HighVista Strategies LLC

Fund of Funds

HighVista Strategies LLC is a Fund of Funds based in Boston, MA led by Richard P Vishton, reporting $5.4B in AUM as of Q3 2025 with 51% Healthcare concentration.

CFORichard P Vishton

Portfolio Value: $413.3M
Positions: 149
Top Holding: DBC at 7.83%
Last Reported: Q3 2025

Address200 Clarendon Street, 50th Floor, Boston, MA, 02116, United States

Top Holdings

Largest long holdings in HighVista Strategies LLC's portfolio (28.7% of total portfolio)

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Holding	Sector	Position	Weight	Traded	Ownership	Owned Since
1 DBC Invesco DB Commodity Index Tracking Fund DBC	Unknown Unknown	$32.4M	7.83%	—	— 1.4M shares	Q4 2022 Held for 2y 11m
2 ABVX Abivax ABVX	Unknown Unknown	$15.7M	3.79%	+$11.3M Bought	— 184.5K shares	Q1 2024 Held for 1y 8m
3 Merus N.V. MRUS	Biotechnology Healthcare	$12.6M	3.04%	+$4.1M Bought	0.18% 133.3K shares	Q4 2021 Held for 3y 11m
4 Viridian Therapeutics, Inc. VRDN	Biotechnology Healthcare	$10.1M	2.45%	-$328.5K Sold	0.57% 469.3K shares	Q1 2022 Held for 3y 8m
5 Revolution Medicines, Inc. RVMD	Biotechnology Healthcare	$8.2M	1.98%	+$5.0M Bought	0.09% 175.4K shares	Q3 2023 Held for 2y 2m
6 Protagonist Therapeutics PTGX	Biotechnology Healthcare	$8.1M	1.96%	+$4.2M Bought	0.20% 121.7K shares	Q2 2023 Held for 2y 5m
7 Nuvalent, Inc. NUVL	Biotechnology Healthcare	$8.1M	1.95%	+$3.7M Bought	0.13% 93.3K shares	Q1 2023 Held for 2y 8m
8 Mineralys Therapeutics, Inc. MLYS	Biotechnology Healthcare	$8.0M	1.93%	+$2.3M Bought	0.27% 209.8K shares	Q2 2025 Held for 5 months
9 Arcellx, Inc. ACLX	Biotechnology Healthcare	$7.9M	1.91%	+$5.0M Bought	0.17% 96.2K shares	Q1 2023 Held for 2y 8m
10 Agios Pharmaceuticals AGIO	Biotechnology Healthcare	$7.8M	1.90%	+$5.0M Bought	0.34% 195.3K shares	Q1 2025 Held for 8 months

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Changes

Portfolio activity, position movements, and quarter-over-quarter changes in HighVista Strategies LLC's latest filing

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Market Value

$413.3M

Prior: $273.9M

Q/Q Change

+50.88%

+$139.4M

Net Flows % of MV

+15.4%

Turnover Ratio

26.88%

New Purchases

17 stocks

$20.4M

Added To

79 stocks

+$111.2M

Sold Out Of

27 stocks

$43.7M

Reduced Holdings

38 stocks

-$24.2M

Increased Positions

Position	Shares Δ	Change
1 Avantor AVTR	New	0 → 172.4K +$2.2M
2 Flowserve FLS	New	0 → 39.0K +$2.1M
3 Fabrinet FN	New	0 → 5.1K +$1.9M
4 Pure Storage, Inc. PSTG	New	0 → 20.4K +$1.7M
5 KBR KBR	New	0 → 35.5K +$1.7M

Decreased Positions

Position	Shares Δ	Change
1 Ansys ANSS	Sold	17.1K → 0 −$6.0M
2 Juniper Networks JNPR	Sold	114.7K → 0 −$4.6M
3 Hess HES	Sold	28.9K → 0 −$4.0M
4 Amedisys AMED	Sold	39.3K → 0 −$3.9M
5 VRNA Verona Pharma VRNA	Sold	28.9K → 0 −$2.7M

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Analytics

Portfolio insights and performance metrics for HighVista Strategies LLC

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Sector Allocation

Healthcare

50.90%

Technology

11.40%

Industrials

6.20%

Financial Services

3.40%

Consumer Cyclical

2.60%

Communication Services

1.70%

Utilities

1.40%

Basic Materials

1.10%

Energy

0.20%

Market Cap Distribution

Mega Cap (> $200B)

8.73%

Large Cap ($10B - $200B)

21.32%

Mid Cap ($2B - $10B)

36.03%

Small Cap ($300M - $2B)

15.62%

Micro Cap ($50M - $300M)

0.45%

Nano Cap (< $50M)

0.28%

N/A (ETF or Unknown)

17.58%

Portfolio Concentration

Top 10 Holdings %

28.73%

Top 20 Holdings %

43.61%

Top 50 Holdings %

68.52%

Top 100 Holdings %

89.66%