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5AM Venture Management, LLC Portfolio Analytics

Investment Analysis & Holdings Breakdown

Comprehensive portfolio analytics for 5AM Venture Management, LLC with $273.0M in long positions as of Q3 2025, 81% allocated to Healthcare, and 70% concentrated in top 10 positions.

Portfolio Value
$273.0M
Top 10 Concentration
70%
Top Sector
Healthcare (81%)
US Exposure
90%
Market Cap Focus
Small Cap
Countries
3

Composition Analysis

Portfolio breakdown by sector, industry, and market capitalization

Sector Allocation

Healthcare: 81.20%Healthcare
Healthcare
81.20%

Industry Breakdown

1 industry across all sectors

Biotechnology: 81.18%Biotechnology
Biotechnology
Healthcare
81.18%

Filter by Sector

Select a sector to filter industries

Market Cap Distribution

Small Cap ($300M - $2B): 52.41%Small Cap ($300M - $2B)Micro Cap ($50M - $300M): 25.89%Micro Cap ($50M - $300M)Nano Cap (< $50M): 14.75%Nano Cap (< $50M)N/A (ETF or Unknown): 6.95%
Small Cap ($300M - $2B)
52.41%
Micro Cap ($50M - $300M)
25.89%
Nano Cap (< $50M)
14.75%
N/A (ETF or Unknown)
6.95%

Portfolio Concentration

Top 10 Holdings %
69.92%
Top 20 Holdings %
97.11%
Top 50 Holdings %
100.0%
Top 100 Holdings %
100.0%

Geographic Exposure

Portfolio breakdown by country of incorporation

Domestic (US)
89.71%
International
10.29%
Countries
3
Largest Int'l Market
Netherlands - 7.29%
United States of America
89.71% ($245.0M)
23 holdings
Netherlands
7.29% ($19.9M)
1 holdings
Ireland
3.00% ($8.2M)
1 holdings

Holding Behavior

Investment patterns and position management analysis

Portfolio Stability & Commitment

Avg. Top 10
8.5 quarters
Avg. Top 20
6.9 quarters
Avg. All Positions
7.4 quarters
Median Holding Period
6 quarters
Persistence Rate
84.0%
Persistent Holdings Weight
89.73%
Persistent Positions
21
Longest Held
Rallybio Corporation Common Stock logo
Rallybio Corporation Common StockRLYB - 16 quarters

Position Sizing & Influence

Current Quarter

Avg. New Position
0.000%
Avg. Position Weight
4.00%
Largest Position
Skye Bioscience, Inc. Common Stock logo
Skye Bioscience, Inc. Common StockSKYE - 13.94%
Largest Ownership Stake
CAMP4 Therapeutics Corporation Common Stock logo
CAMP4 Therapeutics Corporation Common StockCAMP - 29.11%
Avg. Ownership Stake
4.00%
Ownership Stake >5%
4
Ownership Stake >1%
14

Historical (Since Q4 2019)

Avg. New Position
7.16%
Avg. Ownership Stake
7.88%
Largest Position
Vor Biopharma Inc. Common Stock logo
Vor Biopharma Inc. Common StockVOR - 52.15% (Q1 2021)
Largest Ownership Stake
Skye Bioscience, Inc. Common Stock logo
Skye Bioscience, Inc. Common StockSKYE - 36.27% (Q2 2024)

Portfolio Turnover

Current Quarter

Turnover Ratio
13.1%
Value Traded
$35.64M
Positions Added
0
Positions Exited
4

Historical (Since Q4 2019)

Avg. Turnover Ratio
12.7%
Avg. Positions Added
2
Avg. Positions Exited
1
Highest Turnover
50.0%
Q4 2019

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