Lyra Therapeutics, Inc.
LYRA • NASDAQ
Lyra Therapeutics, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Maria Palasis, with a market cap of $6.5M. As of Q3 2025, 27% of shares are held by 25 institutional investors, with PERCEPTIVE ADVISORS LLC as the largest holder at 13.95%.
President and Chief Executive OfficerMaria Palasis
Market Cap$6.5M
Biotechnology
Healthcare
Employees109.0
Websitelyratherapeutics.com
Country
United States of America
Overview
Overview of institutional ownership in LYRA as of Q3 2025 with a market cap of $10.7M
All Institutions
- Institutions
- 25
- Value Held
- $2.9M
- Shares Held
- 448.6K
- Avg Position
- $117.3K
- Median Position
- $2.7K
Hedge Funds
- Hedge Funds
- 3
- Value Held
- $1.8M
- Shares Held
- 270.0K
- Avg Position
- $588.6K
- Median Position
- $139.5K
Ownership Breakdown
Based on market cap of $10.7M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.
Biggest Investors
Institutions with the largest positions in LYRA as of Q3 2025
| Institution | Position Value |
|---|---|
 PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short | $1.5M 0.04% of portfolio |
S SABBY MANAGEMENT, LLC Institution | $832.9K 4.53% of portfolio |
 VANGUARD GROUP INC Institution | $189.5K 0.00% of portfolio |
 Ikarian Capital, LLC Hedge Fund•Event Driven | $139.5K 0.03% of portfolio |
 CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy | $128.4K 0.00% of portfolio |
 GEODE CAPITAL MANAGEMENT LLC ETF Provider | $72.4K 0.00% of portfolio |
 UBS Group AG Institution | $26.1K 0.00% of portfolio |
B BlackRock, Inc. Institution | $11.0K 0.00% of portfolio |
R ROYAL BANK OF CANADA Institution | $8.6K 0.00% of portfolio |
 MORGAN STANLEY RIA/Wealth | $8.3K 0.00% of portfolio |
Net Capital Flow
Institutional buying and selling activity for LYRA in Q3 2025
- Traded
- −$136.6K
- Buyers
- 10
- Sellers
- 17
- Total Bought
- +$170.6K
- Total Sold
- −$307.3K
- Avg Position
- $86.3K
Biggest Buyers
| Institution | Net Bought |
|---|---|
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy | +$128.4K +19.5K shares |
UBS Group AG Institution | +$26.1K +4.0K shares |
S SABBY MANAGEMENT, LLC Institution | +$12.4K +1.9K shares |
R ROYAL BANK OF CANADA Institution | +$1.5K +223.0 shares |
J JONES FINANCIAL COMPANIES LLLP Institution | +$1.3K +200.0 shares |
 Fortitude Family Office, LLC Family Office | +$627.0 +96.0 shares |
A Advisor Group Holdings, Inc. Institution | +$143.0 +22.0 shares |
B BRYN MAWR TRUST CO/PA Institution | +$131.0 +20.0 shares |
 BANK OF AMERICA CORP /DE/ Institution | +$117.0 +-28.5K shares |
 IFP Advisors, Inc RIA/Wealth | +$13.0 +-304.0 shares |
Biggest Sellers
| Institution | Net Sold |
|---|---|
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short | −$168.3K −25.8K shares |
 STATE OF WISCONSIN INVESTMENT BOARD RIA/Wealth | −$94.1K −10.5K shares |
R Russell Investments Group, Ltd. RIA/Wealth | −$14.3K −1.6K shares |
 FMR LLC Institution | −$8.8K −1.3K shares |
T Tower Research Capital LLC Institution | −$6.2K −949.0 shares |
MORGAN STANLEY RIA/Wealth | −$5.8K −887.0 shares |
 VALLEY NATIONAL ADVISERS INC RIA/Wealth | −$4.5K −500.0 shares |
VANGUARD GROUP INC Institution | −$2.8K −424.0 shares |
 JPMORGAN CHASE & CO Institution | −$1.1K −165.0 shares |
 CITIGROUP INC Institution | −$593.1 −90.0 shares |
Entry and Exit Activity
Institutions that initiated new positions or completely exited LYRA in Q3 2025
- New Positions
- 1
- New Value
- $627.0
- Exited Positions
- 8
- Exited Value
- $113.5K
New Positions
| Institution | Position Value |
|---|---|
Fortitude Family Office, LLC Family Office | $627.0 96.0 shares |
Exited Positions
| Institution | Previous Position |
|---|---|
STATE OF WISCONSIN INVESTMENT BOARD RIA/Wealth | $94.1K 10.5K shares |
R Russell Investments Group, Ltd. RIA/Wealth | $14.3K 1.6K shares |
VALLEY NATIONAL ADVISERS INC RIA/Wealth | $4.5K 500.0 shares |
 WELLS FARGO & COMPANY/MN Institution | $349.0 39.0 shares |
 PRINCIPAL SECURITIES, INC. RIA/Wealth | $170.0 19.0 shares |
 NISA INVESTMENT ADVISORS L L C Long Only Manager | $90.0 10.0 shares |
 RAYMOND JAMES FINANCIAL INC RIA/Wealth | $72.0 8.0 shares |
 BARCLAYS PLC Institution | - 48.0 shares |
Options Activity
Institutions with the largest Call and Put options positions in LYRA as of Q3 2025
- Call Positions
- 0
- Call Value
- -
- Put Positions
- 0
- Put Value
- -
Call Positions
| Institution | Position Value |
|---|---|
| No call positions found | |
Put Positions
| Institution | Position Value |
|---|---|
| No put positions found | |
Most Committed Institutions
Institutions with LYRA as the highest % of their portfolio as of Q3 2025
| Institution | Portfolio Weight |
|---|---|
S SABBY MANAGEMENT, LLC Institution | 4.53% $832.9K |
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short | 0.04% $1.5M |
Ikarian Capital, LLC Hedge Fund•Event Driven | 0.03% $139.5K |
0.00% $2.6K | |
Fortitude Family Office, LLC Family Office | 0.00% $627.0 |
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy | 0.00% $128.4K |
T Tower Research Capital LLC Institution | 0.00% $3.5K |
E EverSource Wealth Advisors, LLC RIA/Wealth | 0.00% $2.3K |
S SBI Securities Co., Ltd. Institution | 0.00% $522.0 |
UBS Group AG Institution | 0.00% $26.1K |
Hedge Fund Spotlight
Discover hedge funds investing in LYRA
CITADEL ADVISORS LLC
Hedge Fund • Multi-Strategy
Portfolio ManagerKenneth Cordele Griffin
- Portfolio Value
- $122.08B
- Positions
- 5,531
- Last Reported
- Q3 2025
Sector Allocation
Position in Lyra Therapeutics, Inc.
- Market Value
- $128.4K
- Shares Held
- 19.5K
- Portfolio Weight
- 0.00%
- Owned Since
- 2022-Q3
| Top Holding | Sector | Market Value | Weight |
|---|---|---|---|
Software - Infrastructure Technology | $2.1B | 1.68% | |
Semiconductors Technology | $1.8B | 1.50% | |
Internet Content & Information Communication Services | $1.4B | 1.18% |
