Vertex Pharmaceuticals

VRTX • NASDAQ

Vertex Pharmaceuticals is a biotechnology company in the healthcare sector on NASDAQ, led by Reshma Kewalramani, with a market cap of $116.04B. As of Q3 2025, 90% of shares are held by 1,474 institutional investors, with Capital World Investors as the largest holder at 10.11%.

President and Chief Executive OfficerReshma Kewalramani

Market Cap$116.04B

Biotechnology

Healthcare

Employees5.4K

Websitevrtx.com

Country

United States of America

Overview

Overview of institutional ownership in VRTX as of Q3 2025 with a market cap of $100.41B

All Institutions

Institutions: 1,474
Value Held: $90.3B
Shares Held: 231.0M
Avg Position: $61.3M
Median Position: $1.1M

Hedge Funds

Hedge Funds: 70
Value Held: $1.3B
Shares Held: 3.4M
Avg Position: $19.1M
Median Position: $3.0M

Ownership Breakdown

Institutional (non-HF)

88.61%

$89.0B

Hedge Funds

1.33%

$1.3B

Retail & Other

10.06%

$10.1B

Based on market cap of $100.41B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in VRTX as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
C Capital World Investors Institution	-	$10.1B 1.39% of portfolio	10.11% 25.9M shares	≤ Q2 2013 Held for 12y 5m+	$730.00B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$9.5B 0.14% of portfolio	9.45% 24.2M shares	≤ Q2 2013 Held for 12y 5m+	$6.69T
B BlackRock, Inc. Institution	-	$8.7B 0.15% of portfolio	8.68% 22.3M shares	≤ Q2 2013 Held for 12y 5m+	$5.67T
Capital Research Global Investors RIA/Wealth	Sardar Sheraz Iftikhar CEO	$6.5B 1.22% of portfolio	6.46% 16.6M shares	Q1 2023 Held for 2y 8m	$532.36B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$4.5B 0.16% of portfolio	4.53% 11.6M shares	≤ Q2 2013 Held for 12y 5m+	$2.88T
JPMORGAN CHASE & CO Institution	Jamie Dimon CEO	$2.5B 0.16% of portfolio	2.51% 6.4M shares	≤ Q2 2013 Held for 12y 5m+	$1.56T
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$2.3B 0.15% of portfolio	2.33% 6.0M shares	≤ Q2 2013 Held for 12y 5m+	$1.57T
WELLINGTON MANAGEMENT CO LLP Long Only Manager	Edmund Wellington Iii President	$1.9B 0.33% of portfolio	1.86% 4.8M shares	≤ Q2 2013 Held for 12y 5m+	$571.21B
C Capital International Investors Institution	-	$1.8B 0.30% of portfolio	1.83% 4.7M shares	Q4 2024 Held for 11 months	$615.90B
ALLIANCEBERNSTEIN L.P. Long Only Manager	Seth Perry Bernstein CEO	$1.8B 0.56% of portfolio	1.76% 4.5M shares	≤ Q2 2013 Held for 12y 5m+	$317.45B

Net Capital Flow

Institutional buying and selling activity for VRTX in Q3 2025

Net Flow: −$2.6B
Buyers: 559
Sellers: 751
Total Bought: +$4.7B
Total Sold: −$7.3B
Avg Position: $59.4M

Biggest Buyers

Institution	Net Bought	Current Position
C Capital International Investors Institution	+$804.2M +2.1M shares	$1.8B 4.7M shares
Clearbridge Investments, LLC Long Only Manager	+$437.8M +1.1M shares	$1.0B 2.6M shares
JPMORGAN CHASE & CO Institution	+$221.4M +565.4K shares	$2.5B 6.4M shares
A Assenagon Asset Management S.A. Institution	+$204.0M +520.9K shares	$299.1M 763.7K shares
Capital Research Global Investors RIA/Wealth	+$174.3M +445.0K shares	$6.5B 16.6M shares
S Squarepoint Ops LLC Hedge Fund•Quant	+$169.2M +432.1K shares	$238.1M 607.8K shares
B BlackRock, Inc. Institution	+$149.3M +381.1K shares	$8.7B 22.3M shares
NORDEA INVESTMENT MANAGEMENT AB Institution	+$130.6M +336.6K shares	$140.1M 361.1K shares
ARROWSTREET CAPITAL LIMITED PARTNERSHIP Hedge Fund•Quant	+$125.2M +319.7K shares	$149.3M 381.2K shares
LOOMIS SAYLES & CO L P Long Only Manager	+$120.9M +308.8K shares	$1.6B 4.1M shares

Biggest Sellers

Institution	Net Sold	Current Position
FMR LLC Institution	−$1.2B −3.1M shares	$1.3B 3.3M shares
C Capital World Investors Institution	−$1.1B −2.8M shares	$10.1B 25.9M shares
JENNISON ASSOCIATES LLC Long Only Manager	−$1.1B −2.7M shares	$1.4B 3.5M shares
EDGEWOOD MANAGEMENT LLC Long Only Manager	−$378.9M −967.4K shares	$582.6M 1.5M shares
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ Long Only Manager	−$305.9M −781.2K shares	$197.1M 503.2K shares
Artisan Partners Limited Partnership Long Only Manager	−$289.5M −650.3K shares	Sold Off 0 shares
HENDERSON GROUP PLC Institution	−$196.0M −500.4K shares	$829.9M 2.1M shares
GOLDMAN SACHS GROUP INC Institution	−$175.1M −447.1K shares	$581.5M 1.5M shares
B BNP PARIBAS ARBITRAGE, SA Institution	−$108.4M −276.8K shares	$99.6M 254.3K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	−$105.4M −269.0K shares	$288.2M 735.9K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited VRTX in Q3 2025

New Positions: 46
New Value: $74.4M
Exited Positions: 156
Exited Value: $750.9M

New Positions

Institution	Position Value
F Freestone Grove Partners LP Hedge Fund•Multi-Strategy	$43.2M 110.3K shares
PREVAIL INNOVATIVE WEALTH ADVISORS, LLC RIA/Wealth	$6.0M 15.2K shares
LEUTHOLD WEEDEN CAPITAL MANAGEMENT Long Only Manager	$5.0M 12.8K shares
Stenger Family Office, LLC Family Office	$4.5M 10.7K shares
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	$2.7M 7.0K shares
T Torrey Growth & Income Advisors RIA/Wealth	$2.1M 5.4K shares
Grange Capital, LLC RIA/Wealth	$1.4M 3.6K shares
NLI INTERNATIONAL INC Insurance Manager	$1.1M 2.8K shares
Legacy Capital Group California, Inc. RIA/Wealth	$955.6K 2.4K shares
W Waterfront Wealth Inc. RIA/Wealth	$886.4K 2.1K shares

Exited Positions

Institution	Previous Position
Artisan Partners Limited Partnership Long Only Manager	$289.5M 650.3K shares
ORBIMED ADVISORS LLC Hedge Fund•Sector	$93.6M 210.3K shares
A AXA Institution	$76.2M 171.3K shares
WESTWOOD HOLDINGS GROUP INC Institution	$68.7M 154.2K shares
Polar Capital Holdings Plc Long Only Manager	$39.0M 87.5K shares
C Capitolis Liquid Global Markets LLC Private Equity	$31.6M 71.0K shares
Z Zurich Insurance Group Ltd/FI Institution	$23.3M 52.4K shares
Kingstone Capital Partners Texas, LLC RIA/Wealth	$21.7M 48.8K shares
Steel Peak Wealth Management LLC RIA/Wealth	$10.1M 22.6K shares
T TEXAS PERMANENT SCHOOL FUND Institution	$8.0M 18.0K shares

Options Activity

Institutions with the largest Call and Put options positions in VRTX as of Q3 2025

Call Positions: 36
Call Value: $715.2M
Put Positions: 37
Put Value: $471.4M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$233.7M 6.0K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$107.9M 2.8K contracts
J JANE STREET GROUP, LLC Institution	$56.8M 1.5K contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$51.1M 1.3K contracts
W WOLVERINE TRADING, LLC Institution	$40.4M 1.0K contracts
Centiva Capital, LP Hedge Fund•Multi-Strategy	$39.2M 1.0K contracts
BANK OF AMERICA CORP /DE/ Institution	$19.0M 485.0 contracts
Walleye Trading LLC RIA/Wealth	$17.9M 456.0 contracts
UBS Group AG Institution	$15.3M 391.0 contracts
GOLDMAN SACHS GROUP INC Institution	$14.5M 369.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$135.5M 3.5K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$53.3M 1.4K contracts
BANK OF AMERICA CORP /DE/ Institution	$25.5M 651.0 contracts
GOLDMAN SACHS GROUP INC Institution	$22.2M 567.0 contracts
UBS Group AG Institution	$21.7M 553.0 contracts
W WOLVERINE TRADING, LLC Institution	$21.5M 544.0 contracts
J JANE STREET GROUP, LLC Institution	$21.0M 536.0 contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$19.6M 501.0 contracts
T Twin Tree Management, LP Hedge Fund•Vol Arbitrage	$18.3M 466.0 contracts
P PEAK6 LLC Institution	$17.0M 433.0 contracts

Most Committed Institutions

Institutions with VRTX as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
S SEGER ELVEKROG INC Institution	-	5.30% $60.1M	0.06% 153.4K shares	Q2 2021 Held for 4y 5m	$1.1B
BRIDGER MANAGEMENT, LLC Hedge Fund•Long/Short	Matthew P Truax COO	4.29% $7.4M	0.01% 18.8K shares	Q4 2021 Held for 3y 11m	$171.6M
B Bellevue Group AG Institution	-	4.13% $198.1M	0.20% 505.8K shares	Q1 2016 Held for 9y 8m	$4.8B
A Artia Global Partners LP Hedge Fund•Long/Short	Onusa Nmn Chantanapongwanij Managing Partner	3.80% $21.6M	0.02% 55.1K shares	Q2 2025 Held for 5 months	$568.3M
Sivik Global Healthcare LLC Hedge Fund•Long/Short	Krishen Kumar Sud Managing Partner	2.97% $5.5M	0.01% 14.0K shares	Q3 2025 Held for 2 months	$184.7M
H HealthInvest Partners AB Institution	-	2.86% $738.7K	0.01% 17.8K shares	Q4 2023 Held for 1y 11m	$25.9M
S Sofinnova Ventures Inc Venture Capital	James Irvin Healy Managing Partner	2.83% $46.2M	0.05% 117.9K shares	Q3 2025 Held for 2 months	$1.6B
Intermede Investment Partners Ltd Long Only Manager	Barry Patrick Dargan CEO	2.81% $54.8M	0.05% 140.0K shares	Q1 2025 Held for 8 months	$2.0B
S SIG BROKERAGE, LP Institution	-	2.61% $10.3M	0.01% 26.4K shares	Q4 2024 Held for 11 months	$396.7M
MCRAE CAPITAL MANAGEMENT INC RIA/Wealth	Heather M Nemeth President	2.58% $13.0M	0.01% 33.2K shares	Q1 2022 Held for 3y 8m	$503.8M

Hedge Fund Spotlight

Discover hedge funds investing in VRTX

Artia Global Partners LP

Hedge Fund • Long/Short

Portfolio ManagerOnusa Nmn Chantanapongwanij

Portfolio Value: $568.3M
Positions: 48
Last Reported: Q3 2025

Sector Allocation

Position in Vertex Pharmaceuticals

Market Value: $21.6M
Shares Held: 55.1K
Portfolio Weight: 3.80%
Owned Since: 2025-Q2

Top Holding	Sector	Market Value	Weight
1 Insmed INSM	Biotechnology Healthcare	$105.4M	18.55%
2 ARGX argenx ARGX	Unknown Unknown	$57.8M	10.16%
3 Soleno Therapeutics SLNO	Biotechnology Healthcare	$45.4M	8.00%

View full profile

Vertex Pharmaceuticals

Overview

All Institutions

Hedge Funds

Ownership Breakdown

Biggest Investors

Net Capital Flow

Biggest Buyers

Biggest Sellers

Entry and Exit Activity

New Positions

Exited Positions

Options Activity

Call Positions

Put Positions

Most Committed Institutions

Hedge Fund Spotlight

Position in Vertex Pharmaceuticals

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