Vyne Therapeutics

VYNE • NASDAQ

Vyne Therapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by David Domzalski, with a market cap of $12.5M. As of Q3 2025, 16% of shares are held by 34 institutional investors, with BAKER BROS. ADVISORS LP as the largest holder at 3.34%.

CEO of VYNE Therapeutics Inc.David Domzalski

Market Cap$12.5M

Biotechnology

Healthcare

Employees10.0

Websitevynetherapeutics.com

Country

United States of America

Overview

Overview of institutional ownership in VYNE as of Q3 2025 with a market cap of $8.5M

All Institutions

Institutions: 34
Value Held: $1.3M
Shares Held: 4.0M
Avg Position: $39.3K
Median Position: $13.5K

Hedge Funds

Hedge Funds: 7
Value Held: $520.8K
Shares Held: 1.6M
Avg Position: $74.4K
Median Position: $19.0K

Ownership Breakdown

Institutional (non-HF)

9.54%

$814.3K

Hedge Funds

6.1%

$520.8K

Retail & Other

84.35%

$7.2M

Based on market cap of $8.5M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in VYNE as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	Scott Lawrence Lessing President	$285.2K 0.00% of portfolio	3.34% 851.4K shares	Q3 2025 Held for 2 months	$10.8B
A ACORN CAPITAL ADVISORS, LLC Venture Capital	Anthony Michael Gallo CCO	$199.4K 0.10% of portfolio	2.30% 586.6K shares	Q4 2024 Held for 11 months	$197.0M
S Shay Capital LLC Institution	-	$165.0K 0.03% of portfolio	1.93% 492.6K shares	Q1 2025 Held for 8 months	$548.9M
ACADIAN ASSET MANAGEMENT LLC Long Only Manager	Gillian Morna Therese Savage CEO	$149.5K 0.00% of portfolio	1.75% 446.4K shares	Q2 2025 Held for 5 months	$51.5B
Ikarian Capital, LLC Hedge Fund•Event Driven	Neil Tristan Shahrestani CEO	$97.1K 0.02% of portfolio	1.14% 290.0K shares	Q2 2025 Held for 5 months	$494.3M
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	Scott David Hoffman CEO	$74.0K 0.00% of portfolio	0.87% 220.8K shares	Q3 2025 Held for 2 months	$62.0B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$63.8K 0.00% of portfolio	0.75% 190.4K shares	Q1 2018 Held for 7y 8m	$6.69T
J JANE STREET GROUP, LLC Institution	-	$49.3K 0.00% of portfolio	0.58% 147.1K shares	Q4 2024 Held for 11 months	$84.1B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$45.9K 0.00% of portfolio	0.54% 137.1K shares	Q1 2018 Held for 7y 8m	$1.57T
BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds	Ari Louis Glass Managing Partner	$35.7K 0.00% of portfolio	0.42% 106.5K shares	Q2 2025 Held for 5 months	$3.8B

Net Capital Flow

Institutional buying and selling activity for VYNE in Q3 2025

Traded: −$9.0M
Buyers: 15
Sellers: 23
Total Bought: +$734.0K
Total Sold: −$9.8M
Avg Position: $24.7K

Biggest Buyers

Institution	Net Bought	Current Position
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	+$285.2K +851.4K shares	$285.2K 851.4K shares
S Shay Capital LLC Institution	+$165.0K +492.6K shares	$165.0K 492.6K shares
ACADIAN ASSET MANAGEMENT LLC Long Only Manager	+$142.0K +424.0K shares	$149.5K 446.4K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	+$74.0K +220.8K shares	$74.0K 220.8K shares
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	+$19.0K +56.6K shares	$19.0K 56.6K shares
R Rangeley Capital, LLC Hedge Fund•Event Driven	+$16.8K +50.0K shares	$16.8K 50.0K shares
CORSAIR CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$13.4K +40.0K shares	$16.8K 50.0K shares
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	+$7.5K +22.5K shares	$12.0K 35.9K shares
J JANE STREET GROUP, LLC Institution	+$7.5K +22.3K shares	$49.3K 147.1K shares
UBS Group AG Institution	+$1.9K +5.6K shares	$1.9K 5.6K shares

Biggest Sellers

Institution	Net Sold	Current Position
C Cormorant Asset Management, LLC Hedge Fund•Long/Short	−$2.3M −1.4M shares	Sold Off 0 shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$1.7M −1.0M shares	Sold Off 0 shares
A ADAGE CAPITAL PARTNERS GP LLC Institution	−$1.1M −644.1K shares	Sold Off 0 shares
D DAFNA Capital Management LLC Hedge Fund•Event Driven	−$1.0M −636.1K shares	Sold Off 0 shares
KENNEDY CAPITAL MANAGEMENT, INC. Long Only Manager	−$941.7K −570.7K shares	Sold Off 0 shares
P Palo Alto Investors, LLC Hedge Fund•Long/Short	−$735.0K −445.4K shares	Sold Off 0 shares
Patient Square Capital LP Private Equity	−$523.1K −317.0K shares	Sold Off 0 shares
Exome Asset Management LLC Hedge Fund•Sector	−$344.8K −209.0K shares	Sold Off 0 shares
Schonfeld Strategic Advisors LLC Hedge Fund•Multi-Strategy	−$267.2K −162.0K shares	Sold Off 0 shares
Polygon Management Ltd. Hedge Fund•Multi-Strategy	−$190.4K −115.4K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited VYNE in Q3 2025

New Positions: 3
New Value: $17.0K
Exited Positions: 18
Exited Value: $9.6M

New Positions

Institution	Position Value
R Rangeley Capital, LLC Hedge Fund•Event Driven	$16.8K 50.0K shares
Fortitude Family Office, LLC Family Office	$228.0 680.0 shares
Newbridge Financial Services Group, Inc. RIA/Wealth	$3.0 10.0 shares

Exited Positions

Institution	Previous Position
C Cormorant Asset Management, LLC Hedge Fund•Long/Short	$2.3M 1.4M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.7M 1.0M shares
A ADAGE CAPITAL PARTNERS GP LLC Institution	$1.1M 644.1K shares
D DAFNA Capital Management LLC Hedge Fund•Event Driven	$1.0M 636.1K shares
KENNEDY CAPITAL MANAGEMENT, INC. Long Only Manager	$941.7K 570.7K shares
P Palo Alto Investors, LLC Hedge Fund•Long/Short	$735.0K 445.4K shares
Patient Square Capital LP Private Equity	$523.1K 317.0K shares
Exome Asset Management LLC Hedge Fund•Sector	$344.8K 209.0K shares
Schonfeld Strategic Advisors LLC Hedge Fund•Multi-Strategy	$267.2K 162.0K shares
Polygon Management Ltd. Hedge Fund•Multi-Strategy	$190.4K 115.4K shares

Options Activity

Institutions with the largest Call and Put options positions in VYNE as of Q3 2025

Call Positions: 0
Call Value: -
Put Positions: 0
Put Value: -

Call Positions

Institution	Position Value
No call positions found

Put Positions

Institution	Position Value
No put positions found

Most Committed Institutions

Institutions with VYNE as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
A ACORN CAPITAL ADVISORS, LLC Venture Capital	Anthony Michael Gallo CCO	0.10% $199.4K	2.30% 586.6K shares	Q4 2024 Held for 11 months	$197.0M
S Shay Capital LLC Institution	-	0.03% $165.0K	1.93% 492.6K shares	Q1 2025 Held for 8 months	$548.9M
Ikarian Capital, LLC Hedge Fund•Event Driven	Neil Tristan Shahrestani CEO	0.02% $97.1K	1.14% 290.0K shares	Q2 2025 Held for 5 months	$494.3M
R Rangeley Capital, LLC Hedge Fund•Event Driven	Christopher Clay Demuth Jr. Managing Partner	0.02% $16.8K	0.20% 50.0K shares	Q3 2025 Held for 2 months	$105.5M
CORSAIR CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	Jeffrey Archer Zelin COO	0.00% $16.8K	0.20% 50.0K shares	Q2 2025 Held for 5 months	$563.1M
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	Scott Lawrence Lessing President	0.00% $285.2K	3.34% 851.4K shares	Q3 2025 Held for 2 months	$10.8B
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	David Khabie-Zeitoune CEO	0.00% $12.0K	0.14% 35.9K shares	Q2 2025 Held for 5 months	$1.1B
BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds	Ari Louis Glass Managing Partner	0.00% $35.7K	0.42% 106.5K shares	Q2 2025 Held for 5 months	$3.8B
Harvest Investment Services, LLC RIA/Wealth	Timothy John Newell CEO	0.00% $3.7K	0.04% 11.1K shares	Q2 2025 Held for 5 months	$490.4M
STALEY CAPITAL ADVISERS INC RIA/Wealth	John Adolphus Staley Iv CEO	0.00% $17.2K	0.20% 51.5K shares	Q4 2020 Held for 4y 11m	$2.4B

Hedge Fund Spotlight

Discover hedge funds investing in VYNE

Ikarian Capital, LLC

Hedge Fund • Event Driven

Portfolio ManagerNeil Tristan Shahrestani

Portfolio Value: $494.3M
Positions: 116
Last Reported: Q3 2025

Sector Allocation

Position in Vyne Therapeutics

Market Value: $97.1K
Shares Held: 290.0K
Portfolio Weight: 0.02%
Owned Since: 2025-Q2

Top Holding	Sector	Market Value	Weight
1 GMAB Genmab A/S GMAB	Unknown Unknown	$53.0M	10.73%
2 ABVX Abivax ABVX	Unknown Unknown	$33.4M	6.76%
3 Ionis Pharmaceuticals IONS	Biotechnology Healthcare	$27.2M	5.49%

View full profile

Vyne Therapeutics

Overview

All Institutions

Hedge Funds

Ownership Breakdown

Biggest Investors

Net Capital Flow

Biggest Buyers

Biggest Sellers

Entry and Exit Activity

New Positions

Exited Positions

Options Activity

Call Positions

Put Positions

Most Committed Institutions

Hedge Fund Spotlight

Position in Vyne Therapeutics

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