Day One Biopharmaceuticals

DAWN • NASDAQ

Day One Biopharmaceuticals is a biotechnology company in the healthcare sector on NASDAQ, led by Jeremy Bender, with a market cap of $858.4M. As of Q3 2025, 83% of shares are held by 170 institutional investors, with FMR LLC as the largest holder at 9.86%.

CEOJeremy Bender

Market Cap$858.4M

Biotechnology

Healthcare

Employees174.0

Websitedayonebio.com

Country

United States of America

Overview

Overview of institutional ownership in DAWN as of Q3 2025 with a market cap of $722.1M

All Institutions

Institutions: 170
Value Held: $602.9M
Shares Held: 85.5M
Avg Position: $3.5M
Median Position: $281.2K

Hedge Funds

Hedge Funds: 37
Value Held: $193.3M
Shares Held: 27.4M
Avg Position: $5.2M
Median Position: $975.9K

Ownership Breakdown

Institutional (non-HF)

56.73%

$409.7M

Hedge Funds

26.76%

$193.3M

Retail & Other

16.51%

$119.2M

Based on market cap of $722.1M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in DAWN as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
FMR LLC Institution	-	$71.2M 0.00% of portfolio	9.86% 10.1M shares	Q2 2021 Held for 4y 5m	$1.92T
B BlackRock, Inc. Institution	-	$63.5M 0.00% of portfolio	8.79% 9.0M shares	Q2 2021 Held for 4y 5m	$5.67T
A Atlas Venture Life Science Advisors, LLC Institution	-	$45.3M 6.02% of portfolio	6.28% 6.4M shares	Q4 2021 Held for 3y 11m	$752.6M
VANGUARD GROUP INC Institution	Salim Ramji CEO	$43.6M 0.00% of portfolio	6.03% 6.2M shares	Q2 2021 Held for 4y 5m	$6.69T
DEERFIELD MANAGEMENT CO /NY Hedge Fund•Long/Short	James Edward Flynn President	$33.2M 0.55% of portfolio	4.59% 4.7M shares	Q2 2021 Held for 4y 5m	$6.0B
FRANKLIN RESOURCES INC Institution	Gregory E. Johnson CEO	$24.5M 0.01% of portfolio	3.39% 3.5M shares	Q2 2021 Held for 4y 5m	$395.36B
R Rubric Capital Management LP Hedge Fund•Long/Short	Margaret Kossakowski CFO	$23.8M 0.34% of portfolio	3.30% 3.4M shares	Q3 2025 Held for 2 months	$6.9B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$22.8M 0.00% of portfolio	3.16% 3.2M shares	Q3 2021 Held for 4y 2m	$2.88T
Vestal Point Capital, LP Hedge Fund•Long/Short	Ryan Christopher Wilder CIO	$18.9M 0.96% of portfolio	2.61% 2.7M shares	Q2 2024 Held for 1y 5m	$2.0B
Pictet Asset Management Holding SA Long Only Manager	Elizabeth Retta Dillon CEO	$16.7M 0.02% of portfolio	2.32% 2.4M shares	Q3 2023 Held for 2y 2m	$103.68B

Net Capital Flow

Institutional buying and selling activity for DAWN in Q3 2025

Traded: +$8.2M
Buyers: 86
Sellers: 89
Total Bought: +$94.8M
Total Sold: −$86.6M
Avg Position: $3.0M

Biggest Buyers

Institution	Net Bought	Current Position
R Rubric Capital Management LP Hedge Fund•Long/Short	+$23.8M +3.4M shares	$23.8M 3.4M shares
A AIGH Capital Management LLC Hedge Fund•Long/Short	+$10.7M +1.5M shares	$10.7M 1.5M shares
MAK CAPITAL ONE LLC Hedge Fund•Multi-Strategy	+$10.2M +1.4M shares	$10.2M 1.4M shares
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$9.8M +1.4M shares	$9.8M 1.4M shares
DEERFIELD MANAGEMENT CO /NY Hedge Fund•Long/Short	+$6.9M +982.3K shares	$33.2M 4.7M shares
STATE STREET CORP Institution	+$3.9M +550.8K shares	$22.8M 3.2M shares
ALGERT COLDIRON INVESTORS LLC Hedge Fund•Quant	+$2.9M +411.0K shares	$9.3M 1.3M shares
H HRT FINANCIAL LLC Institution	+$2.3M +321.4K shares	$2.3M 321.4K shares
J JANE STREET GROUP, LLC Institution	+$2.0M +279.3K shares	$2.0M 279.3K shares
J Jump Financial, LLC Institution	+$1.9M +272.5K shares	$1.9M 272.5K shares

Biggest Sellers

Institution	Net Sold	Current Position
Polar Capital Holdings Plc Long Only Manager	−$13.7M −2.1M shares	Sold Off 0 shares
Pictet Asset Management Holding SA Long Only Manager	−$9.5M −1.3M shares	$16.7M 2.4M shares
FMR LLC Institution	−$8.8M −1.2M shares	$71.2M 10.1M shares
B BlackRock, Inc. Institution	−$5.8M −829.0K shares	$63.5M 9.0M shares
A Alyeska Investment Group, L.P. Hedge Fund•Multi-Strategy	−$5.6M −800.0K shares	$15.6M 2.2M shares
EcoR1 Capital, LLC Hedge Fund•Sector	−$5.6M −862.1K shares	Sold Off 0 shares
FRANKLIN RESOURCES INC Institution	−$4.4M −620.6K shares	$24.5M 3.5M shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$3.6M −514.5K shares	$4.9M 693.3K shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	−$2.5M −391.3K shares	Sold Off 0 shares
Vestal Point Capital, LP Hedge Fund•Long/Short	−$2.3M −325.0K shares	$18.9M 2.7M shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited DAWN in Q3 2025

New Positions: 15
New Value: $47.0M
Exited Positions: 31
Exited Value: $28.1M

New Positions

Institution	Position Value
R Rubric Capital Management LP Hedge Fund•Long/Short	$23.8M 3.4M shares
A AIGH Capital Management LLC Hedge Fund•Long/Short	$10.7M 1.5M shares
MAK CAPITAL ONE LLC Hedge Fund•Multi-Strategy	$10.2M 1.4M shares
Susquehanna Portfolio Strategies, LLC Private Equity	$652.5K 92.6K shares
PERKINS CAPITAL MANAGEMENT INC RIA/Wealth	$579.9K 82.3K shares
P PharVision Advisers, LLC Hedge Fund•Long/Short	$298.5K 42.3K shares
L Lion Point Capital, LP Hedge Fund•Event Driven	$296.1K 42.0K shares
F FOX RUN MANAGEMENT, L.L.C. Hedge Fund•Quant	$182.8K 25.9K shares
P Polymer Capital Management LLC Hedge Fund•Multi-Strategy	$134.2K 19.0K shares
O OMERS ADMINISTRATION Corp Institution	$102.9K 14.6K shares

Exited Positions

Institution	Previous Position
Polar Capital Holdings Plc Long Only Manager	$13.7M 2.1M shares
EcoR1 Capital, LLC Hedge Fund•Sector	$5.6M 862.1K shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	$2.5M 391.3K shares
Y Y-Intercept Ltd Institution	$1.8M 281.5K shares
C Cubist Systematic Strategies, LLC Institution	$1.3M 193.9K shares
UBS OCONNOR LLC Long Only Manager	$697.1K 107.2K shares
Woodline Partners LP Hedge Fund•Long/Short	$653.4K 100.5K shares
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	$413.0K 63.5K shares
B Bayesian Capital Management, LP Hedge Fund•Quant	$182.7K 28.1K shares
IEQ CAPITAL, LLC RIA/Wealth	$181.7K 27.9K shares

Options Activity

Institutions with the largest Call and Put options positions in DAWN as of Q3 2025

Call Positions: 5
Call Value: $301.7K
Put Positions: 3
Put Value: $425.1K

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$301.7K 428.0 contracts
Steel Peak Wealth Management LLC RIA/Wealth	- - contracts
Caption Management, LLC Hedge Fund•Long/Short	- - contracts
CITIGROUP INC Institution	- - contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	- - contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$425.1K 603.0 contracts
CITIGROUP INC Institution	- - contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	- - contracts

Most Committed Institutions

Institutions with DAWN as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
A Atlas Venture Life Science Advisors, LLC Institution	-	6.02% $45.3M	6.28% 6.4M shares	Q4 2021 Held for 3y 11m	$752.6M
S Stonepine Capital Management, LLC Institution	-	3.71% $4.6M	0.63% 647.4K shares	Q3 2024 Held for 1y 2m	$123.0M
A AIGH Capital Management LLC Hedge Fund•Long/Short	Orin Zvi Hirschman Managing Partner	3.38% $10.7M	1.48% 1.5M shares	Q3 2025 Held for 2 months	$317.0M
MAK CAPITAL ONE LLC Hedge Fund•Multi-Strategy	Michael Anthony Kaufman CIO	2.04% $10.2M	1.41% 1.4M shares	Q3 2025 Held for 2 months	$501.3M
D DAFNA Capital Management LLC Hedge Fund•Event Driven	Nathan Fischel CEO	1.77% $7.0M	0.98% 999.2K shares	Q2 2023 Held for 2y 5m	$397.7M
L Lion Point Capital, LP Hedge Fund•Event Driven	Carl Didric Marcus Cederholm CIO	1.68% $296.1K	0.04% 42.0K shares	Q3 2025 Held for 2 months	$17.6M
Vestal Point Capital, LP Hedge Fund•Long/Short	Ryan Christopher Wilder CIO	0.96% $18.9M	2.61% 2.7M shares	Q2 2024 Held for 1y 5m	$2.0B
B BRAIDWELL LP Hedge Fund•Multi-Strategy	Brian James Kreiter CEO	0.62% $15.4M	2.13% 2.2M shares	Q4 2022 Held for 2y 11m	$2.5B
DEERFIELD MANAGEMENT CO /NY Hedge Fund•Long/Short	James Edward Flynn President	0.55% $33.2M	4.59% 4.7M shares	Q2 2021 Held for 4y 5m	$6.0B
PERKINS CAPITAL MANAGEMENT INC RIA/Wealth	Harry Allen Lee Lindberg President	0.51% $579.9K	0.08% 82.3K shares	Q3 2025 Held for 2 months	$113.5M

Hedge Fund Spotlight

Discover hedge funds investing in DAWN

Vestal Point Capital, LP

Hedge Fund • Long/Short

Portfolio ManagerRyan Christopher Wilder

Portfolio Value: $2.0B
Positions: 76
Last Reported: Q3 2025

Sector Allocation

Position in Day One Biopharmaceuticals

Market Value: $18.9M
Shares Held: 2.7M
Portfolio Weight: 0.96%
Owned Since: 2024-Q2

Top Holding	Sector	Market Value	Weight
1 Arcellx, Inc. ACLX	Biotechnology Healthcare	$102.6M	5.21%
2 Nuvalent, Inc. NUVL	Biotechnology Healthcare	$95.1M	4.83%
3 Alcon ALC	Medical - Instruments & Supplies Healthcare	$82.0M	4.16%