Sana Biotechnology

SANA • NASDAQ

Sana Biotechnology is a biotechnology company in the healthcare sector on NASDAQ, led by Steven D. Harr, M.D., with a market cap of $1.4B. As of Q3 2025, 62% of shares are held by 178 institutional investors, with FMR LLC as the largest holder at 14.55%.

President, Chief Executive Officer, and DirectorSteven D. Harr, M.D.

Market Cap$1.4B

Biotechnology

Healthcare

Employees328.0

Websitesana.com

Country

United States of America

Overview

Overview of institutional ownership in SANA as of Q3 2025 with a market cap of $913.2M

All Institutions

Institutions: 178
Value Held: $567.7M
Shares Held: 159.9M
Avg Position: $3.2M
Median Position: $148.0K

Hedge Funds

Hedge Funds: 19
Value Held: $74.5M
Shares Held: 21.0M
Avg Position: $3.9M
Median Position: $2.2M

Ownership Breakdown

Institutional (non-HF)

54.01%

$493.2M

Hedge Funds

8.16%

$74.5M

Retail & Other

37.84%

$345.5M

Based on market cap of $913.2M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in SANA as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
FMR LLC Institution	-	$132.9M 0.01% of portfolio	14.55% 37.4M shares	Q1 2021 Held for 4y 8m	$1.92T
Flagship Ventures Management, Inc. Institution	Thomas Allen Goldsmith President	$88.8M 30.33% of portfolio	9.72% 25.0M shares	Q1 2021 Held for 4y 8m	$292.6M
B BAILLIE GIFFORD & CO Institution	-	$40.6M 0.03% of portfolio	4.45% 11.4M shares	Q1 2021 Held for 4y 8m	$134.80B
B BlackRock, Inc. Institution	-	$39.9M 0.00% of portfolio	4.36% 11.2M shares	Q1 2021 Held for 4y 8m	$5.67T
C CANADA PENSION PLAN INVESTMENT BOARD Institution	-	$36.1M 0.03% of portfolio	3.96% 10.2M shares	Q1 2021 Held for 4y 8m	$142.43B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$32.4M 0.00% of portfolio	3.55% 9.1M shares	Q1 2021 Held for 4y 8m	$6.69T
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$23.7M 0.00% of portfolio	2.60% 6.7M shares	Q1 2021 Held for 4y 8m	$2.88T
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	Kenneth Cordele Griffin CEO	$23.3M 0.02% of portfolio	2.55% 6.6M shares	Q1 2021 Held for 4y 8m	$122.08B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$12.2M 0.00% of portfolio	1.33% 3.4M shares	Q1 2021 Held for 4y 8m	$1.57T
Alphabet Inc. Institution	Sundar Pichai CEO	$10.0M 0.41% of portfolio	1.09% 2.8M shares	Q1 2021 Held for 4y 8m	$2.4B

Net Capital Flow

Institutional buying and selling activity for SANA in Q3 2025

Traded: +$75.7M
Buyers: 115
Sellers: 51
Total Bought: +$90.0M
Total Sold: −$14.3M
Avg Position: $2.9M

Biggest Buyers

Institution	Net Bought	Current Position
STATE STREET CORP Institution	+$13.6M +3.8M shares	$23.7M 6.7M shares
FMR LLC Institution	+$12.8M +3.6M shares	$132.9M 37.4M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$12.8M +3.6M shares	$23.3M 6.6M shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	+$6.4M +1.8M shares	$7.1M 2.0M shares
VANGUARD GROUP INC Institution	+$5.4M +1.5M shares	$32.4M 9.1M shares
JPMORGAN CHASE & CO Institution	+$4.9M +1.4M shares	$7.6M 2.1M shares
B BAILLIE GIFFORD & CO Institution	+$4.9M +1.4M shares	$40.6M 11.4M shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$2.9M +822.4K shares	$5.8M 1.6M shares
G GREAT POINT PARTNERS LLC Private Equity	+$2.5M +700.0K shares	$2.5M 700.0K shares
Woodline Partners LP Hedge Fund•Long/Short	+$2.1M +597.0K shares	$4.9M 1.4M shares

Biggest Sellers

Institution	Net Sold	Current Position
MORGAN STANLEY RIA/Wealth	−$2.1M −603.3K shares	$3.1M 876.5K shares
Crestline Management, LP Hedge Fund•Multi-Strategy	−$2.1M −600.0K shares	$6.5M 1.8M shares
A ADAGE CAPITAL PARTNERS GP LLC Institution	−$1.9M −702.0K shares	Sold Off 0 shares
C CI Private Wealth, LLC RIA/Wealth	−$1.1M −319.0K shares	$2.9M 817.0K shares
M MANUFACTURERES LIFE INSURANCE CO Institution	−$862.3K −242.9K shares	$168.7K 47.5K shares
T TD ASSET MANAGEMENT INC Institution	−$843.7K −309.0K shares	Sold Off 0 shares
S Skandinaviska Enskilda Banken AB Institution	−$786.8K −289.3K shares	Sold Off 0 shares
DIMENSIONAL FUND ADVISORS LP Long Only Manager	−$769.2K −216.7K shares	$2.8M 778.1K shares
B Brevan Howard Capital Management LP Institution	−$711.8K −260.7K shares	Sold Off 0 shares
AQR CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$619.8K −174.6K shares	$4.2M 1.2M shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited SANA in Q3 2025

New Positions: 23
New Value: $3.8M
Exited Positions: 18
Exited Value: $5.7M

New Positions

Institution	Position Value
G GREAT POINT PARTNERS LLC Private Equity	$2.5M 700.0K shares
O Ovata Capital Management Ltd Institution	$355.0K 100.0K shares
Hilton Capital Management, LLC Long Only Manager	$238.3K 67.1K shares
T TWO SIGMA SECURITIES, LLC Institution	$118.2K 33.3K shares
JUPITER ASSET MANAGEMENT LTD Long Only Manager	$93.8K 26.4K shares
Larson Financial Group LLC RIA/Wealth	$71.0K 20.0K shares
LaSalle St. Investment Advisors, LLC RIA/Wealth	$60.4K 17.0K shares
P Polymer Capital Management LLC Hedge Fund•Multi-Strategy	$49.0K 13.8K shares
Cresset Asset Management, LLC RIA/Wealth	$43.6K 12.3K shares
WJ Financial Advisors LLC RIA/Wealth	$42.6K 12.0K shares

Exited Positions

Institution	Previous Position
A ADAGE CAPITAL PARTNERS GP LLC Institution	$1.9M 702.0K shares
T TD ASSET MANAGEMENT INC Institution	$843.7K 309.0K shares
S Skandinaviska Enskilda Banken AB Institution	$786.8K 289.3K shares
B Brevan Howard Capital Management LP Institution	$711.8K 260.7K shares
TUDOR INVESTMENT CORP ET AL Hedge Fund•Multi-Strategy	$303.9K 111.3K shares
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	$279.7K 102.5K shares
ExodusPoint Capital Management, LP Hedge Fund•Multi-Strategy	$194.9K 71.4K shares
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	$176.3K 64.6K shares
Bristlecone Advisors, LLC RIA/Wealth	$136.5K 50.0K shares
E Erste Asset Management GmbH Institution	$112.4K 40.0K shares

Options Activity

Institutions with the largest Call and Put options positions in SANA as of Q3 2025

Call Positions: 4
Call Value: $680.9K
Put Positions: 4
Put Value: $1.3M

Call Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$362.1K 1.0K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$140.9K 397.0 contracts
W WOLVERINE TRADING, LLC Institution	$112.2K 317.0 contracts
J JANE STREET GROUP, LLC Institution	$65.7K 185.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$466.8K 1.3K contracts
BANK OF AMERICA CORP /DE/ Institution	$401.2K 1.1K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$349.7K 985.0 contracts
W WOLVERINE TRADING, LLC Institution	$35.8K 101.0 contracts

Most Committed Institutions

Institutions with SANA as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
Flagship Ventures Management, Inc. Institution	Thomas Allen Goldsmith President	30.33% $88.8M	9.72% 25.0M shares	Q1 2021 Held for 4y 8m	$292.6M
Crestline Management, LP Hedge Fund•Multi-Strategy	Douglas Kelvin Bratton CEO	11.13% $6.5M	0.71% 1.8M shares	Q2 2021 Held for 4y 5m	$58.1M
Omega Fund Management Inc. Venture Capital	Alexandra Rankel Pearsall CFO	1.35% $3.0M	0.33% 843.8K shares	Q1 2021 Held for 4y 8m	$222.4M
G GREAT POINT PARTNERS LLC Private Equity	Jeffrey Robert Jay Managing Partner	1.10% $2.5M	0.27% 700.0K shares	Q3 2025 Held for 2 months	$226.8M
Integral Health Asset Management, LLC Hedge Fund•Sector	Bhagwan Jay Rao CIO	0.54% $7.1M	0.78% 2.0M shares	Q1 2024 Held for 1y 8m	$1.3B
Alphabet Inc. Institution	Sundar Pichai CEO	0.41% $10.0M	1.09% 2.8M shares	Q1 2021 Held for 4y 8m	$2.4B
C Clearline Capital LP Hedge Fund•Event Driven	Mohit Bhasin CFO	0.16% $1.9M	0.20% 524.5K shares	Q1 2025 Held for 8 months	$1.2B
Palumbo Wealth Management LLC RIA/Wealth	Philip G Palumbo CEO	0.13% $395.1K	0.04% 111.3K shares	Q2 2025 Held for 5 months	$312.6M
O Ovata Capital Management Ltd Institution	-	0.12% $355.0K	0.04% 100.0K shares	Q3 2025 Held for 2 months	$285.4M
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	Scott Lawrence Lessing President	0.07% $7.2M	0.79% 2.0M shares	Q1 2023 Held for 2y 8m	$10.8B

Hedge Fund Spotlight

Discover hedge funds investing in SANA

Woodline Partners LP

Hedge Fund • Long/Short

Portfolio ManagerKarl Heinz Kroeker

Portfolio Value: $21.3B
Positions: 868
Last Reported: Q3 2025

Sector Allocation

Position in Sana Biotechnology

Market Value: $4.9M
Shares Held: 1.4M
Portfolio Weight: 0.02%
Owned Since: 2021-Q1

Top Holding	Sector	Market Value	Weight
1 Microsoft MSFT	Software - Infrastructure Technology	$615.5M	2.90%
2 Nvidia NVDA	Semiconductors Technology	$603.3M	2.84%
3 Apple AAPL	Consumer Electronics Technology	$522.1M	2.46%