Axsome Therapeutics

AXSM • NASDAQ

Axsome Therapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by Herriot Tabuteau, M.D., with a market cap of $7.5B. As of Q3 2025, 74% of shares are held by 348 institutional investors, with VANGUARD GROUP INC as the largest holder at 8.38%.

CEOHerriot Tabuteau, M.D.

Market Cap$7.5B

Biotechnology

Healthcare

Employees569.0

Websiteaxsome.com

Country

United States of America

Overview

Overview of institutional ownership in AXSM as of Q3 2025 with a market cap of $6.1B

All Institutions

Institutions: 348
Value Held: $4.5B
Shares Held: 37.1M
Avg Position: $13.0M
Median Position: $1.1M

Hedge Funds

Hedge Funds: 53
Value Held: $854.4M
Shares Held: 7.0M
Avg Position: $16.1M
Median Position: $2.0M

Ownership Breakdown

Institutional (non-HF)

60.3%

$3.7B

Hedge Funds

14.1%

$854.4M

Retail & Other

25.6%

$1.6B

Based on market cap of $6.1B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in AXSM as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
VANGUARD GROUP INC Institution	Salim Ramji CEO	$507.7M 0.01% of portfolio	8.38% 4.2M shares	Q1 2016 Held for 9y 8m	$6.69T
B BlackRock, Inc. Institution	-	$460.4M 0.01% of portfolio	7.60% 3.8M shares	Q2 2016 Held for 9y 5m	$5.67T
WELLINGTON MANAGEMENT CO LLP Long Only Manager	Jean Marie Hynes CEO	$162.1M 0.03% of portfolio	2.67% 1.3M shares	Q2 2023 Held for 2y 5m	$571.21B
RTW INVESTMENTS, LLC Hedge Fund•Sector	Peter M Fong President	$135.9M 1.69% of portfolio	2.24% 1.1M shares	Q1 2019 Held for 6y 8m	$8.1B
M MACQUARIE GROUP LTD Institution	-	$131.7M 0.16% of portfolio	2.17% 1.1M shares	Q2 2020 Held for 5y 5m	$82.9B
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	Robert W Sharps President	$126.0M 0.01% of portfolio	2.08% 1.0M shares	Q2 2019 Held for 6y 5m	$912.31B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$121.2M 0.01% of portfolio	2.00% 997.7K shares	Q1 2016 Held for 9y 8m	$1.57T
Invesco Ltd. ETF Provider	Brian Christopher Hartigan CEO	$120.3M 0.02% of portfolio	1.99% 990.6K shares	Q1 2019 Held for 6y 8m	$633.08B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$114.5M 0.00% of portfolio	1.89% 943.0K shares	Q1 2019 Held for 6y 8m	$2.88T
FMR LLC Institution	-	$112.7M 0.01% of portfolio	1.86% 927.9K shares	Q3 2019 Held for 6y 2m	$1.92T

Net Capital Flow

Institutional buying and selling activity for AXSM in Q3 2025

Traded: +$24.5M
Buyers: 194
Sellers: 136
Total Bought: +$556.7M
Total Sold: −$532.2M
Avg Position: $11.7M

Biggest Buyers

Institution	Net Bought	Current Position
WELLINGTON MANAGEMENT CO LLP Long Only Manager	+$74.0M +609.5K shares	$162.1M 1.3M shares
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	+$51.6M +424.7K shares	$126.0M 1.0M shares
Invesco Ltd. ETF Provider	+$50.9M +419.0K shares	$120.3M 990.6K shares
Marshall Wace LLP Institution	+$39.0M +321.3K shares	$45.9M 378.0K shares
S Sofinnova Ventures Inc Venture Capital	+$36.4M +299.9K shares	$47.8M 393.5K shares
VANGUARD GROUP INC Institution	+$28.6M +235.6K shares	$507.7M 4.2M shares
Vestal Point Capital, LP Hedge Fund•Long/Short	+$18.2M +150.0K shares	$18.2M 150.0K shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$17.6M +144.8K shares	$19.2M 158.4K shares
T Tri Locum Partners LP Hedge Fund•Long/Short	+$16.3M +134.3K shares	$35.5M 292.1K shares
J JANE STREET GROUP, LLC Institution	+$15.9M +130.8K shares	$15.9M 130.8K shares

Biggest Sellers

Institution	Net Sold	Current Position
B BVF INC/IL Institution	−$146.2M −1.2M shares	$59.1M 486.8K shares
RTW INVESTMENTS, LLC Hedge Fund•Sector	−$48.3M −398.0K shares	$135.9M 1.1M shares
BANK OF AMERICA CORP /DE/ Institution	−$47.6M −392.2K shares	$43.9M 361.3K shares
UBS Group AG Institution	−$46.5M −383.0K shares	$25.8M 212.5K shares
M Man Group plc Institution	−$28.8M −237.2K shares	$35.0M 287.9K shares
C Cubist Systematic Strategies, LLC Institution	−$16.8M −138.1K shares	$2.6M 21.2K shares
J Jump Financial, LLC Institution	−$12.6M −103.5K shares	$3.0M 25.0K shares
Bridgewater Associates, LP Hedge Fund•Global Macro	−$11.2M −107.3K shares	Sold Off 0 shares
A Avidity Partners Management LP Hedge Fund•Long/Short	−$9.9M −94.5K shares	Sold Off 0 shares
R READYSTATE ASSET MANAGEMENT LP Hedge Fund•Multi-Strategy	−$9.3M −76.7K shares	$2.2M 17.9K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited AXSM in Q3 2025

New Positions: 23
New Value: $19.2M
Exited Positions: 37
Exited Value: $55.7M

New Positions

Institution	Position Value
Summit Financial, LLC RIA/Wealth	$9.4M 77.5K shares
Stanley-Laman Group, Ltd. RIA/Wealth	$2.1M 17.5K shares
Voleon Capital Management LP Hedge Fund•Quant	$2.0M 16.7K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$1.1M 9.0K shares
I INCEPTIONR LLC Hedge Fund•Quant	$1.1M 8.7K shares
CAPSTONE INVESTMENT ADVISORS, LLC Hedge Fund•Multi-Strategy	$795.7K 6.6K shares
CABOT MONEY MANAGEMENT INC RIA/Wealth	$675.3K 5.6K shares
FIDUCIARY FAMILY OFFICE, LLC Family Office	$324.3K 2.7K shares
F Freestone Grove Partners LP Hedge Fund•Multi-Strategy	$302.9K 2.5K shares
B Baader Bank INC Institution	$251.5K 2.1K shares

Exited Positions

Institution	Previous Position
Bridgewater Associates, LP Hedge Fund•Global Macro	$11.2M 107.3K shares
A Avidity Partners Management LP Hedge Fund•Long/Short	$9.9M 94.5K shares
Candriam Luxembourg S.C.A. Long Only Manager	$8.0M 76.7K shares
Affinity Asset Advisors, LLC Hedge Fund•Long/Short	$5.2M 50.0K shares
SCHRODER INVESTMENT MANAGEMENT GROUP RIA/Wealth	$3.9M 37.5K shares
Point72 Europe LLP Digital Asset Manager	$3.5M 33.8K shares
Hudson Bay Capital Management LP Hedge Fund•Multi-Strategy	$2.6M 25.0K shares
Magnetar Financial LLC Hedge Fund•Multi-Strategy	$2.1M 20.3K shares
Q Quadrature Capital Ltd Institution	$1.7M 16.5K shares
W Winton Capital Group Ltd Institution	$997.4K 9.6K shares

Options Activity

Institutions with the largest Call and Put options positions in AXSM as of Q3 2025

Call Positions: 17
Call Value: $67.1M
Put Positions: 12
Put Value: $65.7M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$33.2M 2.7K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$11.0M 907.0 contracts
J JANE STREET GROUP, LLC Institution	$10.7M 879.0 contracts
W WOLVERINE TRADING, LLC Institution	$3.0M 259.0 contracts
Caption Management, LLC Hedge Fund•Long/Short	$3.0M 250.0 contracts
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	$1.7M 141.0 contracts
N NOMURA HOLDINGS INC Institution	$1.2M 100.0 contracts
D D. E. Shaw & Co., Inc. Institution	$801.6K 66.0 contracts
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	$789.4K 65.0 contracts
C Cubist Systematic Strategies, LLC Institution	$716.6K 59.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$34.6M 2.9K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$12.9M 1.1K contracts
J JANE STREET GROUP, LLC Institution	$6.5M 533.0 contracts
W WOLVERINE TRADING, LLC Institution	$3.3M 279.0 contracts
H HB Wealth Management, LLC Institution	$3.1M 258.0 contracts
Caption Management, LLC Hedge Fund•Long/Short	$3.0M 250.0 contracts
N NOMURA HOLDINGS INC Institution	$1.2M 100.0 contracts
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	$534.4K 44.0 contracts
S Squarepoint Ops LLC Hedge Fund•Quant	$340.1K 28.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$97.2K 8.0 contracts

Most Committed Institutions

Institutions with AXSM as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
Alethea Capital Management, LLC Hedge Fund•Multi-Strategy	Tony Hsu Managing Partner	52.44% $81.5M	1.34% 670.9K shares	Q4 2017 Held for 7y 11m	$155.4M
SVB Capital Management, LLC Fund of Funds	Aaron Garth Gershenberg CEO	12.95% $4.1M	0.07% 33.8K shares	Q3 2024 Held for 1y 2m	$31.7M
Fairmount Funds Management LLC Hedge Fund•Sector	Peter Evan Harwin Managing Partner	8.91% $99.0M	1.63% 815.2K shares	Q1 2020 Held for 5y 8m	$1.1B
T Tri Locum Partners LP Hedge Fund•Long/Short	Prashanth Nmn Jayaram CIO	8.16% $35.5M	0.59% 292.1K shares	Q4 2022 Held for 2y 11m	$435.1M
Partner Fund Management, L.P. Hedge Fund•Sector	Jonathan Jude Aljoe CFO	5.57% $64.4M	1.06% 530.3K shares	Q2 2022 Held for 3y 5m	$1.2B
IRIDIAN ASSET MANAGEMENT LLC/CT Hedge Fund•Long/Short	Todd Dunkin Raker CEO	3.99% $10.1M	0.17% 83.6K shares	Q1 2019 Held for 6y 8m	$254.1M
Deep Track Capital, LP Hedge Fund•Long/Short	David Eric Kroin CIO	3.11% $109.3M	1.80% 900.0K shares	Q2 2025 Held for 5 months	$3.5B
N Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. Institution	-	3.06% $39.6M	0.65% 326.3K shares	Q4 2024 Held for 11 months	$1.3B
S Sofinnova Ventures Inc Venture Capital	James Irvin Healy Managing Partner	2.93% $47.8M	0.79% 393.5K shares	Q2 2024 Held for 1y 5m	$1.6B
F First Turn Management, LLC Hedge Fund•Long/Short	Lisa Gable Wheatley Managing Partner	2.78% $18.5M	0.31% 152.6K shares	Q4 2023 Held for 1y 11m	$666.0M

Hedge Fund Spotlight

Discover hedge funds investing in AXSM

J. Goldman & Co LP

Hedge Fund • Multi-Strategy

Portfolio ManagerJay Glenn Goldman

Portfolio Value: $2.6B
Positions: 268
Last Reported: Q3 2025

Sector Allocation

Position in Axsome Therapeutics

Market Value: $1.0M
Shares Held: 8.4K
Portfolio Weight: 0.04%
Owned Since: 2022-Q4

Top Holding	Sector	Market Value	Weight
1 Microsoft MSFT	Software - Infrastructure Technology	$110.0M	4.17%
2 Meta Platforms, Inc. META	Internet Content & Information Communication Services	$81.8M	3.10%
3 SBA Communications SBAC	REIT - Specialty Real Estate	$62.2M	2.36%