CalciMedica
CALC • NASDAQ
CalciMedica is a biotechnology company in the healthcare sector on NASDAQ, led by A. Rachel Leheny, Ph.D., with a market cap of $66.7M. As of Q3 2025, 25% of shares are held by 31 institutional investors, with DEERFIELD MANAGEMENT CO /NY as the largest holder at 9.3%.
Chief Executive OfficerA. Rachel Leheny, Ph.D.
Market Cap$66.7M
Biotechnology
Healthcare
Employees13.0
Websitegraybug.vision
Country
United States of America
Overview
Overview of institutional ownership in CALC as of Q3 2025 with a market cap of $43.0M
All Institutions
- Institutions
- 31
- Value Held
- $10.9M
- Shares Held
- 3.6M
- Avg Position
- $353.2K
- Median Position
- $61.8K
Hedge Funds
- Hedge Funds
- 5
- Value Held
- $6.5M
- Shares Held
- 2.1M
- Avg Position
- $1.3M
- Median Position
- $215.3K
Ownership Breakdown
Based on market cap of $43.0M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.
Biggest Investors
Institutions with the largest positions in CALC as of Q3 2025
| Institution | Position Value |
|---|---|
 DEERFIELD MANAGEMENT CO /NY Hedge Fund•Long/Short | $4.0M 0.07% of portfolio |
 Soleus Capital Management, L.P. Hedge Fund•Long/Short | $2.1M 0.11% of portfolio |
A Aisling Capital Management LP Private Equity | $1.6M 0.35% of portfolio |
 VANGUARD GROUP INC Institution | $1.1M 0.00% of portfolio |
 GEODE CAPITAL MANAGEMENT LLC ETF Provider | $298.5K 0.00% of portfolio |
 ENVESTNET ASSET MANAGEMENT INC Long Only Manager | $235.9K 0.00% of portfolio |
 RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant | $215.3K 0.00% of portfolio |
 MERITAGE PORTFOLIO MANAGEMENT Long Only Manager | $189.3K 0.01% of portfolio |
$165.2K 0.00% of portfolio | |
 Sheets Smith Investment Management RIA/Wealth | $157.2K 0.10% of portfolio |
Net Capital Flow
Institutional buying and selling activity for CALC in Q3 2025
- Traded
- −$102.1K
- Buyers
- 13
- Sellers
- 15
- Total Bought
- +$763.2K
- Total Sold
- −$865.3K
- Avg Position
- $295.9K
Biggest Buyers
| Institution | Net Bought |
|---|---|
+$165.2K +53.7K shares | |
Sheets Smith Investment Management RIA/Wealth | +$157.2K +51.1K shares |
VANGUARD GROUP INC Institution | +$113.2K +37.5K shares |
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant | +$104.6K +34.0K shares |
 Summit Financial, LLC RIA/Wealth | +$77.3K +25.1K shares |
MERITAGE PORTFOLIO MANAGEMENT Long Only Manager | +$47.8K +15.5K shares |
X XTX Topco Ltd Institution | +$46.3K +15.3K shares |
 Rockefeller Capital Management L.P. Long Only Manager | +$30.8K +10.0K shares |
 CITIGROUP INC Institution | +$15.2K +4.9K shares |
GEODE CAPITAL MANAGEMENT LLC ETF Provider | +$5.5K +1.8K shares |
Biggest Sellers
| Institution | Net Sold |
|---|---|
Soleus Capital Management, L.P. Hedge Fund•Long/Short | −$307.6K −100.0K shares |
 WEALTHEDGE INVESTMENT ADVISORS, LLC RIA/Wealth | −$139.9K −87.5K shares |
S Stonepine Capital Management, LLC Institution | −$136.0K −85.0K shares |
C CI Private Wealth, LLC RIA/Wealth | −$60.8K −38.0K shares |
 MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy | −$55.8K −18.5K shares |
ENVESTNET ASSET MANAGEMENT INC Long Only Manager | −$51.5K −16.7K shares |
 Cetera Investment Advisers RIA/Wealth | −$33.9K −11.0K shares |
 180 WEALTH ADVISORS, LLC RIA/Wealth | −$23.8K −7.8K shares |
W Weaver Consulting Group RIA/Wealth | −$21.4K −13.4K shares |
A ATRIA INVESTMENTS LLC Institution | −$20.3K −6.6K shares |
Entry and Exit Activity
Institutions that initiated new positions or completely exited CALC in Q3 2025
- New Positions
- 7
- New Value
- $492.1K
- Exited Positions
- 6
- Exited Value
- $359.3K
New Positions
| Institution | Position Value |
|---|---|
$165.2K 53.7K shares | |
Sheets Smith Investment Management RIA/Wealth | $157.2K 51.1K shares |
Summit Financial, LLC RIA/Wealth | $77.3K 25.1K shares |
X XTX Topco Ltd Institution | $46.3K 15.3K shares |
Rockefeller Capital Management L.P. Long Only Manager | $30.8K 10.0K shares |
CITIGROUP INC Institution | $15.2K 4.9K shares |
 BARCLAYS PLC Institution | $175.0 57.0 shares |
Exited Positions
| Institution | Previous Position |
|---|---|
WEALTHEDGE INVESTMENT ADVISORS, LLC RIA/Wealth | $139.9K 87.5K shares |
S Stonepine Capital Management, LLC Institution | $136.0K 85.0K shares |
C CI Private Wealth, LLC RIA/Wealth | $60.8K 38.0K shares |
W Weaver Consulting Group RIA/Wealth | $21.4K 13.4K shares |
 FMR LLC Institution | $820.0 536.0 shares |
 Federation des caisses Desjardins du Quebec Fund of Funds | $320.0 200.0 shares |
Options Activity
Institutions with the largest Call and Put options positions in CALC as of Q3 2025
- Call Positions
- 0
- Call Value
- -
- Put Positions
- 0
- Put Value
- -
Call Positions
| Institution | Position Value |
|---|---|
| No call positions found | |
Put Positions
| Institution | Position Value |
|---|---|
| No put positions found | |
Most Committed Institutions
Institutions with CALC as the highest % of their portfolio as of Q3 2025
| Institution | Portfolio Weight |
|---|---|
A Aisling Capital Management LP Private Equity | 0.35% $1.6M |
Soleus Capital Management, L.P. Hedge Fund•Long/Short | 0.11% $2.1M |
Sheets Smith Investment Management RIA/Wealth | 0.10% $157.2K |
DEERFIELD MANAGEMENT CO /NY Hedge Fund•Long/Short | 0.07% $4.0M |
180 WEALTH ADVISORS, LLC RIA/Wealth | 0.02% $131.3K |
MERITAGE PORTFOLIO MANAGEMENT Long Only Manager | 0.01% $189.3K |
0.00% $165.2K | |
 Sound View Wealth Advisors Group, LLC RIA/Wealth | 0.00% $61.8K |
 TRITONPOINT WEALTH, LLC RIA/Wealth | 0.00% $46.5K |
X XTX Topco Ltd Institution | 0.00% $46.3K |
Hedge Fund Spotlight
Discover hedge funds investing in CALC
DEERFIELD MANAGEMENT CO /NY
Hedge Fund • Long/Short
Portfolio ManagerJames Edward Flynn
- Portfolio Value
- $6.0B
- Positions
- 142
- Last Reported
- Q3 2025
Sector Allocation
Position in CalciMedica
- Market Value
- $4.0M
- Shares Held
- 1.3M
- Portfolio Weight
- 0.07%
- Owned Since
- 2024-Q1
| Top Holding | Sector | Market Value | Weight |
|---|---|---|---|
Biotechnology Healthcare | $1.6B | 25.79% | |
Medical - Healthcare Plans Healthcare | $322.8M | 5.35% | |
Biotechnology Healthcare | $286.9M | 4.75% |
