Xilio Therapeutics, Inc.

XLO • NASDAQ

Xilio Therapeutics, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by René Russo, with a market cap of $35.8M. As of Q3 2025, 43% of shares are held by 36 institutional investors, with GILEAD SCIENCES, INC. as the largest holder at 17.57%.

Chief Executive Officer and PresidentRené Russo

Market Cap$35.8M

Biotechnology

Healthcare

Employees73.0

Websitexiliotx.com

Country

United States of America

Overview

Overview of institutional ownership in XLO as of Q3 2025 with a market cap of $43.7M

All Institutions

Institutions: 36
Value Held: $18.6M
Shares Held: 22.1M
Avg Position: $517.1K
Median Position: $37.2K

Hedge Funds

Hedge Funds: 5
Value Held: $716.2K
Shares Held: 849.8K
Avg Position: $143.2K
Median Position: $167.6K

Ownership Breakdown

Institutional (non-HF)

40.98%

$17.9M

Hedge Funds

1.64%

$716.2K

Retail & Other

57.38%

$25.1M

Based on market cap of $43.7M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in XLO as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
GILEAD SCIENCES, INC. Institution	Daniel O'Day CEO	$7.7M 0.43% of portfolio	17.57% 9.1M shares	Q4 2024 Held for 11 months	$1.8B
B Bain Capital Life Sciences Investors, LLC Institution	-	$3.8M 0.26% of portfolio	8.81% 4.6M shares	Q4 2021 Held for 3y 11m	$1.5B
Merck & Co., Inc. Institution	Robert M. Davis CEO	$1.3M 0.57% of portfolio	2.86% 1.5M shares	Q4 2024 Held for 11 months	$217.8M
T TAKEDA PHARMACEUTICAL CO LTD Institution	-	$1.2M 7.59% of portfolio	2.85% 1.5M shares	Q4 2023 Held for 1y 11m	$16.4M
VANGUARD GROUP INC Institution	Salim Ramji CEO	$1.1M 0.00% of portfolio	2.42% 1.3M shares	Q4 2021 Held for 3y 11m	$6.69T
MORGAN STANLEY RIA/Wealth	Jed Finn CEO	$810.6K 0.00% of portfolio	1.86% 961.9K shares	Q4 2021 Held for 3y 11m	$1.65T
AJU IB Investment Co., Ltd. Real Assets	Benjamin Jason Weprin CEO	$595.6K 0.52% of portfolio	1.29% 667.7K shares	Q4 2024 Held for 11 months	$115.1M
FMR LLC Institution	-	$431.3K 0.00% of portfolio	0.99% 511.8K shares	Q4 2021 Held for 3y 11m	$1.92T
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$277.3K 0.00% of portfolio	0.63% 329.0K shares	Q4 2021 Held for 3y 11m	$1.57T
S Squarepoint Ops LLC Hedge Fund•Quant	Michael Gottlieb CIO	$277.1K 0.00% of portfolio	0.63% 328.8K shares	Q2 2025 Held for 5 months	$46.9B

Net Capital Flow

Institutional buying and selling activity for XLO in Q3 2025

Traded: −$1.0M
Buyers: 11
Sellers: 6
Total Bought: +$430.3K
Total Sold: −$1.5M
Avg Position: $477.3K

Biggest Buyers

Institution	Net Bought	Current Position
STATE STREET CORP Institution	+$101.5K +120.5K shares	$138.1K 163.9K shares
VANGUARD GROUP INC Institution	+$88.2K +104.7K shares	$1.1M 1.3M shares
S Squarepoint Ops LLC Hedge Fund•Quant	+$78.7K +93.3K shares	$277.1K 328.8K shares
X XTX Topco Ltd Institution	+$34.8K +41.3K shares	$64.1K 76.0K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	+$34.1K +40.5K shares	$172.5K 204.7K shares
T TWO SIGMA SECURITIES, LLC Institution	+$27.1K +32.1K shares	$27.1K 32.1K shares
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	+$25.0K +29.7K shares	$25.0K 29.7K shares
H HRT FINANCIAL LLC Institution	+$20.8K +24.7K shares	$20.8K 24.7K shares
UBS Group AG Institution	+$11.5K +-226.3K shares	$11.5K 13.7K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	+$8.2K +9.8K shares	$74.0K 87.8K shares

Biggest Sellers

Institution	Net Sold	Current Position
Ghisallo Capital Management LLC Hedge Fund•Multi-Strategy	−$906.3K −1.3M shares	Sold Off 0 shares
MORGAN STANLEY RIA/Wealth	−$406.5K −482.4K shares	$810.6K 961.9K shares
HONKAMP KRUEGER FINANCIAL SERVICES INC /ADV RIA/Wealth	−$96.8K −142.3K shares	Sold Off 0 shares
GEODE CAPITAL MANAGEMENT LLC ETF Provider	−$34.3K −40.7K shares	$277.3K 329.0K shares
T Tower Research Capital LLC Institution	−$10.5K −15.4K shares	Sold Off 0 shares
BANK OF AMERICA CORP /DE/ Institution	−$71.5 −85.0 shares	$207.0 246.0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited XLO in Q3 2025

New Positions: 2
New Value: $45.9K
Exited Positions: 3
Exited Value: $1.0M

New Positions

Institution	Position Value
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	$25.0K 29.7K shares
H HRT FINANCIAL LLC Institution	$20.8K 24.7K shares

Exited Positions

Institution	Previous Position
Ghisallo Capital Management LLC Hedge Fund•Multi-Strategy	$906.3K 1.3M shares
HONKAMP KRUEGER FINANCIAL SERVICES INC /ADV RIA/Wealth	$96.8K 142.3K shares
T Tower Research Capital LLC Institution	$10.5K 15.4K shares

Options Activity

Institutions with the largest Call and Put options positions in XLO as of Q3 2025

Call Positions: 0
Call Value: -
Put Positions: 0
Put Value: -

Call Positions

Institution	Position Value
No call positions found

Put Positions

Institution	Position Value
No put positions found

Most Committed Institutions

Institutions with XLO as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
T TAKEDA PHARMACEUTICAL CO LTD Institution	-	7.59% $1.2M	2.85% 1.5M shares	Q4 2023 Held for 1y 11m	$16.4M
Merck & Co., Inc. Institution	Robert M. Davis CEO	0.57% $1.3M	2.86% 1.5M shares	Q4 2024 Held for 11 months	$217.8M
AJU IB Investment Co., Ltd. Real Assets	Benjamin Jason Weprin CEO	0.52% $595.6K	1.29% 667.7K shares	Q4 2024 Held for 11 months	$115.1M
GILEAD SCIENCES, INC. Institution	Daniel O'Day CEO	0.43% $7.7M	17.57% 9.1M shares	Q4 2024 Held for 11 months	$1.8B
B Bain Capital Life Sciences Investors, LLC Institution	-	0.26% $3.8M	8.81% 4.6M shares	Q4 2021 Held for 3y 11m	$1.5B
T Trustees of Columbia University in the City of New York RIA/Wealth	Michael Winston Bain CCO	0.03% $210.4K	0.48% 249.6K shares	Q4 2024 Held for 11 months	$655.3M
T TWO SIGMA SECURITIES, LLC Institution	-	0.00% $27.1K	0.06% 32.1K shares	Q3 2025 Held for 2 months	$675.6M
INVESTORS ASSET MANAGEMENT OF GEORGIA INC /GA/ /ADV RIA/Wealth	Timothy Michael Rigby President	0.00% $8.4K	0.02% 10.0K shares	Q1 2025 Held for 8 months	$234.4M
X XTX Topco Ltd Institution	-	0.00% $64.1K	0.15% 76.0K shares	Q2 2024 Held for 1y 5m	$1.9B
SevenBridge Financial Group, LLC RIA/Wealth	Charles Ronald Eberly CIO	0.00% $19.3K	0.05% 25.0K shares	Q1 2024 Held for 1y 8m	$606.6M

Hedge Fund Spotlight

Discover hedge funds investing in XLO

TWO SIGMA ADVISERS, LLC

Hedge Fund • Multi-Strategy

Portfolio ManagerScott David Hoffman

Portfolio Value: $50.0B
Positions: 2,312
Last Reported: Q3 2025

Sector Allocation

Position in Xilio Therapeutics, Inc.

Market Value: $25.0K
Shares Held: 29.7K
Portfolio Weight: 0.00%
Owned Since: 2025-Q3

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