Leap Therapeutics, Inc.

LPTX • NASDAQ

Leap Therapeutics, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Douglas E. Onsi, with a market cap of $116.1M. As of Q3 2025, 31% of shares are held by 31 institutional investors, with GILEAD SCIENCES, INC. as the largest holder at 12.84%.

President and Chief Executive OfficerDouglas E. Onsi

Market Cap$116.1M

Biotechnology

Healthcare

Employees54.0

Websiteleaptx.com

Country

United States of America

Overview

Overview of institutional ownership in LPTX as of Q3 2025 with a market cap of $18.8M

All Institutions

Institutions: 31
Value Held: $5.8M
Shares Held: 12.7M
Avg Position: $185.8K
Median Position: $28.0K

Hedge Funds

Hedge Funds: 3
Value Held: $89.1K
Shares Held: 196.4K
Avg Position: $29.7K
Median Position: $32.2K

Ownership Breakdown

Institutional (non-HF)

30.14%

$5.7M

Hedge Funds

0.474%

$89.1K

Retail & Other

69.39%

$13.1M

Based on market cap of $18.8M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in LPTX as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
GILEAD SCIENCES, INC. Institution	Daniel O'Day CEO	$2.4M 0.13% of portfolio	12.84% 5.3M shares	Q4 2024 Held for 11 months	$1.8B
BANK OF AMERICA CORP /DE/ Institution	Brian T. Moynihan CEO	$655.8K 0.00% of portfolio	3.49% 1.4M shares	Q4 2023 Held for 1y 11m	$1.33T
ACADIAN ASSET MANAGEMENT LLC Long Only Manager	Gillian Morna Therese Savage CEO	$561.6K 0.00% of portfolio	2.99% 1.2M shares	Q4 2023 Held for 1y 11m	$51.5B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$526.9K 0.00% of portfolio	2.80% 1.2M shares	Q3 2017 Held for 8y 2m	$6.69T
HighTower Advisors, LLC RIA/Wealth	Robert David Oros CEO	$501.6K 0.00% of portfolio	2.67% 1.1M shares	Q3 2024 Held for 1y 2m	$87.7B
S Simplify Asset Management Inc. Institution	-	$442.9K 0.03% of portfolio	2.35% 975.6K shares	Q1 2024 Held for 1y 8m	$1.6B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$141.8K 0.00% of portfolio	0.75% 312.2K shares	Q2 2018 Held for 7y 5m	$1.57T
J JANE STREET GROUP, LLC Institution	-	$75.1K 0.00% of portfolio	0.40% 165.4K shares	Q2 2024 Held for 1y 5m	$84.1B
Key Client Fiduciary Advisors, LLC RIA/Wealth	Richard Anthony Flora Member	$62.6K 0.02% of portfolio	0.33% 138.0K shares	Q4 2021 Held for 3y 11m	$294.6M
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$57.0K 0.00% of portfolio	0.30% 125.6K shares	Q2 2021 Held for 4y 5m	$2.88T

Net Capital Flow

Institutional buying and selling activity for LPTX in Q3 2025

Traded: −$286.0
Buyers: 10
Sellers: 17
Total Bought: +$919.0K
Total Sold: −$919.3K
Avg Position: $128.0K

Biggest Buyers

Institution	Net Bought	Current Position
BANK OF AMERICA CORP /DE/ Institution	+$655.6K +1.4M shares	$655.8K 1.4M shares
J JANE STREET GROUP, LLC Institution	+$75.1K +165.4K shares	$75.1K 165.4K shares
H HRT FINANCIAL LLC Institution	+$53.9K +118.6K shares	$53.9K 118.6K shares
S Simplify Asset Management Inc. Institution	+$53.7K +118.2K shares	$442.9K 975.6K shares
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	+$26.5K +58.4K shares	$45.3K 99.7K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	+$25.9K +57.0K shares	$32.2K 70.8K shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	+$17.0K +37.4K shares	$39.1K 86.2K shares
X XTX Topco Ltd Institution	+$7.6K +16.6K shares	$13.9K 30.7K shares
HighTower Advisors, LLC RIA/Wealth	+$3.6K +8.0K shares	$501.6K 1.1M shares
UBS Group AG Institution	+$182.0 +-121.8K shares	$182.0 400.0 shares

Biggest Sellers

Institution	Net Sold	Current Position
6 683 Capital Management, LLC Hedge Fund•Long/Short	−$428.8K −1.4M shares	Sold Off 0 shares
Monaco Asset Management SAM RIA/Wealth	−$311.7K −1.1M shares	Sold Off 0 shares
Key Client Fiduciary Advisors, LLC RIA/Wealth	−$93.5K −205.9K shares	$62.6K 138.0K shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$22.2K −74.9K shares	Sold Off 0 shares
D Dauntless Investment Group, LLC Institution	−$17.8K −60.0K shares	Sold Off 0 shares
INTEGRITY ALLIANCE, LLC. RIA/Wealth	−$13.1K −44.2K shares	Sold Off 0 shares
V Virtu Financial LLC Institution	−$12.0K −40.4K shares	Sold Off 0 shares
D DRW Securities, LLC Institution	−$8.4K −28.2K shares	Sold Off 0 shares
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	−$6.4K −14.1K shares	$11.7K 25.8K shares
L LPL Financial LLC Institution	−$3.4K −7.5K shares	$16.3K 36.0K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited LPTX in Q3 2025

New Positions: 0
New Value: -
Exited Positions: 13
Exited Value: $815.9K

New Positions

Institution	Position Value
No new positions found

Exited Positions

Institution	Previous Position
6 683 Capital Management, LLC Hedge Fund•Long/Short	$428.8K 1.4M shares
Monaco Asset Management SAM RIA/Wealth	$311.7K 1.1M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$22.2K 74.9K shares
D Dauntless Investment Group, LLC Institution	$17.8K 60.0K shares
INTEGRITY ALLIANCE, LLC. RIA/Wealth	$13.1K 44.2K shares
V Virtu Financial LLC Institution	$12.0K 40.4K shares
D DRW Securities, LLC Institution	$8.4K 28.2K shares
RAYMOND JAMES FINANCIAL INC RIA/Wealth	$1.4K 4.6K shares
A Atlantic Trust Group, LLC Institution	$445.0 1.5K shares
Hanson McClain, Inc. RIA/Wealth	$41.0 135.0 shares

Options Activity

Institutions with the largest Call and Put options positions in LPTX as of Q3 2025

Call Positions: 2
Call Value: $22.2K
Put Positions: 1
Put Value: $15.6K

Call Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$16.7K 368.0 contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$5.5K 122.0 contracts

Put Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$15.6K 343.0 contracts

Most Committed Institutions

Institutions with LPTX as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
GILEAD SCIENCES, INC. Institution	Daniel O'Day CEO	0.13% $2.4M	12.84% 5.3M shares	Q4 2024 Held for 11 months	$1.8B
S Simplify Asset Management Inc. Institution	-	0.03% $442.9K	2.35% 975.6K shares	Q1 2024 Held for 1y 8m	$1.6B
Key Client Fiduciary Advisors, LLC RIA/Wealth	Richard Anthony Flora Member	0.02% $62.6K	0.33% 138.0K shares	Q4 2021 Held for 3y 11m	$294.6M
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	Daniel Pawel Schneeberger Managing Partner	0.00% $11.7K	0.06% 25.8K shares	Q4 2024 Held for 11 months	$993.7M
ACADIAN ASSET MANAGEMENT LLC Long Only Manager	Gillian Morna Therese Savage CEO	0.00% $561.6K	2.99% 1.2M shares	Q4 2023 Held for 1y 11m	$51.5B
C CNB Bank Institution	-	0.00% $2.3K	0.01% 5.0K shares	Q4 2021 Held for 3y 11m	$240.0M
X XTX Topco Ltd Institution	-	0.00% $13.9K	0.07% 30.7K shares	Q2 2025 Held for 5 months	$1.9B
HighTower Advisors, LLC RIA/Wealth	Robert David Oros CEO	0.00% $501.6K	2.67% 1.1M shares	Q3 2024 Held for 1y 2m	$87.7B
H HRT FINANCIAL LLC Institution	-	0.00% $53.9K	0.29% 118.6K shares	Q3 2025 Held for 2 months	$21.1B
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	Scott David Hoffman CEO	0.00% $45.3K	0.24% 99.7K shares	Q2 2025 Held for 5 months	$50.0B

Hedge Fund Spotlight

Discover hedge funds investing in LPTX

ADAR1 Capital Management, LLC

Hedge Fund • Long/Short

Portfolio ManagerDaniel Pawel Schneeberger

Portfolio Value: $993.7M
Positions: 191
Last Reported: Q3 2025

Sector Allocation

Position in Leap Therapeutics, Inc.

Market Value: $11.7K
Shares Held: 25.8K
Portfolio Weight: 0.00%
Owned Since: 2024-Q4

Top Holding	Sector	Market Value	Weight
1 ABVX Abivax ABVX	Unknown Unknown	$114.7M	11.54%
2 Keros Therapeutics KROS	Biotechnology Healthcare	$85.3M	8.58%
3 Protagonist Therapeutics PTGX	Biotechnology Healthcare	$65.7M	6.61%

View full profile

Leap Therapeutics, Inc.

Overview

All Institutions

Hedge Funds

Ownership Breakdown

Biggest Investors

Net Capital Flow

Biggest Buyers

Biggest Sellers

Entry and Exit Activity

New Positions

Exited Positions

Options Activity

Call Positions

Put Positions

Most Committed Institutions

Hedge Fund Spotlight

Position in Leap Therapeutics, Inc.

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