Design Therapeutics, Inc.

DSGN • NASDAQ

Design Therapeutics, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Pratik Shah, Ph.D., with a market cap of $537.2M. As of Q3 2025, 61% of shares are held by 95 institutional investors, with SR ONE CAPITAL MANAGEMENT, LP as the largest holder at 11.46%.

President, Chief Executive Officer and principal financial officerPratik Shah, Ph.D.

Market Cap$537.2M

Biotechnology

Healthcare

Employees57.0

Websitedesigntx.com

Country

United States of America

Overview

Overview of institutional ownership in DSGN as of Q3 2025 with a market cap of $428.8M

All Institutions

Institutions: 95
Value Held: $259.7M
Shares Held: 34.5M
Avg Position: $2.7M
Median Position: $170.9K

Hedge Funds

Hedge Funds: 15
Value Held: $98.1M
Shares Held: 13.0M
Avg Position: $6.5M
Median Position: $3.6M

Ownership Breakdown

Institutional (non-HF)

37.69%

$161.6M

Hedge Funds

22.88%

$98.1M

Retail & Other

39.43%

$169.1M

Based on market cap of $428.8M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in DSGN as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
SR ONE CAPITAL MANAGEMENT, LP Venture Capital	Simeon John George CEO	$49.1M 7.11% of portfolio	11.46% 6.5M shares	Q4 2021 Held for 3y 11m	$691.4M
Logos Global Management LP Hedge Fund•Long/Short	Graham Gordon Walmsley Managing Partner	$27.5M 2.79% of portfolio	6.42% 3.7M shares	Q1 2021 Held for 4y 8m	$987.5M
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	Steven Alan Cohen CEO	$25.2M 0.06% of portfolio	5.87% 3.3M shares	Q1 2023 Held for 2y 8m	$43.2B
B BlackRock, Inc. Institution	-	$15.4M 0.00% of portfolio	3.59% 2.0M shares	Q1 2021 Held for 4y 8m	$5.67T
Frazier Life Sciences Management, L.P. Venture Capital	James Newman Topper Managing Partner	$14.7M 0.44% of portfolio	3.43% 2.0M shares	Q2 2024 Held for 1y 5m	$3.3B
T TANG CAPITAL MANAGEMENT LLC Institution	-	$13.4M 0.53% of portfolio	3.13% 1.8M shares	Q3 2023 Held for 2y 2m	$2.5B
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	Scott Lawrence Lessing President	$12.9M 0.12% of portfolio	3.01% 1.7M shares	Q1 2021 Held for 4y 8m	$10.8B
Almitas Capital LLC RIA/Wealth	Ronald Dean Mass Managing Partner	$11.5M 2.64% of portfolio	2.69% 1.5M shares	Q4 2023 Held for 1y 11m	$435.9M
VANGUARD GROUP INC Institution	Salim Ramji CEO	$10.9M 0.00% of portfolio	2.54% 1.4M shares	Q1 2021 Held for 4y 8m	$6.69T
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	Stephen Thomas Weber CEO	$8.1M 0.06% of portfolio	1.89% 1.1M shares	Q4 2024 Held for 11 months	$13.9B

Net Capital Flow

Institutional buying and selling activity for DSGN in Q3 2025

Traded: +$657.5K
Buyers: 31
Sellers: 50
Total Bought: +$17.9M
Total Sold: −$17.3M
Avg Position: $2.4M

Biggest Buyers

Institution	Net Bought	Current Position
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	+$11.5M +1.5M shares	$25.2M 3.3M shares
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	+$3.6M +475.7K shares	$3.6M 475.7K shares
J JANE STREET GROUP, LLC Institution	+$653.3K +86.8K shares	$887.3K 117.8K shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$518.2K +68.8K shares	$518.2K 68.8K shares
DLD Asset Management, LP Hedge Fund•Multi-Strategy	+$376.5K +50.0K shares	$376.5K 50.0K shares
H HRT FINANCIAL LLC Institution	+$240.2K +31.9K shares	$240.2K 31.9K shares
C China Universal Asset Management Co., Ltd. Institution	+$177.6K +23.6K shares	$263.4K 35.0K shares
GOLDMAN SACHS GROUP INC Institution	+$165.6K +22.0K shares	$2.0M 261.4K shares
S SPHERA FUNDS MANAGEMENT LTD. Institution	+$165.0K +21.9K shares	$165.0K 21.9K shares
KENNEDY CAPITAL MANAGEMENT, INC. Long Only Manager	+$108.4K +14.4K shares	$221.5K 29.4K shares

Biggest Sellers

Institution	Net Sold	Current Position
Logos Global Management LP Hedge Fund•Long/Short	−$4.2M −562.6K shares	$27.5M 3.7M shares
B BlackRock, Inc. Institution	−$2.6M −351.4K shares	$15.4M 2.0M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$2.2M −286.8K shares	$4.2M 554.0K shares
FMR LLC Institution	−$1.6M −210.3K shares	$5.6M 740.8K shares
Woodline Partners LP Hedge Fund•Long/Short	−$1.2M −164.8K shares	$4.6M 612.7K shares
GEODE CAPITAL MANAGEMENT LLC ETF Provider	−$741.1K −98.4K shares	$5.2M 695.6K shares
STATE STREET CORP Institution	−$638.7K −84.8K shares	$4.8M 634.4K shares
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	−$512.0K −68.0K shares	$305.0K 40.5K shares
NORTHERN TRUST CORP Institution	−$496.9K −66.0K shares	$2.2M 296.5K shares
MORGAN STANLEY RIA/Wealth	−$282.8K −37.6K shares	$1.3M 176.0K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited DSGN in Q3 2025

New Positions: 5
New Value: $544.6K
Exited Positions: 11
Exited Value: $764.3K

New Positions

Institution	Position Value
DLD Asset Management, LP Hedge Fund•Multi-Strategy	$376.5K 50.0K shares
S SPHERA FUNDS MANAGEMENT LTD. Institution	$165.0K 21.9K shares
O Optiver Holding B.V. Institution	$2.5K 328.0 shares
V Versant Capital Management, Inc RIA/Wealth	$535.0 71.0 shares
Larson Financial Group LLC RIA/Wealth	$23.0 3.0 shares

Exited Positions

Institution	Previous Position
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	$202.1K 60.0K shares
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	$142.9K 42.4K shares
A Assenagon Asset Management S.A. Institution	$104.9K 31.1K shares
$DEUTSCHE BANK AG\ logo$ DEUTSCHE BANK AG\ Institution	$94.7K 28.1K shares
C CI Private Wealth, LLC RIA/Wealth	$90.9K 27.0K shares
JACOBS LEVY EQUITY MANAGEMENT, INC Hedge Fund•Quant	$45.5K 13.5K shares
LOS ANGELES CAPITAL MANAGEMENT & EQUITY RESEARCH INC Long Only Manager	$42.9K 12.7K shares
M MANUFACTURERES LIFE INSURANCE CO Institution	$40.3K 12.0K shares
Point72 Ltd RIA/Wealth	$66.0 20.0 shares
S Skopos Labs, Inc. RIA/Wealth	$65.0 19.0 shares

Options Activity

Institutions with the largest Call and Put options positions in DSGN as of Q3 2025

Call Positions: 1
Call Value: -
Put Positions: 0
Put Value: -

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	- - contracts

Put Positions

Institution	Position Value
No put positions found

Most Committed Institutions

Institutions with DSGN as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
SR ONE CAPITAL MANAGEMENT, LP Venture Capital	Simeon John George CEO	7.11% $49.1M	11.46% 6.5M shares	Q4 2021 Held for 3y 11m	$691.4M
Logos Global Management LP Hedge Fund•Long/Short	Graham Gordon Walmsley Managing Partner	2.79% $27.5M	6.42% 3.7M shares	Q1 2021 Held for 4y 8m	$987.5M
Almitas Capital LLC RIA/Wealth	Ronald Dean Mass Managing Partner	2.64% $11.5M	2.69% 1.5M shares	Q4 2023 Held for 1y 11m	$435.9M
MPM Oncology Impact Management LP Institution	Christian Albrecht Wulf Von Schimmelmann Managing Partner	0.68% $4.2M	0.97% 555.2K shares	Q4 2024 Held for 11 months	$610.9M
K Kynam Capital Management, LP Hedge Fund•Long/Short	Jared Joseph Keller COO	0.58% $7.8M	1.81% 1.0M shares	Q1 2025 Held for 8 months	$1.3B
T TANG CAPITAL MANAGEMENT LLC Institution	-	0.53% $13.4M	3.13% 1.8M shares	Q3 2023 Held for 2y 2m	$2.5B
Frazier Life Sciences Management, L.P. Venture Capital	James Newman Topper Managing Partner	0.44% $14.7M	3.43% 2.0M shares	Q2 2024 Held for 1y 5m	$3.3B
V Velan Capital Investment Management LP Institution	-	0.14% $150.6K	0.04% 20.0K shares	Q1 2025 Held for 8 months	$106.5M
Palumbo Wealth Management LLC RIA/Wealth	Philip G Palumbo CEO	0.13% $392.2K	0.09% 52.1K shares	Q1 2024 Held for 1y 8m	$312.6M
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	Scott Lawrence Lessing President	0.12% $12.9M	3.01% 1.7M shares	Q1 2021 Held for 4y 8m	$10.8B