Spero Therapeutics, Inc.

SPRO • NASDAQ

Spero Therapeutics, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Satyavrat Shukla, with a market cap of $130.7M. As of Q3 2025, 20% of shares are held by 46 institutional investors, with PFIZER INC as the largest holder at 4.2%.

CEOSatyavrat Shukla

Market Cap$130.7M

Biotechnology

Healthcare

Employees46.0

Websitesperotherapeutics.com

Country

United States of America

Overview

Overview of institutional ownership in SPRO as of Q3 2025 with a market cap of $105.8M

All Institutions

Institutions: 46
Value Held: $21.3M
Shares Held: 11.3M
Avg Position: $462.1K
Median Position: $66.5K

Hedge Funds

Hedge Funds: 7
Value Held: $4.0M
Shares Held: 2.1M
Avg Position: $567.7K
Median Position: $217.2K

Ownership Breakdown

Institutional (non-HF)

16.34%

$17.3M

Hedge Funds

3.76%

$4.0M

Retail & Other

79.91%

$84.5M

Based on market cap of $105.8M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in SPRO as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
PFIZER INC Institution	Albert Bourla CEO	$4.4M 1.02% of portfolio	4.20% 2.4M shares	Q4 2024 Held for 11 months	$437.4M
VANGUARD GROUP INC Institution	Salim Ramji CEO	$3.7M 0.00% of portfolio	3.54% 2.0M shares	Q4 2017 Held for 7y 11m	$6.69T
Frigate Ventures LP RIA/Wealth	Anthony Lawrence Moore CFO	$3.0M 0.36% of portfolio	2.85% 1.6M shares	Q3 2022 Held for 3y 2m	$827.1M
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	Peter Fitzhugh Brown CEO	$2.7M 0.00% of portfolio	2.58% 1.5M shares	Q1 2022 Held for 3y 8m	$75.8B
Alphabet Inc. Institution	Sundar Pichai CEO	$1.7M 0.07% of portfolio	1.58% 890.0K shares	Q4 2017 Held for 7y 11m	$2.4B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$991.9K 0.00% of portfolio	0.94% 527.5K shares	Q1 2018 Held for 7y 8m	$1.57T
B BlackRock, Inc. Institution	-	$817.4K 0.00% of portfolio	0.77% 434.8K shares	Q4 2017 Held for 7y 11m	$5.67T
EAM Investors, LLC Long Only Manager	Derek John Gaertner CEO	$531.0K 0.06% of portfolio	0.50% 282.4K shares	Q2 2025 Held for 5 months	$873.4M
I Ionic Capital Management LLC Hedge Fund•Multi-Strategy	Bart Ethan Baum CIO	$392.4K 0.47% of portfolio	0.37% 208.7K shares	Q2 2025 Held for 5 months	$83.1M
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$359.0K 0.00% of portfolio	0.34% 191.0K shares	Q1 2018 Held for 7y 8m	$2.88T

Net Capital Flow

Institutional buying and selling activity for SPRO in Q3 2025

Traded: −$905.8K
Buyers: 25
Sellers: 17
Total Bought: +$3.0M
Total Sold: −$3.9M
Avg Position: $372.9K

Biggest Buyers

Institution	Net Bought	Current Position
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	+$1.2M +620.6K shares	$2.7M 1.5M shares
ARROWSTREET CAPITAL LIMITED PARTNERSHIP Hedge Fund•Quant	+$283.0K +150.5K shares	$283.0K 150.5K shares
I INTREPID FAMILY OFFICE LLC Institution	+$206.8K +110.0K shares	$206.8K 110.0K shares
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	+$201.0K +106.9K shares	$201.0K 106.9K shares
S Shay Capital LLC Institution	+$119.7K +63.7K shares	$119.7K 63.7K shares
I Ionic Capital Management LLC Hedge Fund•Multi-Strategy	+$110.4K +58.7K shares	$392.4K 208.7K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	+$92.9K +49.4K shares	$92.9K 49.4K shares
EAM Investors, LLC Long Only Manager	+$81.4K +43.3K shares	$531.0K 282.4K shares
J JANE STREET GROUP, LLC Institution	+$80.8K +43.0K shares	$80.8K 43.0K shares
A AMERICAN CENTURY COMPANIES INC Institution	+$75.6K +40.2K shares	$75.6K 40.2K shares

Biggest Sellers

Institution	Net Sold	Current Position
Schonfeld Strategic Advisors LLC Hedge Fund•Multi-Strategy	−$1.5M −510.8K shares	Sold Off 0 shares
M MONIMUS CAPITAL MANAGEMENT, LP Hedge Fund•Long/Short	−$901.6K −310.9K shares	Sold Off 0 shares
S Stonepine Capital Management, LLC Institution	−$455.0K −156.9K shares	Sold Off 0 shares
ACADIAN ASSET MANAGEMENT LLC Long Only Manager	−$327.4K −112.9K shares	Sold Off 0 shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$301.0K −103.8K shares	Sold Off 0 shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	−$202.5K −69.8K shares	Sold Off 0 shares
Q Quadrature Capital Ltd Institution	−$90.5K −31.2K shares	Sold Off 0 shares
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	−$53.4K −28.4K shares	$217.2K 115.5K shares
S SIMPLEX TRADING, LLC Institution	−$42.7K −22.7K shares	$14.3K 7.6K shares
Frigate Ventures LP RIA/Wealth	−$22.4K −11.9K shares	$3.0M 1.6M shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited SPRO in Q3 2025

New Positions: 4
New Value: $368.5K
Exited Positions: 11
Exited Value: $3.8M

New Positions

Institution	Position Value
I INTREPID FAMILY OFFICE LLC Institution	$206.8K 110.0K shares
A AMERICAN CENTURY COMPANIES INC Institution	$75.6K 40.2K shares
R Rangeley Capital, LLC Hedge Fund•Event Driven	$56.4K 30.0K shares
T Torrey Growth & Income Advisors RIA/Wealth	$29.7K 15.8K shares

Exited Positions

Institution	Previous Position
Schonfeld Strategic Advisors LLC Hedge Fund•Multi-Strategy	$1.5M 510.8K shares
M MONIMUS CAPITAL MANAGEMENT, LP Hedge Fund•Long/Short	$901.6K 310.9K shares
S Stonepine Capital Management, LLC Institution	$455.0K 156.9K shares
ACADIAN ASSET MANAGEMENT LLC Long Only Manager	$327.4K 112.9K shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$301.0K 103.8K shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$202.5K 69.8K shares
Q Quadrature Capital Ltd Institution	$90.5K 31.2K shares
R ROYAL BANK OF CANADA Institution	$16.6K 5.7K shares
RAYMOND JAMES FINANCIAL INC RIA/Wealth	$8.9K 3.1K shares
CULLEN/FROST BANKERS, INC. Institution	$5.8K 2.0K shares

Options Activity

Institutions with the largest Call and Put options positions in SPRO as of Q3 2025

Call Positions: 0
Call Value: -
Put Positions: 2
Put Value: $123.5K

Call Positions

Institution	Position Value
No call positions found

Put Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$103.0K 548.0 contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$20.5K 109.0 contracts

Most Committed Institutions

Institutions with SPRO as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
PFIZER INC Institution	Albert Bourla CEO	1.02% $4.4M	4.20% 2.4M shares	Q4 2024 Held for 11 months	$437.4M
I Ionic Capital Management LLC Hedge Fund•Multi-Strategy	Bart Ethan Baum CIO	0.47% $392.4K	0.37% 208.7K shares	Q2 2025 Held for 5 months	$83.1M
Frigate Ventures LP RIA/Wealth	Anthony Lawrence Moore CFO	0.36% $3.0M	2.85% 1.6M shares	Q3 2022 Held for 3y 2m	$827.1M
I INTREPID FAMILY OFFICE LLC Institution	-	0.20% $206.8K	0.20% 110.0K shares	Q3 2025 Held for 2 months	$102.3M
Alphabet Inc. Institution	Sundar Pichai CEO	0.07% $1.7M	1.58% 890.0K shares	Q4 2017 Held for 7y 11m	$2.4B
EAM Investors, LLC Long Only Manager	Derek John Gaertner CEO	0.06% $531.0K	0.50% 282.4K shares	Q2 2025 Held for 5 months	$873.4M
R Rangeley Capital, LLC Hedge Fund•Event Driven	Christopher Clay Demuth Jr. Managing Partner	0.05% $56.4K	0.05% 30.0K shares	Q3 2025 Held for 2 months	$105.5M
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	Daniel Pawel Schneeberger Managing Partner	0.02% $217.2K	0.21% 115.5K shares	Q4 2023 Held for 1y 11m	$993.7M
S Shay Capital LLC Institution	-	0.02% $119.7K	0.11% 63.7K shares	Q3 2025 Held for 2 months	$548.9M
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	David Khabie-Zeitoune CEO	0.02% $201.0K	0.19% 106.9K shares	Q3 2025 Held for 2 months	$1.1B

Hedge Fund Spotlight

Discover hedge funds investing in SPRO

GSA CAPITAL PARTNERS LLP

Hedge Fund • Quant

Portfolio ManagerDavid Khabie-Zeitoune

Portfolio Value: $1.1B
Positions: 1,504
Last Reported: Q3 2025

Sector Allocation

Position in Spero Therapeutics, Inc.

Market Value: $201.0K
Shares Held: 106.9K
Portfolio Weight: 0.02%
Owned Since: 2025-Q3

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