Lexicon Pharmaceuticals

LXRX • NASDAQ

Lexicon Pharmaceuticals is a biotechnology company in the healthcare sector on NASDAQ, led by Michael Exton, Ph.D., with a market cap of $472.4M. As of Q3 2025, 70% of shares are held by 122 institutional investors, with Artal Group S.A. as the largest holder at 37.47%.

Chief Executive OfficerMichael Exton, Ph.D.

Market Cap$472.4M

Biotechnology

Healthcare

Employees285.0

Websitelexpharma.com

Country

United States of America

Overview

Overview of institutional ownership in LXRX as of Q3 2025 with a market cap of $490.6M

All Institutions

Institutions: 122
Value Held: $344.4M
Shares Held: 255.1M
Avg Position: $2.8M
Median Position: $40.7K

Hedge Funds

Hedge Funds: 13
Value Held: $18.4M
Shares Held: 13.6M
Avg Position: $1.4M
Median Position: $754.7K

Ownership Breakdown

Institutional (non-HF)

66.46%

$326.1M

Hedge Funds

3.75%

$18.4M

Retail & Other

29.79%

$146.2M

Based on market cap of $490.6M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in LXRX as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
A Artal Group S.A. Institution	-	$183.8M 24.25% of portfolio	37.47% 136.2M shares	≤ Q2 2013 Held for 12y 5m+	$758.2M
S Siren, L.L.C. Institution	-	$52.5M 2.20% of portfolio	10.71% 38.9M shares	Q3 2024 Held for 1y 2m	$2.4B
FMR LLC Institution	-	$52.2M 0.00% of portfolio	10.64% 38.7M shares	≤ Q2 2013 Held for 12y 5m+	$1.92T
VANGUARD GROUP INC Institution	Salim Ramji CEO	$12.9M 0.00% of portfolio	2.62% 9.5M shares	≤ Q2 2013 Held for 12y 5m+	$6.69T
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	Dan Michael Berkovitz Chairman	$5.2M 0.00% of portfolio	1.05% 3.8M shares	Q3 2020 Held for 5y 2m	$121.98B
B BlackRock, Inc. Institution	-	$4.6M 0.00% of portfolio	0.93% 3.4M shares	≤ Q2 2013 Held for 12y 5m+	$5.67T
Sessa Capital IM, L.P. Hedge Fund•Long/Short	Jae Hong President	$4.1M 0.10% of portfolio	0.83% 3.0M shares	Q2 2025 Held for 5 months	$3.9B
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	Kenneth Cordele Griffin CEO	$3.6M 0.00% of portfolio	0.72% 2.6M shares	≤ Q2 2013 Held for 12y 5m+	$122.08B
A Atlantic Trust Group, LLC Institution	-	$3.2M 0.01% of portfolio	0.66% 2.4M shares	Q3 2022 Held for 3y 2m	$58.4B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$3.2M 0.00% of portfolio	0.66% 2.4M shares	≤ Q2 2013 Held for 12y 5m+	$1.57T

Net Capital Flow

Institutional buying and selling activity for LXRX in Q3 2025

Traded: −$819.0K
Buyers: 48
Sellers: 56
Total Bought: +$12.1M
Total Sold: −$12.9M
Avg Position: $2.4M

Biggest Buyers

Institution	Net Bought	Current Position
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$3.6M +2.6M shares	$3.6M 2.6M shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$3.0M +2.2M shares	$5.2M 3.8M shares
JACOBS LEVY EQUITY MANAGEMENT, INC Hedge Fund•Quant	+$935.2K +692.7K shares	$935.2K 692.7K shares
VANGUARD GROUP INC Institution	+$905.6K +670.8K shares	$12.9M 9.5M shares
FMR LLC Institution	+$732.0K +542.2K shares	$52.2M 38.7M shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	+$394.7K +292.4K shares	$394.7K 292.4K shares
X XTX Topco Ltd Institution	+$355.4K +263.3K shares	$444.9K 329.5K shares
SCHWAB CHARLES INVESTMENT MANAGEMENT INC Long Only Manager	+$352.9K +261.4K shares	$1.5M 1.1M shares
Q Quadrature Capital Ltd Institution	+$309.2K +228.2K shares	$309.2K 228.2K shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	+$278.7K +206.4K shares	$1.3M 962.1K shares

Biggest Sellers

Institution	Net Sold	Current Position
Schonfeld Strategic Advisors LLC Hedge Fund•Multi-Strategy	−$5.1M −3.8M shares	$1.1M 825.6K shares
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	−$2.2M −1.6M shares	$1.6M 1.2M shares
AQR CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$1.5M −1.1M shares	$409.0K 302.9K shares
H HRT FINANCIAL LLC Institution	−$596.7K −442.0K shares	$62.7K 46.4K shares
J JANE STREET GROUP, LLC Institution	−$470.0K −348.1K shares	$616.3K 456.5K shares
WELLINGTON MANAGEMENT CO LLP Long Only Manager	−$460.2K −486.7K shares	Sold Off 0 shares
GOLDMAN SACHS GROUP INC Institution	−$359.6K −266.4K shares	$80.1K 59.3K shares
Monaco Asset Management SAM RIA/Wealth	−$245.2K −181.6K shares	$472.5K 350.0K shares
G GROUP ONE TRADING, L.P. Institution	−$176.2K −130.5K shares	$291.9K 216.2K shares
Jain Global LLC Hedge Fund•Multi-Strategy	−$143.6K −151.8K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited LXRX in Q3 2025

New Positions: 7
New Value: $465.5K
Exited Positions: 18
Exited Value: $1.2M

New Positions

Institution	Position Value
Q Quadrature Capital Ltd Institution	$309.2K 228.2K shares
LEUCADIA NATIONAL CORP Institution	$131.5K 97.4K shares
S State of Wyoming Institution	$11.5K 8.5K shares
G GF FUND MANAGEMENT CO. LTD. Institution	$10.6K 7.8K shares
Caitong International Asset Management Co., Ltd RIA/Wealth	$1.3K 959.0 shares
Federation des caisses Desjardins du Quebec Fund of Funds	$771.0 571.0 shares
TFC Financial Management RIA/Wealth	$675.0 500.0 shares

Exited Positions

Institution	Previous Position
WELLINGTON MANAGEMENT CO LLP Long Only Manager	$460.2K 486.7K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$143.6K 151.8K shares
V Virtu Financial LLC Institution	$139.5K 146.8K shares
Aster Capital Management Ltd RIA/Wealth	$123.4K 130.5K shares
Q Quantessence Capital LLC Hedge Fund•Quant	$79.5K 84.1K shares
Savant Capital, LLC RIA/Wealth	$65.8K 69.6K shares
Pallas Capital Advisors LLC RIA/Wealth	$34.8K 36.8K shares
Hudson Bay Capital Management LP Hedge Fund•Multi-Strategy	$25.5K 27.0K shares
D D. E. Shaw & Co., Inc. Institution	$22.4K 23.7K shares
Merit Financial Group, LLC RIA/Wealth	$15.8K 16.7K shares

Options Activity

Institutions with the largest Call and Put options positions in LXRX as of Q3 2025

Call Positions: 5
Call Value: $3.4M
Put Positions: 4
Put Value: $366.8K

Call Positions

Institution	Position Value
Caption Management, LLC Hedge Fund•Long/Short	$2.7M 20.0K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$482.8K 3.6K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$156.3K 1.2K contracts
W WOLVERINE TRADING, LLC Institution	$39.6K 285.0 contracts
J JANE STREET GROUP, LLC Institution	- - contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$177.4K 1.3K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$130.4K 966.0 contracts
W WOLVERINE TRADING, LLC Institution	$43.8K 315.0 contracts
J JANE STREET GROUP, LLC Institution	$15.3K 113.0 contracts

Most Committed Institutions

Institutions with LXRX as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
A Artal Group S.A. Institution	-	24.25% $183.8M	37.47% 136.2M shares	≤ Q2 2013 Held for 12y 5m+	$758.2M
S Siren, L.L.C. Institution	-	2.20% $52.5M	10.71% 38.9M shares	Q3 2024 Held for 1y 2m	$2.4B
Monaco Asset Management SAM RIA/Wealth	Kirstin Lynn Hark Director	0.18% $472.5K	0.10% 350.0K shares	Q1 2025 Held for 8 months	$256.5M
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	David Khabie-Zeitoune CEO	0.14% $1.6M	0.33% 1.2M shares	Q1 2025 Held for 8 months	$1.1B
Sessa Capital IM, L.P. Hedge Fund•Long/Short	Jae Hong President	0.10% $4.1M	0.83% 3.0M shares	Q2 2025 Held for 5 months	$3.9B
Ikarian Capital, LLC Hedge Fund•Event Driven	Neil Tristan Shahrestani CEO	0.05% $238.2K	0.05% 176.5K shares	Q4 2024 Held for 11 months	$494.3M
Hennion & Walsh Asset Management, Inc. RIA/Wealth	Kevin Douglas Mahn President	0.04% $1.1M	0.21% 779.2K shares	Q2 2024 Held for 1y 5m	$2.8B
V Vermillion & White Wealth Management Group, LLC RIA/Wealth	Philip Nordell Carey CEO	0.03% $43.9K	0.01% 32.5K shares	Q1 2024 Held for 1y 8m	$154.2M
Straight Path Wealth Management RIA/Wealth	Matthew Brian Boersen President	0.02% $84.6K	0.02% 62.7K shares	Q1 2025 Held for 8 months	$355.9M
X XTX Topco Ltd Institution	-	0.02% $444.9K	0.09% 329.5K shares	Q3 2024 Held for 1y 2m	$1.9B

Hedge Fund Spotlight

Discover hedge funds investing in LXRX

RENAISSANCE TECHNOLOGIES LLC

Hedge Fund • Quant

Portfolio ManagerPeter Fitzhugh Brown

Portfolio Value: $75.8B
Positions: 3,419
Last Reported: Q3 2025

Sector Allocation

Position in Lexicon Pharmaceuticals

Market Value: $394.7K
Shares Held: 292.4K
Portfolio Weight: 0.00%
Owned Since: 2025-Q3

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