Mineralys Therapeutics, Inc.

MLYS • NASDAQ

Mineralys Therapeutics, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Jon Congleton, with a market cap of $3.1B. As of Q3 2025, 102% of shares are held by 194 institutional investors, with Catalys Pacific, LLC as the largest holder at 11.48%.

CEOJon Congleton

Market Cap$3.1B

Biotechnology

Healthcare

Employees28.0

Websitemineralystx.com

Country

United States of America

Overview

Overview of institutional ownership in MLYS as of Q3 2025 with a market cap of $2.9B

All Institutions

Institutions: 194
Value Held: $3.0B
Shares Held: 79.5M
Avg Position: $15.5M
Median Position: $1.6M

Hedge Funds

Hedge Funds: 52
Value Held: $1.1B
Shares Held: 28.9M
Avg Position: $21.1M
Median Position: $3.1M

Ownership Breakdown

Institutional (non-HF)

65.08%

$1.9B

Hedge Funds

37.23%

$1.1B

Retail & Other

Based on market cap of $2.9B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in MLYS as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
C Catalys Pacific, LLC Institution	-	$337.6M 96.09% of portfolio	11.48% 8.9M shares	Q4 2023 Held for 1y 11m	$351.4M
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	$277.7M 3.45% of portfolio	9.44% 7.3M shares	Q1 2023 Held for 2y 8m	$8.1B
Samsara BioCapital, LLC Venture Capital	Miran Nasruddin Ahmad CFO	$237.5M 31.01% of portfolio	8.07% 6.3M shares	Q1 2023 Held for 2y 8m	$765.9M
B BlackRock, Inc. Institution	-	$139.2M 0.00% of portfolio	4.73% 3.7M shares	Q1 2023 Held for 2y 8m	$5.67T
VANGUARD GROUP INC Institution	Salim Ramji CEO	$114.5M 0.00% of portfolio	3.89% 3.0M shares	Q1 2023 Held for 2y 8m	$6.69T
C Caligan Partners LP Hedge Fund•Activist	Tiffany Crowley CFO	$105.1M 14.59% of portfolio	3.57% 2.8M shares	Q2 2024 Held for 1y 5m	$720.7M
C Capital International Investors Institution	-	$90.8M 0.01% of portfolio	3.09% 2.4M shares	Q2 2025 Held for 5 months	$615.90B
SUVRETTA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Aaron Leonard Cowen CEO	$80.9M 2.45% of portfolio	2.75% 2.1M shares	Q1 2025 Held for 8 months	$3.3B
SR ONE CAPITAL MANAGEMENT, LP Venture Capital	Simeon John George CEO	$80.2M 11.59% of portfolio	2.73% 2.1M shares	Q1 2023 Held for 2y 8m	$691.4M
FMR LLC Institution	-	$78.5M 0.00% of portfolio	2.67% 2.1M shares	Q1 2023 Held for 2y 8m	$1.92T

Net Capital Flow

Institutional buying and selling activity for MLYS in Q3 2025

Net Flow: +$247.5M
Buyers: 74
Sellers: 77
Total Bought: +$592.3M
Total Sold: −$344.8M
Avg Position: $15.9M

Biggest Buyers

Institution	Net Bought	Current Position
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$77.8M +2.1M shares	$78.4M 2.1M shares
FMR LLC Institution	+$67.0M +1.8M shares	$78.5M 2.1M shares
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	+$44.6M +1.2M shares	$277.7M 7.3M shares
ALLIANCEBERNSTEIN L.P. Long Only Manager	+$32.4M +855.3K shares	$33.5M 882.4K shares
MORGAN STANLEY RIA/Wealth	+$29.9M +789.2K shares	$52.2M 1.4M shares
C Caligan Partners LP Hedge Fund•Activist	+$28.6M +755.3K shares	$105.1M 2.8M shares
ORBIMED ADVISORS LLC Hedge Fund•Sector	+$26.9M +709.1K shares	$55.7M 1.5M shares
VANGUARD GROUP INC Institution	+$26.3M +692.6K shares	$114.5M 3.0M shares
WELLINGTON MANAGEMENT CO LLP Long Only Manager	+$25.3M +668.0K shares	$29.7M 783.4K shares
B BNP PARIBAS ARBITRAGE, SA Institution	+$23.6M +622.0K shares	$23.7M 626.1K shares

Biggest Sellers

Institution	Net Sold	Current Position
Integral Health Asset Management, LLC Hedge Fund•Sector	−$45.5M −1.2M shares	$56.9M 1.5M shares
SR ONE CAPITAL MANAGEMENT, LP Venture Capital	−$38.5M −1.0M shares	$80.2M 2.1M shares
JENNISON ASSOCIATES LLC Long Only Manager	−$32.6M −859.0K shares	$14.3M 376.3K shares
C Capital International Investors Institution	−$19.2M −505.6K shares	$90.8M 2.4M shares
StemPoint Capital LP Hedge Fund•Long/Short	−$18.0M −473.5K shares	$6.0M 158.1K shares
$DEUTSCHE BANK AG\ logo$ DEUTSCHE BANK AG\ Institution	−$16.2M −426.0K shares	$1.2M 30.9K shares
SECTORAL ASSET MANAGEMENT INC Venture Capital	−$13.2M −348.5K shares	$1.3M 33.9K shares
Pictet Asset Management Holding SA Long Only Manager	−$12.8M −338.8K shares	$35.2M 929.2K shares
PRUDENTIAL FINANCIAL INC Institution	−$11.4M −301.8K shares	$1.9M 50.4K shares
D DAFNA Capital Management LLC Hedge Fund•Event Driven	−$10.9M −288.0K shares	$3.2M 83.5K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited MLYS in Q3 2025

New Positions: 33
New Value: $226.1M
Exited Positions: 15
Exited Value: $5.2M

New Positions

Institution	Position Value
FARALLON CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	$63.4M 1.7M shares
Holocene Advisors, LP Hedge Fund•Long/Short	$45.7M 1.2M shares
Polar Capital Holdings Plc Long Only Manager	$40.1M 1.1M shares
N Nearwater Capital Markets, Ltd Institution	$17.1M 450.0K shares
S Swedbank AB Institution	$11.3M 299.3K shares
S Simplify Asset Management Inc. Institution	$8.3M 218.7K shares
Atika Capital Management LLC Hedge Fund•Long/Short	$6.6M 174.0K shares
M MOORE CAPITAL MANAGEMENT, LP Hedge Fund•Global Macro	$6.3M 165.0K shares
Rhenman & Partners Asset Management AB RIA/Wealth	$6.3M 165.0K shares
Burkehill Global Management, LP Hedge Fund•Event Driven	$5.7M 150.0K shares

Exited Positions

Institution	Previous Position
Woodline Partners LP Hedge Fund•Long/Short	$1.2M 87.9K shares
UBS OCONNOR LLC Long Only Manager	$1.1M 79.7K shares
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$1.0M 73.9K shares
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	$654.9K 48.4K shares
M Man Group plc Institution	$295.7K 21.9K shares
INTECH INVESTMENT MANAGEMENT LLC Long Only Manager	$292.6K 21.6K shares
F FOX RUN MANAGEMENT, L.L.C. Hedge Fund•Quant	$219.8K 16.2K shares
S STRS OHIO Institution	$208.4K 15.4K shares
Q Quadrature Capital Ltd Institution	$162.4K 12.0K shares
G GROUP ONE TRADING, L.P. Institution	$137.2K 10.1K shares

Options Activity

Institutions with the largest Call and Put options positions in MLYS as of Q3 2025

Call Positions: 2
Call Value: $1.7M
Put Positions: 4
Put Value: $16.7M

Call Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.2M 318.0 contracts
J J. Goldman & Co LP Hedge Fund•Multi-Strategy	$504.3K 133.0 contracts

Put Positions

Institution	Position Value
Caption Management, LLC Hedge Fund•Long/Short	$12.1M 3.2K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$2.0M 519.0 contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$1.4M 370.0 contracts
J JANE STREET GROUP, LLC Institution	$1.2M 306.0 contracts

Most Committed Institutions

Institutions with MLYS as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
C Catalys Pacific, LLC Institution	-	96.09% $337.6M	11.48% 8.9M shares	Q4 2023 Held for 1y 11m	$351.4M
Samsara BioCapital, LLC Venture Capital	Miran Nasruddin Ahmad CFO	31.01% $237.5M	8.07% 6.3M shares	Q1 2023 Held for 2y 8m	$765.9M
C Caligan Partners LP Hedge Fund•Activist	Tiffany Crowley CFO	14.59% $105.1M	3.57% 2.8M shares	Q2 2024 Held for 1y 5m	$720.7M
SR ONE CAPITAL MANAGEMENT, LP Venture Capital	Simeon John George CEO	11.59% $80.2M	2.73% 2.1M shares	Q1 2023 Held for 2y 8m	$691.4M
Laurion Capital Management LP Hedge Fund•Multi-Strategy	Masih Mohebbi-Forushani CFO	9.60% $65.2M	2.22% 1.7M shares	Q1 2023 Held for 2y 8m	$679.7M
L Lion Point Capital, LP Hedge Fund•Event Driven	Carl Didric Marcus Cederholm CIO	8.40% $1.5M	0.05% 39.0K shares	Q1 2024 Held for 1y 8m	$17.6M
2 22NW, LP Hedge Fund•Long/Short	James Paul Stoner CFO	6.42% $13.6M	0.46% 358.3K shares	Q1 2025 Held for 8 months	$211.7M
V Velan Capital Investment Management LP Institution	-	6.25% $6.7M	0.23% 175.6K shares	Q1 2025 Held for 8 months	$106.5M
FINDELL CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	Ryan Bradley Voerg CFO	4.40% $9.5M	0.32% 250.0K shares	Q1 2025 Held for 8 months	$215.6M
Integral Health Asset Management, LLC Hedge Fund•Sector	Bhagwan Jay Rao CIO	4.30% $56.9M	1.93% 1.5M shares	Q3 2024 Held for 1y 2m	$1.3B

Hedge Fund Spotlight

Discover hedge funds investing in MLYS

Nantahala Capital Management, LLC

Hedge Fund • Multi-Strategy

Portfolio ManagerDaniel J. Mack

Portfolio Value: $1.6B
Positions: 129
Last Reported: Q3 2025

Sector Allocation

Position in Mineralys Therapeutics, Inc.

Market Value: $6.0M
Shares Held: 158.7K
Portfolio Weight: 0.37%
Owned Since: 2024-Q1

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