Tempus AI, Inc.

TEM • NASDAQ

Tempus AI, Inc. is a medical - diagnostics & research company in the healthcare sector on NASDAQ, led by Eric Lefkofsky, with a market cap of $13.6B. As of Q3 2025, 52% of shares are held by 429 institutional investors, with BAILLIE GIFFORD & CO as the largest holder at 5.58%.

Chief Executive OfficerEric Lefkofsky

Market Cap$13.6B

Medical - Diagnostics & Research

Healthcare

Employees2.3K

Websitetempus.com

Overview

Overview of institutional ownership in TEM as of Q3 2025 with a market cap of $14.0B

All Institutions

Institutions: 429
Value Held: $7.3B
Shares Held: 90.9M
Avg Position: $17.1M
Median Position: $739.4K

Hedge Funds

Hedge Funds: 44
Value Held: $627.1M
Shares Held: 7.8M
Avg Position: $14.3M
Median Position: $2.6M

Ownership Breakdown

Institutional (non-HF)

47.89%

$6.7B

Hedge Funds

4.47%

$627.1M

Retail & Other

47.64%

$6.7B

Based on market cap of $14.0B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in TEM as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
B BAILLIE GIFFORD & CO Institution	-	$782.3M 0.58% of portfolio	5.58% 9.7M shares	Q2 2025 Held for 5 months	$134.80B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$762.0M 0.01% of portfolio	5.43% 9.4M shares	Q2 2024 Held for 1y 5m	$6.69T
ARK Investment Management LLC ETF Provider	Catherine Duddy Wood CEO	$579.2M 3.51% of portfolio	4.13% 7.2M shares	Q2 2024 Held for 1y 5m	$16.5B
B BlackRock, Inc. Institution	-	$543.8M 0.01% of portfolio	3.88% 6.7M shares	Q4 2024 Held for 11 months	$5.67T
S SOFTBANK GROUP CORP Institution	-	$436.3M 1.68% of portfolio	3.11% 5.4M shares	Q2 2024 Held for 1y 5m	$25.9B
JPMORGAN CHASE & CO Institution	Jamie Dimon CEO	$397.8M 0.03% of portfolio	2.84% 4.9M shares	Q2 2024 Held for 1y 5m	$1.56T
S Sumitomo Mitsui Trust Holdings, Inc. Institution	-	$279.5M 0.16% of portfolio	1.99% 3.5M shares	Q3 2024 Held for 1y 2m	$173.79B
Nikko Asset Management Americas, Inc. Long Only Manager	James Mark Beyer Wesley CEO	$279.5M 2.71% of portfolio	1.99% 3.5M shares	Q2 2024 Held for 1y 5m	$10.3B
MORGAN STANLEY RIA/Wealth	Jed Finn CEO	$195.0M 0.01% of portfolio	1.39% 2.4M shares	Q2 2024 Held for 1y 5m	$1.65T
BANK OF AMERICA CORP /DE/ Institution	Brian T. Moynihan CEO	$194.4M 0.01% of portfolio	1.39% 2.4M shares	Q2 2024 Held for 1y 5m	$1.33T

Net Capital Flow

Institutional buying and selling activity for TEM in Q3 2025

Net Flow: +$527.2M
Buyers: 168
Sellers: 154
Total Bought: +$1.4B
Total Sold: −$858.2M
Avg Position: $19.5M

Biggest Buyers

Institution	Net Bought	Current Position
B BlackRock, Inc. Institution	+$209.7M +2.6M shares	$543.8M 6.7M shares
VANGUARD GROUP INC Institution	+$137.8M +1.7M shares	$762.0M 9.4M shares
D D. E. Shaw & Co., Inc. Institution	+$129.6M +1.6M shares	$163.6M 2.0M shares
BANK OF AMERICA CORP /DE/ Institution	+$103.1M +1.3M shares	$194.4M 2.4M shares
GEODE CAPITAL MANAGEMENT LLC ETF Provider	+$87.1M +1.1M shares	$139.6M 1.7M shares
VOLORIDGE INVESTMENT MANAGEMENT, LLC Hedge Fund•Multi-Strategy	+$83.9M +1.0M shares	$129.7M 1.6M shares
B BNP PARIBAS ARBITRAGE, SA Institution	+$77.9M +965.7K shares	$102.9M 1.3M shares
UBS Group AG Institution	+$69.0M +854.7K shares	$176.4M 2.2M shares
SCHWAB CHARLES INVESTMENT MANAGEMENT INC Long Only Manager	+$55.3M +685.5K shares	$57.3M 709.7K shares
STATE STREET CORP Institution	+$49.5M +612.8K shares	$118.9M 1.5M shares

Biggest Sellers

Institution	Net Sold	Current Position
GOLDMAN SACHS GROUP INC Institution	−$325.3M −4.0M shares	$18.2M 225.7K shares
B BAILLIE GIFFORD & CO Institution	−$193.8M −2.4M shares	$782.3M 9.7M shares
FRONTIER CAPITAL MANAGEMENT CO LLC Long Only Manager	−$34.4M −425.9K shares	$13.3M 164.9K shares
T Toroso Investments, LLC ETF Provider	−$34.2M −424.1K shares	$2.2M 27.8K shares
S Sumitomo Mitsui Trust Holdings, Inc. Institution	−$32.8M −406.8K shares	$279.5M 3.5M shares
Nikko Asset Management Americas, Inc. Long Only Manager	−$32.8M −406.8K shares	$279.5M 3.5M shares
Q Quadrature Capital Ltd Institution	−$21.9M −344.6K shares	Sold Off 0 shares
ARK Investment Management LLC ETF Provider	−$19.9M −246.0K shares	$579.2M 7.2M shares
RTW INVESTMENTS, LLC Hedge Fund•Sector	−$16.1M −200.0K shares	$16.1M 200.0K shares
Vestmark Advisory Solutions, Inc. Fund of Funds	−$14.4M −177.7K shares	$13.0M 160.6K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited TEM in Q3 2025

New Positions: 105
New Value: $217.3M
Exited Positions: 49
Exited Value: $57.6M

New Positions

Institution	Position Value
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	$35.9M 444.3K shares
Trexquant Investment LP Hedge Fund•Quant	$26.4M 327.5K shares
M Man Group plc Institution	$24.1M 299.2K shares
Casdin Capital, LLC Hedge Fund•Sector	$23.7M 294.1K shares
Kohlberg Kravis Roberts & Co. L.P. Private Equity	$9.5M 117.7K shares
Voleon Capital Management LP Hedge Fund•Quant	$8.8M 109.3K shares
Susquehanna Portfolio Strategies, LLC Private Equity	$8.1M 100.9K shares
VAN ECK ASSOCIATES CORP ETF Provider	$7.4M 91.7K shares
Summit Financial, LLC RIA/Wealth	$6.8M 84.4K shares
MITCHELL CAPITAL MANAGEMENT CO RIA/Wealth	$5.7M 70.3K shares

Exited Positions

Institution	Previous Position
Q Quadrature Capital Ltd Institution	$21.9M 344.6K shares
B Blue Owl Capital Holdings LP Institution	$5.1M 80.2K shares
T TWINBEECH CAPITAL LP Hedge Fund•Quant	$4.1M 63.9K shares
T Tairen Capital Ltd Institution	$3.7M 58.2K shares
PRINCIPAL FINANCIAL GROUP INC Institution	$3.3M 52.0K shares
NTV ASSET MANAGEMENT LLC RIA/Wealth	$2.8M 44.0K shares
W WOLVERINE TRADING, LLC Institution	$2.7M 40.4K shares
E Entropy Technologies, LP Hedge Fund•Quant Macro	$1.9M 29.2K shares
F Fund 1 Investments, LLC Institution	$1.6M 25.0K shares
S Skandinaviska Enskilda Banken AB Institution	$1.3M 21.0K shares

Options Activity

Institutions with the largest Call and Put options positions in TEM as of Q3 2025

Call Positions: 34
Call Value: $1.5B
Put Positions: 32
Put Value: $1.0B

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$396.3M 49.1K contracts
J JANE STREET GROUP, LLC Institution	$378.2M 46.9K contracts
D D. E. Shaw & Co., Inc. Institution	$200.8M 24.9K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$101.3M 12.5K contracts
P PEAK6 LLC Institution	$84.4M 10.5K contracts
TORONTO DOMINION BANK Institution	$72.6M 9.0K contracts
S Squarepoint Ops LLC Hedge Fund•Quant	$37.3M 4.6K contracts
Walleye Trading LLC RIA/Wealth	$35.2M 4.4K contracts
Caption Management, LLC Hedge Fund•Long/Short	$28.7M 3.6K contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$26.9M 3.3K contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$388.7M 48.2K contracts
GOLDMAN SACHS GROUP INC Institution	$112.4M 13.9K contracts
J JANE STREET GROUP, LLC Institution	$109.3M 13.5K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$81.3M 10.1K contracts
D D. E. Shaw & Co., Inc. Institution	$71.8M 8.9K contracts
UBS Group AG Institution	$38.3M 4.7K contracts
Walleye Trading LLC RIA/Wealth	$38.0M 4.7K contracts
P PEAK6 LLC Institution	$31.0M 3.8K contracts
WS MANAGEMENT LLLP Hedge Fund•Long/Short	$29.9M 3.7K contracts
S Squarepoint Ops LLC Hedge Fund•Quant	$20.7M 2.6K contracts

Most Committed Institutions

Institutions with TEM as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
Blue Water Life Science Advisors, LLC RIA/Wealth	Nathaniel Thomas Cornell Managing Partner	5.33% $5.8M	0.04% 72.4K shares	Q3 2025 Held for 2 months	$109.6M
Alphabet Inc. Institution	Sundar Pichai CEO	5.20% $125.2M	0.89% 1.6M shares	Q2 2024 Held for 1y 5m	$2.4B
Renaissance Capital LLC ETF Provider	William Kevin Smith CEO	3.82% $6.8M	0.05% 84.2K shares	Q3 2024 Held for 1y 2m	$177.7M
Green Alpha Advisors, LLC Long Only Manager	Mark Douglas Leimberger CEO	3.57% $3.7M	0.03% 45.8K shares	Q4 2024 Held for 11 months	$103.4M
ARK Investment Management LLC ETF Provider	Catherine Duddy Wood CEO	3.51% $579.2M	4.13% 7.2M shares	Q2 2024 Held for 1y 5m	$16.5B
Nikko Asset Management Americas, Inc. Long Only Manager	James Mark Beyer Wesley CEO	2.71% $279.5M	1.99% 3.5M shares	Q2 2024 Held for 1y 5m	$10.3B
K KADENSA CAPITAL Ltd Institution	-	2.39% $23.2M	0.17% 288.0K shares	Q1 2025 Held for 8 months	$971.1M
Casdin Capital, LLC Hedge Fund•Sector	Eli D Casdin Managing Partner	2.05% $23.7M	0.17% 294.1K shares	Q3 2025 Held for 2 months	$1.2B
FWL INVESTMENT MANAGEMENT, LLC RIA/Wealth	Frederick Wayne Lear Managing Partner	1.72% $6.7M	0.05% 82.6K shares	Q1 2025 Held for 8 months	$387.4M
S SOFTBANK GROUP CORP Institution	-	1.68% $436.3M	3.11% 5.4M shares	Q2 2024 Held for 1y 5m	$25.9B

Hedge Fund Spotlight

Discover hedge funds investing in TEM

CITADEL ADVISORS LLC

Hedge Fund • Multi-Strategy

Portfolio ManagerKenneth Cordele Griffin

Portfolio Value: $122.08B
Positions: 5,531
Last Reported: Q3 2025

Sector Allocation

Position in Tempus AI, Inc.

Market Value: $1.4M
Shares Held: 17.5K
Portfolio Weight: 0.00%
Owned Since: 2024-Q2

Top Holding	Sector	Market Value	Weight
1 Microsoft MSFT	Software - Infrastructure Technology	$2.1B	1.68%
2 Nvidia NVDA	Semiconductors Technology	$1.8B	1.50%
3 Meta Platforms, Inc. META	Internet Content & Information Communication Services	$1.4B	1.18%