Agios Pharmaceuticals

AGIO • NASDAQ

Agios Pharmaceuticals is a biotechnology company in the healthcare sector on NASDAQ, led by Brian Goff, with a market cap of $1.6B. As of Q3 2025, 109% of shares are held by 216 institutional investors, with FARALLON CAPITAL MANAGEMENT LLC as the largest holder at 9.95%.

Chief Executive OfficerBrian Goff

Market Cap$1.6B

Biotechnology

Healthcare

Employees386.0

Websiteagios.com

Country

United States of America

Overview

Overview of institutional ownership in AGIO as of Q3 2025 with a market cap of $2.3B

All Institutions

Institutions: 216
Value Held: $2.5B
Shares Held: 63.3M
Avg Position: $11.8M
Median Position: $655.4K

Hedge Funds

Hedge Funds: 34
Value Held: $699.9M
Shares Held: 17.4M
Avg Position: $20.6M
Median Position: $4.5M

Ownership Breakdown

Institutional (non-HF)

78.84%

$1.8B

Hedge Funds

30.01%

$699.9M

Retail & Other

Based on market cap of $2.3B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in AGIO as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
FARALLON CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	Edric Calvin Saito Managing Partner	$232.1M 1.31% of portfolio	9.95% 5.8M shares	Q4 2019 Held for 5y 11m	$17.7B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$225.0M 0.00% of portfolio	9.65% 5.6M shares	Q3 2013 Held for 12y 2m	$6.69T
B BlackRock, Inc. Institution	-	$182.5M 0.00% of portfolio	7.82% 4.5M shares	Q3 2013 Held for 12y 2m	$5.67T
B Bellevue Group AG Institution	-	$149.1M 3.11% of portfolio	6.39% 3.7M shares	Q2 2019 Held for 6y 5m	$4.8B
E Erste Asset Management GmbH Institution	-	$108.6M 1.05% of portfolio	4.76% 2.8M shares	Q4 2018 Held for 6y 11m	$10.3B
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	Dr. Senai Nmn Asefaw CIO	$107.3M 3.18% of portfolio	4.60% 2.7M shares	Q4 2024 Held for 11 months	$3.4B
WELLINGTON MANAGEMENT CO LLP Long Only Manager	Jean Marie Hynes CEO	$99.2M 0.02% of portfolio	4.25% 2.5M shares	Q3 2013 Held for 12y 2m	$571.21B
COMMODORE CAPITAL LP Hedge Fund•Long/Short	Michael Jonathan Kramarz Managing Partner	$93.9M 4.58% of portfolio	4.02% 2.3M shares	Q1 2025 Held for 8 months	$2.0B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$90.8M 0.00% of portfolio	3.89% 2.3M shares	Q3 2013 Held for 12y 2m	$2.88T
M MACQUARIE GROUP LTD Institution	-	$78.6M 0.09% of portfolio	3.37% 2.0M shares	Q3 2019 Held for 6y 2m	$82.9B

Net Capital Flow

Institutional buying and selling activity for AGIO in Q3 2025

Traded: +$95.4M
Buyers: 112
Sellers: 99
Total Bought: +$354.8M
Total Sold: −$259.4M
Avg Position: $10.1M

Biggest Buyers

Institution	Net Bought	Current Position
WELLINGTON MANAGEMENT CO LLP Long Only Manager	+$82.3M +2.0M shares	$99.2M 2.5M shares
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	+$61.5M +1.5M shares	$107.3M 2.7M shares
TCG Crossover Management, LLC Venture Capital	+$29.4M +733.0K shares	$57.4M 1.4M shares
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$19.9M +495.5K shares	$19.9M 495.5K shares
E Erste Asset Management GmbH Institution	+$17.2M +438.4K shares	$108.6M 2.8M shares
J JANE STREET GROUP, LLC Institution	+$14.5M +361.6K shares	$15.9M 395.1K shares
STATE STREET CORP Institution	+$12.5M +311.6K shares	$90.8M 2.3M shares
SummitTX Capital, L.P. Hedge Fund•Multi-Strategy	+$10.6M +263.0K shares	$10.6M 263.0K shares
L LEGAL & GENERAL GROUP PLC Institution	+$10.4M +258.6K shares	$13.0M 322.9K shares
P PEREGRINE CAPITAL MANAGEMENT LLC Long Only Manager	+$6.5M +162.9K shares	$6.5M 162.9K shares

Biggest Sellers

Institution	Net Sold	Current Position
JPMORGAN CHASE & CO Institution	−$33.9M −844.3K shares	$7.3M 183.1K shares
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	−$24.8M −617.3K shares	$66.5M 1.7M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$23.7M −589.5K shares	$19.7M 492.0K shares
ORBIMED ADVISORS LLC Hedge Fund•Sector	−$18.6M −557.9K shares	Sold Off 0 shares
Marshall Wace LLP Institution	−$18.4M −457.8K shares	$9.1M 226.8K shares
ARMISTICE CAPITAL, LLC Hedge Fund•Long/Short	−$16.2M −404.0K shares	$30.7M 764.0K shares
B BlackRock, Inc. Institution	−$11.6M −288.0K shares	$182.5M 4.5M shares
D D. E. Shaw & Co., Inc. Institution	−$9.2M −228.5K shares	$14.8M 367.7K shares
CenterBook Partners LP Hedge Fund•Market Neutral	−$8.1M −243.1K shares	Sold Off 0 shares
NORDEA INVESTMENT MANAGEMENT AB Institution	−$7.5M −224.7K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited AGIO in Q3 2025

New Positions: 16
New Value: $11.0M
Exited Positions: 33
Exited Value: $80.6M

New Positions

Institution	Position Value
Ikarian Capital, LLC Hedge Fund•Event Driven	$5.1M 127.0K shares
N Nantahala Capital Management, LLC Hedge Fund•Multi-Strategy	$4.0M 100.0K shares
F Freestone Grove Partners LP Hedge Fund•Multi-Strategy	$619.1K 15.4K shares
Cinctive Capital Management LP Hedge Fund•Multi-Strategy	$405.4K 10.1K shares
Voleon Capital Management LP Hedge Fund•Quant	$268.2K 6.7K shares
F FIDUCIARY TRUST CO Institution	$218.9K 5.5K shares
Q Quarry LP Institution	$200.7K 5.0K shares
T TORNO CAPITAL, LLC Institution	$100.4K 2.5K shares
FIRST HORIZON NATIONAL CORP RIA/Wealth	$45.1K 1.1K shares
R Root Financial Partners, LLC RIA/Wealth	$4.3K 106.0 shares

Exited Positions

Institution	Previous Position
ORBIMED ADVISORS LLC Hedge Fund•Sector	$18.6M 557.9K shares
CenterBook Partners LP Hedge Fund•Market Neutral	$8.1M 243.1K shares
NORDEA INVESTMENT MANAGEMENT AB Institution	$7.5M 224.7K shares
A AXA Institution	$7.5M 225.4K shares
VOLORIDGE INVESTMENT MANAGEMENT, LLC Hedge Fund•Multi-Strategy	$6.2M 187.4K shares
C CANTOR FITZGERALD, L. P. Institution	$4.5M 134.2K shares
Casdin Capital, LLC Hedge Fund•Sector	$3.3M 100.0K shares
Trexquant Investment LP Hedge Fund•Quant	$3.3M 98.4K shares
SILVERCREST ASSET MANAGEMENT GROUP LLC RIA/Wealth	$2.7M 82.7K shares
CAPITAL FUND MANAGEMENT S.A. Hedge Fund•Quant Macro	$2.3M 68.5K shares

Options Activity

Institutions with the largest Call and Put options positions in AGIO as of Q3 2025

Call Positions: 14
Call Value: $82.6M
Put Positions: 9
Put Value: $75.5M

Call Positions

Institution	Position Value
ARMISTICE CAPITAL, LLC Hedge Fund•Long/Short	$36.1M 9.0K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$10.7M 2.7K contracts
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$8.9M 2.2K contracts
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	$8.0M 2.0K contracts
Ikarian Capital, LLC Hedge Fund•Event Driven	$6.0M 1.5K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$3.0M 743.0 contracts
J JANE STREET GROUP, LLC Institution	$2.3M 580.0 contracts
BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds	$2.2M 544.0 contracts
Centiva Capital, LP Hedge Fund•Multi-Strategy	$1.7M 429.0 contracts
Caption Management, LLC Hedge Fund•Long/Short	$1.2M 300.0 contracts

Put Positions

Institution	Position Value
C Caligan Partners LP Hedge Fund•Activist	$39.1M 9.8K contracts
Caption Management, LLC Hedge Fund•Long/Short	$15.5M 3.9K contracts
BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds	$11.7M 2.9K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$6.7M 1.7K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.6M 387.0 contracts
J JANE STREET GROUP, LLC Institution	$401.4K 100.0 contracts
T TORNO CAPITAL, LLC Institution	$401.4K 100.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$60.2K 15.0 contracts
Walleye Trading LLC RIA/Wealth	$56.2K 14.0 contracts

Most Committed Institutions

Institutions with AGIO as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
C Caligan Partners LP Hedge Fund•Activist	Tiffany Crowley CFO	6.30% $45.4M	1.95% 1.1M shares	Q4 2022 Held for 2y 11m	$720.7M
COMMODORE CAPITAL LP Hedge Fund•Long/Short	Michael Jonathan Kramarz Managing Partner	4.58% $93.9M	4.02% 2.3M shares	Q1 2025 Held for 8 months	$2.0B
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	Dr. Senai Nmn Asefaw CIO	3.18% $107.3M	4.60% 2.7M shares	Q4 2024 Held for 11 months	$3.4B
B Bellevue Group AG Institution	-	3.11% $149.1M	6.39% 3.7M shares	Q2 2019 Held for 6y 5m	$4.8B
TCG Crossover Management, LLC Venture Capital	Chen Ming Yu Managing Partner	2.87% $57.4M	2.46% 1.4M shares	Q2 2025 Held for 5 months	$2.0B
E Eagle Health Investments LP Hedge Fund•Long/Short	Gary Johnathan Stern Founder	2.59% $9.9M	0.42% 246.2K shares	Q4 2020 Held for 4y 11m	$380.9M
Rock Springs Capital Management LP Hedge Fund•Sector	Nnamdi C Etoh CFO	2.26% $38.5M	1.65% 958.5K shares	Q1 2019 Held for 6y 8m	$1.7B
P Palo Alto Investors, LLC Hedge Fund•Long/Short	Angela Elizabeth Nguyen-Dinh CCO	1.97% $10.7M	0.46% 265.5K shares	Q1 2025 Held for 8 months	$540.4M
HighVista Strategies LLC Fund of Funds	Richard P Vishton CFO	1.90% $7.8M	0.34% 195.3K shares	Q1 2025 Held for 8 months	$413.3M
Frazier Life Sciences Management, L.P. Venture Capital	James Newman Topper Managing Partner	1.54% $51.4M	2.20% 1.3M shares	Q3 2023 Held for 2y 2m	$3.3B

Hedge Fund Spotlight

Discover hedge funds investing in AGIO

ADAR1 Capital Management, LLC

Hedge Fund • Long/Short

Portfolio ManagerDaniel Pawel Schneeberger

Portfolio Value: $993.7M
Positions: 191
Last Reported: Q3 2025

Sector Allocation

Position in Agios Pharmaceuticals

Market Value: $1.5M
Shares Held: 37.0K
Portfolio Weight: 0.15%
Owned Since: 2024-Q3

Top Holding	Sector	Market Value	Weight
1 ABVX Abivax ABVX	Unknown Unknown	$114.7M	11.54%
2 Keros Therapeutics KROS	Biotechnology Healthcare	$85.3M	8.58%
3 Protagonist Therapeutics PTGX	Biotechnology Healthcare	$65.7M	6.61%

View full profile

Agios Pharmaceuticals

Overview

All Institutions

Hedge Funds

Ownership Breakdown

Biggest Investors

Net Capital Flow

Biggest Buyers

Biggest Sellers

Entry and Exit Activity

New Positions

Exited Positions

Options Activity

Call Positions

Put Positions

Most Committed Institutions

Hedge Fund Spotlight

Position in Agios Pharmaceuticals

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