Tango Therapeutics

TNGX • NASDAQ

Tango Therapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by Barbara Weber, M.D., with a market cap of $1.3B. As of Q3 2025, 126% of shares are held by 141 institutional investors, with TRV GP IV, LLC as the largest holder at 12.46%.

President, Chief Executive Officer and DirectorBarbara Weber, M.D.

Market Cap$1.3B

Biotechnology

Healthcare

Employees140.0

Websitetangotx.com

Country

United States of America

Overview

Overview of institutional ownership in TNGX as of Q3 2025 with a market cap of $934.6M

All Institutions

Institutions: 141
Value Held: $1.2B
Shares Held: 140.0M
Avg Position: $8.3M
Median Position: $464.5K

Hedge Funds

Hedge Funds: 31
Value Held: $491.4M
Shares Held: 58.5M
Avg Position: $15.9M
Median Position: $2.5M

Ownership Breakdown

Institutional (non-HF)

73.23%

$684.4M

Hedge Funds

52.58%

$491.4M

Retail & Other

Based on market cap of $934.6M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in TNGX as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
T TRV GP IV, LLC Institution	-	$116.5M 42.51% of portfolio	12.46% 13.9M shares	Q3 2021 Held for 4y 2m	$274.0M
FARALLON CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	Edric Calvin Saito Managing Partner	$90.4M 0.51% of portfolio	9.67% 10.8M shares	Q4 2024 Held for 11 months	$17.7B
EcoR1 Capital, LLC Hedge Fund•Sector	Scott Eric Perlen CFO	$89.3M 4.29% of portfolio	9.55% 10.6M shares	Q3 2021 Held for 4y 2m	$2.1B
Boxer Capital Management, LLC Hedge Fund•Long/Short	Aaron Isaac Davis CEO	$82.1M 27.04% of portfolio	8.78% 9.8M shares	Q4 2024 Held for 11 months	$303.5M
TCG Crossover Management, LLC Venture Capital	Chen Ming Yu Managing Partner	$71.7M 3.58% of portfolio	7.67% 8.5M shares	Q4 2024 Held for 11 months	$2.0B
Woodline Partners LP Hedge Fund•Long/Short	Karl Heinz Kroeker CIO	$50.7M 0.24% of portfolio	5.42% 6.0M shares	Q2 2024 Held for 1y 5m	$21.3B
S Siren, L.L.C. Institution	-	$49.4M 2.07% of portfolio	5.29% 5.9M shares	Q3 2024 Held for 1y 2m	$2.4B
B BlackRock, Inc. Institution	-	$47.4M 0.00% of portfolio	5.08% 5.6M shares	Q3 2021 Held for 4y 2m	$5.67T
N Nextech Invest, Ltd. Institution	-	$46.5M 7.08% of portfolio	4.97% 5.5M shares	Q1 2025 Held for 8 months	$657.0M
VANGUARD GROUP INC Institution	Salim Ramji CEO	$42.4M 0.00% of portfolio	4.54% 5.1M shares	Q3 2021 Held for 4y 2m	$6.69T

Net Capital Flow

Institutional buying and selling activity for TNGX in Q3 2025

Traded: +$109.7M
Buyers: 86
Sellers: 44
Total Bought: +$222.9M
Total Sold: −$113.2M
Avg Position: $7.7M

Biggest Buyers

Institution	Net Bought	Current Position
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	+$25.9M +3.1M shares	$25.9M 3.1M shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	+$24.5M +2.9M shares	$24.5M 2.9M shares
S Siren, L.L.C. Institution	+$21.2M +2.5M shares	$49.4M 5.9M shares
HENDERSON GROUP PLC Institution	+$19.3M +2.3M shares	$19.3M 2.3M shares
STATE STREET CORP Institution	+$16.7M +2.0M shares	$28.3M 3.4M shares
FARALLON CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$13.4M +1.6M shares	$90.4M 10.8M shares
Deep Track Capital, LP Hedge Fund•Long/Short	+$12.2M +1.5M shares	$12.2M 1.5M shares
GOLDMAN SACHS GROUP INC Institution	+$11.8M +1.4M shares	$12.7M 1.5M shares
VANGUARD GROUP INC Institution	+$8.6M +1.0M shares	$42.4M 5.1M shares
Logos Global Management LP Hedge Fund•Long/Short	+$8.0M +950.0K shares	$8.0M 950.0K shares

Biggest Sellers

Institution	Net Sold	Current Position
A ADAGE CAPITAL PARTNERS GP LLC Institution	−$28.5M −3.4M shares	$21.1M 2.5M shares
T TRV GP IV, LLC Institution	−$25.2M −3.0M shares	$116.5M 13.9M shares
TCG Crossover Management, LLC Venture Capital	−$18.5M −2.2M shares	$71.7M 8.5M shares
N Nantahala Capital Management, LLC Hedge Fund•Multi-Strategy	−$13.7M −1.6M shares	$15.2M 1.8M shares
B Blue Owl Capital Holdings LP Institution	−$5.8M −695.0K shares	$1.0M 119.4K shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$4.0M −476.9K shares	$10.9M 1.3M shares
Soleus Capital Management, L.P. Hedge Fund•Long/Short	−$3.6M −430.0K shares	$2.5M 300.0K shares
MORGAN STANLEY RIA/Wealth	−$2.4M −282.8K shares	$2.1M 251.8K shares
Marshall Wace LLP Institution	−$2.1M −253.2K shares	$12.5M 1.5M shares
R READYSTATE ASSET MANAGEMENT LP Hedge Fund•Multi-Strategy	−$1.5M −173.4K shares	$2.1M 245.1K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited TNGX in Q3 2025

New Positions: 16
New Value: $45.0M
Exited Positions: 10
Exited Value: $3.7M

New Positions

Institution	Position Value
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	$25.9M 3.1M shares
Deep Track Capital, LP Hedge Fund•Long/Short	$12.2M 1.5M shares
GREAT LAKES ADVISORS, LLC Long Only Manager	$3.6M 423.9K shares
Trexquant Investment LP Hedge Fund•Quant	$1.7M 199.1K shares
Q Quadrature Capital Ltd Institution	$303.3K 36.2K shares
Creative Planning RIA/Wealth	$296.1K 35.2K shares
Harvest Investment Services, LLC RIA/Wealth	$267.5K 31.8K shares
J J. Goldman & Co LP Hedge Fund•Multi-Strategy	$243.9K 29.0K shares
D DRW Securities, LLC Institution	$128.8K 14.8K shares
A AXQ CAPITAL, LP Hedge Fund•Market Neutral	$113.1K 13.5K shares

Exited Positions

Institution	Previous Position
JACOBS LEVY EQUITY MANAGEMENT, INC Hedge Fund•Quant	$1.1M 218.8K shares
Samsara BioCapital, LLC Venture Capital	$1.1M 210.0K shares
ACADIAN ASSET MANAGEMENT LLC Long Only Manager	$419.6K 82.0K shares
Polar Securities Inc. Hedge Fund•Multi-Strategy	$287.2K 56.1K shares
X XTX Topco Ltd Institution	$285.7K 55.8K shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$281.9K 55.1K shares
S SIMPLEX TRADING, LLC Institution	$255.5K 49.9K shares
S Skopos Labs, Inc. RIA/Wealth	$9.0K 6.6K shares
G GROUP ONE TRADING, L.P. Institution	$7.2K 1.4K shares
TWIN PEAKS WEALTH ADVISORS, LLC RIA/Wealth	$7.0 1.0 shares

Options Activity

Institutions with the largest Call and Put options positions in TNGX as of Q3 2025

Call Positions: 4
Call Value: $1.4M
Put Positions: 3
Put Value: $147.8K

Call Positions

Institution	Position Value
J J. Goldman & Co LP Hedge Fund•Multi-Strategy	$907.2K 1.1K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$519.1K 618.0 contracts
DIADEMA PARTNERS LP Hedge Fund•Long/Short	- - contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	- - contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$120.1K 143.0 contracts
B Belvedere Trading LLC Institution	$27.7K 33.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	- - contracts

Most Committed Institutions

Institutions with TNGX as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
T TRV GP IV, LLC Institution	-	42.51% $116.5M	12.46% 13.9M shares	Q3 2021 Held for 4y 2m	$274.0M
Boxer Capital Management, LLC Hedge Fund•Long/Short	Aaron Isaac Davis CEO	27.04% $82.1M	8.78% 9.8M shares	Q4 2024 Held for 11 months	$303.5M
N Nextech Invest, Ltd. Institution	-	7.08% $46.5M	4.97% 5.5M shares	Q1 2025 Held for 8 months	$657.0M
EcoR1 Capital, LLC Hedge Fund•Sector	Scott Eric Perlen CFO	4.29% $89.3M	9.55% 10.6M shares	Q3 2021 Held for 4y 2m	$2.1B
TCG Crossover Management, LLC Venture Capital	Chen Ming Yu Managing Partner	3.58% $71.7M	7.67% 8.5M shares	Q4 2024 Held for 11 months	$2.0B
GILEAD SCIENCES, INC. Institution	Daniel O'Day CEO	2.28% $40.8M	4.36% 4.9M shares	Q4 2024 Held for 11 months	$1.8B
S Siren, L.L.C. Institution	-	2.07% $49.4M	5.29% 5.9M shares	Q3 2024 Held for 1y 2m	$2.4B
B Bain Capital Life Sciences Investors, LLC Institution	-	1.51% $22.8M	2.44% 2.7M shares	Q3 2021 Held for 4y 2m	$1.5B
T TRV GP VI, LLC Institution	-	1.49% $1.6M	0.17% 194.2K shares	Q4 2024 Held for 11 months	$109.6M
N Nantahala Capital Management, LLC Hedge Fund•Multi-Strategy	Daniel J. Mack Managing Partner	0.94% $15.2M	1.63% 1.8M shares	Q4 2024 Held for 11 months	$1.6B

Hedge Fund Spotlight

Discover hedge funds investing in TNGX

Paradigm Biocapital Advisors LP

Hedge Fund • Long/Short

Portfolio ManagerDr. Senai Nmn Asefaw

Portfolio Value: $3.4B
Positions: 33
Last Reported: Q3 2025

Sector Allocation

Position in Tango Therapeutics

Market Value: $25.9M
Shares Held: 3.1M
Portfolio Weight: 0.77%
Owned Since: 2025-Q3

Top Holding	Sector	Market Value	Weight
1 Nuvalent, Inc. NUVL	Biotechnology Healthcare	$455.7M	13.48%
2 Merus N.V. MRUS	Biotechnology Healthcare	$411.8M	12.18%
3 Arcellx, Inc. ACLX	Biotechnology Healthcare	$381.7M	11.29%