Agenus

AGEN • NASDAQ

Agenus is a biotechnology company in the healthcare sector on NASDAQ, led by Garo H. Armen, with a market cap of $126.2M. As of Q3 2025, 28% of shares are held by 86 institutional investors, with VANGUARD GROUP INC as the largest holder at 8.06%.

CEOGaro H. Armen

Market Cap$126.2M

Biotechnology

Healthcare

Employees389.0

Websiteagenusbio.com

Country

United States of America

Overview

Overview of institutional ownership in AGEN as of Q3 2025 with a market cap of $122.7M

All Institutions

Institutions: 86
Value Held: $33.9M
Shares Held: 8.8M
Avg Position: $393.9K
Median Position: $60.2K

Hedge Funds

Hedge Funds: 11
Value Held: $4.4M
Shares Held: 1.1M
Avg Position: $396.6K
Median Position: $211.1K

Ownership Breakdown

Institutional (non-HF)

24.06%

$29.5M

Hedge Funds

3.56%

$4.4M

Retail & Other

72.39%

$88.8M

Based on market cap of $122.7M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in AGEN as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
VANGUARD GROUP INC Institution	Salim Ramji CEO	$9.9M 0.00% of portfolio	8.06% 2.6M shares	≤ Q2 2013 Held for 12y 5m+	$6.69T
S Siren, L.L.C. Institution	-	$4.1M 0.17% of portfolio	3.34% 1.1M shares	Q3 2024 Held for 1y 2m	$2.4B
MORGAN STANLEY RIA/Wealth	Jed Finn CEO	$2.1M 0.00% of portfolio	1.72% 549.1K shares	≤ Q2 2013 Held for 12y 5m+	$1.65T
B BlackRock, Inc. Institution	-	$2.1M 0.00% of portfolio	1.72% 547.1K shares	Q4 2014 Held for 10y 11m	$5.67T
BANK OF AMERICA CORP /DE/ Institution	Brian T. Moynihan CEO	$1.4M 0.00% of portfolio	1.16% 369.3K shares	Q3 2018 Held for 7y 2m	$1.33T
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	Dan Michael Berkovitz Chairman	$1.3M 0.00% of portfolio	1.09% 348.8K shares	Q2 2025 Held for 5 months	$121.98B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$1.3M 0.00% of portfolio	1.09% 347.0K shares	≤ Q2 2013 Held for 12y 5m+	$1.57T
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	William Dunning England CEO	$1.2M 0.01% of portfolio	0.98% 310.8K shares	Q2 2025 Held for 5 months	$11.2B
ACADIAN ASSET MANAGEMENT LLC Long Only Manager	Gillian Morna Therese Savage CEO	$789.6K 0.00% of portfolio	0.64% 205.1K shares	Q4 2023 Held for 1y 11m	$51.5B
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	-	$735.2K 0.00% of portfolio	0.60% 191.0K shares	≤ Q2 2013 Held for 12y 5m+	$67.9B

Net Capital Flow

Institutional buying and selling activity for AGEN in Q3 2025

Traded: +$910.3K
Buyers: 42
Sellers: 51
Total Bought: +$6.8M
Total Sold: −$5.9M
Avg Position: $305.2K

Biggest Buyers

Institution	Net Bought	Current Position
ACADIAN ASSET MANAGEMENT LLC Long Only Manager	+$789.6K +205.1K shares	$789.6K 205.1K shares
RAYMOND JAMES FINANCIAL INC RIA/Wealth	+$557.8K +144.9K shares	$561.2K 145.8K shares
T Torrey Growth & Income Advisors RIA/Wealth	+$507.0K +131.7K shares	$507.0K 131.7K shares
J Jump Financial, LLC Institution	+$498.1K +129.4K shares	$544.8K 141.5K shares
PANAGORA ASSET MANAGEMENT INC Hedge Fund•Quant	+$485.8K +126.2K shares	$485.8K 126.2K shares
D D. E. Shaw & Co., Inc. Institution	+$440.2K +114.3K shares	$440.2K 114.3K shares
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	+$433.1K +112.5K shares	$1.2M 310.8K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	+$394.1K +102.4K shares	$394.1K 102.4K shares
C Cubist Systematic Strategies, LLC Institution	+$366.0K +95.1K shares	$393.5K 102.2K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	+$254.9K +66.2K shares	$254.9K 66.2K shares

Biggest Sellers

Institution	Net Sold	Current Position
Marshall Wace LLP Institution	−$1.2M −319.2K shares	$436.3K 113.3K shares
MORGAN STANLEY RIA/Wealth	−$881.2K −228.9K shares	$2.1M 549.1K shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$599.7K −155.8K shares	$1.3M 348.8K shares
GOLDMAN SACHS GROUP INC Institution	−$423.1K −109.9K shares	$176.0K 45.7K shares
X XTX Topco Ltd Institution	−$271.9K −59.5K shares	Sold Off 0 shares
IEQ CAPITAL, LLC RIA/Wealth	−$250.8K −54.9K shares	Sold Off 0 shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$238.3K −52.1K shares	Sold Off 0 shares
B Brevan Howard Capital Management LP Institution	−$207.1K −45.3K shares	Sold Off 0 shares
BANK OF AMERICA CORP /DE/ Institution	−$197.8K −51.4K shares	$1.4M 369.3K shares
JPMORGAN CHASE & CO Institution	−$190.8K −49.6K shares	$112.0K 29.1K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited AGEN in Q3 2025

New Positions: 5
New Value: $634.2K
Exited Positions: 25
Exited Value: $2.0M

New Positions

Institution	Position Value
T Torrey Growth & Income Advisors RIA/Wealth	$507.0K 131.7K shares
Post Resch Tallon Group Inc. RIA/Wealth	$77.0K 20.0K shares
Traynor Capital Management, Inc. RIA/Wealth	$50.1K 13.0K shares
R Root Financial Partners, LLC RIA/Wealth	$96.0 25.0 shares
O Optiver Holding B.V. Institution	$77.0 20.0 shares

Exited Positions

Institution	Previous Position
X XTX Topco Ltd Institution	$271.9K 59.5K shares
IEQ CAPITAL, LLC RIA/Wealth	$250.8K 54.9K shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$238.3K 52.1K shares
B Brevan Howard Capital Management LP Institution	$207.1K 45.3K shares
O Ovata Capital Management Ltd Institution	$146.2K 32.0K shares
Aster Capital Management Ltd RIA/Wealth	$126.4K 27.7K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$116.9K 25.6K shares
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC RIA/Wealth	$112.9K 18.6K shares
G GROUP ONE TRADING, L.P. Institution	$94.3K 20.6K shares
Savant Capital, LLC RIA/Wealth	$72.5K 15.9K shares

Options Activity

Institutions with the largest Call and Put options positions in AGEN as of Q3 2025

Call Positions: 4
Call Value: $764.8K
Put Positions: 4
Put Value: $391.5K

Call Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$423.5K 1.1K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$167.1K 434.0 contracts
J JANE STREET GROUP, LLC Institution	$110.9K 288.0 contracts
W WOLVERINE TRADING, LLC Institution	$63.3K 159.0 contracts

Put Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$141.7K 368.0 contracts
J JANE STREET GROUP, LLC Institution	$127.1K 330.0 contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$122.8K 319.0 contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	- - contracts

Most Committed Institutions

Institutions with AGEN as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
S Siren, L.L.C. Institution	-	0.17% $4.1M	3.34% 1.1M shares	Q3 2024 Held for 1y 2m	$2.4B
T Torrey Growth & Income Advisors RIA/Wealth	George Richard Hoover Managing Partner	0.15% $507.0K	0.41% 131.7K shares	Q3 2025 Held for 2 months	$339.8M
Post Resch Tallon Group Inc. RIA/Wealth	Michael Stuart Pfeffer Managing Partner	0.07% $77.0K	0.06% 20.0K shares	Q3 2025 Held for 2 months	$112.5M
Key Client Fiduciary Advisors, LLC RIA/Wealth	Richard Anthony Flora Member	0.05% $151.0K	0.12% 39.2K shares	Q4 2021 Held for 3y 11m	$294.6M
S SHERBROOKE PARK ADVISERS LLC Hedge Fund•Quant	Kun Gao Founder	0.03% $63.7K	0.05% 16.6K shares	Q3 2025 Held for 2 months	$215.3M
Values First Advisors, Inc. RIA/Wealth	Larry Alexander Ellis CEO	0.03% $51.3K	0.04% 13.3K shares	Q2 2022 Held for 3y 5m	$186.1M
Graham Capital Management, L.P. Hedge Fund•Multi-Strategy	Brian Kevin Douglas CEO	0.01% $211.1K	0.17% 54.8K shares	Q3 2025 Held for 2 months	$1.8B
Avestar Capital, LLC RIA/Wealth	Shilpa Konduri Mullan President	0.01% $157.9K	0.13% 41.0K shares	Q2 2024 Held for 1y 5m	$1.4B
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	William Dunning England CEO	0.01% $1.2M	0.98% 310.8K shares	Q2 2025 Held for 5 months	$11.2B
Susquehanna Portfolio Strategies, LLC Private Equity	-	0.01% $647.7K	0.53% 168.2K shares	Q2 2025 Held for 5 months	$6.3B

Hedge Fund Spotlight

Discover hedge funds investing in AGEN

TWO SIGMA INVESTMENTS LLC

Hedge Fund • Multi-Strategy

Portfolio ManagerScott David Hoffman

Portfolio Value: $62.0B
Positions: 3,252
Last Reported: Q3 2025

Sector Allocation

Position in Agenus

Market Value: $394.1K
Shares Held: 102.4K
Portfolio Weight: 0.00%
Owned Since: 2025-Q3

Top Holding	Sector	Market Value	Weight
1 SPDR S&P 500 ETF Trust SPY	ETF ETF	$680.4M	1.10%
2 Financial Select Sector SPDR Fund XLF	ETF ETF	$582.6M	0.94%
3 Consumer Staples Select Sector SPDR Fund XLP	ETF ETF	$489.6M	0.79%