Puma Biotechnology

PBYI • NASDAQ

Puma Biotechnology is a biotechnology company in the healthcare sector on NASDAQ, led by Alan H. Auerbach, with a market cap of $295.3M. As of Q3 2025, 68% of shares are held by 132 institutional investors, with ACORN CAPITAL ADVISORS, LLC as the largest holder at 8.2%.

CEOAlan H. Auerbach

Market Cap$295.3M

Biotechnology

Healthcare

Employees185.0

Websitepumabiotechnology.com

Country

United States of America

Overview

Overview of institutional ownership in PBYI as of Q3 2025 with a market cap of $267.5M

All Institutions

Institutions: 132
Value Held: $182.6M
Shares Held: 34.4M
Avg Position: $1.4M
Median Position: $188.4K

Hedge Funds

Hedge Funds: 10
Value Held: $17.3M
Shares Held: 3.3M
Avg Position: $1.7M
Median Position: $474.8K

Ownership Breakdown

Institutional (non-HF)

61.82%

$165.3M

Hedge Funds

6.46%

$17.3M

Retail & Other

31.72%

$84.9M

Based on market cap of $267.5M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in PBYI as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
A ACORN CAPITAL ADVISORS, LLC Venture Capital	Anthony Michael Gallo CCO	$21.9M 11.14% of portfolio	8.20% 4.1M shares	Q4 2024 Held for 11 months	$197.0M
VANGUARD GROUP INC Institution	Salim Ramji CEO	$19.6M 0.00% of portfolio	7.33% 3.7M shares	≤ Q2 2013 Held for 12y 5m+	$6.69T
B BlackRock, Inc. Institution	-	$19.0M 0.00% of portfolio	7.10% 3.6M shares	≤ Q2 2013 Held for 12y 5m+	$5.67T
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	Peter Fitzhugh Brown CEO	$11.4M 0.02% of portfolio	4.27% 2.2M shares	Q4 2018 Held for 6y 11m	$75.8B
ACADIAN ASSET MANAGEMENT LLC Long Only Manager	Gillian Morna Therese Savage CEO	$10.9M 0.02% of portfolio	4.08% 2.1M shares	Q1 2019 Held for 6y 8m	$51.5B
A AMERICAN CENTURY COMPANIES INC Institution	-	$7.9M 0.00% of portfolio	2.94% 1.5M shares	Q4 2023 Held for 1y 11m	$195.93B
DIMENSIONAL FUND ADVISORS LP Long Only Manager	David Paul Butler CEO	$6.8M 0.00% of portfolio	2.53% 1.3M shares	Q3 2022 Held for 3y 2m	$466.32B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$5.2M 0.00% of portfolio	1.95% 983.5K shares	≤ Q2 2013 Held for 12y 5m+	$1.57T
R Russell Investments Group, Ltd. RIA/Wealth	Harry Leslie Russell President	$5.1M 0.01% of portfolio	1.92% 964.7K shares	Q2 2024 Held for 1y 5m	$87.9B
Connor, Clark & Lunn Investment Management Ltd. Long Only Manager	John Wyatt Ricketts President	$5.0M 0.02% of portfolio	1.87% 943.5K shares	Q4 2021 Held for 3y 11m	$31.7B

Net Capital Flow

Institutional buying and selling activity for PBYI in Q3 2025

Traded: +$12.3M
Buyers: 68
Sellers: 47
Total Bought: +$26.5M
Total Sold: −$14.3M
Avg Position: $1.3M

Biggest Buyers

Institution	Net Bought	Current Position
R Russell Investments Group, Ltd. RIA/Wealth	+$5.1M +964.7K shares	$5.1M 964.7K shares
Marshall Wace LLP Institution	+$2.6M +484.1K shares	$3.0M 557.5K shares
O'SHAUGHNESSY ASSET MANAGEMENT, LLC Long Only Manager	+$2.1M +390.6K shares	$4.4M 828.2K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	+$1.5M +276.5K shares	$11.4M 2.2M shares
Comprehensive Portfolio Management, LLC RIA/Wealth	+$1.5M +273.8K shares	$2.5M 470.8K shares
B BRIDGEWAY CAPITAL MANAGEMENT INC Long Only Manager	+$1.2M +230.8K shares	$2.3M 433.6K shares
NORTHERN TRUST CORP Institution	+$1.2M +224.7K shares	$2.8M 526.7K shares
U Universal- Beteiligungs- und Servicegesellschaft mbH Institution	+$845.4K +159.2K shares	$1.1M 198.5K shares
FRANKLIN RESOURCES INC Institution	+$828.4K +156.0K shares	$922.3K 173.7K shares
WELLINGTON MANAGEMENT CO LLP Long Only Manager	+$794.1K +149.6K shares	$794.1K 149.6K shares

Biggest Sellers

Institution	Net Sold	Current Position
HENDERSON GROUP PLC Institution	−$2.6M −745.5K shares	Sold Off 0 shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$1.7M −507.8K shares	Sold Off 0 shares
B BlackRock, Inc. Institution	−$1.4M −257.8K shares	$19.0M 3.6M shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$1.2M −229.0K shares	$560.9K 105.6K shares
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	−$916.0K −172.5K shares	$388.7K 73.2K shares
LOS ANGELES CAPITAL MANAGEMENT & EQUITY RESEARCH INC Long Only Manager	−$910.3K −171.4K shares	$1.5M 274.1K shares
Eversept Partners, LLC Hedge Fund•Long/Short	−$825.6K −240.7K shares	Sold Off 0 shares
D D. E. Shaw & Co., Inc. Institution	−$755.0K −142.2K shares	$2.6M 498.6K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	−$714.2K −134.5K shares	$298.0K 56.1K shares
KENNEDY CAPITAL MANAGEMENT, INC. Long Only Manager	−$633.9K −119.4K shares	$4.6M 867.6K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited PBYI in Q3 2025

New Positions: 11
New Value: $670.1K
Exited Positions: 12
Exited Value: $6.0M

New Positions

Institution	Position Value
Round Rock Advisors, LLC RIA/Wealth	$329.6K 65.4K shares
S Skopos Labs, Inc. RIA/Wealth	$146.3K 27.5K shares
B Baron Wealth Management LLC RIA/Wealth	$115.6K 21.8K shares
PERKINS CAPITAL MANAGEMENT INC RIA/Wealth	$64.8K 12.2K shares
SRS Capital Advisors, Inc. RIA/Wealth	$6.8K 1.3K shares
O Optiver Holding B.V. Institution	$4.1K 768.0 shares
ROTHSCHILD INVESTMENT LLC RIA/Wealth	$1.3K 250.0 shares
Union Bankshares Corp Institution	$797.0 150.0 shares
GAMMA Investing LLC Long Only Manager	$414.0 78.0 shares
J JONES FINANCIAL COMPANIES LLLP Institution	$329.0 68.0 shares

Exited Positions

Institution	Previous Position
HENDERSON GROUP PLC Institution	$2.6M 745.5K shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.7M 507.8K shares
Eversept Partners, LLC Hedge Fund•Long/Short	$825.6K 240.7K shares
S STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM Institution	$246.0K 71.7K shares
K Kapitalo Investimentos Ltda Institution	$241.0K 70.3K shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$198.0K 57.7K shares
H HSBC HOLDINGS PLC Institution	$66.6K 19.8K shares
IEQ CAPITAL, LLC RIA/Wealth	$49.1K 14.3K shares
ING INVESTMENT MANAGEMENT LLC Insurance Manager	$44.5K 13.0K shares
W Williams & Novak, LLC Institution	$42.9K 12.5K shares

Options Activity

Institutions with the largest Call and Put options positions in PBYI as of Q3 2025

Call Positions: 4
Call Value: $1.4M
Put Positions: 0
Put Value: -

Call Positions

Institution	Position Value
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$721.6K 1.4K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$492.8K 928.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$123.7K 233.0 contracts
W WOLVERINE TRADING, LLC Institution	$61.6K 122.0 contracts

Put Positions

Institution	Position Value
No put positions found

Most Committed Institutions

Institutions with PBYI as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
A ACORN CAPITAL ADVISORS, LLC Venture Capital	Anthony Michael Gallo CCO	11.14% $21.9M	8.20% 4.1M shares	Q4 2024 Held for 11 months	$197.0M
GLOBEFLEX CAPITAL L P Long Only Manager	Marina Loretta Marrelli CEO	0.37% $2.4M	0.90% 452.6K shares	Q2 2020 Held for 5y 5m	$644.8M
Virtus ETF Advisers LLC Long Only Manager	Richard William Smirl President	0.17% $250.5K	0.09% 47.2K shares	Q1 2025 Held for 8 months	$148.9M
C2C Wealth Management, LLC RIA/Wealth	Kevin James Groman CCO	0.10% $122.2K	0.05% 23.0K shares	Q4 2024 Held for 11 months	$116.5M
KENNEDY CAPITAL MANAGEMENT, INC. Long Only Manager	Donald M Cobin CEO	0.10% $4.6M	1.72% 867.6K shares	Q3 2024 Held for 1y 2m	$4.5B
S SHERBROOKE PARK ADVISERS LLC Hedge Fund•Quant	Kun Gao Founder	0.08% $162.1K	0.06% 30.5K shares	Q1 2025 Held for 8 months	$215.3M
PERKINS CAPITAL MANAGEMENT INC RIA/Wealth	Harry Allen Lee Lindberg President	0.06% $64.8K	0.02% 12.2K shares	Q3 2025 Held for 2 months	$113.5M
Round Rock Advisors, LLC RIA/Wealth	Bert Thomas Bowler Managing Partner	0.05% $329.6K	0.13% 65.4K shares	Q3 2025 Held for 2 months	$631.2M
B BRIDGEWAY CAPITAL MANAGEMENT INC Long Only Manager	John Noland Ryan Montgomery CEO	0.05% $2.3M	0.86% 433.6K shares	Q4 2021 Held for 3y 11m	$4.7B
Comprehensive Portfolio Management, LLC RIA/Wealth	William James Artzerounian Managing Partner	0.05% $2.5M	0.93% 470.8K shares	Q4 2023 Held for 1y 11m	$5.1B