aTyr Pharma

ATYR • NASDAQ

aTyr Pharma is a biotechnology company in the healthcare sector on NASDAQ, with a market cap of $76.0M. As of Q3 2025, 62% of shares are held by 100 institutional investors, with FMR LLC as the largest holder at 15.0%.

Market Cap$76.0M

Biotechnology

Healthcare

Employees59.0

Websiteatyrpharma.com

Country

United States of America

Overview

Overview of institutional ownership in ATYR as of Q3 2025 with a market cap of $70.7M

All Institutions

Institutions: 100
Value Held: $43.9M
Shares Held: 60.9M
Avg Position: $439.2K
Median Position: $25.5K

Hedge Funds

Hedge Funds: 10
Value Held: $2.7M
Shares Held: 3.8M
Avg Position: $273.0K
Median Position: $116.5K

Ownership Breakdown

Institutional (non-HF)

58.27%

$41.2M

Hedge Funds

3.86%

$2.7M

Retail & Other

37.87%

$26.8M

Based on market cap of $70.7M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in ATYR as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
FMR LLC Institution	-	$10.6M 0.00% of portfolio	15.00% 14.7M shares	Q2 2024 Held for 1y 5m	$1.92T
FEDERATED INVESTORS INC /PA/ Long Only Manager	Gregory Philip Dulski Chairman	$7.6M 0.01% of portfolio	10.76% 10.5M shares	Q2 2024 Held for 1y 5m	$56.6B
B BlackRock, Inc. Institution	-	$4.7M 0.00% of portfolio	6.61% 6.5M shares	Q2 2024 Held for 1y 5m	$5.67T
VANGUARD GROUP INC Institution	Salim Ramji CEO	$4.1M 0.00% of portfolio	5.75% 5.6M shares	Q2 2024 Held for 1y 5m	$6.69T
UBS Group AG Institution	Sergio P. Ermotti CEO	$3.2M 0.00% of portfolio	4.60% 4.5M shares	Q4 2024 Held for 11 months	$511.54B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$3.0M 0.00% of portfolio	4.28% 4.2M shares	Q2 2024 Held for 1y 5m	$2.88T
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$1.6M 0.00% of portfolio	2.22% 2.2M shares	Q2 2024 Held for 1y 5m	$1.57T
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	Dan Michael Berkovitz Chairman	$1.4M 0.00% of portfolio	1.93% 1.9M shares	Q2 2024 Held for 1y 5m	$121.98B
MORGAN STANLEY RIA/Wealth	Jed Finn CEO	$512.4K 0.00% of portfolio	0.72% 710.3K shares	Q4 2023 Held for 1y 11m	$1.65T
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	David Khabie-Zeitoune CEO	$509.8K 0.05% of portfolio	0.72% 706.7K shares	Q2 2024 Held for 1y 5m	$1.1B

Net Capital Flow

Institutional buying and selling activity for ATYR in Q3 2025

Traded: −$47.5M
Buyers: 69
Sellers: 58
Total Bought: +$10.4M
Total Sold: −$57.9M
Avg Position: $316.0K

Biggest Buyers

Institution	Net Bought	Current Position
STATE STREET CORP Institution	+$2.1M +3.0M shares	$3.0M 4.2M shares
UBS Group AG Institution	+$2.0M +2.8M shares	$3.2M 4.5M shares
FMR LLC Institution	+$972.0K +1.3M shares	$10.6M 14.7M shares
VANGUARD GROUP INC Institution	+$703.6K +975.9K shares	$4.1M 5.6M shares
B BlackRock, Inc. Institution	+$498.7K +691.3K shares	$4.7M 6.5M shares
GOLDMAN SACHS GROUP INC Institution	+$470.3K +651.9K shares	$496.4K 688.2K shares
MORGAN STANLEY RIA/Wealth	+$324.9K +450.4K shares	$512.4K 710.3K shares
STATE OF WISCONSIN INVESTMENT BOARD RIA/Wealth	+$316.2K +438.3K shares	$316.2K 438.3K shares
A Artia Global Partners LP Hedge Fund•Long/Short	+$268.6K +372.3K shares	$268.6K 372.3K shares
X XTX Topco Ltd Institution	+$225.4K +312.4K shares	$225.4K 312.4K shares

Biggest Sellers

Institution	Net Sold	Current Position
Octagon Capital Advisors LP Hedge Fund•Sector	−$19.4M −3.8M shares	Sold Off 0 shares
A Alyeska Investment Group, L.P. Hedge Fund•Multi-Strategy	−$7.2M −1.4M shares	Sold Off 0 shares
Integral Health Asset Management, LLC Hedge Fund•Sector	−$5.3M −1.1M shares	Sold Off 0 shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	−$5.0M −988.7K shares	Sold Off 0 shares
E Erste Asset Management GmbH Institution	−$3.0M −600.0K shares	Sold Off 0 shares
FEDERATED INVESTORS INC /PA/ Long Only Manager	−$3.0M −4.1M shares	$7.6M 10.5M shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	−$2.6M −518.4K shares	Sold Off 0 shares
Marshall Wace LLP Institution	−$2.6M −511.4K shares	Sold Off 0 shares
Ally Bridge Group LLC Hedge Fund•Sector	−$1.5M −287.7K shares	Sold Off 0 shares
T Tikvah Management LLC Institution	−$1.4M −2.0M shares	$332.4K 460.8K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited ATYR in Q3 2025

New Positions: 29
New Value: $1.2M
Exited Positions: 38
Exited Value: $53.1M

New Positions

Institution	Position Value
STATE OF WISCONSIN INVESTMENT BOARD RIA/Wealth	$316.2K 438.3K shares
A Artia Global Partners LP Hedge Fund•Long/Short	$268.6K 372.3K shares
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	$126.2K 175.0K shares
R Rafferty Asset Management, LLC Institution	$123.1K 170.6K shares
Graham Capital Management, L.P. Hedge Fund•Multi-Strategy	$106.7K 147.9K shares
TORONTO DOMINION BANK Institution	$78.9K 109.4K shares
LOS ANGELES CAPITAL MANAGEMENT & EQUITY RESEARCH INC Long Only Manager	$33.1K 45.8K shares
DLD Asset Management, LP Hedge Fund•Multi-Strategy	$28.9K 40.0K shares
P PROFUND ADVISORS LLC Institution	$26.5K 36.8K shares
S SEI INVESTMENTS CO Institution	$24.4K 33.8K shares

Exited Positions

Institution	Previous Position
Octagon Capital Advisors LP Hedge Fund•Sector	$19.4M 3.8M shares
A Alyeska Investment Group, L.P. Hedge Fund•Multi-Strategy	$7.2M 1.4M shares
Integral Health Asset Management, LLC Hedge Fund•Sector	$5.3M 1.1M shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	$5.0M 988.7K shares
E Erste Asset Management GmbH Institution	$3.0M 600.0K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	$2.6M 518.4K shares
Marshall Wace LLP Institution	$2.6M 511.4K shares
Ally Bridge Group LLC Hedge Fund•Sector	$1.5M 287.7K shares
T THOROUGHBRED FINANCIAL SERVICES, LLC RIA/Wealth	$1.1M 210.8K shares
D Dauntless Investment Group, LLC Institution	$803.1K 158.4K shares

Options Activity

Institutions with the largest Call and Put options positions in ATYR as of Q3 2025

Call Positions: 16
Call Value: $3.5M
Put Positions: 15
Put Value: $4.1M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$661.7K 9.2K contracts
J JANE STREET GROUP, LLC Institution	$493.3K 6.8K contracts
A Artia Global Partners LP Hedge Fund•Long/Short	$432.8K 6.0K contracts
Ally Bridge Group LLC Hedge Fund•Sector	$432.8K 6.0K contracts
Caption Management, LLC Hedge Fund•Long/Short	$367.9K 5.1K contracts
DLD Asset Management, LP Hedge Fund•Multi-Strategy	$223.5K 3.1K contracts
R READYSTATE ASSET MANAGEMENT LP Hedge Fund•Multi-Strategy	$216.4K 3.0K contracts
W WOLVERINE TRADING, LLC Institution	$163.1K 2.1K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$144.1K 2.0K contracts
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$92.8K 1.3K contracts

Put Positions

Institution	Position Value
Affinity Asset Advisors, LLC Hedge Fund•Long/Short	$1.5M 21.0K contracts
Eversept Partners, LLC Hedge Fund•Long/Short	$474.7K 6.6K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$461.1K 6.4K contracts
L LMR Partners LLP Institution	$410.4K 5.7K contracts
TUDOR INVESTMENT CORP ET AL Hedge Fund•Multi-Strategy	$360.7K 5.0K contracts
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	$288.6K 4.0K contracts
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	$160.5K 2.2K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$134.2K 1.9K contracts
W WOLVERINE TRADING, LLC Institution	$110.5K 1.4K contracts
TORONTO DOMINION BANK Institution	$78.9K 1.1K contracts

Most Committed Institutions

Institutions with ATYR as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
T Tikvah Management LLC Institution	-	0.10% $332.4K	0.47% 460.8K shares	Q2 2024 Held for 1y 5m	$330.6M
A Artia Global Partners LP Hedge Fund•Long/Short	Onusa Nmn Chantanapongwanij Managing Partner	0.05% $268.6K	0.38% 372.3K shares	Q3 2025 Held for 2 months	$568.3M
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	David Khabie-Zeitoune CEO	0.05% $509.8K	0.72% 706.7K shares	Q2 2024 Held for 1y 5m	$1.1B
T TANG CAPITAL MANAGEMENT LLC Institution	-	0.02% $484.2K	0.68% 671.1K shares	Q2 2024 Held for 1y 5m	$2.5B
FEDERATED INVESTORS INC /PA/ Long Only Manager	Gregory Philip Dulski Chairman	0.01% $7.6M	10.76% 10.5M shares	Q2 2024 Held for 1y 5m	$56.6B
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	Daniel Pawel Schneeberger Managing Partner	0.01% $126.2K	0.18% 175.0K shares	Q2 2025 Held for 5 months	$993.7M
X XTX Topco Ltd Institution	-	0.01% $225.4K	0.32% 312.4K shares	Q3 2024 Held for 1y 2m	$1.9B
Blue Rock Wealth Management LLC RIA/Wealth	Wesley Robert Reed CCO	0.01% $12.3K	0.02% 17.0K shares	Q2 2025 Held for 5 months	$155.2M
Main Street Financial Solutions, LLC RIA/Wealth	Brett Robert Danko CEO	0.01% $104.6K	0.15% 145.0K shares	Q2 2024 Held for 1y 5m	$1.6B
Graham Capital Management, L.P. Hedge Fund•Multi-Strategy	Brian Kevin Douglas CEO	0.01% $106.7K	0.15% 147.9K shares	Q3 2025 Held for 2 months	$1.8B

Hedge Fund Spotlight

Discover hedge funds investing in ATYR

TWO SIGMA INVESTMENTS LLC

Hedge Fund • Multi-Strategy

Portfolio ManagerScott David Hoffman

Portfolio Value: $62.0B
Positions: 3,252
Last Reported: Q3 2025

Sector Allocation

Position in aTyr Pharma

Market Value: $152.2K
Shares Held: 211.0K
Portfolio Weight: 0.00%
Owned Since: 2024-Q4

Top Holding	Sector	Market Value	Weight
1 SPDR S&P 500 ETF Trust SPY	ETF ETF	$680.4M	1.10%
2 Financial Select Sector SPDR Fund XLF	ETF ETF	$582.6M	0.94%
3 Consumer Staples Select Sector SPDR Fund XLP	ETF ETF	$489.6M	0.79%