Lexeo Therapeutics, Inc.

LXEO • NASDAQ

Lexeo Therapeutics, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Tim Van Hauwermeiren, with a market cap of $713.1M. As of Q3 2025, 91% of shares are held by 110 institutional investors, with HENDERSON GROUP PLC as the largest holder at 11.31%.

Chief Executive OfficerTim Van Hauwermeiren

Market Cap$713.1M

Biotechnology

Healthcare

Employees61.0

Websitelexeotx.com

Country

United States of America

Overview

Overview of institutional ownership in LXEO as of Q3 2025 with a market cap of $358.6M

All Institutions

Institutions: 110
Value Held: $327.7M
Shares Held: 49.4M
Avg Position: $3.0M
Median Position: $159.1K

Hedge Funds

Hedge Funds: 22
Value Held: $185.6M
Shares Held: 27.9M
Avg Position: $8.4M
Median Position: $4.5M

Ownership Breakdown

Institutional (non-HF)

39.65%

$142.2M

Hedge Funds

51.75%

$185.6M

Retail & Other

8.6%

$30.9M

Based on market cap of $358.6M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in LXEO as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
HENDERSON GROUP PLC Institution	Ali Dibadj CEO	$40.5M 0.02% of portfolio	11.31% 6.1M shares	Q4 2023 Held for 1y 11m	$218.74B
Frazier Life Sciences Management, L.P. Venture Capital	James Newman Topper Managing Partner	$29.4M 0.88% of portfolio	8.19% 4.4M shares	Q3 2024 Held for 1y 2m	$3.3B
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	Dmitry Balyasny CIO	$26.0M 0.05% of portfolio	7.25% 3.9M shares	Q2 2025 Held for 5 months	$48.1B
Affinity Asset Advisors, LLC Hedge Fund•Long/Short	Jonathan Bo-Shing Chu Founder	$25.7M 2.61% of portfolio	7.17% 3.9M shares	Q1 2025 Held for 8 months	$983.0M
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	Kenneth Cordele Griffin CEO	$24.7M 0.02% of portfolio	6.89% 3.7M shares	Q4 2023 Held for 1y 11m	$122.08B
Vestal Point Capital, LP Hedge Fund•Long/Short	Ryan Christopher Wilder CIO	$21.6M 1.09% of portfolio	6.02% 3.3M shares	Q1 2024 Held for 1y 8m	$2.0B
Woodline Partners LP Hedge Fund•Long/Short	Karl Heinz Kroeker CIO	$17.1M 0.08% of portfolio	4.76% 2.6M shares	Q1 2024 Held for 1y 8m	$21.3B
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	Dan Michael Berkovitz Chairman	$15.4M 0.01% of portfolio	4.28% 2.3M shares	Q4 2023 Held for 1y 11m	$121.98B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$14.8M 0.00% of portfolio	4.12% 2.2M shares	Q4 2023 Held for 1y 11m	$6.69T
B BlackRock, Inc. Institution	-	$14.4M 0.00% of portfolio	4.02% 2.2M shares	Q4 2023 Held for 1y 11m	$5.67T

Net Capital Flow

Institutional buying and selling activity for LXEO in Q3 2025

Traded: +$52.6M
Buyers: 77
Sellers: 21
Total Bought: +$65.8M
Total Sold: −$13.2M
Avg Position: $2.8M

Biggest Buyers

Institution	Net Bought	Current Position
HENDERSON GROUP PLC Institution	+$16.1M +2.4M shares	$40.5M 6.1M shares
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	+$9.2M +1.4M shares	$10.2M 1.5M shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	+$8.6M +1.3M shares	$12.9M 1.9M shares
6 683 Capital Management, LLC Hedge Fund•Long/Short	+$6.1M +922.7K shares	$6.1M 922.7K shares
DIMENSIONAL FUND ADVISORS LP Long Only Manager	+$5.7M +865.5K shares	$6.1M 912.5K shares
SILVERARC CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	+$5.2M +778.6K shares	$5.2M 778.6K shares
B BlackRock, Inc. Institution	+$2.3M +343.1K shares	$14.4M 2.2M shares
Affinity Asset Advisors, LLC Hedge Fund•Long/Short	+$1.9M +281.2K shares	$25.7M 3.9M shares
VANGUARD GROUP INC Institution	+$1.5M +223.4K shares	$14.8M 2.2M shares
AMERIPRISE FINANCIAL INC Institution	+$1.1M +166.5K shares	$1.1M 166.5K shares

Biggest Sellers

Institution	Net Sold	Current Position
Omega Fund Management Inc. Venture Capital	−$4.8M −1.2M shares	Sold Off 0 shares
Ally Bridge Group LLC Hedge Fund•Sector	−$3.5M −867.3K shares	Sold Off 0 shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$3.5M −522.7K shares	$15.4M 2.3M shares
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$633.1K −95.3K shares	$26.0M 3.9M shares
UBS Group AG Institution	−$146.0K −22.0K shares	$1.7M 249.9K shares
D DAFNA Capital Management LLC Hedge Fund•Event Driven	−$132.8K −20.0K shares	$2.4M 358.1K shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	−$126.7K −19.1K shares	$192.1K 28.9K shares
Q Quadrature Capital Ltd Institution	−$120.3K −29.8K shares	Sold Off 0 shares
B BNP PARIBAS ARBITRAGE, SA Institution	−$117.6K −17.7K shares	$204.0K 30.7K shares
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	−$58.4K −14.5K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited LXEO in Q3 2025

New Positions: 23
New Value: $13.8M
Exited Positions: 6
Exited Value: $8.4M

New Positions

Institution	Position Value
6 683 Capital Management, LLC Hedge Fund•Long/Short	$6.1M 922.7K shares
SILVERARC CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	$5.2M 778.6K shares
AMERIPRISE FINANCIAL INC Institution	$1.1M 166.5K shares
V Virtu Financial LLC Institution	$287.3K 43.3K shares
A AMERICAN CENTURY COMPANIES INC Institution	$240.1K 36.2K shares
X XTX Topco Ltd Institution	$177.4K 26.7K shares
H HRT FINANCIAL LLC Institution	$142.8K 21.5K shares
B Brevan Howard Capital Management LP Institution	$122.2K 18.4K shares
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC RIA/Wealth	$118.8K 14.2K shares
Scientech Research LLC Hedge Fund•Market Neutral	$89.7K 13.5K shares

Exited Positions

Institution	Previous Position
Omega Fund Management Inc. Venture Capital	$4.8M 1.2M shares
Ally Bridge Group LLC Hedge Fund•Sector	$3.5M 867.3K shares
Q Quadrature Capital Ltd Institution	$120.3K 29.8K shares
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	$58.4K 14.5K shares
S Skopos Labs, Inc. RIA/Wealth	$15.5K 3.9K shares
Caitong International Asset Management Co., Ltd RIA/Wealth	$4.0 1.0 shares

Options Activity

Institutions with the largest Call and Put options positions in LXEO as of Q3 2025

Call Positions: 0
Call Value: -
Put Positions: 1
Put Value: $85.7K

Call Positions

Institution	Position Value
No call positions found

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$85.7K 129.0 contracts

Most Committed Institutions

Institutions with LXEO as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
Affinity Asset Advisors, LLC Hedge Fund•Long/Short	Jonathan Bo-Shing Chu Founder	2.61% $25.7M	7.17% 3.9M shares	Q1 2025 Held for 8 months	$983.0M
Vestal Point Capital, LP Hedge Fund•Long/Short	Ryan Christopher Wilder CIO	1.09% $21.6M	6.02% 3.3M shares	Q1 2024 Held for 1y 8m	$2.0B
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	Daniel Pawel Schneeberger Managing Partner	1.02% $10.2M	2.84% 1.5M shares	Q2 2024 Held for 1y 5m	$993.7M
Frazier Life Sciences Management, L.P. Venture Capital	James Newman Topper Managing Partner	0.88% $29.4M	8.19% 4.4M shares	Q3 2024 Held for 1y 2m	$3.3B
Ikarian Capital, LLC Hedge Fund•Event Driven	Neil Tristan Shahrestani CEO	0.76% $3.8M	1.05% 567.6K shares	Q3 2024 Held for 1y 2m	$494.3M
SILVERARC CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Devesh Sharad Gandhi Founder	0.75% $5.2M	1.44% 778.6K shares	Q3 2025 Held for 2 months	$689.7M
D DAFNA Capital Management LLC Hedge Fund•Event Driven	Nathan Fischel CEO	0.60% $2.4M	0.66% 358.1K shares	Q3 2024 Held for 1y 2m	$397.7M
6 683 Capital Management, LLC Hedge Fund•Long/Short	Ari Jonathan Zweiman Managing Partner	0.58% $6.1M	1.71% 922.7K shares	Q3 2025 Held for 2 months	$1.1B
C CAXTON CORP Institution	-	0.50% $115.1K	0.03% 17.3K shares	Q4 2023 Held for 1y 11m	$22.9M
P Privium Fund Management B.V. Institution	-	0.23% $1.3M	0.36% 192.4K shares	Q4 2024 Held for 11 months	$556.3M

Hedge Fund Spotlight

Discover hedge funds investing in LXEO

Vestal Point Capital, LP

Hedge Fund • Long/Short

Portfolio ManagerRyan Christopher Wilder

Portfolio Value: $2.0B
Positions: 76
Last Reported: Q3 2025

Sector Allocation

Position in Lexeo Therapeutics, Inc.

Market Value: $21.6M
Shares Held: 3.3M
Portfolio Weight: 1.09%
Owned Since: 2024-Q1

Top Holding	Sector	Market Value	Weight
1 Arcellx, Inc. ACLX	Biotechnology Healthcare	$102.6M	5.21%
2 Nuvalent, Inc. NUVL	Biotechnology Healthcare	$95.1M	4.83%
3 Alcon ALC	Medical - Instruments & Supplies Healthcare	$82.0M	4.16%