Shattuck Labs, Inc.

STTK • NASDAQ

Shattuck Labs, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Taylor Schreiber, with a market cap of $196.2M. As of Q3 2025, 76% of shares are held by 54 institutional investors, with ORBIMED ADVISORS LLC as the largest holder at 13.16%.

Chief Executive OfficerTaylor Schreiber

Market Cap$196.2M

Biotechnology

Healthcare

Employees75.0

Websiteshattucklabs.com

Country

United States of America

Overview

Overview of institutional ownership in STTK as of Q3 2025 with a market cap of $114.5M

All Institutions

Institutions: 54
Value Held: $86.8M
Shares Held: 36.3M
Avg Position: $1.6M
Median Position: $97.7K

Hedge Funds

Hedge Funds: 10
Value Held: $48.5M
Shares Held: 20.3M
Avg Position: $4.8M
Median Position: $1.3M

Ownership Breakdown

Institutional (non-HF)

33.5%

$38.3M

Hedge Funds

42.36%

$48.5M

Retail & Other

24.15%

$27.6M

Based on market cap of $114.5M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in STTK as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
ORBIMED ADVISORS LLC Hedge Fund•Sector	Sam Block Iii CFO	$15.1M 0.37% of portfolio	13.16% 6.3M shares	Q3 2025 Held for 2 months	$4.1B
A ADAGE CAPITAL PARTNERS GP LLC Institution	-	$15.1M 0.02% of portfolio	13.16% 6.3M shares	Q4 2023 Held for 1y 11m	$63.0B
R Redmile Group, LLC Hedge Fund•Sector	Amrit Nmn Nagpal Managing Partner	$13.2M 1.29% of portfolio	11.56% 5.5M shares	Q4 2020 Held for 4y 11m	$1.0B
Prosight Management, LP Hedge Fund•Long/Short	William Lawrence Hawkins Managing Partner	$13.0M 3.46% of portfolio	11.38% 5.5M shares	Q3 2021 Held for 4y 2m	$376.7M
VANGUARD GROUP INC Institution	Salim Ramji CEO	$5.1M 0.00% of portfolio	4.44% 2.1M shares	Q4 2020 Held for 4y 11m	$6.69T
6 683 Capital Management, LLC Hedge Fund•Long/Short	Ari Jonathan Zweiman Managing Partner	$3.7M 0.35% of portfolio	3.20% 1.5M shares	Q4 2024 Held for 11 months	$1.1B
C CLARK ESTATES INC/NY Institution	-	$3.5M 0.84% of portfolio	3.08% 1.5M shares	Q4 2020 Held for 4y 11m	$421.5M
PINNACLE ASSOCIATES LTD Long Only Manager	Joel Michael Heyman President	$3.3M 0.04% of portfolio	2.90% 1.4M shares	Q2 2023 Held for 2y 5m	$7.5B
BANK OF AMERICA CORP /DE/ Institution	Brian T. Moynihan CEO	$2.7M 0.00% of portfolio	2.36% 1.1M shares	Q3 2022 Held for 3y 2m	$1.33T
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	Dan Michael Berkovitz Chairman	$1.7M 0.00% of portfolio	1.44% 690.9K shares	Q1 2021 Held for 4y 8m	$121.98B

Net Capital Flow

Institutional buying and selling activity for STTK in Q3 2025

Traded: +$20.5M
Buyers: 26
Sellers: 37
Total Bought: +$26.7M
Total Sold: −$6.2M
Avg Position: $1.2M

Biggest Buyers

Institution	Net Bought	Current Position
ORBIMED ADVISORS LLC Hedge Fund•Sector	+$15.1M +6.3M shares	$15.1M 6.3M shares
A ADAGE CAPITAL PARTNERS GP LLC Institution	+$3.9M +1.6M shares	$15.1M 6.3M shares
BANK OF AMERICA CORP /DE/ Institution	+$2.6M +1.1M shares	$2.7M 1.1M shares
Marshall Wace LLP Institution	+$1.6M +656.7K shares	$1.6M 656.7K shares
6 683 Capital Management, LLC Hedge Fund•Long/Short	+$1.0M +437.2K shares	$3.7M 1.5M shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	+$792.7K +331.7K shares	$976.5K 408.6K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	+$427.3K +178.8K shares	$518.3K 216.9K shares
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	+$235.8K +98.7K shares	$269.3K 112.7K shares
S Standard Life Aberdeen plc Institution	+$225.9K +94.5K shares	$225.9K 94.5K shares
L LBJ Family Wealth Advisors, Ltd. Family Office	+$196.4K +82.2K shares	$196.4K 82.2K shares

Biggest Sellers

Institution	Net Sold	Current Position
Prosight Management, LP Hedge Fund•Long/Short	−$2.8M −1.2M shares	$13.0M 5.5M shares
B BlackRock, Inc. Institution	−$1.1M −470.1K shares	$983.0K 411.3K shares
J JANE STREET GROUP, LLC Institution	−$455.6K −190.6K shares	$236.7K 99.0K shares
Pathstone Holdings, LLC Family Office	−$375.4K −157.1K shares	$375.4K 157.1K shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$364.1K −152.4K shares	$1.7M 690.9K shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	−$306.4K −128.2K shares	$162.8K 68.1K shares
B BRIDGEWAY CAPITAL MANAGEMENT INC Long Only Manager	−$119.5K −50.0K shares	$101.1K 42.3K shares
Y Y-Intercept Ltd Institution	−$97.5K −123.2K shares	Sold Off 0 shares
Q Qube Research & Technologies Ltd Institution	−$94.2K −39.4K shares	$38.1K 16.0K shares
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	−$81.5K −102.9K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited STTK in Q3 2025

New Positions: 8
New Value: $15.4M
Exited Positions: 18
Exited Value: $315.9K

New Positions

Institution	Position Value
ORBIMED ADVISORS LLC Hedge Fund•Sector	$15.1M 6.3M shares
S Standard Life Aberdeen plc Institution	$225.9K 94.5K shares
X XTX Topco Ltd Institution	$62.7K 26.2K shares
Creative Planning RIA/Wealth	$29.5K 12.3K shares
Turtle Creek Wealth Advisors, LLC Family Office	$29.2K 12.2K shares
AssuredPartners Investment Advisors, LLC RIA/Wealth	$23.9K 10.0K shares
O Optiver Holding B.V. Institution	$158.0 66.0 shares
SRS Capital Advisors, Inc. RIA/Wealth	$33.0 14.0 shares

Exited Positions

Institution	Previous Position
Y Y-Intercept Ltd Institution	$97.5K 123.2K shares
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	$81.5K 102.9K shares
AQR CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	$30.1K 38.0K shares
JACOBS LEVY EQUITY MANAGEMENT, INC Hedge Fund•Quant	$28.3K 35.8K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$27.3K 34.5K shares
Summit Trail Advisors, LLC RIA/Wealth	$18.7K 23.6K shares
T Tower Research Capital LLC Institution	$13.4K 16.9K shares
H HSBC HOLDINGS PLC Institution	$12.9K 16.1K shares
M Mallini Complete Financial Planning LLC RIA/Wealth	$1.8K 22.6K shares
BARCLAYS PLC Institution	$1.7K 2.1K shares

Options Activity

Institutions with the largest Call and Put options positions in STTK as of Q3 2025

Call Positions: 1
Call Value: $53.1K
Put Positions: 0
Put Value: -

Call Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$53.1K 222.0 contracts

Put Positions

Institution	Position Value
No put positions found

Most Committed Institutions

Institutions with STTK as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
T TAKEDA PHARMACEUTICAL CO LTD Institution	-	7.53% $1.2M	1.08% 515.6K shares	Q4 2023 Held for 1y 11m	$16.4M
PIPER JAFFRAY & CO. Long Only Manager	Jonathan Jay Doyle Managing Partner	6.38% $94.3K	0.08% 39.5K shares	Q4 2020 Held for 4y 11m	$1.5M
Prosight Management, LP Hedge Fund•Long/Short	William Lawrence Hawkins Managing Partner	3.46% $13.0M	11.38% 5.5M shares	Q3 2021 Held for 4y 2m	$376.7M
R Redmile Group, LLC Hedge Fund•Sector	Amrit Nmn Nagpal Managing Partner	1.29% $13.2M	11.56% 5.5M shares	Q4 2020 Held for 4y 11m	$1.0B
C CLARK ESTATES INC/NY Institution	-	0.84% $3.5M	3.08% 1.5M shares	Q4 2020 Held for 4y 11m	$421.5M
ORBIMED ADVISORS LLC Hedge Fund•Sector	Sam Block Iii CFO	0.37% $15.1M	13.16% 6.3M shares	Q3 2025 Held for 2 months	$4.1B
6 683 Capital Management, LLC Hedge Fund•Long/Short	Ari Jonathan Zweiman Managing Partner	0.35% $3.7M	3.20% 1.5M shares	Q4 2024 Held for 11 months	$1.1B
L LBJ Family Wealth Advisors, Ltd. Family Office	Faith Creighton Vincent CIO	0.11% $196.4K	0.17% 82.2K shares	Q2 2024 Held for 1y 5m	$182.7M
PINNACLE ASSOCIATES LTD Long Only Manager	Joel Michael Heyman President	0.04% $3.3M	2.90% 1.4M shares	Q2 2023 Held for 2y 5m	$7.5B
A ADAGE CAPITAL PARTNERS GP LLC Institution	-	0.02% $15.1M	13.16% 6.3M shares	Q4 2023 Held for 1y 11m	$63.0B

Hedge Fund Spotlight

Discover hedge funds investing in STTK

ORBIMED ADVISORS LLC

Hedge Fund • Sector

Portfolio ManagerSam Block Iii

Portfolio Value: $4.1B
Positions: 96
Last Reported: Q3 2025

Sector Allocation

Position in Shattuck Labs, Inc.

Market Value: $15.1M
Shares Held: 6.3M
Portfolio Weight: 0.37%
Owned Since: 2025-Q3

Top Holding	Sector	Market Value	Weight
1 Edgewise Therapeutics, Inc. EWTX	Biotechnology Healthcare	$251.7M	6.11%
2 Boston Scientific BSX	Medical - Devices Healthcare	$237.2M	5.75%
3 Eli Lilly LLY	Drug Manufacturers - General Healthcare	$229.8M	5.57%