Septerna, Inc.
SEPN • XNAS
Septerna, Inc. is a publicly traded company on XNAS, led by Jeffrey Finer, M.D., Ph.D., with a market cap of $1.1B. As of Q3 2025, 100% of shares are held by 82 institutional investors, with RA CAPITAL MANAGEMENT, LLC as the largest holder at 15.69%.
Chief Executive OfficerJeffrey Finer, M.D., Ph.D.
Market Cap$1.1B
Websitesepterna.com
Overview
Overview of institutional ownership in SEPN as of Q3 2025 with a market cap of $838.6M
All Institutions
- Institutions
- 82
- Value Held
- $838.0M
- Shares Held
- 44.5M
- Avg Position
- $10.2M
- Median Position
- $463.1K
Hedge Funds
- Hedge Funds
- 19
- Value Held
- $297.4M
- Shares Held
- 15.8M
- Avg Position
- $15.7M
- Median Position
- $1.7M
Ownership Breakdown
Based on market cap of $838.6M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.
Biggest Investors
Institutions with the largest positions in SEPN as of Q3 2025
| Institution | Position Value |
|---|---|
 RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short | $131.6M 1.63% of portfolio |
T TRV GP V, LLC Institution | $116.9M 33.07% of portfolio |
 DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven | $92.5M 0.66% of portfolio |
T TRV GP VI, LLC Institution | $79.2M 72.26% of portfolio |
B BVF INC/IL Institution | $75.5M 3.06% of portfolio |
 Samsara BioCapital, LLC Venture Capital | $59.2M 7.73% of portfolio |
S Siren, L.L.C. Institution | $41.4M 1.74% of portfolio |
 VANGUARD GROUP INC Institution | $28.6M 0.00% of portfolio |
B BlackRock, Inc. Institution | $27.5M 0.00% of portfolio |
 GOLDMAN SACHS GROUP INC Institution | $27.4M 0.00% of portfolio |
Net Capital Flow
Institutional buying and selling activity for SEPN in Q3 2025
- Traded
- +$6.6M
- Buyers
- 42
- Sellers
- 32
- Total Bought
- +$36.1M
- Total Sold
- −$29.6M
- Avg Position
- $8.6M
Biggest Buyers
| Institution | Net Bought |
|---|---|
 MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy | +$6.2M +332.3K shares |
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short | +$6.2M +329.3K shares |
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven | +$4.5M +239.5K shares |
 Invesco Ltd. ETF Provider | +$3.1M +165.2K shares |
VANGUARD GROUP INC Institution | +$2.0M +104.4K shares |
 venBio Select Advisor LLC RIA/Wealth | +$1.9M +100.0K shares |
 Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy | +$1.5M +80.3K shares |
 VR Adviser, LLC Venture Capital | +$1.3M +70.4K shares |
B BlackRock, Inc. Institution | +$1.3M +69.0K shares |
 GEODE CAPITAL MANAGEMENT LLC ETF Provider | +$1.1M +57.7K shares |
Biggest Sellers
| Institution | Net Sold |
|---|---|
 Sio Capital Management, LLC Hedge Fund•Long/Short | −$7.4M −395.2K shares |
B BVF INC/IL Institution | −$7.2M −380.3K shares |
 Checkpoint Capital L.P. Hedge Fund•Sector | −$5.7M −303.3K shares |
 SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity | −$1.8M −166.5K shares |
 Deep Track Capital, LP Hedge Fund•Long/Short | −$1.3M −121.7K shares |
 Soleus Capital Management, L.P. Hedge Fund•Long/Short | −$1.1M −57.2K shares |
 BANK OF AMERICA CORP /DE/ Institution | −$897.6K −47.7K shares |
N Nuveen, LLC Institution | −$639.7K −34.0K shares |
 MORGAN STANLEY RIA/Wealth | −$571.9K −30.4K shares |
 Logos Global Management LP Hedge Fund•Long/Short | −$482.6K −25.7K shares |
Entry and Exit Activity
Institutions that initiated new positions or completely exited SEPN in Q3 2025
- New Positions
- 7
- New Value
- $2.7M
- Exited Positions
- 16
- Exited Value
- $5.1M
New Positions
| Institution | Position Value |
|---|---|
L Longaeva Partners L.P. Institution | $1.1M 57.1K shares |
 JACOBS LEVY EQUITY MANAGEMENT, INC Hedge Fund•Quant | $673.0K 35.8K shares |
A AMERICAN CENTURY COMPANIES INC Institution | $475.6K 25.3K shares |
 TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy | $389.4K 20.7K shares |
R Russell Investments Group, Ltd. RIA/Wealth | $35.7K 1.9K shares |
V Versant Capital Management, Inc RIA/Wealth | $4.9K 261.0 shares |
 SRS Capital Advisors, Inc. RIA/Wealth | $1.2K 63.0 shares |
Exited Positions
| Institution | Previous Position |
|---|---|
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity | $1.8M 166.5K shares |
Deep Track Capital, LP Hedge Fund•Long/Short | $1.3M 121.7K shares |
 UBS GLOBAL ASSET MANAGEMENT AMERICAS INC Long Only Manager | $303.4K 28.7K shares |
 BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds | $255.2K 24.1K shares |
 GSA CAPITAL PARTNERS LLP Hedge Fund•Quant | $248.7K 23.5K shares |
S SIMPLEX TRADING, LLC Institution | $248.7K 23.5K shares |
X XTX Topco Ltd Institution | $236.0K 22.3K shares |
 CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy | $187.9K 17.8K shares |
 TUDOR INVESTMENT CORP ET AL Hedge Fund•Multi-Strategy | $177.2K 16.8K shares |
 INTECH INVESTMENT MANAGEMENT LLC Long Only Manager | $129.0K 12.2K shares |
Options Activity
Institutions with the largest Call and Put options positions in SEPN as of Q3 2025
- Call Positions
- 2
- Call Value
- $1.6M
- Put Positions
- 3
- Put Value
- $12.8M
Call Positions
| Institution | Position Value |
|---|---|
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity | $1.4M 726.0 contracts |
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy | $282.2K 150.0 contracts |
Put Positions
| Institution | Position Value |
|---|---|
J JANE STREET GROUP, LLC Institution | $6.6M 3.5K contracts |
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity | $6.0M 3.2K contracts |
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy | $188.1K 100.0 contracts |
Most Committed Institutions
Institutions with SEPN as the highest % of their portfolio as of Q3 2025
| Institution | Portfolio Weight |
|---|---|
T TRV GP VI, LLC Institution | 72.26% $79.2M |
T TRV GP V, LLC Institution | 33.07% $116.9M |
Samsara BioCapital, LLC Venture Capital | 7.73% $59.2M |
B BVF INC/IL Institution | 3.06% $75.5M |
Checkpoint Capital L.P. Hedge Fund•Sector | 2.84% $5.3M |
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short | 2.23% $22.1M |
S Siren, L.L.C. Institution | 1.74% $41.4M |
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short | 1.63% $131.6M |
R Rangeley Capital, LLC Hedge Fund•Event Driven | 1.57% $1.7M |
 Catalio Capital Management, LP Venture Capital | 1.02% $5.5M |
Hedge Fund Spotlight
Discover hedge funds investing in SEPN
Logos Global Management LP
Hedge Fund • Long/Short
Portfolio ManagerGraham Gordon Walmsley
- Portfolio Value
- $987.5M
- Positions
- 51
- Last Reported
- Q3 2025
Sector Allocation
Position in Septerna, Inc.
- Market Value
- $1.6M
- Shares Held
- 83.5K
- Portfolio Weight
- 0.16%
- Owned Since
- 2024-Q4
| Top Holding | Sector | Market Value | Weight |
|---|---|---|---|
Biotechnology Healthcare | $81.7M | 8.28% | |
Biotechnology Healthcare | $61.2M | 6.20% | |
Biotechnology Healthcare | $57.0M | 5.77% |
