CytomX Therapeutics

CTMX • NASDAQ

CytomX Therapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by Sean A. McCarthy, with a market cap of $709.9M. As of Q3 2025, 83% of shares are held by 103 institutional investors, with VR Adviser, LLC as the largest holder at 9.44%.

Chief Executive OfficerSean A. McCarthy

Market Cap$709.9M

Biotechnology

Healthcare

Employees122.0

Websitecytomx.com

Country

United States of America

Overview

Overview of institutional ownership in CTMX as of Q3 2025 with a market cap of $526.1M

All Institutions

Institutions: 103
Value Held: $438.5M
Shares Held: 137.5M
Avg Position: $4.3M
Median Position: $390.8K

Hedge Funds

Hedge Funds: 25
Value Held: $211.4M
Shares Held: 66.3M
Avg Position: $8.5M
Median Position: $7.5M

Ownership Breakdown

Institutional (non-HF)

43.17%

$227.1M

Hedge Funds

40.18%

$211.4M

Retail & Other

16.64%

$87.5M

Based on market cap of $526.1M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in CTMX as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
VR Adviser, LLC Venture Capital	Jessica Tong Baron CFO	$49.6M 2.79% of portfolio	9.44% 15.6M shares	Q2 2025 Held for 5 months	$1.8B
FMR LLC Institution	-	$49.1M 0.00% of portfolio	9.34% 15.4M shares	Q4 2015 Held for 9y 11m	$1.92T
T TANG CAPITAL MANAGEMENT LLC Institution	-	$35.3M 1.39% of portfolio	6.71% 11.1M shares	Q4 2021 Held for 3y 11m	$2.5B
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	Joseph Eric Edelman CEO	$30.9M 0.89% of portfolio	5.87% 9.7M shares	Q2 2025 Held for 5 months	$3.5B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$28.5M 0.00% of portfolio	5.43% 8.9M shares	Q4 2015 Held for 9y 11m	$6.69T
ORBIMED ADVISORS LLC Hedge Fund•Sector	Sam Block Iii CFO	$27.0M 0.65% of portfolio	5.13% 8.5M shares	Q2 2025 Held for 5 months	$4.1B
COMMODORE CAPITAL LP Hedge Fund•Long/Short	Michael Jonathan Kramarz Managing Partner	$24.5M 1.20% of portfolio	4.66% 7.7M shares	Q2 2025 Held for 5 months	$2.0B
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	Scott Lawrence Lessing President	$13.6M 0.13% of portfolio	2.58% 4.3M shares	Q2 2025 Held for 5 months	$10.8B
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	Steven Alan Cohen CEO	$13.0M 0.03% of portfolio	2.47% 4.1M shares	Q4 2024 Held for 11 months	$43.2B
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	Daniel Pawel Schneeberger Managing Partner	$12.9M 1.30% of portfolio	2.45% 4.0M shares	Q1 2024 Held for 1y 8m	$993.7M

Net Capital Flow

Institutional buying and selling activity for CTMX in Q3 2025

Traded: +$26.1M
Buyers: 63
Sellers: 35
Total Bought: +$97.6M
Total Sold: −$71.5M
Avg Position: $3.8M

Biggest Buyers

Institution	Net Bought	Current Position
FMR LLC Institution	+$19.6M +6.2M shares	$49.1M 15.4M shares
Ikarian Capital, LLC Hedge Fund•Event Driven	+$10.8M +3.4M shares	$10.8M 3.4M shares
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	+$8.6M +2.7M shares	$30.9M 9.7M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$5.5M +1.7M shares	$5.7M 1.8M shares
VR Adviser, LLC Venture Capital	+$5.1M +1.6M shares	$49.6M 15.6M shares
K Kynam Capital Management, LP Hedge Fund•Long/Short	+$4.8M +1.5M shares	$11.6M 3.6M shares
F Financial Engines Advisors L.L.C. Institution	+$4.4M +1.4M shares	$4.4M 1.4M shares
BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds	+$3.9M +1.2M shares	$3.9M 1.2M shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$3.7M +1.2M shares	$4.4M 1.4M shares
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$3.3M +1.0M shares	$12.5M 3.9M shares

Biggest Sellers

Institution	Net Sold	Current Position
FRANKLIN RESOURCES INC Institution	−$13.1M −5.8M shares	Sold Off 0 shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	−$12.8M −4.0M shares	$13.0M 4.1M shares
Prosight Management, LP Hedge Fund•Long/Short	−$9.4M −3.0M shares	$1.8M 564.8K shares
Vivo Capital, LLC Venture Capital	−$9.2M −2.9M shares	$9.2M 2.9M shares
Fairmount Funds Management LLC Hedge Fund•Sector	−$8.8M −3.9M shares	Sold Off 0 shares
Marshall Wace LLP Institution	−$4.0M −1.2M shares	$3.5M 1.1M shares
Soleus Capital Management, L.P. Hedge Fund•Long/Short	−$3.0M −1.3M shares	Sold Off 0 shares
ACADIAN ASSET MANAGEMENT LLC Long Only Manager	−$2.9M −903.3K shares	$2.1M 653.7K shares
R READYSTATE ASSET MANAGEMENT LP Hedge Fund•Multi-Strategy	−$1.9M −844.6K shares	Sold Off 0 shares
VANGUARD GROUP INC Institution	−$1.4M −432.0K shares	$28.5M 8.9M shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited CTMX in Q3 2025

New Positions: 18
New Value: $10.1M
Exited Positions: 12
Exited Value: $28.2M

New Positions

Institution	Position Value
F Financial Engines Advisors L.L.C. Institution	$4.4M 1.4M shares
Exome Asset Management LLC Hedge Fund•Sector	$2.4M 745.3K shares
Precision Wealth Strategies, LLC RIA/Wealth	$756.3K 237.1K shares
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$591.1K 185.3K shares
Q Quadrature Capital Ltd Institution	$398.9K 125.0K shares
S Stonepine Capital Management, LLC Institution	$398.8K 125.0K shares
S Skopos Labs, Inc. RIA/Wealth	$278.0K 87.2K shares
Merit Financial Group, LLC RIA/Wealth	$169.8K 53.2K shares
LEUCADIA NATIONAL CORP Institution	$168.8K 52.9K shares
P Persistent Asset Partners Ltd Institution	$136.0K 42.6K shares

Exited Positions

Institution	Previous Position
FRANKLIN RESOURCES INC Institution	$13.1M 5.8M shares
Fairmount Funds Management LLC Hedge Fund•Sector	$8.8M 3.9M shares
Soleus Capital Management, L.P. Hedge Fund•Long/Short	$3.0M 1.3M shares
R READYSTATE ASSET MANAGEMENT LP Hedge Fund•Multi-Strategy	$1.9M 844.6K shares
EAM Investors, LLC Long Only Manager	$577.9K 254.6K shares
B BRIDGEWAY CAPITAL MANAGEMENT INC Long Only Manager	$286.0K 126.0K shares
COMMONWEALTH EQUITY SERVICES, LLC. RIA/Wealth	$120.9K 53.2K shares
B Bayesian Capital Management, LP Hedge Fund•Quant	$113.8K 50.1K shares
T TWO SIGMA SECURITIES, LLC Institution	$107.4K 47.3K shares
LAZARD ASSET MANAGEMENT LLC Long Only Manager	$98.3K 43.3K shares

Options Activity

Institutions with the largest Call and Put options positions in CTMX as of Q3 2025

Call Positions: 5
Call Value: $4.8M
Put Positions: 3
Put Value: $823.3K

Call Positions

Institution	Position Value
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	$2.9M 9.0K contracts
Caption Management, LLC Hedge Fund•Long/Short	$797.2K 2.5K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$523.2K 1.6K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$429.1K 1.3K contracts
J JANE STREET GROUP, LLC Institution	$131.4K 412.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$643.7K 2.0K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$138.8K 435.0 contracts
J JANE STREET GROUP, LLC Institution	$40.8K 128.0 contracts

Most Committed Institutions

Institutions with CTMX as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
VR Adviser, LLC Venture Capital	Jessica Tong Baron CFO	2.79% $49.6M	9.44% 15.6M shares	Q2 2025 Held for 5 months	$1.8B
Ikarian Capital, LLC Hedge Fund•Event Driven	Neil Tristan Shahrestani CEO	2.18% $10.8M	2.05% 3.4M shares	Q3 2025 Held for 2 months	$494.3M
Exome Asset Management LLC Hedge Fund•Sector	Alex R Forschner President	1.61% $2.4M	0.45% 745.3K shares	Q3 2025 Held for 2 months	$148.0M
T TANG CAPITAL MANAGEMENT LLC Institution	-	1.39% $35.3M	6.71% 11.1M shares	Q4 2021 Held for 3y 11m	$2.5B
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	Daniel Pawel Schneeberger Managing Partner	1.30% $12.9M	2.45% 4.0M shares	Q1 2024 Held for 1y 8m	$993.7M
COMMODORE CAPITAL LP Hedge Fund•Long/Short	Michael Jonathan Kramarz Managing Partner	1.20% $24.5M	4.66% 7.7M shares	Q2 2025 Held for 5 months	$2.0B
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	Joseph Eric Edelman CEO	0.89% $30.9M	5.87% 9.7M shares	Q2 2025 Held for 5 months	$3.5B
K Kynam Capital Management, LP Hedge Fund•Long/Short	Jared Joseph Keller COO	0.87% $11.6M	2.21% 3.6M shares	Q2 2025 Held for 5 months	$1.3B
Vivo Capital, LLC Venture Capital	Jack Bech Nielsen Managing Partner	0.74% $9.2M	1.75% 2.9M shares	Q2 2025 Held for 5 months	$1.2B
ORBIMED ADVISORS LLC Hedge Fund•Sector	Sam Block Iii CFO	0.65% $27.0M	5.13% 8.5M shares	Q2 2025 Held for 5 months	$4.1B

Hedge Fund Spotlight

Discover hedge funds investing in CTMX

Jain Global LLC

Hedge Fund • Multi-Strategy

Portfolio ManagerRobert Nmn Jain

Portfolio Value: $7.1B
Positions: 839
Last Reported: Q3 2025

Sector Allocation

Position in CytomX Therapeutics

Market Value: $107.4K
Shares Held: 33.7K
Portfolio Weight: 0.00%
Owned Since: 2025-Q3

Top Holding	Sector	Market Value	Weight
1 iShares Core S&P 500 ETF IVV	ETF ETF	$663.4M	9.30%
2 GLD SPDR Gold Trust GLD	Unknown Unknown	$530.3M	7.44%
3 Tesla, Inc. TSLA	Auto - Manufacturers Consumer Cyclical	$371.5M	5.21%

View full profile

CytomX Therapeutics

Overview

All Institutions

Hedge Funds

Ownership Breakdown

Biggest Investors

Net Capital Flow

Biggest Buyers

Biggest Sellers

Entry and Exit Activity

New Positions

Exited Positions

Options Activity

Call Positions

Put Positions

Most Committed Institutions

Hedge Fund Spotlight

Position in CytomX Therapeutics

Cookie Preferences