SR ONE CAPITAL MANAGEMENT, LP
Venture Capital
SR ONE CAPITAL MANAGEMENT, LP is a Venture Capital based in Wayne, PA led by Simeon John George, reporting $2.1B in AUM as of Q3 2025 with 82% Healthcare concentration, 98% concentrated in top 10 holdings, and 28% allocation to ACLX.
CEOSimeon John George
- Portfolio Value
- $691.4M
- Positions
- 12
- Top Holding
- ACLX at 27.86%
- Last Reported
- Q3 2025
Top Holdings
Largest long holdings in SR ONE CAPITAL MANAGEMENT, LP's portfolio (98.4% of total portfolio)
GthenH
| Holding | Sector | Position | Weight | Traded | Ownership |
|---|---|---|---|---|---|
Biotechnology Healthcare | $192.7M | 27.86% | — | 4.23% 2.3M shares | |
Biotechnology Healthcare | $132.1M | 19.11% | +$64.1M Bought | 2.24% 2.0M shares | |
Unknown Unknown | $109.0M | 15.77% | — | — 4.9M shares | |
Biotechnology Healthcare | $80.2M | 11.59% | -$38.5M Sold | 2.73% 2.1M shares | |
Biotechnology Healthcare | $54.2M | 7.84% | — | 4.65% 4.5M shares | |
Biotechnology Healthcare | $49.1M | 7.11% | — | 11.46% 6.5M shares | |
Biotechnology Healthcare | $40.3M | 5.83% | — | 4.06% 4.0M shares | |
Unknown Unknown | $8.3M | 1.20% | — | 0.89% 430.3K shares | |
Unknown Unknown | $7.8M | 1.13% | — | 1.88% 2.0M shares | |
Biotechnology Healthcare | $6.9M | 1.00% | — | 4.69% 3.3M shares |
Changes
Portfolio activity, position movements, and quarter-over-quarter changes in SR ONE CAPITAL MANAGEMENT, LP's latest filing
GthenC
Market Value
Q/Q Change
Net Flows % of MV
Turnover Ratio
New Purchases
Added To
Sold Out Of
Reduced Holdings
Increased Positions
| Position | Shares Δ |
|---|---|
+94.36% |
Decreased Positions
| Position | Shares Δ |
|---|---|
Sold | |
-32.42% |
Analytics
Portfolio insights and performance metrics for SR ONE CAPITAL MANAGEMENT, LP
GthenA