Caribou Biosciences, Inc.

CRBU • NASDAQ

Caribou Biosciences, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Rachel Haurwitz, with a market cap of $167.3M. As of Q3 2025, 40% of shares are held by 117 institutional investors, with PFIZER INC as the largest holder at 5.04%.

President and Chief Executive OfficerRachel Haurwitz

Market Cap$167.3M

Biotechnology

Healthcare

Employees137.0

Websitecariboubio.com

Country

United States of America

Overview

Overview of institutional ownership in CRBU as of Q3 2025 with a market cap of $217.0M

All Institutions

Institutions: 117
Value Held: $86.7M
Shares Held: 37.2M
Avg Position: $740.6K
Median Position: $78.2K

Hedge Funds

Hedge Funds: 15
Value Held: $29.8M
Shares Held: 12.8M
Avg Position: $2.0M
Median Position: $1.3M

Ownership Breakdown

Institutional (non-HF)

26.22%

$56.9M

Hedge Funds

13.72%

$29.8M

Retail & Other

60.06%

$130.3M

Based on market cap of $217.0M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in CRBU as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
PFIZER INC Institution	Albert Bourla CEO	$10.9M 2.50% of portfolio	5.04% 4.7M shares	Q4 2024 Held for 11 months	$437.4M
VANGUARD GROUP INC Institution	Salim Ramji CEO	$9.8M 0.00% of portfolio	4.54% 4.2M shares	Q3 2021 Held for 4y 2m	$6.69T
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	Dan Michael Berkovitz Chairman	$7.5M 0.01% of portfolio	3.45% 3.2M shares	Q3 2021 Held for 4y 2m	$121.98B
K Kynam Capital Management, LP Hedge Fund•Long/Short	Jared Joseph Keller COO	$7.1M 0.53% of portfolio	3.29% 3.1M shares	Q3 2023 Held for 2y 2m	$1.3B
B BlackRock, Inc. Institution	-	$3.4M 0.00% of portfolio	1.57% 1.5M shares	Q3 2021 Held for 4y 2m	$5.67T
S Standard Life Aberdeen plc Institution	-	$3.2M 0.01% of portfolio	1.49% 1.4M shares	Q4 2023 Held for 1y 11m	$63.2B
Partner Fund Management, L.P. Hedge Fund•Sector	Jonathan Jude Aljoe CFO	$3.2M 0.27% of portfolio	1.46% 1.4M shares	Q3 2021 Held for 4y 2m	$1.2B
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	Scott David Hoffman CEO	$2.9M 0.01% of portfolio	1.32% 1.2M shares	Q3 2023 Held for 2y 2m	$50.0B
DIMENSIONAL FUND ADVISORS LP Long Only Manager	David Paul Butler CEO	$2.8M 0.00% of portfolio	1.30% 1.2M shares	Q4 2022 Held for 2y 11m	$466.32B
BANK OF AMERICA CORP /DE/ Institution	Brian T. Moynihan CEO	$2.5M 0.00% of portfolio	1.15% 1.1M shares	Q3 2021 Held for 4y 2m	$1.33T

Net Capital Flow

Institutional buying and selling activity for CRBU in Q3 2025

Traded: −$6.7M
Buyers: 41
Sellers: 70
Total Bought: +$9.7M
Total Sold: −$16.4M
Avg Position: $597.6K

Biggest Buyers

Institution	Net Bought	Current Position
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$3.9M +1.7M shares	$7.5M 3.2M shares
S Standard Life Aberdeen plc Institution	+$1.1M +491.3K shares	$3.2M 1.4M shares
X XTX Topco Ltd Institution	+$783.6K +336.3K shares	$1.0M 441.5K shares
BANK OF AMERICA CORP /DE/ Institution	+$618.7K +265.5K shares	$2.5M 1.1M shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	+$578.5K +248.3K shares	$1.8M 780.4K shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	+$421.7K +181.0K shares	$1.0M 445.6K shares
VANGUARD GROUP INC Institution	+$319.3K +137.1K shares	$9.8M 4.2M shares
Graham Capital Management, L.P. Hedge Fund•Multi-Strategy	+$299.1K +128.4K shares	$299.1K 128.4K shares
Marshall Wace LLP Institution	+$293.2K +125.8K shares	$293.2K 125.8K shares
A AMERICAN CENTURY COMPANIES INC Institution	+$190.6K +81.8K shares	$190.6K 81.8K shares

Biggest Sellers

Institution	Net Sold	Current Position
Schonfeld Strategic Advisors LLC Hedge Fund•Multi-Strategy	−$4.0M −1.7M shares	$1.3M 558.6K shares
JACOBS LEVY EQUITY MANAGEMENT, INC Hedge Fund•Quant	−$1.4M −607.9K shares	$813.4K 349.1K shares
AQR CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$1.4M −585.7K shares	$143.1K 61.4K shares
GOLDMAN SACHS GROUP INC Institution	−$1.3M −546.8K shares	$570.4K 244.8K shares
B BlackRock, Inc. Institution	−$988.3K −424.2K shares	$3.4M 1.5M shares
W WILEY BROS.-AINTREE CAPITAL, LLC Institution	−$681.4K −292.4K shares	$102.8K 44.1K shares
ENVESTNET ASSET MANAGEMENT INC Long Only Manager	−$652.1K −279.9K shares	$90.3K 38.8K shares
THRIVENT FINANCIAL FOR LUTHERANS Insurance Manager	−$556.7K −238.9K shares	$82.9K 35.6K shares
MILESTONE ASSET MANAGEMENT, LLC RIA/Wealth	−$544.3K −233.6K shares	$410.0K 176.0K shares
AMERIPRISE FINANCIAL INC Institution	−$521.0K −223.6K shares	$198.9K 85.4K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited CRBU in Q3 2025

New Positions: 7
New Value: $168.0K
Exited Positions: 28
Exited Value: $1.7M

New Positions

Institution	Position Value
C CREDIT AGRICOLE S A Institution	$67.6K 29.0K shares
LIBERTY WEALTH MANAGEMENT LLC RIA/Wealth	$45.4K 19.5K shares
R Squared Ltd Private Equity	$28.6K 12.3K shares
Sontag Advisory, LLC RIA/Wealth	$17.5K 7.5K shares
Union Bankshares Corp Institution	$7.5K 3.2K shares
SRS Capital Advisors, Inc. RIA/Wealth	$1.2K 506.0 shares
Sunbelt Securities, Inc. RIA/Wealth	$315.0 135.0 shares

Exited Positions

Institution	Previous Position
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	$209.7K 166.4K shares
B Brevan Howard Capital Management LP Institution	$196.0K 155.5K shares
Y Y-Intercept Ltd Institution	$172.9K 137.2K shares
Woodline Partners LP Hedge Fund•Long/Short	$154.8K 122.8K shares
H HRT FINANCIAL LLC Institution	$133.4K 105.9K shares
Aster Capital Management Ltd RIA/Wealth	$132.3K 105.0K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$127.5K 101.2K shares
IEQ CAPITAL, LLC RIA/Wealth	$126.3K 100.2K shares
Q Quadrature Capital Ltd Institution	$114.3K 91.1K shares
Eqis Capital Management, Inc. RIA/Wealth	$41.0K 32.5K shares

Options Activity

Institutions with the largest Call and Put options positions in CRBU as of Q3 2025

Call Positions: 2
Call Value: $98.3K
Put Positions: 2
Put Value: $217.2K

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$51.0K 219.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$47.3K 203.0 contracts

Put Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$171.7K 737.0 contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$45.4K 195.0 contracts

Most Committed Institutions

Institutions with CRBU as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
PFIZER INC Institution	Albert Bourla CEO	2.50% $10.9M	5.04% 4.7M shares	Q4 2024 Held for 11 months	$437.4M
7 72 Investment Holdings, LLC Institution	-	1.63% $1.1M	0.51% 474.1K shares	Q3 2021 Held for 4y 2m	$67.9M
Green Alpha Advisors, LLC Long Only Manager	Garvin Frederic Jabusch Founder	0.82% $847.4K	0.39% 363.7K shares	Q3 2021 Held for 4y 2m	$103.4M
K Kynam Capital Management, LP Hedge Fund•Long/Short	Jared Joseph Keller COO	0.53% $7.1M	3.29% 3.1M shares	Q3 2023 Held for 2y 2m	$1.3B
Partner Fund Management, L.P. Hedge Fund•Sector	Jonathan Jude Aljoe CFO	0.27% $3.2M	1.46% 1.4M shares	Q3 2021 Held for 4y 2m	$1.2B
P Pale Fire Capital SE Institution	-	0.20% $1.8M	0.83% 775.1K shares	Q4 2023 Held for 1y 11m	$912.4M
Bruce & Co., Inc. Long Only Manager	Robert Jeffrey Bruce President	0.18% $582.5K	0.27% 250.0K shares	Q1 2023 Held for 2y 8m	$322.9M
MILESTONE ASSET MANAGEMENT, LLC RIA/Wealth	Richard Todd Baker Managing Partner	0.08% $410.0K	0.19% 176.0K shares	Q2 2024 Held for 1y 5m	$506.3M
X XTX Topco Ltd Institution	-	0.05% $1.0M	0.47% 441.5K shares	Q2 2025 Held for 5 months	$1.9B
C Catalyst Funds Management Pty Ltd Institution	-	0.03% $205.7K	0.09% 88.3K shares	Q2 2025 Held for 5 months	$658.5M

Hedge Fund Spotlight

Discover hedge funds investing in CRBU

CITADEL ADVISORS LLC

Hedge Fund • Multi-Strategy

Portfolio ManagerKenneth Cordele Griffin

Portfolio Value: $122.08B
Positions: 5,531
Last Reported: Q3 2025

Sector Allocation

Position in Caribou Biosciences, Inc.

Market Value: $617.7K
Shares Held: 265.1K
Portfolio Weight: 0.00%
Owned Since: 2021-Q4

Top Holding	Sector	Market Value	Weight
1 Microsoft MSFT	Software - Infrastructure Technology	$2.1B	1.68%
2 Nvidia NVDA	Semiconductors Technology	$1.8B	1.50%
3 Meta Platforms, Inc. META	Internet Content & Information Communication Services	$1.4B	1.18%