Sangamo Therapeutics, Inc.

SGMO • NASDAQ

Sangamo Therapeutics, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Alexander (Sandy) Macrae, with a market cap of $151.4M. As of Q3 2025, 21% of shares are held by 111 institutional investors, with VANGUARD GROUP INC as the largest holder at 3.85%.

CEOAlexander (Sandy) Macrae

Market Cap$151.4M

Biotechnology

Healthcare

Employees405.0

Websitesangamo.com

Country

United States of America

Overview

Overview of institutional ownership in SGMO as of Q3 2025 with a market cap of $203.2M

All Institutions

Institutions: 111
Value Held: $42.1M
Shares Held: 62.6M
Avg Position: $379.7K
Median Position: $23.4K

Hedge Funds

Hedge Funds: 14
Value Held: $15.7M
Shares Held: 23.3M
Avg Position: $1.1M
Median Position: $413.3K

Ownership Breakdown

Institutional (non-HF)

13.01%

$26.4M

Hedge Funds

7.73%

$15.7M

Retail & Other

79.26%

$161.0M

Based on market cap of $203.2M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in SGMO as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
VANGUARD GROUP INC Institution	Salim Ramji CEO	$7.8M 0.00% of portfolio	3.85% 11.6M shares	≤ Q2 2013 Held for 12y 5m+	$6.69T
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	Peter Fitzhugh Brown CEO	$6.9M 0.01% of portfolio	3.37% 10.2M shares	Q3 2020 Held for 5y 2m	$75.8B
B BlackRock, Inc. Institution	-	$3.1M 0.00% of portfolio	1.51% 4.6M shares	≤ Q2 2013 Held for 12y 5m+	$5.67T
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	David Khabie-Zeitoune CEO	$2.5M 0.22% of portfolio	1.21% 3.7M shares	Q3 2021 Held for 4y 2m	$1.1B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$2.2M 0.00% of portfolio	1.09% 3.3M shares	≤ Q2 2013 Held for 12y 5m+	$1.57T
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	Scott David Hoffman CEO	$1.7M 0.00% of portfolio	0.82% 2.5M shares	Q3 2019 Held for 6y 2m	$62.0B
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	-	$1.6M 0.00% of portfolio	0.80% 2.4M shares	≤ Q2 2013 Held for 12y 5m+	$67.9B
J JANE STREET GROUP, LLC Institution	-	$1.5M 0.00% of portfolio	0.73% 2.2M shares	Q2 2023 Held for 2y 5m	$84.1B
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	Scott David Hoffman CEO	$1.4M 0.00% of portfolio	0.70% 2.1M shares	Q3 2017 Held for 8y 2m	$50.0B
SCHWAB CHARLES INVESTMENT MANAGEMENT INC Long Only Manager	Omar Aguilar Chavez CEO	$1.0M 0.00% of portfolio	0.51% 1.5M shares	≤ Q2 2013 Held for 12y 5m+	$620.51B

Net Capital Flow

Institutional buying and selling activity for SGMO in Q3 2025

Traded: −$4.0M
Buyers: 58
Sellers: 35
Total Bought: +$13.5M
Total Sold: −$17.5M
Avg Position: $324.2K

Biggest Buyers

Institution	Net Bought	Current Position
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	+$2.3M +3.3M shares	$6.9M 10.2M shares
VANGUARD GROUP INC Institution	+$1.5M +2.2M shares	$7.8M 11.6M shares
J JANE STREET GROUP, LLC Institution	+$1.5M +2.2M shares	$1.5M 2.2M shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	+$1.1M +1.6M shares	$1.6M 2.4M shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	+$1.1M +1.6M shares	$1.7M 2.5M shares
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	+$954.2K +1.4M shares	$2.5M 3.7M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$682.3K +1.0M shares	$813.7K 1.2M shares
O ORACLE INVESTMENT MANAGEMENT INC Institution	+$676.6K +1.0M shares	$676.6K 1.0M shares
GEODE CAPITAL MANAGEMENT LLC ETF Provider	+$642.7K +954.2K shares	$2.2M 3.3M shares
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	+$607.2K +901.6K shares	$1.4M 2.1M shares

Biggest Sellers

Institution	Net Sold	Current Position
Yorkville Advisors Global, LP Hedge Fund•Multi-Strategy	−$11.9M −22.0M shares	Sold Off 0 shares
WASATCH ADVISORS INC Long Only Manager	−$4.5M −6.7M shares	$960.6K 1.4M shares
S Squarepoint Ops LLC Hedge Fund•Quant	−$338.3K −625.0K shares	Sold Off 0 shares
FMR LLC Institution	−$221.9K −329.5K shares	$170.3K 252.9K shares
B BlackRock, Inc. Institution	−$170.0K −252.5K shares	$3.1M 4.6M shares
H HRT FINANCIAL LLC Institution	−$110.8K −205.2K shares	Sold Off 0 shares
V Virtu Financial LLC Institution	−$101.2K −187.4K shares	Sold Off 0 shares
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC RIA/Wealth	−$56.0K −80.3K shares	$7.2K 10.3K shares
X XTX Topco Ltd Institution	−$41.4K −76.4K shares	Sold Off 0 shares
INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC RIA/Wealth	−$18.4K −34.0K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited SGMO in Q3 2025

New Positions: 6
New Value: $1.1M
Exited Positions: 19
Exited Value: $12.6M

New Positions

Institution	Position Value
O ORACLE INVESTMENT MANAGEMENT INC Institution	$676.6K 1.0M shares
Diametric Capital, LP Hedge Fund•Long/Short	$241.8K 359.0K shares
LUMINUS MANAGEMENT LLC Hedge Fund•Sector	$168.4K 250.0K shares
TFC Financial Management RIA/Wealth	$3.1K 4.6K shares
Rise Advisors, LLC RIA/Wealth	$574.0 853.0 shares
Point72 Europe LLP Digital Asset Manager	$468.0 695.0 shares

Exited Positions

Institution	Previous Position
Yorkville Advisors Global, LP Hedge Fund•Multi-Strategy	$11.9M 22.0M shares
S Squarepoint Ops LLC Hedge Fund•Quant	$338.3K 625.0K shares
H HRT FINANCIAL LLC Institution	$110.8K 205.2K shares
V Virtu Financial LLC Institution	$101.2K 187.4K shares
X XTX Topco Ltd Institution	$41.4K 76.4K shares
INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC RIA/Wealth	$18.4K 34.0K shares
FRANKLIN RESOURCES INC Institution	$9.0K 16.6K shares
RAYMOND JAMES FINANCIAL INC RIA/Wealth	$8.4K 15.5K shares
Kestra Advisory Services, LLC RIA/Wealth	$7.9K 14.6K shares
T Tower Research Capital LLC Institution	$7.5K 13.9K shares

Options Activity

Institutions with the largest Call and Put options positions in SGMO as of Q3 2025

Call Positions: 5
Call Value: $643.4K
Put Positions: 3
Put Value: $742.5K

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$324.0K 4.8K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$156.6K 2.3K contracts
W WOLVERINE TRADING, LLC Institution	$85.0K 1.2K contracts
V Vontobel Holding Ltd. Institution	$45.4K 674.0 contracts
J JANE STREET GROUP, LLC Institution	$32.5K 482.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$566.2K 8.5K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$166.7K 2.5K contracts
W WOLVERINE TRADING, LLC Institution	$9.5K 136.0 contracts

Most Committed Institutions

Institutions with SGMO as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
O ORACLE INVESTMENT MANAGEMENT INC Institution	-	0.47% $676.6K	0.33% 1.0M shares	Q3 2025 Held for 2 months	$142.6M
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	David Khabie-Zeitoune CEO	0.22% $2.5M	1.21% 3.7M shares	Q3 2021 Held for 4y 2m	$1.1B
Ikarian Capital, LLC Hedge Fund•Event Driven	Neil Tristan Shahrestani CEO	0.18% $871.8K	0.43% 1.3M shares	Q4 2024 Held for 11 months	$494.3M
LUMINUS MANAGEMENT LLC Hedge Fund•Sector	Jonathan Dan Barrett CEO	0.15% $168.4K	0.08% 250.0K shares	Q3 2025 Held for 2 months	$110.9M
Diametric Capital, LP Hedge Fund•Long/Short	David Richard Salvietti COO	0.09% $241.8K	0.12% 359.0K shares	Q3 2025 Held for 2 months	$264.8M
W Wealth Management Associates, Inc. RIA/Wealth	James Burroughs Johnston Managing Partner	0.08% $226.1K	0.11% 335.8K shares	Q4 2024 Held for 11 months	$281.8M
Golden State Equity Partners RIA/Wealth	John Emile Nahas Managing Partner	0.05% $282.1K	0.14% 418.9K shares	Q2 2024 Held for 1y 5m	$590.2M
R Squared Ltd Private Equity	-	0.03% $81.1K	0.04% 120.5K shares	Q2 2025 Held for 5 months	$232.5M
SANDERS MORRIS HARRIS INC. Long Only Manager	Anthony Paul Coniaris Chairman	0.03% $204.0K	0.10% 303.0K shares	Q2 2025 Held for 5 months	$750.1M
G GROUP ONE TRADING, L.P. Institution	-	0.01% $338.0K	0.17% 502.0K shares	≤ Q2 2013 Held for 12y 5m+	$3.3B

Hedge Fund Spotlight

Discover hedge funds investing in SGMO

Engineers Gate Manager LP

Hedge Fund • Quant

Portfolio ManagerRobert Gregory Eisner

Portfolio Value: $8.8B
Positions: 2,112
Last Reported: Q3 2025

Sector Allocation

Position in Sangamo Therapeutics, Inc.

Market Value: $163.3K
Shares Held: 242.5K
Portfolio Weight: 0.00%
Owned Since: 2023-Q2

Top Holding	Sector	Market Value	Weight
1 Invesco QQQ Trust QQQ	ETF ETF	$155.2M	1.77%
2 SPDR S&P 500 ETF Trust SPY	ETF ETF	$115.3M	1.32%
3 Sabra Healthcare SBRA	REIT - Healthcare Facilities Real Estate	$112.9M	1.29%