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Opaleye Management Inc.
Hedge Fund • Long/Short
Opaleye Management Inc. is a Long/Short Hedge Fund based in Boston, MA led by James Aaron Silverman, managing $702.7M across 42 long positions as of Q3 2025 with 93% Healthcare concentration, 73% concentrated in top 10 holdings, and 27% allocation to HROW.
PresidentJames Aaron Silverman
- Portfolio Value
- $702.7M
- Positions
- 42
- Top Holding
- HROW at 26.77%
- Last Reported
- Q3 2025
Top Holdings
Largest long holdings in Opaleye Management Inc.'s portfolio (73.4% of total portfolio)
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| Holding | Sector | Position | Weight | Traded | Ownership |
|---|---|---|---|---|---|
Medical - Pharmaceuticals Healthcare | $188.1M | 26.77% | — | 10.55% 3.9M shares | |
Biotechnology Healthcare | $62.1M | 8.84% | — | 10.66% 2.9M shares | |
Biotechnology Healthcare | $59.5M | 8.46% | +$3.2M Bought | 3.04% 2.6M shares | |
Biotechnology Healthcare | $46.6M | 6.64% | -$1.3M Sold | 0.70% 461.7K shares | |
Biotechnology Healthcare | $37.3M | 5.31% | -$4.0M Sold | 3.66% 3.2M shares | |
Unknown Unknown | $36.7M | 5.23% | — | 11.44% 980.0K shares | |
Biotechnology Healthcare | $31.2M | 4.44% | +$475.8K Bought | 14.17% 12.8M shares | |
Biotechnology Healthcare | $19.3M | 2.75% | — | 0.34% 535.0K shares | |
Biotechnology Healthcare | $18.6M | 2.65% | — | 0.92% 1.6M shares | |
Biotechnology Healthcare | $16.5M | 2.35% | +$5.8M Bought | 0.54% 410.0K shares |
Changes
Portfolio activity, position movements, and quarter-over-quarter changes in Opaleye Management Inc.'s latest filing
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Net Flows % of MV
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Increased Positions
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Decreased Positions
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Analytics
Portfolio insights and performance metrics for Opaleye Management Inc.
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