Zymeworks

ZYME • NASDAQ

Zymeworks is a biotechnology company in the healthcare sector on NASDAQ, led by Kenneth Galbraith, with a market cap of $1.9B. As of Q3 2025, 97% of shares are held by 181 institutional investors, with EcoR1 Capital, LLC as the largest holder at 30.33%.

Chair, President and Chief Executive OfficerKenneth Galbraith

Market Cap$1.9B

Biotechnology

Healthcare

Employees275.0

Websitezymeworks.com

Country

United States of America

Overview

Overview of institutional ownership in ZYME as of Q3 2025 with a market cap of $1.3B

All Institutions

Institutions: 181
Value Held: $1.3B
Shares Held: 73.6M
Avg Position: $6.9M
Median Position: $577.7K

Hedge Funds

Hedge Funds: 26
Value Held: $670.0M
Shares Held: 39.2M
Avg Position: $25.8M
Median Position: $2.2M

Ownership Breakdown

Institutional (non-HF)

45.34%

$586.5M

Hedge Funds

51.8%

$670.0M

Retail & Other

2.87%

$37.1M

Based on market cap of $1.3B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in ZYME as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
EcoR1 Capital, LLC Hedge Fund•Sector	Scott Eric Perlen CFO	$392.3M 18.83% of portfolio	30.33% 23.0M shares	Q4 2022 Held for 2y 11m	$2.1B
R Rubric Capital Management LP Hedge Fund•Long/Short	Margaret Kossakowski CFO	$80.5M 1.16% of portfolio	6.22% 4.7M shares	Q4 2022 Held for 2y 11m	$6.9B
B BlackRock, Inc. Institution	-	$68.1M 0.00% of portfolio	5.27% 4.0M shares	Q1 2020 Held for 5y 8m	$5.67T
MORGAN STANLEY RIA/Wealth	Jed Finn CEO	$68.1M 0.00% of portfolio	5.26% 4.0M shares	Q2 2018 Held for 7y 5m	$1.65T
B BVF INC/IL Institution	-	$67.3M 2.73% of portfolio	5.20% 3.9M shares	Q4 2022 Held for 2y 11m	$2.5B
R Redmile Group, LLC Hedge Fund•Sector	Amrit Nmn Nagpal Managing Partner	$63.3M 6.16% of portfolio	4.89% 3.7M shares	Q1 2020 Held for 5y 8m	$1.0B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$36.8M 0.00% of portfolio	2.84% 2.2M shares	Q2 2020 Held for 5y 5m	$6.69T
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	Joseph Eric Edelman CEO	$35.7M 1.03% of portfolio	2.76% 2.1M shares	Q2 2017 Held for 8y 5m	$3.5B
Vestal Point Capital, LP Hedge Fund•Long/Short	Ryan Christopher Wilder CIO	$30.1M 1.53% of portfolio	2.33% 1.8M shares	Q2 2024 Held for 1y 5m	$2.0B
UBS GLOBAL ASSET MANAGEMENT AMERICAS INC Long Only Manager	James Poucher CEO	$29.2M 0.01% of portfolio	2.26% 1.7M shares	Q1 2023 Held for 2y 8m	$460.61B

Net Capital Flow

Institutional buying and selling activity for ZYME in Q3 2025

Traded: −$12.5M
Buyers: 85
Sellers: 87
Total Bought: +$98.5M
Total Sold: −$111.0M
Avg Position: $6.2M

Biggest Buyers

Institution	Net Bought	Current Position
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$16.9M +988.7K shares	$18.9M 1.1M shares
A Assenagon Asset Management S.A. Institution	+$14.2M +834.0K shares	$22.7M 1.3M shares
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	+$13.9M +815.4K shares	$35.7M 2.1M shares
Vestal Point Capital, LP Hedge Fund•Long/Short	+$10.5M +615.0K shares	$30.1M 1.8M shares
ARROWSTREET CAPITAL LIMITED PARTNERSHIP Hedge Fund•Quant	+$5.4M +313.8K shares	$5.4M 313.8K shares
B BlackRock, Inc. Institution	+$3.3M +195.3K shares	$68.1M 4.0M shares
Q Qube Research & Technologies Ltd Institution	+$3.2M +185.1K shares	$4.4M 255.0K shares
Marshall Wace LLP Institution	+$2.6M +154.9K shares	$2.6M 154.9K shares
J JANE STREET GROUP, LLC Institution	+$2.3M +132.7K shares	$2.5M 145.2K shares
M Man Group plc Institution	+$2.1M +123.2K shares	$2.7M 158.6K shares

Biggest Sellers

Institution	Net Sold	Current Position
B BNP Paribas Investment Partners S.A. Institution	−$25.6M −2.0M shares	Sold Off 0 shares
UBS GLOBAL ASSET MANAGEMENT AMERICAS INC Long Only Manager	−$12.8M −749.1K shares	$29.2M 1.7M shares
Prosight Management, LP Hedge Fund•Long/Short	−$9.6M −560.3K shares	$12.8M 749.6K shares
R Redmile Group, LLC Hedge Fund•Sector	−$7.6M −444.9K shares	$63.3M 3.7M shares
B BVF INC/IL Institution	−$6.3M −370.3K shares	$67.3M 3.9M shares
VANGUARD GROUP INC Institution	−$5.3M −310.3K shares	$36.8M 2.2M shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	−$3.5M −207.1K shares	$889.1K 52.1K shares
UBS Group AG Institution	−$3.4M −199.7K shares	$885.4K 51.8K shares
MORGAN STANLEY RIA/Wealth	−$3.3M −193.0K shares	$68.1M 4.0M shares
Trexquant Investment LP Hedge Fund•Quant	−$2.8M −221.0K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited ZYME in Q3 2025

New Positions: 9
New Value: $1.5M
Exited Positions: 21
Exited Value: $35.3M

New Positions

Institution	Position Value
Vinva Investment Management Ltd Hedge Fund•Quant	$382.4K 14.6K shares
DLD Asset Management, LP Hedge Fund•Multi-Strategy	$341.6K 20.0K shares
P PharVision Advisers, LLC Hedge Fund•Long/Short	$303.9K 17.8K shares
T TWO SIGMA SECURITIES, LLC Institution	$208.8K 12.2K shares
E Ewing Morris & Co. Investment Partners Ltd. Institution	$185.3K 10.9K shares
Q Quarry LP Institution	$50.2K 2.9K shares
O Optiver Holding B.V. Institution	$25.8K 1.5K shares
W WHITE BAY PT LLC Institution	$8.1K 472.0 shares
Sunbelt Securities, Inc. RIA/Wealth	$461.0 27.0 shares

Exited Positions

Institution	Previous Position
B BNP Paribas Investment Partners S.A. Institution	$25.6M 2.0M shares
Trexquant Investment LP Hedge Fund•Quant	$2.8M 221.0K shares
A AXA Institution	$2.2M 175.1K shares
C Cubist Systematic Strategies, LLC Institution	$1.5M 120.0K shares
Weiss Asset Management LP Hedge Fund•Multi-Strategy	$679.8K 54.2K shares
ExodusPoint Capital Management, LP Hedge Fund•Multi-Strategy	$648.4K 51.7K shares
X XTX Topco Ltd Institution	$389.3K 31.0K shares
LANDSCAPE CAPITAL MANAGEMENT, L.L.C. Hedge Fund•Market Neutral	$334.7K 26.7K shares
Graham Capital Management, L.P. Hedge Fund•Multi-Strategy	$271.8K 21.7K shares
ING INVESTMENT MANAGEMENT LLC Insurance Manager	$186.8K 14.9K shares

Options Activity

Institutions with the largest Call and Put options positions in ZYME as of Q3 2025

Call Positions: 5
Call Value: $7.9M
Put Positions: 3
Put Value: $4.1M

Call Positions

Institution	Position Value
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$3.4M 2.0K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$2.6M 1.5K contracts
DLD Asset Management, LP Hedge Fund•Multi-Strategy	$904.1K 529.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$766.9K 449.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$249.4K 146.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$2.4M 1.4K contracts
BANK OF AMERICA CORP /DE/ Institution	$1.7M 1.0K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	- - contracts

Most Committed Institutions

Institutions with ZYME as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
EcoR1 Capital, LLC Hedge Fund•Sector	Scott Eric Perlen CFO	18.83% $392.3M	30.33% 23.0M shares	Q4 2022 Held for 2y 11m	$2.1B
R Redmile Group, LLC Hedge Fund•Sector	Amrit Nmn Nagpal Managing Partner	6.16% $63.3M	4.89% 3.7M shares	Q1 2020 Held for 5y 8m	$1.0B
Prosight Management, LP Hedge Fund•Long/Short	William Lawrence Hawkins Managing Partner	3.40% $12.8M	0.99% 749.6K shares	Q3 2023 Held for 2y 2m	$376.7M
N Nextech Invest, Ltd. Institution	-	2.90% $19.0M	1.47% 1.1M shares	Q1 2025 Held for 8 months	$657.0M
B BVF INC/IL Institution	-	2.73% $67.3M	5.20% 3.9M shares	Q4 2022 Held for 2y 11m	$2.5B
Vestal Point Capital, LP Hedge Fund•Long/Short	Ryan Christopher Wilder CIO	1.53% $30.1M	2.33% 1.8M shares	Q2 2024 Held for 1y 5m	$2.0B
L Longwood Capital Partners LLC Institution	-	1.41% $1.4M	0.11% 80.1K shares	Q4 2024 Held for 11 months	$96.8M
R Rubric Capital Management LP Hedge Fund•Long/Short	Margaret Kossakowski CFO	1.16% $80.5M	6.22% 4.7M shares	Q4 2022 Held for 2y 11m	$6.9B
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	Joseph Eric Edelman CEO	1.03% $35.7M	2.76% 2.1M shares	Q2 2017 Held for 8y 5m	$3.5B
T Tejara Capital Ltd Institution	-	0.80% $1.5M	0.11% 85.2K shares	Q4 2022 Held for 2y 11m	$182.4M