iShares Biotechnology

IBB • NASDAQ

iShares Biotechnology is an exchange-traded fund on NASDAQ. As of Q3 2025, 786 institutional investors hold shares in this ETF, with total holdings valued at $4.6B. BANK OF AMERICA CORP /DE/ is the largest holder with a position valued at $850.9M.

Overview

Overview of institutional ownership in IBB as of Q3 2025

All Institutions

Institutions: 786
Value Held: $4.6B
Shares Held: 31.9M
Avg Position: $5.9M
Median Position: $427.1K

Hedge Funds

Hedge Funds: 31
Value Held: $134.3M
Shares Held: 899.0K
Avg Position: $4.3M
Median Position: $941.9K

Biggest Investors

Institutions with the largest positions in IBB as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
BANK OF AMERICA CORP /DE/ Institution	Brian T. Moynihan CEO	$850.9M 0.06% of portfolio	5.9M shares	≤ Q2 2013 Held for 12y 5m+	$1.33T
CITIGROUP INC Institution	Jane Fraser CEO	$537.2M 0.37% of portfolio	3.7M shares	≤ Q2 2013 Held for 12y 5m+	$144.32B
MORGAN STANLEY RIA/Wealth	Jed Finn CEO	$451.5M 0.03% of portfolio	3.1M shares	≤ Q2 2013 Held for 12y 5m+	$1.65T
GOLDMAN SACHS GROUP INC Institution	David M. Solomon CEO	$367.8M 0.05% of portfolio	2.5M shares	≤ Q2 2013 Held for 12y 5m+	$691.34B
B BNP PARIBAS ARBITRAGE, SA Institution	-	$276.5M 0.22% of portfolio	1.9M shares	Q1 2014 Held for 11y 8m	$126.06B
UBS Group AG Institution	Sergio P. Ermotti CEO	$157.5M 0.03% of portfolio	1.1M shares	Q4 2014 Held for 10y 11m	$511.54B
JPMORGAN CHASE & CO Institution	Jamie Dimon CEO	$153.0M 0.01% of portfolio	1.1M shares	≤ Q2 2013 Held for 12y 5m+	$1.56T
H HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND Institution	-	$108.3M 0.20% of portfolio	750.0K shares	Q4 2019 Held for 5y 11m	$53.3B
COMMERCE BANK RIA/Wealth	Joseph Vincent Robinson CEO	$84.7M 0.47% of portfolio	586.9K shares	Q1 2013 Held for 12y 8m	$18.0B
WELLS FARGO & COMPANY/MN Institution	Charles W. Scharf CEO	$83.0M 0.02% of portfolio	575.1K shares	≤ Q2 2013 Held for 12y 5m+	$488.50B

Net Capital Flow

Institutional buying and selling activity for IBB in Q3 2025

Traded: +$136.7M
Buyers: 235
Sellers: 381
Total Bought: +$528.3M
Total Sold: −$391.6M
Avg Position: $5.4M

Biggest Buyers

Institution	Net Bought	Current Position
B BNP PARIBAS ARBITRAGE, SA Institution	+$209.6M +1.5M shares	$276.5M 1.9M shares
LEUCADIA NATIONAL CORP Institution	+$65.1M +450.8K shares	$65.1M 450.8K shares
J JANE STREET GROUP, LLC Institution	+$40.4M +280.0K shares	$41.4M 286.7K shares
JPMORGAN CHASE & CO Institution	+$32.8M +226.9K shares	$153.0M 1.1M shares
H HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND Institution	+$21.7M +150.0K shares	$108.3M 750.0K shares
Calamos Advisors LLC Long Only Manager	+$20.1M +139.1K shares	$20.1M 139.1K shares
Caption Management, LLC Hedge Fund•Long/Short	+$11.3M +78.5K shares	$11.3M 78.5K shares
F Florin Court Capital LLP Institution	+$11.1M +77.0K shares	$11.1M 77.0K shares
GOLDMAN SACHS GROUP INC Institution	+$9.5M +65.7K shares	$367.8M 2.5M shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	+$9.5M +65.7K shares	$9.5M 65.7K shares

Biggest Sellers

Institution	Net Sold	Current Position
MORGAN STANLEY RIA/Wealth	−$71.3M −493.6K shares	$451.5M 3.1M shares
UBS Group AG Institution	−$54.3M −376.3K shares	$157.5M 1.1M shares
CITIGROUP INC Institution	−$51.0M −353.3K shares	$537.2M 3.7M shares
BANK OF AMERICA CORP /DE/ Institution	−$35.1M −243.1K shares	$850.9M 5.9M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$16.0M −110.6K shares	$6.9M 47.8K shares
WELLS FARGO & COMPANY/MN Institution	−$14.9M −103.4K shares	$83.0M 575.1K shares
CAPITAL FUND MANAGEMENT S.A. Hedge Fund•Quant Macro	−$11.7M −92.6K shares	Sold Off 0 shares
R ROYAL BANK OF CANADA Institution	−$9.5M −65.9K shares	$81.5M 564.7K shares
R RWM Asset Management, LLC RIA/Wealth	−$8.6M −59.4K shares	$2.4M 16.4K shares
G Gray Foundation RIA/Wealth	−$7.8M −61.5K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited IBB in Q3 2025

New Positions: 21
New Value: $15.6M
Exited Positions: 61
Exited Value: $49.8M

New Positions

Institution	Position Value
TIFF ADVISORY SERVICES INC Fund of Funds	$7.9M 55.0K shares
V Volterra Technologies LP Hedge Fund•Quant	$1.9M 13.5K shares
Aster Capital Management Ltd RIA/Wealth	$1.9M 13.2K shares
C Cubist Systematic Strategies, LLC Institution	$1.0M 6.9K shares
KORNITZER CAPITAL MANAGEMENT INC /KS Long Only Manager	$884.3K 6.1K shares
VestGen Advisors, LLC RIA/Wealth	$467.2K 3.2K shares
M MERIDIAN INVESTMENT COUNSEL INC. RIA/Wealth	$344.3K 2.4K shares
Parcion Private Wealth LLC RIA/Wealth	$280.1K 1.9K shares
Ignite Planners, LLC RIA/Wealth	$237.3K 1.6K shares
Broyhill Asset Management Hedge Fund•Multi-Strategy	$216.6K 1.5K shares

Exited Positions

Institution	Previous Position
CAPITAL FUND MANAGEMENT S.A. Hedge Fund•Quant Macro	$11.7M 92.6K shares
G Gray Foundation RIA/Wealth	$7.8M 61.5K shares
M MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. Institution	$4.1M 32.5K shares
Aristides Capital LLC Real Assets	$3.6M 28.5K shares
WELLINGTON MANAGEMENT CO LLP Long Only Manager	$2.7M 21.3K shares
CAZ INVESTMENTS LP Fund of Funds	$2.5M 20.0K shares
P Parallax Volatility Advisers, LLC Hedge Fund•Vol Arbitrage	$2.5M 19.4K shares
H HRT FINANCIAL LLC Institution	$1.3M 10.1K shares
C Counterweight Ventures, LLC Institution	$1.2M 9.3K shares
P Patriot Financial Group Insurance Agency, LLC Institution	$838.3K 6.6K shares

Options Activity

Institutions with the largest Call and Put options positions in IBB as of Q3 2025

Call Positions: 15
Call Value: $184.4M
Put Positions: 18
Put Value: $253.3M

Call Positions

Institution	Position Value
Calamos Advisors LLC Long Only Manager	$48.2M 3.8K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$26.9M 1.9K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$26.3M 1.8K contracts
P PEAK6 LLC Institution	$20.6M 1.4K contracts
CAPITAL FUND MANAGEMENT S.A. Hedge Fund•Quant Macro	$18.3M 1.3K contracts
Marshall Wace LLP Institution	$11.4M 787.0 contracts
J JANE STREET GROUP, LLC Institution	$7.6M 524.0 contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$7.2M 500.0 contracts
W WOLVERINE TRADING, LLC Institution	$6.2M 433.0 contracts
C Cubist Systematic Strategies, LLC Institution	$4.9M 342.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$67.7M 4.7K contracts
S Sofinnova Ventures Inc Venture Capital	$46.9M 3.3K contracts
DLD Asset Management, LP Hedge Fund•Multi-Strategy	$39.7M 2.8K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$33.8M 2.3K contracts
J JANE STREET GROUP, LLC Institution	$24.0M 1.7K contracts
CAPITAL FUND MANAGEMENT S.A. Hedge Fund•Quant Macro	$16.1M 1.1K contracts
W WOLVERINE TRADING, LLC Institution	$8.3M 582.0 contracts
Marshall Wace LLP Institution	$4.8M 333.0 contracts
P PEAK6 LLC Institution	$3.7M 253.0 contracts
J J. Goldman & Co LP Hedge Fund•Multi-Strategy	$2.9M 200.0 contracts

Most Committed Institutions

Institutions with IBB as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
F Florin Court Capital LLP Institution	-	8.71% $11.1M	77.0K shares	Q1 2024 Held for 1y 8m	$127.6M
Bronte Capital Management Pty Ltd. Hedge Fund•Long/Short	John Lawrence Hempton CIO	4.72% $45.4M	281.4K shares	Q2 2022 Held for 3y 5m	$962.3M
M Michelson Medical Research Foundation, Inc. Institution	-	4.41% $5.1M	35.1K shares	Q4 2022 Held for 2y 11m	$115.0M
Rye Brook Capital LLC Hedge Fund•Long/Short	Carlos Gustavo Ribeiro Fernandes Managing Partner	3.89% $3.5M	24.3K shares	Q4 2020 Held for 4y 11m	$90.1M
D DAFNA Capital Management LLC Hedge Fund•Event Driven	Nathan Fischel CEO	3.72% $14.8M	102.5K shares	Q1 2016 Held for 9y 8m	$397.7M
CUMBERLAND ADVISORS INC Long Only Manager	Mark James Myers CEO	3.62% $9.4M	65.4K shares	Q3 2023 Held for 2y 2m	$260.5M
Audent Global Asset Management, LLC Hedge Fund•Multi-Strategy	John Matthew Hughes COO	2.35% $3.2M	22.4K shares	Q4 2021 Held for 3y 11m	$137.5M
LITTLEJOHN FINANCIAL SERVICES, INC. RIA/Wealth	Fred David Littlejohn CCO	1.98% $2.7M	18.8K shares	Q2 2025 Held for 5 months	$137.2M
G Generali Investments CEE, investicni spolecnost, a.s. Institution	-	1.70% $16.8M	116.1K shares	Q4 2024 Held for 11 months	$983.3M
TIFF ADVISORY SERVICES INC Fund of Funds	Clarence Kane Brenan CEO	1.65% $7.9M	55.0K shares	Q3 2025 Held for 2 months	$480.3M

Hedge Fund Spotlight

Discover hedge funds investing in IBB

RENAISSANCE TECHNOLOGIES LLC

Hedge Fund • Quant

Portfolio ManagerPeter Fitzhugh Brown

Portfolio Value: $75.8B
Positions: 3,419
Last Reported: Q3 2025

Sector Allocation

Position in iShares Biotechnology

Market Value: $4.0M
Shares Held: 27.5K
Portfolio Weight: 0.01%
Owned Since: 2025-Q3

Top Holding	Sector	Market Value	Weight
1 Palantir Technologies Inc. PLTR	Software - Infrastructure Technology	$1.6B	2.06%
2 Nvidia NVDA	Semiconductors Technology	$1.1B	1.39%
3 Roblox RBLX	Electronic Gaming & Multimedia Technology	$953.5M	1.26%