Samsara BioCapital, LLC

Venture Capital

Samsara BioCapital, LLC is a Venture Capital led by Miran Nasruddin Ahmad, reporting $1.9B in AUM as of Q3 2025 with 76% Healthcare concentration, 89% concentrated in top 10 holdings, and 31% allocation to MLYS.

CFOMiran Nasruddin Ahmad

Portfolio Value: $765.9M
Positions: 27
Top Holding: MLYS at 31.01%
Last Reported: Q3 2025

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Top Holdings

Largest long holdings in Samsara BioCapital, LLC's portfolio (89.4% of total portfolio)

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Holding	Sector	Position	Weight	Traded	Ownership	Owned Since
1 Mineralys Therapeutics, Inc. MLYS	Biotechnology Healthcare	$237.5M	31.01%	+$22.3M Bought	8.07% 6.3M shares	Q1 2023 Held for 2y 8m
2 Scholar Rock SRRK	Biotechnology Healthcare	$209.0M	27.29%	—	5.84% 5.6M shares	Q1 2022 Held for 3y 8m
3 Kalaris Therapeutics, Inc. Common Stock KLRS	Unknown Unknown	$66.2M	8.64%	—	61.21% 11.4M shares	Q1 2025 Held for 8 months
4 Septerna, Inc. SEPN	Unknown Unknown	$59.2M	7.73%	—	7.06% 3.1M shares	Q4 2024 Held for 11 months
5 Neurogene NGNE	Biotechnology Healthcare	$29.8M	3.89%	—	12.03% 1.7M shares	Q4 2023 Held for 1y 11m
6 Alumis Inc. ALMS	Unknown Unknown	$19.2M	2.50%	—	4.61% 4.8M shares	Q3 2024 Held for 1y 2m
7 Upstream Bio, Inc. UPB	Unknown Unknown	$18.1M	2.36%	-$9.0M Sold	1.78% 962.2K shares	Q4 2024 Held for 11 months
8 Gossamer Bio, Inc. GOSS	Biotechnology Healthcare	$16.1M	2.10%	—	2.68% 6.1M shares	Q3 2023 Held for 2y 2m
9 LENZ Therapeutics, Inc. LENZ	Biotechnology Healthcare	$16.0M	2.09%	—	1.20% 343.0K shares	Q1 2024 Held for 1y 8m
10 Aquestive Therapeutics, Inc. AQST	Drug Manufacturers - Specialty & Generic Healthcare	$14.0M	1.82%	+$14.0M New	2.07% 2.5M shares	Q3 2025 Held for 2 months

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Changes

Portfolio activity, position movements, and quarter-over-quarter changes in Samsara BioCapital, LLC's latest filing

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Market Value

$765.9M

Prior: $488.9M

Q/Q Change

+56.65%

+$277.0M

Net Flows % of MV

-0.817%

Turnover Ratio

6.07%

New Purchases

1 stocks

$14.0M

Added To

2 stocks

+$26.2M

Sold Out Of

4 stocks

$20.5M

Reduced Holdings

9 stocks

-$26.0M

Increased Positions

Position	Shares Δ	Change
1 Aquestive Therapeutics, Inc. AQST	New	0 → 2.5M +$14.0M
2 vTv Therapeutics VTVT	+81.09%	206.8K → 374.5K +$3.9M
3 Mineralys Therapeutics, Inc. MLYS	+10.37%	5.7M → 6.3M +$22.3M

Decreased Positions

Position	Shares Δ	Change
1 CARGO Therapeutics, Inc. CRGX	Sold	4.4M → 0 −$18.2M
2 Tango Therapeutics TNGX	Sold	210.0K → 0 −$1.1M
3 HilleVax, Inc. HLVX	Sold	399.6K → 0 −$795.3K
4 Artiva Biotherapeutics, Inc. ARTV	Sold	291.7K → 0 −$440.4K
5 Aura Biosciences, Inc. AURA	-41.52%	1.0M → 584.8K −$2.6M