Arrowhead Research
ARWR • NASDAQ
Arrowhead Research is a biotechnology company in the healthcare sector on NASDAQ, led by Christopher Anzalone, with a market cap of $9.5B. As of Q3 2025, 80% of shares are held by 299 institutional investors, with BlackRock, Inc. as the largest holder at 14.63%.
CEO of Arrowhead Research CorporationChristopher Anzalone
Market Cap$9.5B
Biotechnology
Healthcare
Employees525.0
Websitearrowheadpharma.com
Country
United States of America
Overview
Overview of institutional ownership in ARWR as of Q3 2025 with a market cap of $4.8B
All Institutions
- Institutions
- 299
- Value Held
- $3.8B
- Shares Held
- 111.1M
- Avg Position
- $12.8M
- Median Position
- $685.5K
Hedge Funds
- Hedge Funds
- 39
- Value Held
- $567.8M
- Shares Held
- 16.5M
- Avg Position
- $14.6M
- Median Position
- $2.8M
Ownership Breakdown
Based on market cap of $4.8B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.
Biggest Investors
Institutions with the largest positions in ARWR as of Q3 2025
| Institution | Position Value |
|---|---|
B BlackRock, Inc. Institution | $697.6M 0.01% of portfolio |
 VANGUARD GROUP INC Institution | $553.1M 0.01% of portfolio |
 venBio Select Advisor LLC RIA/Wealth | $375.9M 4.86% of portfolio |
 STATE STREET CORP Institution | $220.6M 0.01% of portfolio |
 FMR LLC Institution | $198.7M 0.01% of portfolio |
 Slate Path Capital LP Hedge Fund•Long/Short | $171.8M 2.52% of portfolio |
 GEODE CAPITAL MANAGEMENT LLC ETF Provider | $108.0M 0.01% of portfolio |
S Siren, L.L.C. Institution | $92.1M 3.86% of portfolio |
 DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven | $72.4M 0.52% of portfolio |
 ARROWSTREET CAPITAL LIMITED PARTNERSHIP Hedge Fund•Quant | $71.8M 0.05% of portfolio |
Net Capital Flow
Institutional buying and selling activity for ARWR in Q3 2025
- Traded
- +$328.5M
- Buyers
- 172
- Sellers
- 115
- Total Bought
- +$549.0M
- Total Sold
- −$220.5M
- Avg Position
- $11.3M
Biggest Buyers
| Institution | Net Bought |
|---|---|
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven | +$72.4M +2.1M shares |
ARROWSTREET CAPITAL LIMITED PARTNERSHIP Hedge Fund•Quant | +$69.6M +2.0M shares |
 DEERFIELD MANAGEMENT CO /NY Hedge Fund•Long/Short | +$34.2M +993.0K shares |
 HENDERSON GROUP PLC Institution | +$31.8M +923.7K shares |
B BlackRock, Inc. Institution | +$27.6M +799.9K shares |
 BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy | +$27.3M +793.0K shares |
B BAKER BROS. ADVISORS LP Hedge Fund•Sector | +$25.2M +731.6K shares |
F Fisher Asset Management, LLC Institution | +$20.8M +602.1K shares |
FMR LLC Institution | +$20.3M +589.5K shares |
VANGUARD GROUP INC Institution | +$17.6M +510.8K shares |
Biggest Sellers
| Institution | Net Sold |
|---|---|
 UBS GLOBAL ASSET MANAGEMENT AMERICAS INC Long Only Manager | −$31.9M −924.8K shares |
 Marshall Wace LLP Institution | −$24.8M −719.2K shares |
 UBS Group AG Institution | −$23.5M −682.4K shares |
S Standard Life Aberdeen plc Institution | −$15.2M −439.6K shares |
T T. Rowe Price Investment Management, Inc. Insurance Manager | −$13.0M −822.3K shares |
R ROYAL BANK OF CANADA Institution | −$12.4M −359.5K shares |
 GOLDMAN SACHS GROUP INC Institution | −$11.8M −341.4K shares |
 Invesco Ltd. ETF Provider | −$9.0M −259.8K shares |
Slate Path Capital LP Hedge Fund•Long/Short | −$8.6M −250.0K shares |
 Trexquant Investment LP Hedge Fund•Quant | −$8.0M −503.7K shares |
Entry and Exit Activity
Institutions that initiated new positions or completely exited ARWR in Q3 2025
- New Positions
- 19
- New Value
- $12.7M
- Exited Positions
- 40
- Exited Value
- $38.6M
New Positions
| Institution | Position Value |
|---|---|
L Longaeva Partners L.P. Institution | $4.3M 125.7K shares |
 Polygon Management Ltd. Hedge Fund•Multi-Strategy | $2.8M 81.8K shares |
 HBK Sorce Advisory LLC Hedge Fund•Multi-Strategy | $2.8M 76.4K shares |
 Cresset Asset Management, LLC RIA/Wealth | $501.9K 14.6K shares |
I IvyRock Asset Management Ltd Hedge Fund•Multi-Strategy | $362.1K 10.5K shares |
E Entropy Technologies, LP Hedge Fund•Quant Macro | $361.2K 10.5K shares |
 Summit Global Investments Long Only Manager | $342.6K 9.9K shares |
 M&T BANK CORP Institution | $311.3K 9.0K shares |
 Quantinno Capital Management LP Hedge Fund•Market Neutral | $302.5K 8.8K shares |
V Velan Capital Investment Management LP Institution | $224.2K 6.5K shares |
Exited Positions
| Institution | Previous Position |
|---|---|
T T. Rowe Price Investment Management, Inc. Insurance Manager | $13.0M 822.3K shares |
Trexquant Investment LP Hedge Fund•Quant | $8.0M 503.7K shares |
N Neo Ivy Capital Management Hedge Fund•Quant | $2.2M 138.1K shares |
 TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy | $2.1M 133.4K shares |
 KORNITZER CAPITAL MANAGEMENT INC /KS Long Only Manager | $2.0M 126.5K shares |
M Man Group plc Institution | $1.9M 118.8K shares |
O ONTARIO TEACHERS PENSION PLAN BOARD Institution | $1.5M 97.3K shares |
 Engineers Gate Manager LP Hedge Fund•Quant | $1.2M 74.4K shares |
S SIMPLEX TRADING, LLC Institution | $905.5K 57.3K shares |
Q Qube Research & Technologies Ltd Institution | $737.2K 46.7K shares |
Options Activity
Institutions with the largest Call and Put options positions in ARWR as of Q3 2025
- Call Positions
- 12
- Call Value
- $32.7M
- Put Positions
- 10
- Put Value
- $9.0M
Call Positions
| Institution | Position Value |
|---|---|
 SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity | $18.4M 5.3K contracts |
 CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy | $4.3M 1.3K contracts |
J JANE STREET GROUP, LLC Institution | $3.3M 947.0 contracts |
P PEAK6 LLC Institution | $2.7M 771.0 contracts |
GOLDMAN SACHS GROUP INC Institution | $1.7M 497.0 contracts |
W WOLVERINE TRADING, LLC Institution | $1.3M 386.0 contracts |
 Walleye Trading LLC RIA/Wealth | $544.9K 158.0 contracts |
 Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy | $469.1K 136.0 contracts |
R Raiffeisen Bank International AG Institution | $17.2K 5.0 contracts |
 BANK OF AMERICA CORP /DE/ Institution | - - contracts |
Put Positions
| Institution | Position Value |
|---|---|
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity | $5.5M 1.6K contracts |
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy | $2.2M 650.0 contracts |
J JANE STREET GROUP, LLC Institution | $793.3K 230.0 contracts |
W WOLVERINE TRADING, LLC Institution | $347.9K 103.0 contracts |
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy | $89.7K 26.0 contracts |
 Caption Management, LLC Hedge Fund•Long/Short | - - contracts |
 CAPITAL FUND MANAGEMENT S.A. Hedge Fund•Quant Macro | - - contracts |
Walleye Trading LLC RIA/Wealth | - - contracts |
D D. E. Shaw & Co., Inc. Institution | - - contracts |
N NOMURA HOLDINGS INC Institution | - - contracts |
Most Committed Institutions
Institutions with ARWR as the highest % of their portfolio as of Q3 2025
| Institution | Portfolio Weight |
|---|---|
W Western Financial Corp/CA Institution | 12.31% $28.3M |
venBio Select Advisor LLC RIA/Wealth | 4.86% $375.9M |
S Siren, L.L.C. Institution | 3.86% $92.1M |
 M28 Capital Management LP Hedge Fund•Long/Short | 3.42% $2.3M |
P Privium Fund Management B.V. Institution | 2.94% $16.3M |
Slate Path Capital LP Hedge Fund•Long/Short | 2.52% $171.8M |
 Exome Asset Management LLC Hedge Fund•Sector | 2.43% $3.6M |
 WEALTH EFFECTS LLC RIA/Wealth | 1.87% $5.8M |
 JOHNSON & JOHNSON Institution | 1.70% $8.5M |
L Longaeva Partners L.P. Institution | 0.93% $4.3M |
Hedge Fund Spotlight
Discover hedge funds investing in ARWR
ISAM Funds Ltd
Hedge Fund • Quant
Portfolio ManagerRoy Sher
- Portfolio Value
- $489.3M
- Positions
- 601
- Last Reported
- Q3 2025
Sector Allocation
Position in Arrowhead Research
- Market Value
- $28.8K
- Shares Held
- 834.0
- Portfolio Weight
- 0.01%
- Owned Since
- 2025-Q3
| Top Holding | Sector | Market Value | Weight |
|---|---|---|---|
Drug Manufacturers - General Healthcare | $4.9M | 1.00% | |
Insurance - Property & Casualty Financial Services | $4.9M | 1.00% | |
Drug Manufacturers - General Healthcare | $4.9M | 0.99% |
