9K shares
R Redmile Group, LLC Hedge Fund•Sector	−$4.7M −200.4K shares	$98.1M 4.2M shares
GOLDMAN SACHS GROUP INC Institution	−$3.5M −150.5K shares	$27.0M 1.2M shares
C Cormorant Asset Management, LLC Hedge Fund•Long/Short	−$2.9M −254.2K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited STOK in Q3 2025

New Positions: 22
New Value: $60.7M
Exited Positions: 20
Exited Value: $13.3M

New Positions

Institution	Position Value
B BVF INC/IL Institution	$38.9M 1.7M shares
Parkman Healthcare Partners LLC Hedge Fund•Long/Short	$5.9M 250.0K shares
Rhenman & Partners Asset Management AB RIA/Wealth	$5.9M 250.0K shares
FIRST TRUST ADVISORS LP ETF Provider	$3.6M 152.3K shares
N NOMURA HOLDINGS INC Institution	$1.9M 81.2K shares
Q Quantedge Capital Pte Ltd Institution	$940.0K 40.0K shares
Cresset Asset Management, LLC RIA/Wealth	$770.7K 32.8K shares
C Campbell & CO Investment Adviser LLC Hedge Fund•Quant Macro	$714.8K 30.4K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$572.0K 24.3K shares
S SEI INVESTMENTS CO Institution	$386.6K 16.5K shares

Exited Positions

Institution	Previous Position
C CI Private Wealth, LLC RIA/Wealth	$7.5M 659.8K shares
C Cormorant Asset Management, LLC Hedge Fund•Long/Short	$2.9M 254.2K shares
STATE OF WISCONSIN INVESTMENT BOARD RIA/Wealth	$395.0K 34.8K shares
J JANE STREET GROUP, LLC Institution	$394.3K 34.7K shares
Engineers Gate Manager LP Hedge Fund•Quant	$377.7K 33.3K shares
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	$309.7K 27.3K shares
S Squarepoint Ops LLC Hedge Fund•Quant	$266.2K 23.5K shares
Verition Fund Management LLC Hedge Fund•Multi-Strategy	$239.0K 21.1K shares
Integrated Quantitative Investments LLC Long Only Manager	$219.1K 19.3K shares
LAZARD ASSET MANAGEMENT LLC Long Only Manager	$157.0K 13.8K shares

Options Activity

Institutions with the largest Call and Put options positions in STOK as of Q3 2025

Call Positions: 4
Call Value: $13.2M
Put Positions: 2
Put Value: $2.4M

Call Positions

Institution	Position Value
Caption Management, LLC Hedge Fund•Long/Short	$11.8M 5.0K contracts
J J. Goldman & Co LP Hedge Fund•Multi-Strategy	$794.3K 338.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$373.7K 159.0 contracts
J JANE STREET GROUP, LLC Institution	$244.4K 104.0 contracts

Put Positions

Institution	Position Value
Caption Management, LLC Hedge Fund•Long/Short	$1.4M 600.0 contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$951.8K 405.0 contracts

Most Committed Institutions

Institutions with STOK as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
S Skorpios Trust Institution	-	99.68% $53.0M	4.12% 2.3M shares	Q4 2021 Held for 3y 11m	$53.2M
L Lynx1 Capital Management LP Hedge Fund•Sector	Weston Agnew Nichols CIO	22.37% $109.9M	9.86% 5.4M shares	Q3 2023 Held for 2y 2m	$491.3M
R Redmile Group, LLC Hedge Fund•Sector	Jeremy Charles Green Managing Partner	9.55% $98.1M	7.62% 4.2M shares	Q2 2019 Held for 6y 5m	$1.0B
B Birchview Capital, LP Hedge Fund•Value	Matthew William Strobeck CIO	3.79% $4.9M	0.38% 210.0K shares	Q1 2020 Held for 5y 8m	$130.3M
MPM Oncology Impact Management LP Institution	Christian Albrecht Wulf Von Schimmelmann Managing Partner	3.04% $18.6M	1.44% 789.7K shares	Q3 2024 Held for 1y 2m	$610.9M
Checkpoint Capital L.P. Hedge Fund•Sector	Tony Michael Berta CFO	2.65% $5.0M	0.39% 212.0K shares	Q3 2024 Held for 1y 2m	$187.8M
O Opaleye Management Inc. Hedge Fund•Long/Short	James Aaron Silverman President	2.28% $16.0M	1.24% 682.0K shares	Q4 2024 Held for 11 months	$702.7M
S Siren, L.L.C. Institution	-	2.21% $52.8M	4.10% 2.2M shares	Q4 2024 Held for 11 months	$2.4B
B BVF INC/IL Institution	-	1.58% $38.9M	3.02% 1.7M shares	Q3 2025 Held for 2 months	$2.5B
RTW INVESTMENTS, LLC Hedge Fund•Sector	Peter M Fong President	1.49% $120.4M	9.35% 5.1M shares	Q2 2019 Held for 6y 5m	$8.1B

Hedge Fund Spotlight

Discover hedge funds investing in STOK

Redmile Group, LLC

Hedge Fund • Sector

Portfolio ManagerJeremy Charles Green

Portfolio Value: $1.0B
Positions: 40
Last Reported: Q3 2025

Sector Allocation

Position in Stoke Therapeutics, Inc.

Market Value: $98.1M
Shares Held: 4.2M
Portfolio Weight: 9.55%
Owned Since: 2019-Q2

Top Holding	Sector	Market Value	Weight
1 Scholar Rock SRRK	Biotechnology Healthcare	$145.4M	14.15%
2 Krystal Biotech, Inc. KRYS	Biotechnology Healthcare	$116.8M	11.36%
3 Stoke Therapeutics, Inc. STOK	Biotechnology Healthcare	$98.1M	9.55%