Tri Locum Partners LP

Hedge Fund • Long/Short

Tri Locum Partners LP is a Long/Short Hedge Fund based in New York, NY led by Prashanth Nmn Jayaram, reporting $752.9M in AUM as of Q3 2025 with 85% Healthcare concentration and 84% concentrated in top 10 holdings.

CIOPrashanth Nmn Jayaram

Portfolio Value: $435.1M
Positions: 18
Top Holding: JNJ at 12.91%
Last Reported: Q3 2025

Address287 Park Avenue South, New York, NY, 10010, United States

Top Holdings

Largest long holdings in Tri Locum Partners LP's portfolio (83.7% of total portfolio)

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Holding	Sector	Position	Weight	Traded	Ownership	Owned Since
1 Johnson & Johnson JNJ	Drug Manufacturers - General Healthcare	$56.2M	12.91%	+$56.2M Bought	0.01% 302.8K shares	Q3 2025 Held for 2 months
2 United Therapeutics UTHR	Biotechnology Healthcare	$51.2M	11.77%	+$51.2M Bought	0.27% 122.2K shares	Q3 2025 Held for 2 months
3 Merck & Co. MRK	Drug Manufacturers - General Healthcare	$37.5M	8.62%	+$37.5M Bought	0.02% 446.9K shares	Q3 2025 Held for 2 months
4 Axsome Therapeutics AXSM	Biotechnology Healthcare	$35.5M	8.16%	+$16.3M Bought	0.59% 292.1K shares	Q4 2022 Held for 2y 11m
5 ASND Ascendis Pharma ASND	Unknown Unknown	$34.8M	7.99%	+$5.4M Bought	— 174.8K shares	Q1 2025 Held for 8 months
6 Vera Therapeutics VERA	Biotechnology Healthcare	$34.6M	7.95%	+$22.6M Bought	1.86% 1.2M shares	Q1 2025 Held for 8 months
7 ARGX argenx ARGX	Unknown Unknown	$32.0M	7.36%	-$3.2M Sold	— 43.4K shares	Q3 2023 Held for 2y 2m
8 Madrigal Pharmaceuticals, Inc. MDGL	Biotechnology Healthcare	$31.1M	7.14%	-$13.8M Sold	0.30% 67.7K shares	Q4 2022 Held for 2y 11m
9 Soleno Therapeutics SLNO	Biotechnology Healthcare	$30.5M	7.00%	+$10.9M Bought	0.85% 450.6K shares	Q1 2025 Held for 8 months
10 AbbVie ABBV	Drug Manufacturers - General Healthcare	$20.8M	4.77%	+$7.9M Bought	0.01% 89.6K shares	Q2 2025 Held for 5 months

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Changes

Portfolio activity, position movements, and quarter-over-quarter changes in Tri Locum Partners LP's latest filing

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Market Value

$435.1M

Prior: $329.5M

Q/Q Change

+32.03%

+$105.5M

Net Flows % of MV

-25.04%

Turnover Ratio

50.18%

New Purchases

1 stocks

$7.2M

Added To

6 stocks

+$72.6M

Sold Out Of

11 stocks

$155.6M

Reduced Holdings

6 stocks

-$33.1M

Increased Positions

Position	Shares Δ	Change
1 Dianthus Therapeutics DNTH	New	0 → 182.9K +$7.2M
2 Vera Therapeutics VERA	+188.11%	413.1K → 1.2M +$22.6M
3 Korro Bio, Inc. KRRO	+142.14%	139.5K → 337.8K +$9.5M
4 Axsome Therapeutics AXSM	+85.06%	157.9K → 292.1K +$16.3M
5 AbbVie ABBV	+61.01%	55.7K → 89.6K +$7.9M

Decreased Positions

Position	Shares Δ	Change
1 TEVA Teva Pharmaceutical Industries Limited TEVA	Sold	2.0M → 0 −$34.3M
2 Alnylam Pharmaceuticals ALNY	Sold	89.5K → 0 −$29.2M
3 VRNA Verona Pharma VRNA	Sold	216.6K → 0 −$20.5M
4 Inspire Medical Systems INSP	Sold	149.2K → 0 −$19.4M
5 UnitedHealth Group UNH	Sold	60.6K → 0 −$18.9M