Amicus Therapeutics

FOLD • NASDAQ

Amicus Therapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by John F. Crowley, with a market cap of $3.3B. As of Q3 2025, 101% of shares are held by 280 institutional investors, with VANGUARD GROUP INC as the largest holder at 9.58%.

Chairman and Chief Executive OfficerJohn F. Crowley

Market Cap$3.3B

Biotechnology

Healthcare

Employees517.0

Websiteamicusrx.com

Country

United States of America

Overview

Overview of institutional ownership in FOLD as of Q3 2025 with a market cap of $2.4B

All Institutions

Institutions: 280
Value Held: $2.5B
Shares Held: 312.4M
Avg Position: $8.8M
Median Position: $502.6K

Hedge Funds

Hedge Funds: 54
Value Held: $631.4M
Shares Held: 80.1M
Avg Position: $11.7M
Median Position: $3.3M

Ownership Breakdown

Institutional (non-HF)

75.34%

$1.8B

Hedge Funds

26.0%

$631.4M

Retail & Other

Based on market cap of $2.4B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in FOLD as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
VANGUARD GROUP INC Institution	Salim Ramji CEO	$232.7M 0.00% of portfolio	9.58% 29.5M shares	≤ Q2 2013 Held for 12y 5m+	$6.69T
WELLINGTON MANAGEMENT CO LLP Long Only Manager	Jean Marie Hynes CEO	$225.6M 0.04% of portfolio	9.29% 28.6M shares	Q2 2015 Held for 10y 5m	$571.21B
B BlackRock, Inc. Institution	-	$203.7M 0.00% of portfolio	8.39% 25.8M shares	Q2 2015 Held for 10y 5m	$5.67T
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC Long Only Manager	Brent Walker Gledhill CEO	$124.1M 0.32% of portfolio	5.11% 15.7M shares	Q3 2020 Held for 5y 2m	$38.7B
venBio Select Advisor LLC RIA/Wealth	Behzad Aghazadeh Managing Partner	$118.4M 1.53% of portfolio	4.87% 15.0M shares	Q4 2014 Held for 10y 11m	$7.7B
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	Dan Michael Berkovitz Chairman	$93.1M 0.08% of portfolio	3.83% 11.8M shares	Q1 2024 Held for 1y 8m	$121.98B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$91.1M 0.00% of portfolio	3.75% 11.6M shares	≤ Q2 2013 Held for 12y 5m+	$2.88T
Vestal Point Capital, LP Hedge Fund•Long/Short	Ryan Christopher Wilder CIO	$76.8M 3.90% of portfolio	3.16% 9.8M shares	Q4 2024 Held for 11 months	$2.0B
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	Kenneth Cordele Griffin CEO	$65.0M 0.05% of portfolio	2.68% 8.3M shares	Q3 2014 Held for 11y 2m	$122.08B
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	Steven Alan Cohen CEO	$56.4M 0.13% of portfolio	2.32% 7.2M shares	Q3 2024 Held for 1y 2m	$43.2B

Net Capital Flow

Institutional buying and selling activity for FOLD in Q3 2025

Traded: −$6.0M
Buyers: 157
Sellers: 119
Total Bought: +$306.3M
Total Sold: −$312.3M
Avg Position: $7.9M

Biggest Buyers

Institution	Net Bought	Current Position
Soleus Capital Management, L.P. Hedge Fund•Long/Short	+$37.0M +4.7M shares	$37.0M 4.7M shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$34.6M +4.4M shares	$93.1M 11.8M shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	+$30.6M +3.9M shares	$56.4M 7.2M shares
Pictet Asset Management Holding SA Long Only Manager	+$22.8M +2.9M shares	$53.6M 6.8M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$17.9M +2.3M shares	$65.0M 8.3M shares
Iron Triangle Partners LP Hedge Fund•Long/Short	+$15.5M +2.0M shares	$15.5M 2.0M shares
Schonfeld Strategic Advisors LLC Hedge Fund•Multi-Strategy	+$10.4M +1.3M shares	$10.7M 1.4M shares
$DEUTSCHE BANK AG\ logo$ DEUTSCHE BANK AG\ Institution	+$9.6M +1.2M shares	$19.5M 2.5M shares
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC Long Only Manager	+$8.7M +1.1M shares	$124.1M 15.7M shares
Parkman Healthcare Partners LLC Hedge Fund•Long/Short	+$8.5M +1.1M shares	$13.3M 1.7M shares

Biggest Sellers

Institution	Net Sold	Current Position
M MACQUARIE GROUP LTD Institution	−$24.9M −3.2M shares	$35.9M 4.6M shares
venBio Select Advisor LLC RIA/Wealth	−$23.4M −3.0M shares	$118.4M 15.0M shares
D D. E. Shaw & Co., Inc. Institution	−$19.7M −2.5M shares	$30.5M 3.9M shares
Vestal Point Capital, LP Hedge Fund•Long/Short	−$16.9M −2.2M shares	$76.8M 9.8M shares
Prosight Management, LP Hedge Fund•Long/Short	−$14.0M −1.8M shares	$13.5M 1.7M shares
Q Qube Research & Technologies Ltd Institution	−$13.5M −1.7M shares	$13.8M 1.7M shares
A Assenagon Asset Management S.A. Institution	−$13.3M −1.7M shares	$14.6M 1.8M shares
B BlackRock, Inc. Institution	−$13.3M −1.7M shares	$203.7M 25.8M shares
VOLORIDGE INVESTMENT MANAGEMENT, LLC Hedge Fund•Multi-Strategy	−$12.1M −1.5M shares	$5.4M 686.3K shares
M M&G Plc Institution	−$11.3M −1.9M shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited FOLD in Q3 2025

New Positions: 23
New Value: $31.5M
Exited Positions: 31
Exited Value: $32.1M

New Positions

Institution	Position Value
Iron Triangle Partners LP Hedge Fund•Long/Short	$15.5M 2.0M shares
I Ion Asset Management Ltd. Institution	$6.9M 872.4K shares
F Freestone Grove Partners LP Hedge Fund•Multi-Strategy	$3.5M 440.8K shares
NFJ INVESTMENT GROUP, LLC Long Only Manager	$2.7M 336.7K shares
Polygon Management Ltd. Hedge Fund•Multi-Strategy	$955.2K 121.2K shares
V Vise Technologies, Inc. Institution	$498.2K 63.2K shares
S Sender Co & Partners, Inc. Institution	$272.2K 34.5K shares
IEQ CAPITAL, LLC RIA/Wealth	$266.3K 33.8K shares
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC RIA/Wealth	$194.9K 23.9K shares
PARK NATIONAL CORP /OH/ Institution	$129.1K 16.4K shares

Exited Positions

Institution	Previous Position
M M&G Plc Institution	$11.3M 1.9M shares
SCHRODER INVESTMENT MANAGEMENT GROUP RIA/Wealth	$5.8M 1.0M shares
CAPITAL FUND MANAGEMENT S.A. Hedge Fund•Quant Macro	$4.4M 762.7K shares
C Campbell & CO Investment Adviser LLC Hedge Fund•Quant Macro	$3.8M 656.1K shares
R READYSTATE ASSET MANAGEMENT LP Hedge Fund•Multi-Strategy	$1.9M 329.9K shares
OSTERWEIS CAPITAL MANAGEMENT INC Long Only Manager	$1.4M 250.9K shares
H HRT FINANCIAL LLC Institution	$927.8K 161.9K shares
H HSBC HOLDINGS PLC Institution	$376.6K 65.0K shares
Tempus Wealth Planning, LLC RIA/Wealth	$304.4K 53.1K shares
A AXQ CAPITAL, LP Hedge Fund•Market Neutral	$289.6K 50.5K shares

Options Activity

Institutions with the largest Call and Put options positions in FOLD as of Q3 2025

Call Positions: 13
Call Value: $8.6M
Put Positions: 10
Put Value: $8.2M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$3.4M 4.3K contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$1.4M 1.7K contracts
N NOMURA HOLDINGS INC Institution	$1.2M 1.5K contracts
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$1.0M 1.3K contracts
Caption Management, LLC Hedge Fund•Long/Short	$394.0K 500.0 contracts
T TORNO CAPITAL, LLC Institution	$394.0K 500.0 contracts
W WOLVERINE TRADING, LLC Institution	$227.1K 286.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$192.3K 244.0 contracts
J JANE STREET GROUP, LLC Institution	$153.7K 195.0 contracts
Walleye Trading LLC RIA/Wealth	$108.0K 137.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$3.3M 4.2K contracts
N NOMURA HOLDINGS INC Institution	$1.2M 1.5K contracts
J JANE STREET GROUP, LLC Institution	$1.1M 1.4K contracts
BARCLAYS PLC Institution	$898.3K 1.1K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$460.2K 584.0 contracts
Caption Management, LLC Hedge Fund•Long/Short	$394.0K 500.0 contracts
T TORNO CAPITAL, LLC Institution	$394.0K 500.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$174.1K 221.0 contracts
W WOLVERINE TRADING, LLC Institution	$162.8K 205.0 contracts
Walleye Trading LLC RIA/Wealth	$82.7K 105.0 contracts

Most Committed Institutions

Institutions with FOLD as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
P Palo Alto Investors, LLC Hedge Fund•Long/Short	Angela Elizabeth Nguyen-Dinh CCO	7.83% $42.3M	1.74% 5.4M shares	≤ Q2 2013 Held for 12y 5m+	$540.4M
Vestal Point Capital, LP Hedge Fund•Long/Short	Ryan Christopher Wilder CIO	3.90% $76.8M	3.16% 9.8M shares	Q4 2024 Held for 11 months	$2.0B
Prosight Management, LP Hedge Fund•Long/Short	William Lawrence Hawkins Managing Partner	3.58% $13.5M	0.55% 1.7M shares	Q4 2024 Held for 11 months	$376.7M
Sovereign's Capital Management, LLC Private Equity	Thomsen Paul Jacob Managing Partner	3.57% $6.6M	0.27% 834.4K shares	Q4 2024 Held for 11 months	$184.3M
C CM Management, LLC Institution	-	2.96% $3.5M	0.15% 450.0K shares	Q4 2020 Held for 4y 11m	$119.9M
Iron Triangle Partners LP Hedge Fund•Long/Short	Michael John O'Brien CFO	2.21% $15.5M	0.64% 2.0M shares	Q3 2025 Held for 2 months	$703.3M
Soleus Capital Management, L.P. Hedge Fund•Long/Short	Guy Bezalel Levy CIO	2.02% $37.0M	1.52% 4.7M shares	Q3 2025 Held for 2 months	$1.8B
S SPHERA FUNDS MANAGEMENT LTD. Institution	-	1.88% $7.8M	0.32% 991.1K shares	Q2 2025 Held for 5 months	$416.3M
venBio Select Advisor LLC RIA/Wealth	Behzad Aghazadeh Managing Partner	1.53% $118.4M	4.87% 15.0M shares	Q4 2014 Held for 10y 11m	$7.7B
B Birchview Capital, LP Hedge Fund•Value	Matthew William Strobeck CIO	1.53% $2.0M	0.08% 253.0K shares	Q3 2017 Held for 8y 2m	$130.3M