Dyne Therapeutics, Inc.

DYN • NASDAQ

Dyne Therapeutics, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Lawrence Klein, with a market cap of $3.1B. As of Q3 2025, 109% of shares are held by 203 institutional investors, with HENDERSON GROUP PLC as the largest holder at 10.36%.

Lawrence Klein

Market Cap$3.1B

Biotechnology

Healthcare

Employees143.0

Websitedyne-tx.com

Country

United States of America

Overview

Overview of institutional ownership in DYN as of Q3 2025 with a market cap of $1.8B

All Institutions

Institutions: 203
Value Held: $2.0B
Shares Held: 155.7M
Avg Position: $9.7M
Median Position: $816.1K

Hedge Funds

Hedge Funds: 47
Value Held: $494.1M
Shares Held: 39.1M
Avg Position: $10.5M
Median Position: $5.2M

Ownership Breakdown

Institutional (non-HF)

81.95%

$1.5B

Hedge Funds

27.46%

$494.1M

Retail & Other

Based on market cap of $1.8B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in DYN as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
HENDERSON GROUP PLC Institution	Ali Dibadj CEO	$186.5M 0.09% of portfolio	10.36% 14.7M shares	Q3 2020 Held for 5y 2m	$218.74B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$123.5M 0.00% of portfolio	6.86% 9.8M shares	Q3 2020 Held for 5y 2m	$6.69T
B BlackRock, Inc. Institution	-	$121.9M 0.00% of portfolio	6.77% 9.6M shares	Q3 2020 Held for 5y 2m	$5.67T
A Atlas Venture Life Science Advisors, LLC Institution	-	$115.5M 15.35% of portfolio	6.42% 9.1M shares	Q4 2021 Held for 3y 11m	$752.6M
FCPM III SERVICES B.V. Real Assets	Andrew David Lindner Managing Partner	$69.1M 13.81% of portfolio	3.84% 5.5M shares	Q4 2023 Held for 1y 11m	$500.4M
FMR LLC Institution	-	$68.3M 0.00% of portfolio	3.80% 5.4M shares	Q4 2021 Held for 3y 11m	$1.92T
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$66.7M 0.00% of portfolio	3.70% 5.3M shares	Q4 2020 Held for 4y 11m	$2.88T
S Siren, L.L.C. Institution	-	$59.8M 2.51% of portfolio	3.32% 4.7M shares	Q3 2024 Held for 1y 2m	$2.4B
TCG Crossover Management, LLC Venture Capital	Chen Ming Yu Managing Partner	$58.4M 2.91% of portfolio	3.24% 4.6M shares	Q1 2023 Held for 2y 8m	$2.0B
A ADAGE CAPITAL PARTNERS GP LLC Institution	-	$45.0M 0.07% of portfolio	2.50% 3.6M shares	Q1 2024 Held for 1y 8m	$63.0B

Net Capital Flow

Institutional buying and selling activity for DYN in Q3 2025

Traded: +$390.2M
Buyers: 148
Sellers: 63
Total Bought: +$567.8M
Total Sold: −$177.6M
Avg Position: $8.6M

Biggest Buyers

Institution	Net Bought	Current Position
HENDERSON GROUP PLC Institution	+$67.1M +5.3M shares	$186.5M 14.7M shares
Marshall Wace LLP Institution	+$32.5M +2.6M shares	$38.1M 3.0M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$31.2M +2.5M shares	$43.2M 3.4M shares
VANGUARD GROUP INC Institution	+$26.7M +2.1M shares	$123.5M 9.8M shares
Vestal Point Capital, LP Hedge Fund•Long/Short	+$25.9M +2.0M shares	$35.1M 2.8M shares
Deep Track Capital, LP Hedge Fund•Long/Short	+$25.3M +2.0M shares	$25.3M 2.0M shares
STATE STREET CORP Institution	+$24.2M +1.9M shares	$66.7M 5.3M shares
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	+$24.0M +1.9M shares	$24.0M 1.9M shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	+$20.2M +1.6M shares	$21.7M 1.7M shares
B BlackRock, Inc. Institution	+$19.7M +1.6M shares	$121.9M 9.6M shares

Biggest Sellers

Institution	Net Sold	Current Position
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	−$92.5M −9.7M shares	Sold Off 0 shares
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	−$21.6M −1.7M shares	$6.8M 540.4K shares
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	−$12.5M −985.9K shares	$17.7M 1.4M shares
B BRAIDWELL LP Hedge Fund•Multi-Strategy	−$6.9M −542.9K shares	$34.5M 2.7M shares
Woodline Partners LP Hedge Fund•Long/Short	−$5.5M −574.9K shares	Sold Off 0 shares
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$4.7M −488.5K shares	Sold Off 0 shares
Ikarian Capital, LLC Hedge Fund•Event Driven	−$3.2M −250.0K shares	$1.4M 113.8K shares
C Cubist Systematic Strategies, LLC Institution	−$2.7M −278.4K shares	Sold Off 0 shares
$DEUTSCHE BANK AG\ logo$ DEUTSCHE BANK AG\ Institution	−$2.4M −192.8K shares	$1.6M 125.9K shares
PDT Partners, LLC Hedge Fund•Quant	−$2.3M −184.0K shares	$2.5M 201.2K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited DYN in Q3 2025

New Positions: 16
New Value: $38.8M
Exited Positions: 26
Exited Value: $114.1M

New Positions

Institution	Position Value
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	$24.0M 1.9M shares
University of Wisconsin Foundation RIA/Wealth	$6.5M 517.8K shares
C CANADA PENSION PLAN INVESTMENT BOARD Institution	$3.6M 284.0K shares
Burkehill Global Management, LP Hedge Fund•Event Driven	$1.5M 120.0K shares
SILVERARC CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	$1.3M 100.0K shares
W Winton Capital Group Ltd Institution	$987.6K 78.1K shares
Lighthouse Investment Partners, LLC Fund of Funds	$253.0K 20.0K shares
Quantinno Capital Management LP Hedge Fund•Market Neutral	$156.1K 12.3K shares
Arkadios Wealth Advisors RIA/Wealth	$127.8K 10.1K shares
Eversept Partners, LLC Hedge Fund•Long/Short	$126.5K 10.0K shares

Exited Positions

Institution	Previous Position
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	$92.5M 9.7M shares
Woodline Partners LP Hedge Fund•Long/Short	$5.5M 574.9K shares
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	$4.7M 488.5K shares
C Cubist Systematic Strategies, LLC Institution	$2.7M 278.4K shares
Exome Asset Management LLC Hedge Fund•Sector	$1.9M 195.9K shares
A AXA Institution	$1.5M 162.7K shares
Y Y-Intercept Ltd Institution	$1.2M 124.6K shares
SPRINGBOK CAPITAL MANAGEMENT, LLC Fund of Funds	$1.1M 115.8K shares
MUTUAL OF AMERICA CAPITAL MANAGEMENT CORP Long Only Manager	$485.6K 51.0K shares
ExodusPoint Capital Management, LP Hedge Fund•Multi-Strategy	$440.5K 46.3K shares

Options Activity

Institutions with the largest Call and Put options positions in DYN as of Q3 2025

Call Positions: 5
Call Value: $2.3M
Put Positions: 5
Put Value: $3.1M

Call Positions

Institution	Position Value
Caption Management, LLC Hedge Fund•Long/Short	$1.3M 1.0K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$388.4K 307.0 contracts
J JANE STREET GROUP, LLC Institution	$291.0K 230.0 contracts
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	$253.0K 200.0 contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$135.4K 107.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$1.1M 893.0 contracts
J JANE STREET GROUP, LLC Institution	$824.8K 652.0 contracts
BARCLAYS PLC Institution	$800.7K 633.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$175.8K 139.0 contracts
Caption Management, LLC Hedge Fund•Long/Short	$140.4K 111.0 contracts

Most Committed Institutions

Institutions with DYN as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
MPM ASSET MANAGEMENT LLC Venture Capital	Ansbert Karl Gadicke Managing Partner	19.40% $8.6M	0.48% 682.4K shares	Q3 2020 Held for 5y 2m	$44.5M
A Atlas Venture Life Science Advisors, LLC Institution	-	15.35% $115.5M	6.42% 9.1M shares	Q4 2021 Held for 3y 11m	$752.6M
FCPM III SERVICES B.V. Real Assets	Andrew David Lindner Managing Partner	13.81% $69.1M	3.84% 5.5M shares	Q4 2023 Held for 1y 11m	$500.4M
S Saturn V Capital Management LLC Hedge Fund•Sector	Xiaoying (Nmn) Tian Partner	7.42% $33.8M	1.88% 2.7M shares	Q2 2025 Held for 5 months	$456.0M
University of Wisconsin Foundation RIA/Wealth	Scott Allen Hayes President	5.55% $6.5M	0.36% 517.8K shares	Q3 2025 Held for 2 months	$118.1M
Logos Global Management LP Hedge Fund•Long/Short	Graham Gordon Walmsley Managing Partner	3.07% $30.4M	1.69% 2.4M shares	Q3 2020 Held for 5y 2m	$987.5M
MPM Oncology Impact Management LP Institution	Christian Albrecht Wulf Von Schimmelmann Managing Partner	3.00% $18.3M	1.02% 1.4M shares	Q2 2025 Held for 5 months	$610.9M
P Palo Alto Investors, LLC Hedge Fund•Long/Short	Angela Elizabeth Nguyen-Dinh CCO	2.96% $16.0M	0.89% 1.3M shares	Q1 2025 Held for 8 months	$540.4M
TCG Crossover Management, LLC Venture Capital	Chen Ming Yu Managing Partner	2.91% $58.4M	3.24% 4.6M shares	Q1 2023 Held for 2y 8m	$2.0B
Vivo Capital, LLC Venture Capital	Jack Bech Nielsen Managing Partner	2.66% $33.1M	1.84% 2.6M shares	Q3 2020 Held for 5y 2m	$1.2B

Hedge Fund Spotlight

Discover hedge funds investing in DYN

Point72 Asset Management, L.P.

Hedge Fund • Multi-Strategy

Portfolio ManagerSteven Alan Cohen

Portfolio Value: $43.2B
Positions: 1,279
Last Reported: Q3 2025

Sector Allocation

Position in Dyne Therapeutics, Inc.

Market Value: $21.7M
Shares Held: 1.7M
Portfolio Weight: 0.05%
Owned Since: 2020-Q3

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